公开(公告)号：US11866498B2

公开(公告)日：2024-01-09

申请号：US16271410

申请日：2019-02-08

Applicant: Genentech, Inc.

Inventor： Diego Ellerman ,  Teemu T. Junttila ,  Twyla Noelle Lombana ,  Dionysos Slaga ,  Christoph Spiess

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/32 ,  A61K39/395 ,  A61K47/65 ,  A61K9/00 ,  C07K16/46 ,  C07K16/10 ,  A61P35/02

CPC classification number: C07K16/2809 ,  A61K9/0019 ,  A61K39/3955 ,  A61K47/65 ,  A61P35/00 ,  A61P35/02 ,  C07K16/1063 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/32 ,  C07K16/468

Abstract: The present invention provides bispecific antigen-binding molecules having a monovalent arm specific to a first target antigen (e.g., a T cell antigen, such as CD3) and a bivalent arm specific for a second target antigen (e.g., a tumor antigen, such as HER2). Bispecific antigen-binding molecules are useful in the treatment of disorders, such as cancer (e.g., HER2-positive cancer). The invention also features methods of producing bispecific antigen-binding molecules, methods of treating disorders using bispecific antigen-binding molecules, and compositions including bispecific antigen-binding molecules.

公开(公告)号：US11434482B2

公开(公告)日：2022-09-06

申请号：US15782616

申请日：2017-10-12

Applicant: Genentech, Inc.

Inventor： Twyla Noelle Lombana ,  Rebekah McKenna ,  Christoph Spiess ,  Karthik Veeravalli ,  Michael Dillon

IPC: G01N33/53 ,  C12N15/10 ,  C07K16/22 ,  C07K16/24 ,  C07K14/195 ,  C07K16/12 ,  C12Q1/689 ,  G01N33/569 ,  G01N33/68

Abstract: The invention provides methods of identifying bacteria comprising binding polypeptides. The invention also provides methods of identifying bacteria with improved expression of binding polypeptides. The invention also provides methods of identifying binding polypeptides with improved expression. The invention also provides engineered bacteria suitable for use in the methods of the invention. The invention also provides compositions that can be obtained using the methods, for example, anti-interleukin-13 (IL-13) antibodies with improved expression and/or stability. The invention also provides libraries comprising binding polypeptide (e.g., antibody) variants.

公开(公告)号：US20220064331A1

公开(公告)日：2022-03-03

申请号：US17341990

申请日：2021-06-08

Applicant: GENENTECH, INC.

Inventor： Yongmei Chen ,  James Ernst ,  Hok Seon Kim ,  Junichiro Sonoda ,  Christoph Spiess ,  Scott Stawicki ,  Yan Wu

IPC: C07K16/40 ,  C07K14/71 ,  C07K16/28

Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.

公开(公告)号：US20190177432A1

公开(公告)日：2019-06-13

申请号：US16284774

申请日：2019-02-25

Applicant: GENENTECH, INC.

Inventor： Yongmei Chen ,  James Ernst ,  Hok Seon Kim ,  Junichiro Sonoda ,  Christoph Spiess ,  Scott Stawicki ,  Yan Wu

IPC: C07K16/40 ,  C07K14/71 ,  C07K16/28

Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.

公开(公告)号：US20190040142A1

公开(公告)日：2019-02-07

申请号：US15974369

申请日：2018-05-08

Applicant: GENENTECH, INC.

Inventor： Diana Ronai Dunshee ,  Joanne Hongo ,  Hok Seon Kim ,  Junichiro Sonoda ,  Christoph Spiess ,  Angie Grace Yee

IPC: C07K16/28

Abstract: The presently disclosed subject matter relates to multispecific antibodies, e.g., bispecific antibodies and biepitopic antibodies, and methods for screening for such antibodies, and a novel antibody structure that can be used to screen for such bispecific antibodies and biepitopic antibodies. The present disclosure further provides bispecific anti-KLB antibodies and methods

公开(公告)号：US20180305462A1

公开(公告)日：2018-10-25

申请号：US15967154

申请日：2018-04-30

Applicant: GENENTECH, INC.

