公开(公告)号：US20250019731A1

公开(公告)日：2025-01-16

申请号：US18595947

申请日：2024-03-05

Applicant: Genomatica, Inc.

Inventor： Andreas W. SCHIRMER ,  Haibo WANG ,  Stephen B. DEL CARDAYRE ,  Zhihao HU ,  Louis G. HOM ,  Baolong ZHU ,  Cindy CHANG ,  Emanuela E. POPOVA

IPC: C12P7/6409 ,  C12N9/02 ,  C12N9/04 ,  C12N15/52 ,  C12N15/62 ,  C12P7/18 ,  C12P7/42 ,  C12P7/6436

Abstract: The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.

公开(公告)号：US20240309405A1

公开(公告)日：2024-09-19

申请号：US18339397

申请日：2023-06-22

Applicant: Genomatica, Inc.

Inventor： Andreas W. SCHIRMER ,  Risha Lindig Bond ,  Erin Frances Perry

IPC: C12P7/18 ,  C07C68/00 ,  C07C69/22 ,  C07C69/30 ,  C12N15/52

CPC classification number: C12P7/18 ,  C07C68/00 ,  C07C69/22 ,  C07C69/30 ,  C12N15/52

Abstract: The disclosure relates to the field of specialty chemicals and methods for their synthesis. In embodiments, the disclosure provides novel multifunctional fatty acid derivative molecules such as e.g., fatty triols, fatty tetrols, dihydroxy fatty acids, etc. The disclosure further provides derivatives of the disclosed multifunctional molecules which are useful e.g., in the production of personal care products, surfactants, detergents, polymers, paints, coatings, and as emulsifiers, emollients, and thickeners in cosmetics and foods, as industrial solvents and plasticizers, etc. The disclosure further provides biochemical pathways, recombinant microorganisms and methods for the biological production of various multifuctional fatty acid derivatives.

公开(公告)号：US20240229086A1

公开(公告)日：2024-07-11

申请号：US18284349

申请日：2022-03-22

Applicant: GENOMATICA, INC.

Inventor： Andreas W. SCHIRMER ,  Erin Frances PERRY ,  Alma Itzel RAMOS-SOLIS ,  Angelica ZABALA-BAUTISTA

IPC: C12P7/6409 ,  C12N1/20 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/12 ,  C12N9/16 ,  C12N9/88

CPC classification number: C12P7/6409 ,  C12N1/20 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/0071 ,  C12N9/1029 ,  C12N9/1288 ,  C12N9/16 ,  C12N9/88 ,  C12Y114/19002 ,  C12Y203/01084 ,  C12Y207/08007 ,  C12Y301/02014 ,  C12Y402/01059

Abstract: Recombinant proteobacteria, including γ-proteobacteria, comprising a heterologous acyl-ACP desaturase and a heterologous acyl-ACP thioesterase, wherein the native dual 3-hydroxy acyl-ACP dehydratase/isomerase is deleted are provided herein. The recombinant proteobacteria produce non-native monounsaturated free fatty acids or derivatives thereof. Methods of producing non-native monounsaturated free fatty acids or derivatives thereof are also provided, in addition to cell cultures and fatty acid compositions produced by the recombinant proteobacteria. The recombinant proteobacteria may be used to produce insect pheromones or precursors thereof, and fragrances or precursors thereof.

公开(公告)号：US20220259623A1

公开(公告)日：2022-08-18

申请号：US17508400

申请日：2021-10-22

Applicant: Genomatica, Inc.

Inventor： Andreas W. SCHIRMER ,  Mathew A. RUDE ,  Shane A. BRUBAKER

IPC: C12P7/64 ,  C12N9/02 ,  C10L1/02 ,  C12N9/88 ,  C12P7/04 ,  C12P7/24 ,  C12P7/6409 ,  C12P7/6436 ,  C12P7/649 ,  C12P5/02

Abstract: Compositions and methods for producing aldehydes, alkanes, and alkenes are described herein. The aldehydes, alkanes, and alkenes can be used in biofuels.

公开(公告)号：US20210324431A1

公开(公告)日：2021-10-21

申请号：US17169845

申请日：2021-02-08

Applicant: Genomatica, Inc.

Inventor： Grace J. LEE ,  John HALIBURTON ,  Zhihao HU ,  Andreas W. SCHIRMER ,  Kevin HOLDEN

IPC: C12P7/64 ,  C12N9/10 ,  C12N9/16 ,  C12N9/04 ,  C12N9/18 ,  C12N9/12 ,  C12N9/90 ,  C12N9/88 ,  C07C53/126 ,  C07C57/03

Abstract: Recombinant microbial cells are provided which have been engineered to produce fatty acid derivatives having linear chains containing an odd number of carbon atoms by the fatty acid biosynthetic pathway. Also provided are methods of making odd chain fatty acid derivatives using the recombinant microbial cells, and compositions comprising odd chain fatty acid derivatives produced by such methods.