公开(公告)号：US20060073489A1

公开(公告)日：2006-04-06

申请号：US10959442

申请日：2004-10-05

Applicant: Gangqiang Li ,  Richard Pittaro

Inventor： Gangqiang Li ,  Richard Pittaro

IPC: C12Q1/68 ,  C07H21/04 ,  C12M1/34

CPC classification number: C12N15/1003 ,  B01D57/02 ,  C12Q1/6816 ,  C12Q1/6825 ,  G01N33/48721 ,  C12Q2565/607 ,  C12Q2565/631

Abstract: The invention relates to nanopore-based separation devices and systems, and methods and kits for using these. The devices may be used to separate and evaluate biopolymers such as nucleic acids and proteins.

Abstract translation: 本发明涉及基于纳米孔的分离装置和系统，以及使用它们的方法和试剂盒。 该装置可用于分离和评估生物聚合物，例如核酸和蛋白质。

公开(公告)号：US06700118B2

公开(公告)日：2004-03-02

申请号：US09930835

申请日：2001-08-15

Applicant: George Yefchak ,  Carl Myerholtz ,  Gangqiang Li

Inventor： George Yefchak ,  Carl Myerholtz ,  Gangqiang Li

IPC: B01D5944

CPC classification number: H01J49/40

Abstract: Adjustment systems, methods, computerized methods and computer readable-mediums that can be used in time-of-flight mass spectrometry (TOFMS) to account for thermal drift or mechanical strain are provided.

Abstract translation: 提供了可在飞行时间质谱（TOFMS）中用于考虑热漂移或机械应变的调整系统，方法，计算机化方法和计算机可读介质。

公开(公告)号：US06462337B1

公开(公告)日：2002-10-08

申请号：US09552962

申请日：2000-04-20

Applicant: Gangqiang Li ,  Hongfeng Yin

Inventor： Gangqiang Li ,  Hongfeng Yin

IPC: H01J4910

CPC classification number: H01J49/165 ,  C07D417/12 ,  C12P17/14 ,  C12P17/16

Abstract: A method of providing ions to a mass spectrometer having an interface member with an orifice through which ions are received for analysis. A fluid is provided at a capillary tip of an electrospray ionization source and a potential difference applied between the tip and the interface member so as to direct an ion beam from the tip toward and through the orifice. A field enhancing potential is applied at an auxiliary electrode so as to increase the electric field gradient from the capillary tip at least part way toward the interface member. A focussing potential may be applied to the auxiliary electrode to generate an electric field which decreases beam divergence from at least part way toward the interface member. Both the field enhancing and focusing potential may alternately be applied to the auxiliary electrode.

Abstract translation: 向质谱仪提供离子的方法，所述质谱仪具有接口部件，所述接口部件具有接口用于分析的离子。 在电喷雾电离源的毛细管尖端处设置有流体，并且在尖端和界面部件之间施加电位差，以便将尖端的离子束引导并穿过孔口。 在辅助电极处施加场强增强电位，以便使毛细管尖端的电场梯度至少部分地向接口部件增加。 可以将辅助电极施加聚焦电位以产生电场，该电场将波束发散从至少部分地朝向接口部件减小。 场增强和聚焦电位都可以替代地施加到辅助电极。

公开(公告)号：US5017780A

公开(公告)日：1991-05-21

申请号：US409671

申请日：1989-09-20

Applicant: Roland Kutscher ,  Raimund Grix ,  Gangqiang Li ,  Hermann Wollnik

Inventor： Roland Kutscher ,  Raimund Grix ,  Gangqiang Li ,  Hermann Wollnik

IPC: H01J49/44

CPC classification number: H01J49/405

Abstract: The invention covers novel ion reflectors which are conceived principally for use in time-of-flight mass spectrometry. Caused by special electrodes of conical construction, such ion reflectors also have special ion-optical properties which are made possible through optimum compensation of the spherical and chromatic aberrations both of the ion flight times and of the ion flight paths. The time and place focusing of the ions hereby achieved means for time-of-flight mass spectrometers high mass resolution capability and high transmissions.

