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1.发明公开公开(公告)号：US20240341670A1
公开(公告)日：2024-10-17
申请号：US18752120
申请日：2024-06-24
发明人： Ivan Osorio
CPC分类号： A61B5/4094 , A61B5/316 , A61B5/346 , A61B5/372 , A61B5/1117
摘要： We report a method comprising receiving a first indication to gather a first biological signal or feature thereof from a patient; gathering the first biological signal or feature thereof; receiving a second indication to stop gathering the first biological signal or feature thereof, wherein the second indication relates to a detection of an end of a brain state change; and stopping gathering the first biological signal or feature thereof. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.
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公开(公告)号：US11272874B2
公开(公告)日：2022-03-15
申请号：US16729689
申请日：2019-12-30
发明人： Ivan Osorio
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/08 , A61B5/11 , A61B5/113 , A61B5/318 , A61B5/021 , A61N1/36 , A61B5/026 , A61B5/0245 , A61N1/365 , A61B5/024 , A61B5/0531 , A61B7/04 , A61B8/08 , A61B5/389
摘要： Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.
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公开(公告)号：US10682515B2
公开(公告)日：2020-06-16
申请号：US15437155
申请日：2017-02-20
发明人： Ivan Osorio
摘要： Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.
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公开(公告)号：US20170150916A1
公开(公告)日：2017-06-01
申请号：US15387417
申请日：2016-12-21
发明人： Ivan Osorio
IPC分类号： A61B5/00 , A61N1/36 , A61B5/0205
CPC分类号： A61B5/4094 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02405 , A61B5/0245 , A61B5/026 , A61B5/0402 , A61B5/0488 , A61B5/0531 , A61B5/0816 , A61B5/1117 , A61B5/113 , A61B5/4266 , A61B5/686 , A61B5/7264 , A61B5/746 , A61B7/04 , A61B8/0883 , A61B2562/0219 , A61N1/36064 , A61N1/36135 , A61N1/36139 , A61N1/36585
摘要： A method, comprising receiving at least one of a signal relating to a first cardiac activity and a signal relating to a first body movement from a patient; triggering at least one of a test of the patient's responsiveness, awareness, a second cardiac activity, a second body movement, a spectral analysis test of the second cardiac activity, and a spectral analysis test of the second body movement, based on at least one of the signal relating to the first cardiac activity and the signal relating to the first body movement; determining an occurrence of an epileptic event based at least in part on said one or more triggered tests; and performing a further action in response to said determination of said occurrence of said epileptic event. Further methods allow classification of epileptic events. Apparatus and systems capable of implementing the method.
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5.发明申请公开(公告)号：US20170143273A1
公开(公告)日：2017-05-25
申请号：US15377922
申请日：2016-12-13
发明人： Ivan Osorio , Alexey Lyubushin , Didier Sornette
IPC分类号： A61B5/00 , A61B5/0205
CPC分类号： A61B5/02055 , A61B5/0205 , A61B5/024 , A61B5/04001 , A61B5/0476 , A61B5/048 , A61B5/0816 , A61B5/0833 , A61B5/1118 , A61B5/14542 , A61B5/16 , A61B5/165 , A61B5/4094 , A61B5/4836 , A61B5/726 , A61B5/746
摘要： Methods for detecting a seizure, by use of a wavelet transform maximum modulus (WTMM) algorithm applied to body data. A non-transitive, computer-readable storage device for storing data that when executed by a processor, perform such a method.
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公开(公告)号：US09579457B2
公开(公告)日：2017-02-28
申请号：US13836974
申请日：2013-03-15
发明人： Ivan Osorio
CPC分类号： A61M5/1723 , A61B3/11 , A61B5/0205 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/087 , A61B5/1118 , A61B5/14552 , A61B5/165 , A61B5/42 , A61B5/4803 , A61B5/4827 , A61B5/483 , A61B5/486 , A61M5/14244 , A61M5/14276 , A61M2005/1405 , A61M2205/332 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/50 , A61M2205/8206 , A61M2230/005 , A61M2230/04 , A61M2230/06 , A61M2230/08 , A61M2230/30 , A61M2230/40 , A61M2230/42 , A61M2230/50 , A61M2230/62 , A61M2230/63 , A61N1/025 , A61N1/08 , A61N1/36021 , A61N5/0625 , A61N2005/067 , G06F19/00 , G06F19/3456 , G16H10/60 , G16H50/30
摘要： We disclose methods and medical device systems for automated delivery of therapies for pain and determination of need for and safety of treatment. In one embodiment, such a medical device system may comprise a sensor configured to sense at least one body signal from a patient; and a medical device configured to receive a first sensed body signal from the sensor; determine a patient pain index based at least in part on said first sensed body signal; determine whether said patient pain index is above at least a first pain index threshold; determine a safety index based at least in part on a second sensed body signal; select a pain treatment regimen based on at least one of said safety index and or a determination that said pain index is above said first pain index threshold; and deliver said pain treatment regimen.
