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11.发明授权N8 -and c8 -linked purine based and structurally related heterocycles as universal nucleosides used oligonucleotides hybridization 有权N8-和c8连接的基于嘌呤和结构相关的杂环作为通用核苷使用寡核苷酸杂交公开(公告)号：US07063945B2
公开(公告)日：2006-06-20
申请号：US10221306
申请日：2001-03-27
摘要： The present invention is directed to a nucleic acid binding compound comprising N8- or C8-linked purine bases or structurally related heterocycles, a compound useful for the preparation of such compound, a binding product of this nucleic acid binding compound with a nucleic acid, a method for the determination of a nucleic acid using said compound, and several uses of 8-linked purine bases and structurally related heterocycles. Compounds according to the present invention have advantageous properties when used in hybridization methods.
摘要翻译： 本发明涉及包含N 8 - 或C 8 - 连接的嘌呤碱基或结构相关杂环的核酸结合化合物，可用于制备该化合物的化合物 ，该核酸结合化合物与核酸的结合产物，使用所述化合物测定核酸的方法，以及8-连接的嘌呤碱基和结构相关杂环的若干用途。 当用于杂交方法时，根据本发明的化合物具有有利的性质。
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12.发明申请CONJUGATE BETWEEN A THIOPHILIC SOLID PHASE AND AN OLIGONUCLEOTIDE COMPRISING A THIOOXONUCLEOTIDE 有权一个硫代固体相与一个含有硫代核苷酸的寡核苷酸之间的结合公开(公告)号：US20130210009A1
公开(公告)日：2013-08-15
申请号：US13866412
申请日：2013-04-19
申请人： Simone Budow , Ping Ding , Dieter Heindl , Alfons Nichtl , Frank Seela
发明人： Simone Budow , Ping Ding , Dieter Heindl , Alfons Nichtl , Frank Seela
CPC分类号： C12Q1/6876 , C07H21/02
摘要： An oligonucleotide-solid phase conjugate, wherein the solid phase is thiophilic and the oligonucleotide comprises at least one thiooxonucleobase according to Formula I, wherein X is CH or N, R1 is H or NH2, --- indicates a covalent bond, and said oligonucleotide is bound to said solid phase via the sulfur atom of said thiooxonucleotide. Also disclosed are methods for producing such conjugate as well as various uses for such oligonucleotide metal conjugate.
摘要翻译： 一种寡核苷酸 - 固相缀合物，其中所述固相是亲核的，并且所述寡核苷酸包含至少一种根据式I的硫氧基核碱基，其中X为CH或N，R 1为H或NH 2，表示共价键，所述寡核苷酸 通过所述硫代核苷酸的硫原子与所述固相结合。 还公开了用于生产这种缀合物的方法以及这种寡核苷酸金属缀合物的各种用途。
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13.发明授权Oligo-2′-deoxynucleotides and their use as pharmaceutical agents with antiviral activity 失效寡脱氧核苷酸及其作为具有抗病毒活性的药物的用途公开(公告)号：US06329346B1
公开(公告)日：2001-12-11
申请号：US08991183
申请日：1997-12-16
IPC分类号： A01N4304
摘要： Oligodeoxyribonucleotides in which at least two 2′-deoxy-&bgr;-D-erythro-pentofuranosyl groups are replaced by 2′-deoxy-&bgr;-D-threo-pentofuranosyl groups at both the 5′ end and 3′ end, and oligodeoxyribonucleotides in which at least 20% of the 2′-deoxy-&bgr;-D-erythro-pentofuranosyl groups in consecutive nucleotide building blocks are replaced by 2′-deoxy-&bgr;-D-threo-pentofuranosyl groups and which are composed of 6 to 100 nucleotide building blocks, are suitable for the inhibition of the expression of viral genes and oncogenes by the antisense principle and can be used for the production of pharmaceutical agents with antiviral activity.