Abstract translation: 本发明涵盖了主要用于飞行时间质谱的新型离子反射器。 由于具有锥形结构的特殊电极，这种离子反射器也具有特殊的离子 - 光学性能，可以通过对离子飞行时间和离子飞行路径的球面和色差的最佳补偿来实现。 离子的时间和地点聚焦实现了飞行时间质谱仪高质量分辨率和高传输的手段。

公开(公告)号：US20120280121A1

公开(公告)日：2012-11-08

申请号：US13101008

申请日：2011-05-04

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: H01J49/40 ,  H01J3/18

CPC classification number: H01J49/405 ,  H01J3/16

Abstract: Devices and systems for reflecting ions are provided. In general, the devices and systems include a plurality of curved lens plates adapted for connection to at least one voltage source and having a passage therein to allow the ions to pass therethrough. The plurality of curved lens plates generates electric fields having elliptic equipotential surfaces that reflect and focus the ions as they pass through the passage. Reflectron time-of-flight (RE-TOF) spectrometers are also provided that include an ion source, ion detector, and such a reflectron as described above. Mass spectrometer systems are provided that comprise an ion source that generates ions and a reflectron TOF spectrometer such as described above.

Abstract translation: 提供了用于反射离子的装置和系统。 通常，装置和系统包括适于连接至少一个电压源的多个弯曲透镜板，并且其中具有允许离子通过的通道。 多个弯曲透镜板产生具有椭圆等电位面的电场，它们在通过通道时反射和聚焦离子。 还提供了反射器飞行时间（RE-TOF）光谱仪，其包括如上所述的离子源，离子检测器和反射器。 提供包括产生离子的离子源和如上所述的反射体TOF光谱仪的质谱仪系统。

公开(公告)号：US20100193702A1

公开(公告)日：2010-08-05

申请号：US12363685

申请日：2009-01-30

Applicant: Gangqiang Li ,  Hongfeng Yin

Inventor： Gangqiang Li ,  Hongfeng Yin

IPC: H01J27/02 ,  H01J49/04 ,  H01J49/10 ,  H01J49/14 ,  H01J27/20

CPC classification number: H01J49/107 ,  H01J49/165

Abstract: An ion source a first ionizer comprising: an electrospray needle comprising a tip; and a conduit disposed annularly about the needle and configured to pass an inert gas in proximity of the tip to nebulize a fluid emerging from the tip, the nebulized fluid comprising analytes and a mobile phase. The ion source comprises a capillary in tandem with the first ionizer and configured to receive the droplets; a heater configured to heat the capillary to a temperature at which mobile phase vaporizes; and a second ionizer in tandem with the capillary and configured to receive the vaporized mobile phase and the analytes. A method is also described.

Abstract translation: 离子源，第一离子发生器，包括：电喷针，包括尖端; 以及围绕所述针环设置的导管，其被配置成使所述尖端附近的惰性气体通过，以使从所述尖端出来的流体雾化，所述雾化流体包含分析物和流动相。 离子源包括与第一离子发生器串联的毛细管并且构造成接收液滴; 加热器，被配置为将毛细管加热至流动相蒸发的温度; 以及第二离子发生器，其与所述毛细管串联并且被配置为接收蒸发的流动相和所述分析物。 还描述了一种方法。

公开(公告)号：US20100084550A1

公开(公告)日：2010-04-08

申请号：US12246586

申请日：2008-10-07

Applicant: Viorica Lopez-Avila ,  Gangqiang Li

Inventor： Viorica Lopez-Avila ,  Gangqiang Li

IPC: H01J49/40

CPC classification number: H01J49/004 ,  G01N27/622 ,  G01N33/6848 ,  H01J49/107

Abstract: A device and a method for identifying metalloproteins are disclosed. The device includes a first separation device for separating sample molecules according to their retention times, a first ionization device for ionizing the separated molecules into molecular ions, a second separation device for separating the molecular ions by their size-to-charge ratio, a second ionization device for atomizing the molecular ions and creating atomic ions of interest, and a mass spectrometer for separating and identifying both the molecular ions and the atomic ions by their mass-to-charge ratios. A method includes separating sample molecules according to their retention time, ionizing the separated molecules to form molecular ions, separating the molecular ions according to their size-to-charge ratio, atomizing and ionizing a portion of the molecular ions and identifying the atomic and molecular ions by their mass-to-charge ratio.

