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公开(公告)号：US11103345B2
公开(公告)日：2021-08-31
申请号：US16262188
申请日：2019-01-30
Applicant: Edwards Lifesciences Corporation
Inventor： Tamir S. Levi , Ron Sharoni , Elena Sherman , Oren H. Wintner , Kevin D. Rupp , Son V. Nguyen , Ajay Chadha , Jeff Lindstrom
Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. The prosthetic valve can comprise an annular frame, leaflets, an inner skirt, and an outer skirt. The outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack that buckles outward radially when the valve is in the expanded configuration and which lies flat when the valve is in the collapsed configuration. In some embodiments, the outer skirt is stiffer in the axial direction of the valve than in the circumferential direction of the valve. In additional embodiments, the outer skirt comprises a self-expandable fabric comprising fibers made of a shape memory material having a shape memory set to enhance the radially outward buckling of the outer skirt. Methods of crimping such valves to a collapsed or partially collapsed configuration are also disclosed.
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公开(公告)号：US20200100895A1
公开(公告)日：2020-04-02
申请号：US16697065
申请日：2019-11-26
Applicant: Edwards Lifesciences Corporation
Inventor： Tamir S. Levi , Son V. Nguyen , Netanel Benichou , David Maimon , Ziv Yohanan , Nikolay Gurovich , Bella Felsen , Larisa Dadonkina , Ron Sharoni , Elena Sherman
IPC: A61F2/24
Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.
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公开(公告)号：US10537423B2
公开(公告)日：2020-01-21
申请号：US15194375
申请日：2016-06-27
Applicant: Edwards Lifesciences Corporation
Inventor： Tamir S. Levi , Son V. Nguyen , Netanel Benichou , David Maimon , Ziv Yohanan , Nikolay Gurovich , Bella Felsen , Larisa Dadonkina , Ron Sharoni , Elena Sherman
IPC: A61F2/24
Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.
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公开(公告)号：US10433959B2
公开(公告)日：2019-10-08
申请号：US16202701
申请日：2018-11-28
Applicant: Edwards Lifesciences Corporation
Inventor： Tamir S. Levi , Son V. Nguyen , Netanel Benichou , David Maimon , Ziv Yohanan , Nikolay Gurovich , Bella Felsen , Larisa Dadonkina , Ron Sharoni , Elena Sherman
IPC: A61F2/24
Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.
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公开(公告)号：US20160317305A1
公开(公告)日：2016-11-03
申请号：US15140387
申请日：2016-04-27
Applicant: Edwards Lifesciences Corporation
Inventor： Itai Pelled , Elena Sherman , Eran Goldberg , Kevin D. Rupp , Noam Nir
CPC classification number: B29C66/53245 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2433 , A61F2210/0076 , A61F2230/0069 , A61F2240/001 , A61F2250/0069
Abstract: The present disclosure relates to laminated sealing members for prosthetic valves and methods of making the same. In a representative embodiment, an implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration comprises an annular frame having an inflow end and an outflow end, a leaflet structure positioned within the frame and secured thereto, and a laminate sealing member comprising an encapsulating material. The laminate sealing member has a main portion that encapsulates at least a portion of the frame and an end portion extending from the inflow end of the frame, and the end portion of the laminate sealing member is folded to form a cuff adjacent the inflow end of the frame and secured to the main portion of the laminate sealing member.
Abstract translation: 本公开涉及用于人造瓣的层压密封构件及其制造方法。 在代表性的实施例中，可径向可折叠到收缩构造并且可径向扩张到扩张构造的可植入假体瓣包括具有流入端和流出端的环形框架，定位在框架内并固定到其上的小叶结构， 层压密封件包括封装材料。 层叠密封构件具有封闭框架的至少一部分的主要部分和从框架的流入端延伸的端部，并且层叠密封构件的端部折叠形成邻近流入端的套筒 框架并固定到层压密封件的主要部分。
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Patent Agency Ranking
公开(公告)号：US09168131B2
公开(公告)日：2015-10-27
申请号：US13708598
申请日：2012-12-07
Applicant: Edwards Lifesciences Corporation
Inventor： Ziv Yohanan , Tamir S. Levi , Netanel Benichou , Michael Bukin , Nik Gurovich , Elena Sherman
IPC: A61F2/24
CPC classification number: A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2433 , A61F2220/0075 , A61F2230/0013 , A61F2230/0054 , A61F2250/0036 , A61F2250/0039
Abstract: A prosthetic heart valve according to the present disclosure comprises a radially collapsible and expandable annular frame and a leaflet structure comprising a plurality of leaflets mounted within the frame. The frame in particular embodiments can have commissure attachment portions that are configured to support the commissures of the leaflets at locations spaced radially inwardly toward the longitudinal flow axis of the prosthetic valve relative to the frame portions circumscribing the moveable portions of the leaflets. When the leaflets open under pressure of blood flowing through the prosthetic valve, the moveable portions of the leaflets are retained at positions spaced inwardly from the inner surface of the frame to protect against abrasion of the leaflets.
