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公开(公告)号：US20190175221A1
公开(公告)日：2019-06-13
申请号：US16275926
申请日：2019-02-14
Applicant: Cook Medical Technologies LLC
Inventor： Fionán Keady , John Neilan , James Butler , Shay Joseph Lavelle
Abstract: A single-wire stylet may be constructed as an elongate single-wire, memory-metal alloy body with a generally cylindrical body profile, extending distally from a proximal end terminus, where embodiments include a polymeric distal tip member fixedly attached directly at a distal end of the single-wire body. At least one lengthwise portion of the single-wire body is at least partially in martensitic phase at operating temperatures at and below about 37° C. Where present, the polymeric distal tip member has a generally cylindrical body profile circumferentially bounded by an outer circumference substantially equal to or greater than that of the metal body. The polymeric distal tip member may be overmolded upon a distal-end tip length of an elongate single-wire, memory-metal alloy stylet body, where the distal end and/or discrete intermediate distal-portion length(s) that include martensitic-phase alloy and any polymeric member have greater flexibility than a proximal-most length of the alloy stylet body.
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公开(公告)号：US20130284326A1
公开(公告)日：2013-10-31
申请号：US13863760
申请日：2013-04-16
Applicant: University of Limerick , Cook Medical Technologies LLC
Inventor： Syed A.M. Tofail , James M. Carlson , Abbasi A. Gandhi , James Butler , Peter Tiernan , Lisa O'Donoghue
IPC: C22F1/10
Abstract: A nickel-titanium-rare earth (Ni—Ti-RE) alloy comprises nickel at a concentration of from about 35 at. % to about 65 at. %, a rare earth element at a concentration of from about 1.5 at. % to about 15 at. %, boron at a concentration of up to about 0.1 at. %, with the balance of the alloy being titanium. In addition to enhanced radiopacity compared to binary Ni—Ti alloys and improved workability, the Ni—Ti-RE alloy preferably exhibits superelastic behavior. A method of processing a Ni—Ti-RE alloy includes providing a nickel-titanium-rare earth alloy comprising nickel at a concentration of from about 35 at. % to about 65 at. %, a rare earth element at a concentration of from about 1.5 at. % to about 15 at. %, the balance being titanium; heating the alloy in a homogenization temperature range below a critical temperature; and forming spheroids of a rare earth-rich second phase in the alloy while in the homogenization temperature range.
Abstract translation: 镍 - 钛 - 稀土（Ni-Ti-RE）合金包含浓度为约35at％的镍。 ％至约65英寸 ％，浓度为约1.5at。的稀土元素。 ％至约15英寸 ％，硼浓度高达约0.1at。 ％，合金的余量为钛。 除了与二元Ni-Ti合金相比增强的不透射线性和改进的可加工性之外，Ni-Ti-RE合金优选表现出超弹性行为。 一种加工Ni-Ti-RE合金的方法包括提供镍 - 稀土合金，其包含浓度为约35at％的镍。 ％至约65英寸 ％，浓度为约1.5at。的稀土元素。 ％至约15英寸 ％，余量为钛; 在低于临界温度的均质化温度范围内加热合金; 并且在均质化温度范围内在合金中形成稀土富二烯的球体。
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公开(公告)号：US12115288B2
公开(公告)日：2024-10-15
申请号：US16510352
申请日：2019-07-12
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
CPC classification number: A61L31/08 , A61F2/90 , A61L27/54 , A61L31/16 , A61F2250/0067 , A61L27/28 , A61L2300/416 , A61L2420/02
Abstract: A medical device such as a stent (10) or medical balloon (40) is at least partially coated with a saturated carboxylic acid layer in order to enhance biocompatibility, reduce thrombogenesis and increase endothelialisation. The coating is preferably of citric acid in non-crosslinked form and preferably non-porous so as to mask the underlying structure of the medical device. The acid coating forms an outer surface of at least a part of the medical device, that is has no other layer or material overlying it, save for in some embodiments a partial coating of a bioactive material.
