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    Systems and methods for spectroscopy of biological tissue
    14.
    发明授权
    Systems and methods for spectroscopy of biological tissue 有权
    生物组织光谱系统和方法

    公开(公告)号：US07647092B2

    公开(公告)日：2010-01-12

    申请号：US10178062

    申请日：2002-06-21

    申请人： Jason T. Motz ,  Luis H. Galindo ,  Martin Hunter ,  Ramachandra Dasari ,  Michael S. Feld

    发明人： Jason T. Motz ,  Luis H. Galindo ,  Martin Hunter ,  Ramachandra Dasari ,  Michael S. Feld

    IPC分类号： A61B6/06

    CPC分类号： A61B5/02007 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/0091 ,  A61B5/415 ,  A61B5/4312 ,  A61B5/4519 ,  A61B5/7232 ,  G01N21/474 ,  G01N21/65 ,  G01N2021/4745 ,  G01N2021/4759 ,  G01N2021/656

    摘要： The system and method of the present invention relates to using spectroscopy, for example, Raman spectroscopic methods for diagnosis of tissue conditions such as vascular disease or cancer. In accordance with a preferred embodiment of the present invention, a system for measuring tissue includes a fiber optic probe having a proximal end, a distal end, and a diameter of 2 mm or less. This small diameter allows the system to be used for the diagnosis of coronary artery disease or other small lumens or soft tissue with minimal trauma. A delivery optical fiber is included in the probe coupled at the proximal end to a light source. A filter for the delivery fibers is included at the distal end. The system includes a collection optical fiber (or fibers) in the probe that collects Raman scattered radiation from tissue, the collection optical fiber is coupled at the proximal end to a detector. A second filter is disposed at the distal end of the collection fibers. An optical lens system is disposed at the distal end of the probe including a delivery waveguide coupled to the delivery fiber, a collection waveguide coupled to the collection fiber and a lens.

    摘要翻译： 本发明的系统和方法涉及使用光谱学，例如用于诊断诸如血管疾病或癌症的组织条件的拉曼光谱方法。 根据本发明的优选实施例，用于测量组织的系统包括具有近端，远端和2mm或更小直径的光纤探针。 这种小直径允许系统用于诊断冠状动脉疾病或其他小腔或软组织，具有最小的创伤。 输送光纤包括在近端耦合到光源的探针中。 用于输送纤维的过滤器包括在远端。 该系统包括在探针中收集来自组织的拉曼散射辐射的收集光纤（或纤维），收集光纤在近端耦合到检测器。 第二过滤器设置在收集纤维的远端。 光学透镜系统设置在探头的远端，包括耦合到输送纤维的输送波导，耦合到收集光纤的收集波导和透镜。

    3-D HOLOGRAPHIC IMAGING FLOW CYTOMETRY
    15.
    发明申请
    3-D HOLOGRAPHIC IMAGING FLOW CYTOMETRY 审中-公开
    3-D全息成像流程细胞计数

    公开(公告)号：US20140333929A1

    公开(公告)日：2014-11-13

    申请号：US14173804

    申请日：2014-02-05

    申请人： Yongjin Sung ,  Niyom Lue ,  Zahid Yagoob ,  Ramachandra Dasari ,  Peter T.C. So

    发明人： Yongjin Sung ,  Niyom Lue ,  Zahid Yagoob ,  Ramachandra Dasari ,  Peter T.C. So

    IPC分类号： G01N15/14 ,  G01N21/64

    摘要： Refractive index of biological specimens is a source of intrinsic contrast that can be explored without any concerns of photobleaching or harmful effects caused by extra contrast agents. This feature also contains rich information that can be related to the metabolism of cells at the cellular and subcellular levels. The present invention relates to systems and methods that can provide, without any moving parts, the 3-D refractive index map of continuously flowing biological samples in a micro-fluidic channel, for example.

    摘要翻译： 生物标本的折射率是内在对比的来源，可以在没有光漂白或额外造影剂引起的有害影响的任何问题的情况下进行探索。 该特征还包含可以与细胞和亚细胞水平的细胞代谢相关的丰富信息。 本发明涉及可以提供例如在微流体通道中连续流动的生物样品的3-D折射率图的无任何移动部件的系统和方法。

    Angle-tunable transmissive grating
    16.
    发明申请
    Angle-tunable transmissive grating 审中-公开
    角度可调透射光栅

    公开(公告)号：US20070160325A1

    公开(公告)日：2007-07-12

    申请号：US11482545

    申请日：2006-07-07

    申请人： Hyungbin Son ,  Jing Kong ,  Ramachandra Dasari ,  Mildred Dresselhaus

    发明人： Hyungbin Son ,  Jing Kong ,  Ramachandra Dasari ,  Mildred Dresselhaus

    IPC分类号： G02B6/34 ,  H01S3/08

    CPC分类号： G02B6/34 ,  G01J3/02 ,  G01J3/021 ,  G01J3/06 ,  G01J3/1804 ,  G01J3/22 ,  G02B5/1828 ,  G02B5/1866 ,  G02B27/4244 ,  H01S3/1055 ,  H01S3/213 ,  H01S5/141

    摘要： A tunable transmissive grating comprises a transmissive dispersive element, a reflective element, and an angle θ formed between the two elements. A first optical path is formed according to the angle θ, wherein light dispersing from the dispersive element is directed onto the reflective element and reflects therefrom. At least one element is rotatable about a rotational center to cause a second optical path and thereby tune the wavelength of the light reflecting from the reflective element. Both elements can be rotatable together around a common rotational center point according to certain embodiments, and/or each element can be independently rotated around a rotational axis associated only with that element. According to some embodiments, the relative angle θ formed between the elements is held constant; however, in other embodiments θ can vary.

    摘要翻译： 可调透射光栅包括透射色散元件，反射元件和在两个元件之间形成的角度θ。 根据角度θ形成第一光路，其中从分散元件分散的光被引导到反射元件上并从其反射。 至少一个元件可围绕旋转中心旋转以产生第二光路，从而调谐从反射元件反射的光的波长。 根据某些实施例，两个元件可围绕公共旋转中心点一起旋转，和/或每个元件可以围绕仅与该元件相关联的旋转轴独立地旋转。 根据一些实施例，在元件之间形成的相对角度θ保持恒定; 然而，在其它实施例中，θ可以变化。