公开(公告)号：US20180215769A1

公开(公告)日：2018-08-02

申请号：US15669569

申请日：2017-08-04

Applicant: Gilead Sciences, Inc.

Inventor： Haolun Jin ,  Scott E. Lazerwith ,  Hyung-Jung Pyun

IPC: C07D498/18 ,  C07D498/14 ,  C07D471/22

CPC classification number: C07D498/18 ,  C07D471/18 ,  C07D471/22 ,  C07D487/18 ,  C07D498/04 ,  C07D498/14

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, Z2, or Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20180022757A1

公开(公告)日：2018-01-25

申请号：US15639833

申请日：2017-06-30

Applicant: Gilead Sciences, Inc.

Inventor： Anna Chiu ,  John Enquist, JR. ,  Nolan Griggs ,  Christopher Hale ,  Norihiro Ikemoto ,  Katie Ann Keaton ,  Matt Kraft ,  Scott E. Lazerwith ,  Michel Leeman ,  Zhihui Peng ,  Kate Schrier ,  Jonathan Trinidad ,  Jochem Van Herpt ,  Andrew W. Waltman

IPC: C07D498/14 ,  C07D213/82 ,  C07C237/20 ,  C07D319/06 ,  C07C237/16 ,  C07D309/40 ,  C07C235/80 ,  C07C231/02 ,  C07D498/22 ,  C07C231/12

Abstract: Methods of making compounds of Formula I are disclosed:

公开(公告)号：US09522912B2

公开(公告)日：2016-12-20

申请号：US14977347

申请日：2015-12-21

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Zhenhong R. Cai ,  Jeromy J. Cottell ,  Mingzhe Ji ,  Haolun Jin ,  Scott E. Lazerwith ,  Philip Anthony Morganelli ,  Hyung-jung Pyun

IPC: A61K31/4985 ,  C07D471/04 ,  C07D491/147 ,  C07D491/20 ,  A61K45/06

CPC classification number: A61K31/4985 ,  A61K45/06 ,  C07D471/04 ,  C07D491/147 ,  C07D491/20

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A′, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20160176885A1

公开(公告)日：2016-06-23

申请号：US14815504

申请日：2015-07-31

Applicant: Gilead Sciences, Inc.

Inventor： Haolun Jin ,  Scott E. Lazerwith ,  Hyung-Jung Pyun ,  Manoj C. Desai ,  Teresa Alejandra Trejo Martin ,  Elizabeth Bacon ,  Jeromy J. Cottell ,  Zhenhong R. Cai ,  Philip Anthony Morganelli ,  Mingzhe Ji ,  James G. Taylor ,  Xiaowu Chen ,  Michael R. Mish

IPC: C07D487/14

CPC classification number: C07D498/14 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/529 ,  A61K31/537 ,  A61K31/551 ,  A61K31/553 ,  A61K45/06 ,  C07D471/18 ,  C07D471/22 ,  C07D487/14 ,  C07D498/18 ,  A61K2300/00

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了用于治疗人类免疫缺陷病毒（HIV）感染的化合物。 所述化合物具有下式（I）：其包括立体异构体及其药学上可接受的盐，其中R1，X，W，Y1，Y2，Z1和Z4如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

公开(公告)号：US20160108030A1

公开(公告)日：2016-04-21

申请号：US14771779

申请日：2014-02-28

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas Brizgys ,  Eda Canales ,  Chien-Hung Chou ,  Michael Graupe ,  Yunfeng Eric Hu ,  Scott E. Lazerwith ,  John O. Link ,  Qi Liu ,  Yafan Lu ,  Roland D. Saito ,  Scott D. Schroeder ,  John R. Somoza ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D471/04 ,  A61K45/06 ,  C07D401/14 ,  A61K31/517 ,  A61K31/4439 ,  C07D417/14 ,  A61K31/506 ,  A61K31/4709 ,  C07D413/14 ,  A61K31/496 ,  A61K31/5377 ,  C07D491/052 ,  A61K31/444 ,  C07D401/12

CPC classification number: C07D401/12 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052

Abstract: Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

Abstract translation: 公开了式（I）化合物或其盐。 还公开了包含式I化合物的药物组合物，制备式I化合物的方法，可用于制备式I化合物的中间体和用于治疗包括HIV病毒引起的感染的逆转录病毒科病毒感染的治疗方法。

公开(公告)号：US12161625B2

公开(公告)日：2024-12-10

申请号：US18059806

申请日：2022-11-29

Applicant: Gilead Sciences, Inc.

Inventor： Jinfa Du ,  Joshua A. Kaplan ,  Thorsten A. Kirschberg ,  Tetsuya Kobayashi ,  Scott E. Lazerwith ,  Rick Andrew Lee ,  Jonathan William Medley ,  Michael L. Mitchell ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun ,  Sophia L. Shevick ,  Neil H. Squires ,  William J. Watkins

IPC: A61K31/403 ,  A61K31/03 ,  A61K31/16 ,  A61K31/38 ,  A61K31/4192 ,  A61P31/20 ,  C07D487/04 ,  C07D519/00

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

公开(公告)号：US20240239807A1

公开(公告)日：2024-07-18

申请号：US18365919

申请日：2023-08-04

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Xinpei Cai ,  Eda Y. Canales ,  Weng K. Chang ,  Gregory F. Chin ,  Henok H. Kinfe ,  Scott E. Lazerwith ,  Jessica L. McKinley ,  Michael R. Mish ,  Devan Naduthambi ,  Jason K. Perry ,  Kevin X. Rodriguez ,  Scott D. Schroeder ,  Christopher J. Swank ,  Joshua J. Van Veldhuizen

IPC: C07D495/04 ,  A61P31/14 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10 ,  C07D491/107 ,  C07D491/113 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D495/04 ,  A61P31/14 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10 ,  C07D491/107 ,  C07D491/113 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present disclosure relates to compounds of Formula I:




and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, useful in the treatment of treating viral infections, for example, coronaviridae infections.

公开(公告)号：US12030904B2

公开(公告)日：2024-07-09

申请号：US18301179

申请日：2023-04-14

Applicant: Gilead Sciences, Inc.

Inventor： Scott E. Lazerwith ,  Jonathan William Medley ,  Philip A. Morganelli ,  Devan Naduthambi ,  Thomas P. Stratton ,  Peiyuan Wang

IPC: C07F9/6561 ,  A61P31/12

CPC classification number: C07F9/6561 ,  A61P31/12

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US11773122B2

公开(公告)日：2023-10-03

申请号：US17409261

申请日：2021-08-23

Applicant: Gilead Sciences, Inc.

Inventor： Scott E. Lazerwith ,  Jonathan William Medley ,  Philip A. Morganelli ,  Devan Naduthambi ,  Thomas P. Stratton ,  Peiyuan Wang

IPC: C07F9/6561 ,  A61P31/12

CPC classification number: C07F9/6561 ,  A61P31/12

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US20220340535A1

公开(公告)日：2022-10-27

申请号：US17171201

申请日：2021-02-09

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Tae H. Hwang ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  John E. Knox ,  Scott E. Lazerwith ,  Xiaofen Li ,  David W. Lin ,  Jonathan W. Medley ,  Michael L. Mitchell ,  Devan Naduthambi ,  Zachary Newby ,  Neil H. Squires ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang

IPC: C07D267/20 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.