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公开(公告)号：US11846016B2
公开(公告)日：2023-12-19
申请号：US17543054
申请日：2021-12-06
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
IPC: A61F2/82 , A61L31/02 , C23C16/02 , A61L31/08 , A61L31/16 , A61L27/30 , A61L27/06 , A61L27/54 , C23C16/40 , C23C16/50 , H01J37/32
CPC classification number: C23C16/0227 , A61F2/82 , A61L27/06 , A61L27/306 , A61L27/54 , A61L31/022 , A61L31/088 , A61L31/16 , C23C16/40 , C23C16/50 , H01J37/32449 , H01J37/32513 , A61F2210/0014 , A61F2210/0076 , A61F2240/001 , A61F2250/0067 , A61L2300/416 , A61L2400/18 , A61L2420/02 , H01J2237/335 , H01J2237/3321
Abstract: A method of modifying a surface of a medical device for implantation or disposition inside a patient is described. The medical device comprises a structure having at least one surface. The method includes the steps of: placing the medical device into a plasma chamber substantially free from contaminants and substantially sealing the plasma chamber from the atmosphere; removing at least an outermost layer of any oxide layer from the at least one surface of the structure by a plasma oxide-removal process, whilst maintaining the plasma chamber under seal from the atmosphere; and subsequently forming a new oxide layer at the least one surface of the structure by introducing at least one gas into the plasma chamber, whilst maintaining the plasma chamber under seal from the atmosphere. A medical device including a bulk material and an oxide layer disposed over at least one surface of the medical device. The oxide layer is substantially pure and free from contaminants.
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公开(公告)号：US10327927B2
公开(公告)日：2019-06-25
申请号：US14852895
申请日：2015-09-14
Applicant: Cook Medical Technologies LLC
Inventor： Olivia Ryan , James Butler , Joe Hayes , Sean Cummins
Abstract: A vascular intervention device delivery system includes a catheter with a proximal end attached to a handle, and a distal carrier segment for mounting a vascular intervention device thereon. A retractable sheath is movable from a first position covering the distal carrier segment to a second position retracted proximally uncovering the distal carrier segment. A pull is attached to the retractable sheath and extends proximally from the retractable sheath toward the handle. A majority of the length of the pull has a cross sectional shape with a concave side that faces the longitudinal axis and is opposite to a convex side that faces away from the longitudinal axis. The cross sectional shape has a width that is greater than a thickness.
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Patent Agency Ranking
公开(公告)号：US10105247B2
公开(公告)日：2018-10-23
申请号：US14825631
申请日：2015-08-13
Applicant: Cook Medical Technologies LLC
Inventor： Sean Cummins , Darach McGrath , Olivia Ryan , James Butler , Joe Hayes
Abstract: A vascular intervention device delivery system, such as for implanting a self expanding stent, includes a thumbwheel rotatably mounted in a handle. A catheter has a proximal end attached to the handle and a distal carrier segment for mounting a stent thereon. A retractable sheath is movable to a position retracted proximally to uncover the distal carrier segment. A pull with a curved cross section extends between the thumbwheel and the retractable sheath. An idler wheel with a perimeter notch is rotatably mounted in the handle proximal to the thumbwheel. A pin is movably in the handle between a first position received in the perimeter notch to block rotation of the idler wheel, and a second position outside of the perimeter notch to permit rotation of the idler wheel. The pull wraps around the idler wheel to return in a direction for being wound onto a spool of the thumbwheel.
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公开(公告)号：US20180236143A1
公开(公告)日：2018-08-23
申请号：US15899436
申请日：2018-02-20
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
CPC classification number: A61L31/084 , A61F2/90 , A61F2/915 , A61L27/04 , A61L27/303 , A61L27/54 , A61L31/022 , A61L31/16 , A61L2300/416 , A61L2400/18 , A61L2420/02 , B05D3/12
Abstract: There is disclosed a method of improving the reliability of coating an implantable medical device, such as a stent, with bioactive material in the absence of a carrier material such as a matrix or polymer layer. The method involves cleaning volatile components from the exposed surfaces of the medical device, removing carbon deposits and then applying a uniform carbon layer in a controlled environment. The deliberately applied carbon layer masks impurities of the underlying native oxide layer and leads to more uniform bioactive material coating not only a over the surfaces of a single medical device but also from device to device within a batch and between batches of devices. This improves production as well as optimising the amount and release of drug on the medical device without the need for a carrier material.
