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公开(公告)号：US20210123078A1
公开(公告)日：2021-04-29
申请号：US16894600
申请日：2020-06-05
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Mark J. Burk , Robin E. Osterhout , Jun Sun , Priti Pharkya
Abstract: Provided herein is a non-naturally occurring microbial organism having a 1,3-butanediol (1,3-BDO) pathway and comprising at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. In some embodiments, the pathway includes reducing equivalents from CO or hydrogen. In certain embodiments, a 1,3-BDO pathway proceeds by way of central metabolites pyruvate, succinate or alpha-ketoglutarate. Also provided herein is a method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.
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公开(公告)号：US20210087591A1
公开(公告)日：2021-03-25
申请号：US16816064
申请日：2020-03-11
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC: C12P7/18 , C12N9/04 , C12N9/06 , C12N9/10 , C07D207/12 , C08G18/32 , C08G63/06 , C08G63/12 , C08G63/66 , C08G69/26 , C12N9/88 , C12P7/24 , C12P19/02
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (BDO). Also provided herein are methods for using such an organism to produce BDO.
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公开(公告)号：US10597684B2
公开(公告)日：2020-03-24
申请号：US15108259
申请日：2014-12-23
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Priti Pharkya , Tae Hoon Yang , Jungik Choi
IPC: C12P7/18 , C12P7/42 , C07K14/245 , C12N9/00 , C12N1/20 , C12N9/88 , C12N9/52 , C12N15/52 , C12N9/16 , C12N9/02 , C12N9/12
Abstract: The invention is directed to a non-naturally occurring microbial organism comprising a first attenuation of a succinyl-CoA synthetase or transferase and at least a second attenuation of a succinyl-CoA converting enzyme or a gene encoding a succinate producing enzyme within a multi-step pathway having a net conversion of succinyl-CoA to succinate.
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公开(公告)号：US20190153454A1
公开(公告)日：2019-05-23
申请号：US16194943
申请日：2018-11-19
Applicant: Genomatica, Inc.
Inventor： Priti Pharkya
Abstract: A non-naturally occurring microbial organism having an aniline pathway includes at least one exogenous nucleic acid encoding an aniline pathway enzyme expressed in a sufficient amount to produce aniline. The aniline pathway includes (1) an aminodeoxychorismate synthase, an aminodeoxychorismate lyase, and a 4-aminobenzoate carboxylyase or (2) an anthranilate synthase and an anthranilate decarboxylase. A method for producing aniline, includes culturing these non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce aniline.
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公开(公告)号：US20190127764A1
公开(公告)日：2019-05-02
申请号：US16004285
申请日：2018-06-08
Applicant: Genomatica, Inc.
Inventor： Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
Abstract: The invention provides non-naturally occurring microbial organisms having a butadiene or crotyl alcohol pathway. The invention additionally provides methods of using such organisms to produce butadiene or crotyl alcohol.
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Patent Agency Ranking
公开(公告)号：US10208320B2
公开(公告)日：2019-02-19
申请号：US14987489
申请日：2016-01-04
Applicant: Genomatica, Inc.
Inventor： Jun Sun , Anthony P. Burgard , Priti Pharkya
Abstract: The invention provides a non-naturally occurring microbial organism having a microbial organism having at least one exogenous gene insertion and/or one or more gene disruptions that confer production of primary alcohols. A method for producing long chain alcohols includes culturing these non-naturally occurring microbial organisms.
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公开(公告)号：US10150976B2
公开(公告)日：2018-12-11
申请号：US14107832
申请日：2013-12-16
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC: C12P17/10 , C12P13/02 , C12P7/24 , C12P19/02 , C12P7/44 , C12P13/00 , C12N9/04 , C08G63/78 , C08G73/02 , C08G69/16 , C08G69/08 , C12N15/52 , A23L29/00
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as adipate, 6-aminocaproate, hexamethylenediamine or caprolactam. Also provided herein are methods for using such an organism to produce adipate, 6-aminocaproate, hexamethylenediamine or caprolactam.
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公开(公告)号：US10081587B2
公开(公告)日：2018-09-25
申请号：US15182245
申请日：2016-06-14
Applicant: Genomatica, Inc.
Inventor： Mark J. Burk , Priti Pharkya , Stephen J. Van Dien , Anthony P. Burgard , Christophe H. Schilling
IPC: C07C51/353 , C12P7/46 , C07C51/38 , C07C67/32 , C07C57/04 , C07C67/08 , C07C67/333 , C12P7/40 , C12P7/62
CPC classification number: C07C51/353 , C07C51/38 , C07C57/04 , C07C67/08 , C07C67/32 , C07C67/333 , C12P7/40 , C12P7/46 , C12P7/62 , Y02P20/125 , C07C69/60 , C07C69/54
Abstract: The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. Also provided is an acrylate ester. The method includes contacting fumarate diester with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylate ester per mole of fumarate diester. An integrated process for process for producing acrylic acid or acrylate ester is provided which couples bioproduction of fumaric acid with metathesis transformation. An acrylic acid and an acrylate ester production also is provided.
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公开(公告)号：US10000758B2
公开(公告)日：2018-06-19
申请号：US15133150
申请日：2016-04-19
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
IPC: C12N15/52 , C12P7/42 , C08F120/06 , C08G63/664 , C12N15/63 , C12P7/24 , C12P7/40 , C12N9/04 , C12N9/06 , C12N9/10 , C12P7/62
CPC classification number: C12N15/52 , C08F120/06 , C08G63/664 , C12N9/0006 , C12N9/0028 , C12N9/1007 , C12N15/63 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/62 , C12Y101/01244 , C12Y105/0102 , C12Y201/0109
Abstract: Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 3-hydroxyisobutyrate or MAA. Also provided herein are methods for using such an organism to produce 3-hydroxyisobutyrate or MAA.
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公开(公告)号：US09719118B2
公开(公告)日：2017-08-01
申请号：US14995069
申请日：2016-01-13
Applicant: Genomatica, Inc.
Inventor： Anthony P. Burgard , Robin E. Osterhout , Priti Pharkya , Mark J. Burk
IPC: C08G63/02 , C12P17/08 , C12N15/70 , C07D313/04 , C12N15/63 , C12P17/02 , C08G18/42 , C12N5/00 , C08G63/08 , C12N15/52
CPC classification number: C12P17/08 , C07D313/04 , C08G18/4277 , C08G63/08 , C12N5/0018 , C12N15/52 , C12N15/63 , C12N15/70 , C12P17/02
Abstract: The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce caprolactone. The invention additionally provides methods of using such microbial organisms to produce caprolactone by culturing a non-naturally occurring microbial organism containing caprolactone pathways as described herein under conditions and for a sufficient period of time to produce caprolactone.
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