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    SYSTEMS APPROACH TO DISEASE STATE AND HEALTH ASSESSMENT
    15.
    发明申请
    SYSTEMS APPROACH TO DISEASE STATE AND HEALTH ASSESSMENT 审中-公开
    疾病状态和健康评估系统方法

    公开(公告)号：US20150119658A1

    公开(公告)日：2015-04-30

    申请号：US14581662

    申请日：2014-12-23

    申请人： Flint Hills Scientific, L.L.C.

    发明人： Ivan Osorio

    IPC分类号： A61B5/00 ,  A61B5/16 ,  A61B5/0488 ,  A61B5/11 ,  G06F19/00 ,  A61B5/0205

    CPC分类号： A61B5/4842 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/0488 ,  A61B5/0531 ,  A61B5/08 ,  A61B5/11 ,  A61B5/16 ,  A61B5/4035 ,  A61B5/4094 ,  A61B5/42 ,  A61B5/7246 ,  A61B5/7275 ,  A61B5/7282 ,  A61B5/746 ,  G06F19/00 ,  G06F19/3418 ,  G16H50/20 ,  G16H50/30 ,  G16H50/70

    摘要： Methods, systems, and apparatus for assessing a state of an epilepsy disease or a comorbidity thereof are provided. The methods comprise receiving at least one autonomic index, neurologic index, stress marker index, psychiatric index, endocrine index, adverse effect of therapy index, physical fitness index, or quality of life index of a patient; comparing the at least one index to at least one reference value; and assessing a state of an epilepsy disease or a body system of the patient based on the comparison. A computer readable program storage device encoded with instructions that, when executed by a computer, perform the method described above is also provided. A medical device system capable of implementing the method described above is also provided.

    摘要翻译： 提供了用于评估癫痫病状态或其共病的方法，系统和装置。 所述方法包括接受患者的至少一个自主指数，神经学指标，应激标志物指数，精神指数，内分泌指数，治疗指数的不良影响，身体健康指数或生活质量指数。 将所述至少一个索引与至少一个参考值进行比较; 并且基于比较来评估患者的癫痫病或身体系统的状态。 一种计算机可读程序存储装置，其编码有指令，当由计算机执行时执行上述方法。 还提供了能够实现上述方法的医疗装置系统。

    Systems approach to comorbidity assessment
    16.
    发明授权
    Systems approach to comorbidity assessment 有权
    系统方法进行合并症评估

    公开(公告)号：US08951189B2

    公开(公告)日：2015-02-10

    申请号：US14183342

    申请日：2014-02-18

    申请人： Flint Hills Scientific, L.L.C.

    发明人： Ivan Osorio

    IPC分类号： G06F19/00 ,  A61B5/00 ,  A61B5/01 ,  A61B5/0205 ,  A61B5/16 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/11

    CPC分类号： A61B5/7275 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/11 ,  A61B5/16 ,  A61B5/165 ,  A61B5/4035 ,  A61B5/4094 ,  A61B5/417 ,  A61B5/42 ,  A61B5/4842 ,  A61B5/4866 ,  A61B5/4884 ,  A61B5/746 ,  G16H15/00 ,  G16H50/20 ,  G16H50/30

    摘要： Methods, systems, and apparatus for assessing a state of a comorbidity associated with a primary disease are provided. The methods comprise receiving at least one autonomic index, neurologic index, stress marker index, psychiatric index, endocrine index, adverse effect of therapy index, physical fitness index, or quality of life index of a patient; comparing the at least one index to at least one reference value; and assessing a state of a body system of the patient that is a site of the comorbidity, based on the comparison. A computer readable program storage device encoded with instructions that, when executed by a computer, perform the method described above is also provided. A medical device system capable of implementing the method described above is also provided.