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公开(公告)号：US20160074188A1
公开(公告)日：2016-03-17
申请号：US14852895
申请日：2015-09-14
Applicant: Cook Medical Technologies LLC
Inventor： Olivia Ryan , James Butler , Joe Hayes , Sean Cummins
IPC: A61F2/962
CPC classification number: A61F2/95 , A61B2017/00407 , A61F2/844 , A61F2/962 , A61F2/966 , A61F2002/9517 , A61F2230/0069
Abstract: A vascular intervention device delivery system includes a catheter with a proximal end attached to a handle, and a distal carrier segment for mounting a vascular intervention device thereon. A retractable sheath is movable from a first position covering the distal carrier segment to a second position retracted proximally uncovering the distal carrier segment. A pull is attached to the retractable sheath and extends proximally from the retractable sheath toward the handle. A majority of the length of the pull has a cross sectional shape with a concave side that faces the longitudinal axis and is opposite to a convex side that faces away from the longitudinal axis. The cross sectional shape has a width that is greater than a thickness.
Abstract translation: 血管干预装置递送系统包括具有附接到手柄的近端的导管和用于在其上安装血管介入装置的远端载体片段。 可伸缩护套可以从覆盖远侧托架段的第一位置移动到靠近近侧露出远侧托架段的第二位置。 拉伸附接到可伸缩护套并且从可伸缩护套向手柄向近侧延伸。 拉伸的长度的大部分具有横截面形状，其具有面向纵向轴线的凹面并且与背向纵向轴线的凸面相对。 横截面形状的宽度大于厚度。
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公开(公告)号：US20230302263A1
公开(公告)日：2023-09-28
申请号：US18159970
申请日：2023-01-26
Applicant: Cook Medical Technologies LLC
Inventor： John Savage , Thomas Mindel , Michael Sayers , Joe Dervan , James Butler , Eugene Folan , Alec Cerchiari , Aaron Reid
IPC: A61M25/10
CPC classification number: A61M25/1029 , A61M2025/1081
Abstract: A medical device assembly including a catheter having a proximal end, a distal end, and a lumen therethrough. A medical device is disposed about a distal portion of the catheter. A removable loading tool and protector is disposed about the catheter and the medical device, and includes a body having a generally tubular configuration and having a proximal end, a distal end, an intermediate region disposed between the proximal end and the distal end, and a lumen disposed therethrough; and a proximal region having a length and extending from the proximal end of the body, the proximal region having at least one slit positioned adjacent to the proximal end of the body. The proximal region has a first inner diameter and the intermediate region has a second inner diameter, the first inner diameter of the proximal region being greater than the second inner diameter of the intermediate region.
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公开(公告)号：US10980923B2
公开(公告)日：2021-04-20
申请号：US15932323
申请日：2018-02-16
Applicant: Cook Medical Technologies LLC
Inventor： John Neilan , David Murray , James Butler
Abstract: There are disclosed implantable medical devices and apparatus for treating implantable medical devices during production, so as to cause the implantable medical devices to have abluminal surfaces and luminal surfaces with different functional characteristics and in particular surface energies. The luminal surfaces of the medical device are preferably coated with carbon, so as to have a low surface energy, which reduces the risk of thrombi forming when implanted into a patient's vessels. The abluminal surfaces are treated so as to have a high surface energy, such that a therapeutic, preferably bioactive, material, such as a drug, can adhere to the abluminal surfaces and preferably without any need for a containment layer such as polymer or other matrix material. Once the therapeutic material has been delivered into the tissue wall, the stent can remain within the patient's vessel without leaving any delivery artefacts, as occurs with some prior art drug eluting medical devices.
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