公开(公告)号：US10470876B2

公开(公告)日：2019-11-12

申请号：US15345857

申请日：2016-11-08

Applicant: Edwards Lifesciences Corporation

Inventor： Nikolay Gurovich ,  Mohammad Jafari ,  Liron Tayeb ,  Ilan Tamir ,  Ziv Yohanan ,  Noam Nir ,  David Maimon ,  Boaz Manash

IPC: A61F2/24

Abstract: Embodiments of prosthetic valves for implantation within a native mitral valve are provided. A prosthetic valve may comprise a radially compressible main body and a one-way valve portion. The prosthetic valve may further comprise one or more ventricular anchors coupled to the main body and disposed outside of the main body. The ventricular anchors may be configured such that a reduced profile of the prosthetic valve is possible. A space may be provided between an outer surface of the main body and the ventricular anchors for receiving native mitral valve leaflets. The prosthetic valve may include an atrial sealing member adapted for placement above the annulus of the mitral valve. Methods and devices for receiving the native mitral valve leaflets between the ventricular anchors and the main body are described.

公开(公告)号：US20180303613A1

公开(公告)日：2018-10-25

申请号：US15956031

申请日：2018-04-18

Applicant: Edwards Lifesciences Corporation

Inventor： David Maimon ,  Noam Nir ,  Tomer Saar

IPC: A61F2/24

CPC classification number: A61F2/2454 ,  A61F2/243

Abstract: A method for improving leaflet prolapse and/or valve regurgitation associated with a heart valve involves delivering a spacer device into a ventricle of a heart using a delivery system comprising a catheter, fixing the spacer device to a wall of the ventricle, expanding the spacer device to reposition a papillary muscle disposed in the ventricle away from the wall, the papillary muscle being connected to a leaflet of an atrioventricular heart valve via chordae tendineae, and releasing the spacer device from the catheter.

公开(公告)号：US20170231761A1

公开(公告)日：2017-08-17

申请号：US15425029

申请日：2017-02-06

Applicant: Edwards Lifesciences Corporation

Inventor： Hanoch Cohen-Tzemach ,  Tamir S. Levi ,  Noam Nir ,  Bella Felsen

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2210/0014 ,  A61F2220/0075 ,  A61F2230/0017 ,  A61F2230/0026 ,  A61F2230/0069 ,  A61F2250/0069 ,  A61F2250/0098

Abstract: Embodiments of a prosthetic heart valve are disclosed. An implantable prosthetic valve may be radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. The prosthetic valve may comprise an annular frame, a leaflet structure positioned within the frame and a plurality of outer skirts positioned around an outer surface of the frame, each outer skirt comprising an inflow edge secured to the frame and an outflow edge secured at intervals to the frame. The plurality of outer skirts may include a first outer skirt and a second outer skirt, wherein in the expanded configuration the first and second outer skirts include openings unsecured to the frame between the intervals. The inflow edge of the first annular outer skirt may be secured to the frame with sutures including radiopaque material. The first annular outer skirt may include radiopaque dye.

公开(公告)号：US12295833B2

公开(公告)日：2025-05-13

申请号：US17496670

申请日：2021-10-07

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Elena Sherman ,  Noam Nir

IPC: A61F2/24

Abstract: A method of assembling a prosthetic heart valve comprises securing a suture loop having at least first and second windings to an outflow edge portion of an inner skirt. The first and second windings are arranged in a repeating pattern of figure-eight shape curves and each winding has a plurality of first sections attached to the outflow edge portion of the inner skirt and a plurality of second sections unattached to the inner skirt. The inner skirt is placed inside of an annular frame and the second sections of the first and second windings are placed over apices of an outflow end of the frame such that the second sections of the first and second windings reside outside of the frame. The second sections of the windings are inserted inwardly through openings in the frame and attached to selected locations on the inner skirt.

公开(公告)号：US20240423793A1

公开(公告)日：2024-12-26

申请号：US18827555

申请日：2024-09-06

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Dikla Kersh ,  Michael Bukin ,  Tamir S. Levi ,  Noam Nir

IPC: A61F2/24

Abstract: A prosthetic valve assembly includes a radially expandable and compressible annular frame. The frame includes a plurality of interconnected struts, which include a plurality of inner struts and a plurality of outer struts. The inner struts overlap adjacent outer struts at a plurality of pivot joints. Radial expansion or compression of the annular frame causes the inner struts to pivot relative to the outer struts at the pivot joints. The assembly also includes a valvular structure having a plurality of leaflets, each leaflet having a cusp edge portion. The assembly further includes one or more leaflet-supporting cords, each having a plurality of anchoring portions and a plurality of suspended portions, each suspended portion extending between two adjacent anchoring portions. The anchoring portions are affixed to respective anchoring features of the frame adjacent the pivot joints. The cusp edge portions of the leaflets are connected to the suspended portions.