Abstract translation: 根据本公开的假体心脏瓣膜包括径向可折叠和可扩张的环形框架和包括安装在框架内的多个传单的小叶结构。 在特定实施例中的框架可以具有接合连接部分，其被构造成在相对于限定传单的可移动部分的框架部分的支撑下，支撑传播叶片在与假肢瓣膜的纵向流动轴线径向向内间隔的位置处的连接。 当小叶在血液流过人工瓣膜的压力下打开时，小叶的可移动部分被保持在与框架的内表面向内间隔开的位置处，以防止小叶的磨损。
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公开(公告)号：US12295832B2
公开(公告)日：2025-05-13
申请号：US17486361
申请日：2021-09-27
Applicant: Edwards Lifesciences Corporation
Inventor： Ziv Yohanan , Tamir S. Levi , Netanel Benichou , Michael Bukin , Nikolai Gurovich , Elena Sherman
IPC: A61F2/24
Abstract: A method of implanting a prosthetic heart valve within a patient can comprise inserting a distal end portion of a delivery apparatus and a prosthetic heart valve into the patient and advancing the prosthetic heart valve to a deployment location within the heart of the patient and inflating one or more of a plurality of differently-sized balloons in a balloon-assembly on the distal end portion of the delivery apparatus. The prosthetic heart valve can be mounted on the balloon assembly in a crimped state and the inflating of the one or more of the plurality of differently-sized balloons can expand the prosthetic heart valve from the crimped state to a radially expanded state having a non-cylindrical shape.
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公开(公告)号：US12102528B2
公开(公告)日：2024-10-01
申请号：US17460079
申请日：2021-08-27
Applicant: Edwards Lifesciences Corporation
Inventor： Tamir S. Levi , Ron Sharoni , Elena Sherman , Oren H. Wintner , Kevin D. Rupp , Son V. Nguyen , Ajay Chadha , Jeff Lindstrom
CPC classification number: A61F2/2418 , A61F2/2412 , A61F2/2427 , A61F2/9522 , A61F2220/0025 , A61F2220/0075 , A61F2230/0019 , A61F2230/0054 , A61F2250/0018 , A61F2250/0039 , A61F2250/0069 , Y10T29/49927
Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve and method for crimping the prosthetic heart valve are disclosed. A method of radially compressing a prosthetic valve can include partially inserting the valve while in a radially expanded configuration into a crimping device comprising crimper jaws, wherein a portion of the valve comprising an outer skirt extends outside of the crimper jaws. The method can further include crimping the valve to a first partially collapsed configuration, further inserting the valve into the crimping device, such that the outer skirt is between the crimper jaws, and crimping the valve to a second partially collapsed configuration, wherein a diameter of the valve is smaller in the second partially collapsed configuration than in the first partially collapsed configuration.
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19.发明公开公开(公告)号：US20240285398A1
公开(公告)日：2024-08-29
申请号：US18656929
申请日：2024-05-07
Applicant: EDWARDS LIFESCIENCES CORPORATION
Inventor： Tamir S. Levi , Elena Sherman , Shir Lazovski , Ziv Yohanan , Nikolai Gurovich , Bich Hoang Pham
IPC: A61F2/24
CPC classification number: A61F2/2415 , A61F2/2418 , A61F2220/0075
Abstract: A prosthetic heart valve including a plurality of leaflets attached to the frame is disclosed. The plurality of leaflets is disposed within the frame and configured to regulate the flow of blood through the frame in one direction, each leaflet comprising a cusp edge portion. The prosthetic heart valve can further include at least one suture extending along a cusp edge portion of at least a first leaflet of the plurality of leaflets, a plurality of in-and-out stitches extending through the suture and the cusp edge portion of the first leaflet, and a plurality of whip stitches that extend around selected struts of the frame and the suture to couple the cusp edge portion of the first leaflet to the frame.
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公开(公告)号：US12048623B2
公开(公告)日：2024-07-30
申请号：US17492408
申请日：2021-10-01
Applicant: Edwards Lifesciences Corporation
Inventor： Nikolay Gurovich , Michael Bukin , Alexey Tsypenyuk , Elena Sherman , Dikla Kersh , Boaz Manash , Liron Tayeb , Ziv Yohanan , Alexander Barash , Yair A. Neumann , Tomer Saar
IPC: A61F2/24
CPC classification number: A61F2/2418 , A61F2220/0033 , A61F2220/0075 , A61F2220/0091 , A61F2230/0069
Abstract: A prosthetic valve has an annular frame including a plurality of strut members that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. A leaflet structure is situated at least partially within the frame. The leaflet structure includes a plurality of leaflets, each leaflet having opposing commissure tab portions on opposite sides of the leaflet. Each commissure tab portion is paired with an adjacent commissure tab portion of an adjacent leaflet to form a commissure. The commissure tab portions of each leaflet are folded to form a plurality of layers positioned on the inside of the frame. A reinforcement member is positioned between the layers of each commissure tab portion.
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