摘要翻译： 在5'末端和3'末端两个脱氧-β-D-赤 - 呋喃糖基被2'-脱氧-β-D-苏 - 戊呋喃糖基取代的寡脱氧核糖核苷酸和其中的寡脱氧核糖核苷酸 连续核苷酸构建单元中2'-脱氧-β-D-赤型 - 戊呋喃糖基的至少20％被2'-脱氧-β-D-苏糖 - 呋喃糖基取代，它们由6至100个核苷酸构建 适用于通过反义原理抑制病毒基因和癌基因的表达，并可用于生产具有抗病毒活性的药剂。
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公开(公告)号：US4804748A
公开(公告)日：1989-02-14
申请号：US896657
申请日：1986-08-13
申请人： Frank Seela
发明人： Frank Seela
摘要： The present invention provides 7-deaza-2'-deoxy-guanosine nucleotides of the general formula: ##STR1## wherein R is a --PO.sub.3 H.sub.2, --P.sub.2 O.sub.6 H.sub.3 or --P.sub.3 O.sub.9 H.sub.4 residue or an alkali metal, alkaline earth metal or ammonium salt of the phosphate groups. The present invention also provides processes for the preparation of these nucleotides and is also concerned with the use thereof in the sequencing of DNA.
摘要翻译： 本发明提供了以下通式的7-脱氮-2'-脱氧鸟苷核苷酸：其中R是-PO 3 H 2，-P 2 O 6 H 3或-P 3 O 9 H 4残基或磷酸碱金属，碱土金属或铵盐 团体 本发明还提供了制备这些核苷酸的方法，并且还涉及其在DNA测序中的应用。
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公开(公告)号：US06479651B1
公开(公告)日：2002-11-12
申请号：US09643233
申请日：2000-08-22
申请人： Frank Seela , Horst Thomas
发明人： Frank Seela , Horst Thomas
IPC分类号： C12Q168
CPC分类号： C07H19/10 , C07H19/044 , C07H19/14 , C07H21/00
摘要： Modified oligonucleotides which possess at least one substituted 7-deazapurine base form more stable hybridization complexes with nucleic acids than unsubstituted analogs. They are useful as inhibitors of gene expression, as probes for detecting nucleic acids, as aids in molecular biology and as pharmaceuticals or diagnostic agents. Processes for preparing them are provided.
摘要翻译： 具有至少一个取代的7-脱氮嘌呤碱基的修饰的寡核苷酸与核酸形成比未取代的类似物更稳定的杂交复合物。 它们可用作基因表达的抑制剂，作为用于检测核酸的探针，作为分子生物学的辅助物质以及药物或诊断剂。 提供了制备方法。
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16.发明授权公开(公告)号：US06320035B1
公开(公告)日：2001-11-20
申请号：US09695210
申请日：2000-10-25
IPC分类号： C12Q168
摘要： The invention concerns pyrrolo-[3,2-d]pyrimidine, pyrazolo-[4,3-d]pyrimidine and pyrimidine-furanosides i.e. so-called C-nucleosides of the general formulae I-V or appropriate derivatives as well as processes for their production.
摘要翻译： 本发明涉及吡咯并[3,2-d]嘧啶，吡唑并[4,3-d]嘧啶和嘧啶 - 呋喃糖苷，即所谓的通式I-V的C-核苷和合适的衍生物，以及它们 生产。
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17.发明授权Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof for nucleic acid sequencing and as antiviral agents 失效脱氮嘌呤核苷酸衍生物，其制备方法，含有它们的药物组合物及其用于核酸测序的用途和作为抗病毒剂公开(公告)号：US06211158B1
公开(公告)日：2001-04-03
申请号：US07908513
申请日：1992-06-26
申请人： Frank Seela , Heinz-Peter Muth , Klaus Kaiser , Werner Bourgeois , Klaus Mühlegger , Herbert Von der Eltz , Hans-Georg Batz
发明人： Frank Seela , Heinz-Peter Muth , Klaus Kaiser , Werner Bourgeois , Klaus Mühlegger , Herbert Von der Eltz , Hans-Georg Batz
IPC分类号： A01N4304
CPC分类号： C07D471/04 , C07D487/04 , C07H19/14 , C07H19/16 , C07H19/20
摘要： The present invention provides desazapurine-nucleoside derivatives of the general formula: wherein X is a nitrogen atom or a methine radical, W is a nitrogen atom or a C—R4 radical, R1, R2, R3 and R4, which can be the same or different, are hydrogen or halogen atoms, hydroxyl or mercapto groups, lower alkyl, lower alkylthio, lower alkoxy, aralkyl, aralkoxy or aryloxy radicals or amino groups optionally substituted once or twice, R5 is a hydrogen atom or a hydroxyl group, R6 and R7 are each hydrogen atoms or one of them is a halogen atom or a cyano or azido group or an amino group optionally substituted once or twice, whereby one of R6 and R7 can also be a hydroxyl group when X is a methine radical and, in addition, R5 and R7 can together also represent a further valency bond between C-2′ and C-3′ and Y is a hydrogen atom or a mono-, di- or tri-phosphate group.