公开(公告)号：US20240285400A1

公开(公告)日：2024-08-29

申请号：US18656741

申请日：2024-05-07

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Eran Grosu ,  Nikolai Gurovich ,  Michael Bukin ,  Anatoly Dvorsky ,  Noam Nir ,  Joseph Mordechai Leichner ,  Ziv Yohanan

IPC: A61F2/24 ,  A61F2/00

CPC classification number: A61F2/2418 ,  A61F2/243 ,  A61F2002/0081 ,  A61F2230/0017 ,  A61F2250/001

Abstract: Examples of prosthetic heart valves and frames for use in prosthetic heart valve are disclosed herein. The prosthetic heart valves comprise frames that are movable between a radially compressed configuration and a radially-expanded configuration and comprise a row of inlet cells, a row of outlet cells, and a row of intermediate cells. The frames of the prosthetic heart valves include actuation members and locking mechanisms configured to secure the frame in one or more radially-expanded configurations. In some examples, the actuation members and locking members are integrally formed with the frame. The frames of the prosthetic heart valves can be coupled to one or more shafts of a delivery apparatus via a threaded connection or a non-threaded connection.

公开(公告)号：US20240261090A1

公开(公告)日：2024-08-08

申请号：US18596062

申请日：2024-03-05

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Ilan Tamir ,  Arie Tylis ,  Ofir Witzman ,  Noam Nir ,  Michal Aliza Ruchelsman ,  Giolnara Pinhas ,  Sirous Darabian ,  Travis Zenyo Oba

IPC: A61F2/24 ,  A61L27/04 ,  A61L27/36

CPC classification number: A61F2/2409 ,  A61F2/2418 ,  A61L27/04 ,  A61L27/3625 ,  A61F2/2412 ,  A61F2/2436 ,  A61F2220/0008 ,  A61F2220/0075 ,  A61F2230/0093 ,  A61F2250/0018 ,  A61F2250/0039 ,  A61F2250/0063 ,  A61L2430/20

Abstract: A replacement valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an internal valve frame and an external sealing frame. The valve frame supports the flexible leaflets. The sealing frame is adapted to conform to the shape of the native heart valve annulus. The sealing frame may be coupled to an inlet end of the valve frame, an outlet end of the valve frame, or both. A plurality of anchors is coupled to the outlet end of the valve frame. The anchors extend radially outwardly for placement behind native leaflets. The prosthesis preferably includes a skirt disposed along an exterior of the external sealing frame. The prosthesis is collapsible for delivery into the heart via a delivery catheter. The prosthesis is configured to self-expand for deployment in the heart when released from the delivery catheter.

公开(公告)号：US20240173123A1

公开(公告)日：2024-05-30

申请号：US18433626

申请日：2024-02-06

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Noam Nir ,  Elena Sherman ,  Tamir S. Levi ,  Michael Bukin

IPC: A61F2/24 ,  B29C65/00 ,  B29C65/62 ,  B29L31/00

CPC classification number: A61F2/2415 ,  A61F2/2418 ,  B29C65/62 ,  B29C66/1142 ,  A61F2220/0075 ,  A61F2240/001 ,  B29L2031/7534

Abstract: Assembly methods for installing a leaflet assembly to an expandable frame of a prosthetic heart valve are described. The leaflet assembly comprises a plurality of leaflets coupled together at adjacent tabs, which form respective commissure tab assemblies. The commissure tab assemblies are inserted into corresponding windows of support members of the expandable frame. One or more wedge members are inserted into the commissure tab assembly, e.g., between the adjacent tabs or with the adjacent tabs therebetween, to restrain radial motion of the commissure tab assembly with respect to the window. The window can be a closed window, and the wedge member insertion can be after the commissure tab assembly is inserted into the window. Alternatively, the window can be an open window or channel, and the wedge member insertion can be before the commissure tab assembly is installed in the window.

公开(公告)号：US20240164898A1

公开(公告)日：2024-05-23

申请号：US18430453

申请日：2024-02-01

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Noam Nir ,  Michael Bukin ,  Eran Goldberg

IPC: A61F2/24 ,  A61B17/00

CPC classification number: A61F2/243 ,  A61B17/00234 ,  A61B2017/00243 ,  A61B2017/0046 ,  A61F2220/0025

Abstract: A prosthetic heart valve includes an annular frame that is movable between a radially expanded state and a radially compressed state. The prosthetic heart valve includes one or more compliant actuators coupled to the annular frame. Each compliant actuator is configured to produce radial expansion of the annular frame and retain the annular frame in the radially expanded state. The prosthetic heart valve can be coupled to a handle of a delivery apparatus for delivery to an implantation site.

公开(公告)号：US20240074851A1

公开(公告)日：2024-03-07

申请号：US18235720

申请日：2023-08-18

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Noam Nir ,  Michael Bukin ,  Boaz Manash

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2415 ,  A61F2/243 ,  A61F2/2436 ,  A61F2/9517 ,  A61F2220/0033 ,  A61F2220/0075 ,  A61F2220/0091

Abstract: In one embodiment, a prosthetic valve assembly includes an annular frame being radially expandable and compressible between a radially compressed configuration and a radially expanded configuration, a valvular structure comprising a plurality of leaflets mounted inside the annular frame, a plurality of posts mounted on an interior surface of the annular frame, and a pair of commissure attachment members extending outwardly from each post and away from each other. Each two adjacent leaflets can form a pair of commissure tabs. Each pair of commissure tabs can be attached to a corresponding pair of the commissure attachment members.