摘要翻译： 我们公开了用于自动化递送治疗疼痛和确定治疗需要和安全性的方法和医疗设备系统。 在一个实施例中，这样的医疗设备系统可以包括被配置为感测来自患者的至少一个身体信号的传感器; 以及被配置为从所述传感器接收第一检测到的身体信号的医疗装置; 至少部分地基于所述第一感测身体信号确定患者疼痛指数; 确定所述患者疼痛指数是否高于至少第一疼痛指数阈值; 至少部分地基于第二感测身体信号确定安全指数; 基于所述安全性指标和/或所述疼痛指数高于所述第一疼痛指数阈值的确定来选择疼痛治疗方案; 并提供所述疼痛治疗方案。
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公开(公告)号：US20170035368A1
公开(公告)日：2017-02-09
申请号：US15333802
申请日：2016-10-25
发明人： Ivan Osorio
IPC分类号： A61B5/00 , A61N1/365 , A61N1/36 , G06F19/00 , A61F7/00 , A61B5/16 , A61B5/0452 , A61N1/39 , A61M5/172
CPC分类号： A61B5/746 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02455 , A61B5/0452 , A61B5/0826 , A61B5/1118 , A61B5/162 , A61B5/4094 , A61B5/4836 , A61B5/4839 , A61B5/7275 , A61F7/00 , A61M5/1723 , A61M2230/06 , A61M2230/20 , A61M2230/201 , A61M2230/208 , A61M2230/30 , A61M2230/42 , A61M2230/63 , A61N1/36064 , A61N1/36139 , A61N1/36142 , A61N1/36514 , A61N1/36585 , A61N1/37247 , A61N1/37258 , A61N1/3987 , G06F19/00 , G16H50/30
摘要： A method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy is provided. The method includes receiving cardiac data and determining a cardiac index based upon the cardiac data. The method includes determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. Also presented is a second method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy comprising receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively. The second method includes determining an increased risk of death related to epilepsy if indices are extreme values, issuing a warning of the increased risk of death and logging information related to the increased risk of death. A computer readable program storage device is also provided. Also provided is a method for receiving body data, determining a cardiac, an arousal, a responsiveness, or a kinetic index, determining an increased or increasing risk of death over a first time window relating to a patient with epilepsy and issuing a warning and logging relevant information.