Abstract translation: 公开了一种用于鉴定金属蛋白的装置和方法。 该装置包括用于根据其保留时间分离样品分子的第一分离装置，用于将分离的分子离子化成分子离子的第一离子化装置，用于将分子离子分离成其尺寸与电荷比的第二分离装置，第二分离装置 用于雾化分子离子并产生感兴趣的原子离子的离子化装置，以及用于通过其质荷比分离和鉴定分子离子和原子离子的质谱仪。 一种方法包括根据其保留时间分离样品分子，将分离的分子电离形成分子离子，根据其大小与电荷比分离分子离子，雾化并离子化一部分分子离子并鉴定原子和分子 离子的质荷比。

公开(公告)号：US20090242748A1

公开(公告)日：2009-10-01

申请号：US12058770

申请日：2008-03-31

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: B01D59/44

CPC classification number: H01J49/0045

Abstract: A tandem mass spectrometer operable to determine properties of chemical and biochemical compounds (analytes) comprises an ion source, a monopole ion processing cell positioned to receive primary ions from the ion source and a mass analyzer positioned to receive secondary ions output from the monopole ion processing cell. The monopole ion processing cell comprises an elongate inner electrode and an elongate outer electrode radially offset from and partially surrounding the inner electrode. In one embodiment, the elongate inner and outer electrodes of monopole ion processing cell are segmented, and at least one of the outer electrode segments defines an axial slot through which the secondary ions are radially output to the mass analyzer.

Abstract translation: 可用于确定化学和生物化学化合物（分析物）性质的串联质谱仪包括离子源，定位为从离子源接收初级离子的单极离子处理单元和定位成接收从单极离子处理输出的二次离子的质量分析器 细胞。 单极离子处理单元包括细长的内部电极和沿内部电极径向偏移并且部分地围绕内部电极的细长外部电极。 在一个实施例中，分离单极离子处理单元的细长的内部和外部电极，并且外部电极段中的至少一个限定轴向狭槽，次级离子通过该轴向狭缝径向输出到质量分析器。

公开(公告)号：US07397027B2

公开(公告)日：2008-07-08

申请号：US11442250

申请日：2006-05-30

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: B01D59/46

CPC classification number: G01N27/624

Abstract: A multi-channel high field asymmetric waveform ion mobility spectrometer (FAIMS) is provided. The apparatus provides for substantially simultaneous FAIMS analysis of plurality of ions from a single sample. The apparatus has a analyzer region comprising a hollow electrode, a plurality of plate electrodes positioned parallel to and distanced from the hollow electrode, a contact for applying an high voltage asymmetric waveform to the hollow electrode and a plurality of contacts for applying a compensation voltage to the plurality of plate electrodes. A method for substantially simultaneous FAIMS analysis of plurality of ions from a single sample is also provided.

Abstract translation: 提供了多通道高场非对称波形离子迁移谱仪（FAIMS）。 该装置提供来自单个样品的多个离子的基本上同时的FAIMS分析。 该装置具有分析器区域，该分析器区域包括中空电极，多个平行于中空电极并远离中空电极的平板电极，用于向中空电极施加高电压不对称波形的触点和多个用于施加补偿电压的触点 多个平板电极。 还提供了用于从单个样品基本上同时对多个离子进行FAIMS分析的方法。

公开(公告)号：US20080104064A1

公开(公告)日：2008-05-01

申请号：US11548218

申请日：2006-10-10

Applicant: Gangqiang Li

Inventor： Gangqiang Li

IPC: G06F17/30

CPC classification number: H01J49/165 ,  H01J49/044

Abstract: The invention provides a mass spectrometry interface for collecting ions and directing a drying gas. The mass spectrometer interface may be used independently or in combination with an ion source and a mass spectrometry system. The mass spectrometer interface, includes a body portion having a first open end; and a tip portion in contact with the body portion having a second open end and a wall with an aperture for receiving ion, the wall having a cross-sectional area that tapers from the first open end of the body portion toward the second open end of the tip portion, wherein the mass spectrometer interface may direct a gas from the first open end of the body portion toward the second open end of the tip portion and the aperture in the wall of the tip portion may receive ions for drying by the gas.The invention also provides methods for ion collection and drying. The method for collecting and drying molecules, includes directing ions through an aperture of a closed mass spectrometry interface; and drying the molecules using a drying gas.

Abstract translation: 本发明提供了用于收集离子和引导干燥气体的质谱界面。 质谱仪界面可以独立使用或与离子源和质谱系统组合使用。 质谱界面包括具有第一开口端的主体部分; 以及与所述主体部分接触的具有第二开口端的尖端部分和具有用于接收离子的孔的壁，所述壁具有从所述主体部分的第一开口端向第二开口端逐渐变细的横截面面积 尖端部分，其中质谱仪界面可以将气体从主体部分的第一开口端引导到尖端部分的第二开口端，并且尖端部分的壁中的孔可以接收由气体干燥的离子。 本发明还提供了用于离子收集和干燥的方法。 收集和干燥分子的方法包括将离子引导通过闭合质谱界面的孔; 并使用干燥气体干燥分子。