    摘要翻译： 提供了用于评估与原发性疾病相关的共病状态的方法，系统和装置。 所述方法包括接受患者的至少一个自主指数，神经学指标，应激标志物指数，精神指数，内分泌指数，治疗指数的不良影响，身体健康指数或生活质量指数。 将所述至少一个索引与至少一个参考值进行比较; 并且基于比较来评估作为合并症的部位的患者的身体系统的状态。 一种计算机可读程序存储装置，其编码有指令，当由计算机执行时执行上述方法。 还提供了能够实现上述方法的医疗装置系统。

    PROGRAMMABLE AUTOTITRATING OF ELECTRICAL PARAMETERS OF IMPLANTABLE MEDICAL DEVICE
    17.
    发明申请
    PROGRAMMABLE AUTOTITRATING OF ELECTRICAL PARAMETERS OF IMPLANTABLE MEDICAL DEVICE 审中-公开
    可植入医疗器械的电气参数可编程自动化

    公开(公告)号：US20140277256A1

    公开(公告)日：2014-09-18

    申请号：US14203394

    申请日：2014-03-10

    申请人： Flint Hills Scientific, L.L.C.

    发明人： Ivan Osorio

    IPC分类号： A61N1/36 ,  A61N1/372

    CPC分类号： A61N1/36146 ,  A61N1/36053 ,  A61N1/36064 ,  A61N1/36139 ,  A61N1/37235 ,  A61N1/37247

    摘要： We report a method of automatically titrating an electrical therapy administered to a patient by an implanted medical device to a target dosage, comprising programming the medical device with a programmed electrical therapy comprising a first target value for a first therapy parameter; programming at least one titration parameter for automatically adjusting the first therapy parameter from a first value to the first target value over a titration time period initiating the electrical therapy, wherein the first therapy parameter comprises said first value; and automatically titrating the electrical therapy by making a plurality of adjustments to the value of the first therapy parameter, whereby the first electrical therapy parameter is changed from the first value to the first target value according to a titration function. We also report a medical device system configured to implement the method.

    摘要翻译： 我们报告一种自动滴定通过植入的医疗装置给予患者的电疗法达到目标剂量的方法，包括用包括第一治疗参数的第一目标值的编程电疗法编程医疗装置; 编程至少一个滴定参数，用于在启动所述电疗法的滴定时间段内自动将所述第一治疗参数从第一值调整到所述第一目标值，其中所述第一治疗参数包括所述第一值; 并通过对第一治疗参数的值进行多次调整来自动滴定电疗法，由此根据滴定功能将第一电疗参数从第一值改变为第一目标值。 我们还报告配置为实施该方法的医疗设备系统。

    Epileptic seizure prevention or treatment via heart rate clamping
    19.
    发明授权
    Epileptic seizure prevention or treatment via heart rate clamping 有权

    公开(公告)号：US11524111B2

    公开(公告)日：2022-12-13

    申请号：US16447045

    申请日：2019-06-20

    申请人： FLINT HILLS SCIENTIFIC, L.L.C.

    发明人： Ivan Osorio

    IPC分类号： A61M5/172 ,  A61N1/36 ,  A61F7/12 ,  A61B17/132 ,  A61F7/00 ,  A61F7/10 ,  A61F7/02

    摘要： We report a method of treating an epileptic seizure in a patient, comprising: detecting said epileptic seizure, based on body data from said patient; and reducing a flow of blood to a brain of said patient in response to said detected seizure; wherein said reducing is effected by: increasing the parasympathetic input to said patient's heart, such as by electrically stimulating a parasympathetic nervous structure, applying cooling energy to a sympathetic nervous structure, or administering a cholinergic or a sympatho-blocking agent to said patient. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

    Programmable autotitrating of electrical parameters of implantable medical device
    20.
    发明授权
    Programmable autotitrating of electrical parameters of implantable medical device 有权

    公开(公告)号：US11305121B2

    公开(公告)日：2022-04-19

    申请号：US14203394

    申请日：2014-03-10

    申请人： Flint Hills Scientific, L.L.C.

    发明人： Ivan Osorio

    IPC分类号： A61N1/36 ,  A61N1/372

    摘要： We report a method of automatically titrating an electrical therapy administered to a patient by an implanted medical device to a target dosage, comprising programming the medical device with a programmed electrical therapy comprising a first target value for a first therapy parameter; programming at least one titration parameter for automatically adjusting the first therapy parameter from a first value to the first target value over a titration time period initiating the electrical therapy, wherein the first therapy parameter comprises said first value; and automatically titrating the electrical therapy by making a plurality of adjustments to the value of the first therapy parameter, whereby the first electrical therapy parameter is changed from the first value to the first target value according to a titration function. We also report a medical device system configured to implement the method.