摘要翻译： 提供了一种用于确定和响应于与癫痫患者相关的死亡风险增加的实时方法。 该方法包括接收心脏数据并基于心脏数据确定心脏指数。 该方法包括确定如果指数极端，与癫痫相关的死亡风险增加，发出与死亡风险增加有关的死亡风险增加和记录信息的警告。 还提出了用于确定和响应于与癫痫患者相关的死亡风险增加的第二种方法，其包括接收觉醒数据，响应性数据或感知数据中的至少一个，并且确定觉醒指数，响应指数或 意识指数，其中指数分别基于觉醒数据，响应性数据或意识数据。 第二种方法包括确定与癫痫相关的死亡风险增加，如果指标是极端值，发出与死亡风险增加有关的死亡风险增加警报。 还提供了一种计算机可读程序存储装置。 还提供了一种用于接收身体数据，确定心脏，唤醒，反应性或动力学指标的方法，在与癫痫患者相关的第一时间窗口中确定增加或增加的死亡风险并发出警告和记录 相关信息。
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公开(公告)号：US09504390B2
公开(公告)日：2016-11-29
申请号：US14026998
申请日：2013-09-13
发明人： Ivan Osorio
IPC分类号： A61B5/02 , A61B5/0205 , A61B5/08 , A61B5/021 , A61B5/0245 , A61B5/00 , A61B5/11 , A61N1/39 , A61N1/36 , A61N1/365 , A61B5/0452 , A61B5/16 , G06F19/00 , A61N1/372
CPC分类号： A61B5/746 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02455 , A61B5/0452 , A61B5/0826 , A61B5/1118 , A61B5/162 , A61B5/4094 , A61B5/4836 , A61B5/4839 , A61B5/7275 , A61F7/00 , A61M5/1723 , A61M2230/06 , A61M2230/20 , A61M2230/201 , A61M2230/208 , A61M2230/30 , A61M2230/42 , A61M2230/63 , A61N1/36064 , A61N1/36139 , A61N1/36142 , A61N1/36514 , A61N1/36585 , A61N1/37247 , A61N1/37258 , A61N1/3987 , G06F19/00 , G16H50/30
摘要： A method includes receiving cardiac data and determining a cardiac index based upon the cardiac data; determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. A second method comprises receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively; determining an increased risk of death related to epilepsy if indices are extreme values, issuing a warning of the increased risk of death and logging information related to the increased risk of death. A non-transitory computer readable program storage device encoded with instructions that, when executed by a computer, perform a method is also provided.
摘要翻译： 一种方法包括接收心脏数据并基于心脏数据确定心脏指数; 如果指数极端，确定与癫痫相关的死亡风险增加，发出与死亡风险增加有关的死亡风险增加和记录信息的警告。 第二种方法包括分别接收唤醒数据，响应性数据或感知数据中的至少一个，并且分别确定指数基于唤醒数据，响应性数据或意识数据的唤醒指数，响应度指数或意识指数; 如果指标是极端值，则确定与癫痫相关的死亡风险增加，发出与死亡风险增加有关的死亡风险增加和记录信息的警告。 一种非暂时性的计算机可读程序存储装置，其被编码为在由计算机执行时执行方法的指令。
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公开(公告)号：US20160128580A9
公开(公告)日：2016-05-12
申请号：US14026998
申请日：2013-09-13
发明人： Ivan Osorio
IPC分类号： A61B5/0205 , A61B5/021 , A61B5/0245 , A61B5/00 , G06F19/00 , A61N1/39 , A61N1/36 , A61N1/365 , A61B5/0452 , A61B5/16 , A61B5/08 , A61B5/11
CPC分类号： A61B5/746 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02455 , A61B5/0452 , A61B5/0826 , A61B5/1118 , A61B5/162 , A61B5/4094 , A61B5/4836 , A61B5/4839 , A61B5/7275 , A61F7/00 , A61M5/1723 , A61M2230/06 , A61M2230/20 , A61M2230/201 , A61M2230/208 , A61M2230/30 , A61M2230/42 , A61M2230/63 , A61N1/36064 , A61N1/36139 , A61N1/36142 , A61N1/36514 , A61N1/36585 , A61N1/37247 , A61N1/37258 , A61N1/3987 , G06F19/00 , G16H50/30
摘要： A method includes receiving cardiac data and determining a cardiac index based upon the cardiac data; determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. A second method comprises receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively; determining an increased risk of death related to epilepsy if indices are extreme values, issuing a warning of the increased risk of death and logging information related to the increased risk of death. A non-transitory computer readable program storage device encoded with instructions that, when executed by a computer, perform a method is also provided.
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10.发明授权公开(公告)号：US09265433B2
公开(公告)日：2016-02-23
申请号：US14658007
申请日：2015-03-13
发明人： Ivan Osorio , Mark G. Frei
IPC分类号： A61B5/04 , A61B5/024 , A61B5/0452 , A61B5/00 , A61B5/0468 , A61B5/0456 , A61N1/36
CPC分类号： A61B5/4094 , A61B5/02405 , A61B5/0245 , A61B5/04012 , A61B5/04014 , A61B5/0452 , A61B5/04525 , A61B5/0456 , A61B5/0468 , A61B5/7246 , A61B5/7275 , A61N1/36053 , A61N1/36064
摘要： Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
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