Inventor： Yu-Ju G. Meng ,  Hok Seon Kim ,  Ingrid Kim ,  Christoph Spiess

IPC: C07K16/42

CPC classification number: C07K16/4283 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/71 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/94

Abstract: The instant disclosure provides antibody fragments (e.g., Fab and F(ab′)2) having reduced or no reactivity towards pre-existing anti-hinge antibodies (AHA) and compositions comprising such antibody fragments, as well as methods of making and using such antibody fragments and compositions.

公开(公告)号：US20240383984A1

公开(公告)日：2024-11-21

申请号：US18675452

申请日：2024-05-28

Applicant: Genentech, Inc.

Inventor： Isidro Hotzel ,  Teemu T. Junttila ,  Ji Li ,  Justin Scheer ,  Danielle Dicara ,  Diego Ellerman ,  Christoph Spiess ,  Paul J. Carter

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K47/68 ,  C07K16/30 ,  G01N33/574

Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.

公开(公告)号：US12053525B2

公开(公告)日：2024-08-06

申请号：US17395400

申请日：2021-08-05

Applicant: Genentech, Inc.

Inventor： Paul Carter ,  Christoph Spiess ,  Yiyuan Yin ,  Jianhui Zhou ,  Wendy Sandoval ,  Jacob Corn ,  Michael Dillon

IPC: C07H21/04 ,  A61K39/395 ,  A61K39/44 ,  C07K16/46 ,  G16B20/30 ,  G16B20/50 ,  A61K39/00 ,  G01N33/68 ,  G16B5/00 ,  G16B20/00

CPC classification number: A61K39/44 ,  A61K39/39558 ,  C07K16/468 ,  G16B20/30 ,  G16B20/50 ,  A61K39/3955 ,  A61K39/39566 ,  A61K2039/507 ,  C07K2317/31 ,  C07K2317/522 ,  C07K2317/56 ,  G01N33/6848 ,  G16B5/00 ,  G16B20/00

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

公开(公告)号：US12030947B2

公开(公告)日：2024-07-09

申请号：US17514824

申请日：2021-10-29

Applicant: Genentech, Inc.

Inventor： Isidro Hotzel ,  Teemu T. Junttila ,  Ji Li ,  Justin Scheer ,  Danielle Dicara ,  Diego Ellerman ,  Christoph Spiess ,  Paul J. Carter

IPC: A61K39/395 ,  A61K39/40 ,  A61K45/06 ,  A61K47/68 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574 ,  A61K39/00 ,  C07K16/00

CPC classification number: C07K16/283 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6849 ,  A61K47/6851 ,  C07K16/2809 ,  C07K16/2827 ,  C07K16/30 ,  G01N33/57492 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/62 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N2333/70535

Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.

公开(公告)号：US20240092906A1

公开(公告)日：2024-03-21

申请号：US18517327

申请日：2023-11-22

Applicant: Genentech, Inc.

Inventor： Diego ELLERMAN ,  Teemu T. Junttila ,  Twyla Noelle Lombana ,  Dionysos Slaga ,  Christoph Spiess

IPC: C07K16/28 ,  A61K9/00 ,  A61K39/395 ,  A61K47/65 ,  A61P35/00 ,  A61P35/02 ,  C07K16/10 ,  C07K16/32 ,  C07K16/46

CPC classification number: C07K16/2809 ,  A61K9/0019 ,  A61K39/3955 ,  A61K47/65 ,  A61P35/00 ,  A61P35/02 ,  C07K16/1063 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/32 ,  C07K16/468

Abstract: The present invention provides bispecific antigen-binding molecules having a monovalent arm specific to a first target antigen (e.g., a T cell antigen, such as CD3) and a bivalent arm specific for a second target antigen (e.g., a tumor antigen, such as HER2). Bispecific antigen-binding molecules are useful in the treatment of disorders, such as cancer (e.g., HER2-positive cancer). The invention also features methods of producing bispecific antigen-binding molecules, methods of treating disorders using bispecific antigen-binding molecules, and compositions including bispecific antigen-binding molecules.