摘要翻译： 本发明提供了以下通式的脱氮嘌呤 - 核苷衍生物：其中X是氮原子或次甲基，W是氮原子或C-R 4基团，R 1，R 2，R 3和R 4可以相同或 不同的是氢或卤素原子，羟基或巯基，低级烷基，低级烷硫基，低级烷氧基，芳烷基，芳烷氧基或芳氧基或任选取代一次或两次的氨基，R5是氢原子或羟基，R6和R7 各自为氢原子或其中一个为卤素原子或氰基或叠氮基或任选取代一次或两次的氨基，其中当X为次甲基时，R6和R7中的一个也可为羟基，另外 ，R 5和R 7一起也代表C-2'和C-3'之间的进一步的价键，Y是氢原子或一，二或三磷酸基。
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公开(公告)号：US5990303A
公开(公告)日：1999-11-23
申请号：US858054
申请日：1997-05-16
申请人： Frank Seela
发明人： Frank Seela
摘要： The present invention provides 7-deaza-2'-deoxy-guanosine nucleotides of the general formula: ##STR1## wherein R is a --PO.sub.3 H.sub.2, --P.sub.2 O.sub.6 H.sub.3 or --P.sub.3 O.sub.9 H.sub.4 residue or an alkali metal, alkaline earth metal or ammonium salt of the phosphate groups.The present invention also provides processes for the preparation of these nucleotides and is also concerned with the use thereof in the sequencing of DNA.
摘要翻译： 本发明提供了以下通式的7-脱氮-2'-脱氧鸟苷核苷酸：其中R是-PO 3 H 2，-P 2 O 6 H 3或-P 3 O 9 H 4残基或磷酸酯基团的碱金属，碱土金属或铵盐。 本发明还提供了制备这些核苷酸的方法，并且还涉及其在DNA测序中的应用。
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19.发明授权
公开(公告)号：US5480980A
公开(公告)日：1996-01-02
申请号：US269999
申请日：1988-11-14
申请人： Frank Seela
发明人： Frank Seela
摘要： The present invention provides 7-deaza-2'-deoxy-guanosine nucleotides of the general formula: ##STR1## wherein R is a --PO.sub.3 H.sub.2, --P.sub.2 O.sub.6 H.sub.3 or --P.sub.3 O.sub.9 H.sub.4 residue or an alkali metal, alkaline earth metal or ammonium salt of the phosphate groups.The present invention also provides processes for the preparation of these nucleotides and is also concerned with the use thereof in the sequencing of DNA.
摘要翻译： 本发明提供了以下通式的7-脱氮-2'-脱氧鸟苷核苷酸：其中R是-PO 3 H 2，-P 2 O 6 H 3或-P 3 O 9 H 4残基或磷酸碱金属，碱土金属或铵盐 团体 本发明还提供了制备这些核苷酸的方法，并且还涉及其在DNA测序中的应用。
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20.发明授权2-deoxy-isoguanosines isosteric analogues and isoguanosine derivatives as well as their synthesis 失效2-脱氧 - 异鸟嘌呤等位基因类似物和异鸟苷衍生物及其合成公开(公告)号：US06498241B1
公开(公告)日：2002-12-24
申请号：US09712454
申请日：2000-11-13
IPC分类号： C07H2104
摘要： 2′-Deoxyisoguanosine, isosteric analogues and isoguanosine derivatives of formulae I-V, processes for their production via compounds of the general formulae a or b and reaction with aroyl isocyanates or from compounds of the general formulae VI-IX by photochemical irradiation. A further production process is the conversion of deoxyguanosines or guanosines by means of persilylation, reaction with ammonia and deamination in the 2 position. The compounds are suitable as pharmaceutical agents with antiviral efficacy.
摘要翻译： 2-脱氧异鸟苷，式I-V的异构体类似物和异鸟嘌呤衍生物，其通过通式a或b的化合物生产并通过光化学辐射与芳酰基异氰酸酯或通式VI-IX的化合物反应。 进一步的生产过程是通过去硅藻土或鸟氨酸的转化，通过与二氨基反应和脱氨作用。 该化合物适合作为具有抗病毒功效的药剂。
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