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公开(公告)号：US07422849B1
公开(公告)日：2008-09-09
申请号：US09325095
申请日：1999-06-03
申请人： Ian D. Hiles , Michael J. Fry , Ritu Dhand , Michael D. Waterfield , Peter J. Parker , Masayuki Otsu , George Panayoutou , Stefano Volinia , Ivan Gout
发明人： Ian D. Hiles , Michael J. Fry , Ritu Dhand , Michael D. Waterfield , Peter J. Parker , Masayuki Otsu , George Panayoutou , Stefano Volinia , Ivan Gout
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/567 , C12P19/34 , C12N9/12
摘要： This invention relates to new polypeptides which exhibit kinase activity or, more specifically, which show phosphoinositide (PI) 3-kinase activity. Such polypeptides are involved in pathways responsible for cellular growth and differentiation. An isolated polypeptide which possesses PI3-kinase activity when produced by recombinant production in insect cells is disclosed.
摘要翻译： 本发明涉及表现出激酶活性的新多肽，更具体地说，其表现出磷酸肌醇（PI）3-激酶活性。 这些多肽参与负责细胞生长和分化的途径。 公开了在昆虫细胞中通过重组生产产生时具有PI3-激酶活性的分离的多肽。
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12.发明授权Identification and functional characterization of a novel ribosomal S6 protein kinase 失效新型核糖体S6蛋白激酶的鉴定和功能表征公开(公告)号：US06830909B1
公开(公告)日：2004-12-14
申请号：US09762258
申请日：2001-05-29
申请人： Ivan Gout , Kenta Hara , Mike Waterfield , Kazu Yonezawa
发明人： Ivan Gout , Kenta Hara , Mike Waterfield , Kazu Yonezawa
IPC分类号： C12N912
CPC分类号： C12N9/1205 , A61K38/00 , C07K2319/00
摘要： A novel S6 kinase, p70&bgr;S6k, is described, along with methods of making and using p70&bgr;S6k and related nucleic acids. The invention also discloses methods of identifying agents which modulate the activity of p70&bgr;S6k and/or its ligands.
摘要翻译： 描述了新型S6激酶p70beta
，以及制备和使用p70beta 和相关核酸的方法。 本发明还公开了鉴定调节p70beta S6k和/或其配体的活性的试剂的方法。 -
13.发明授权Identification and functional characterization of a novel ribosomal S6 protein kinase 有权新型核糖体S6蛋白激酶的鉴定和功能表征公开(公告)号：US07998718B2
公开(公告)日：2011-08-16
申请号：US11004840
申请日：2004-12-07
申请人： Ivan Gout , Kenta Hara , Mike Waterfield , Kazu Yonezawa
发明人： Ivan Gout , Kenta Hara , Mike Waterfield , Kazu Yonezawa
CPC分类号： C12N9/1205 , A61K38/00 , C07K2319/00
摘要： A novel S6 kinase, p70βS6k is described, along with methods of making and using p70βS6k protein and related nucleic acids. The invention also discloses methods of identifying agents which modulate the activity of p70βS6k protein and/or its ligands.
摘要翻译： 描述了一种新型S6激酶，p70和bgr; S6k，以及制备和使用p70和bgr; S6k蛋白和相关核酸的方法。 本发明还公开了鉴定调节p70bgr S6k蛋白和/或其配体的活性的试剂的方法。
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公开(公告)号：US20090181003A1
公开(公告)日：2009-07-16
申请号：US11990226
申请日：2006-08-08
申请人： Ivan Gout , Timothy Robert Fenton , Heba Ismail
发明人： Ivan Gout , Timothy Robert Fenton , Heba Ismail
CPC分类号： C12N9/1029
摘要： The invention encompasses agents and their methods of use for modulating the activity of kinases by effecting their acetylation or their binding to nucleic acids. The invention thus encompasses the modulation of S6 kinase by effecting its acetylation by p300. The invention further encompasses the modulation of S6 kinase 2 by affecting its binding to DNA.
摘要翻译： 本发明包括通过进行其乙酰化或其与核酸的结合来调节激酶活性的药剂及其使用方法。 因此，本发明包括通过p300进行其乙酰化来调节S6激酶。 本发明还包括通过影响其与DNA的结合来调节S6激酶2。
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公开(公告)号：US5824492A
公开(公告)日：1998-10-20
申请号：US162081
申请日：1994-02-07
申请人： Ian D. Hiles , Michael J. Fry , Ritu Dhand , Michael D. Waterfield , Peter J. Parker , Masayuki Otsu , George Panayoutou , Stefano Volinia , Ivan Gout
发明人： Ian D. Hiles , Michael J. Fry , Ritu Dhand , Michael D. Waterfield , Peter J. Parker , Masayuki Otsu , George Panayoutou , Stefano Volinia , Ivan Gout
IPC分类号： A61K38/45 , A61K38/00 , A61K38/55 , A61K39/395 , A61P3/08 , A61P7/00 , A61P43/00 , C07K14/00 , C07K16/00 , C07K16/40 , C07K19/00 , C12N5/10 , C12N9/12 , C12N9/99 , C12N15/09 , C12N15/54 , C12P9/00 , C12P21/08 , C12R1/91 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/573 , G01N33/577 , C12Q1/48
摘要： This invention relates to new polypeptides which exhibit kinase activity or, more specifically, which show phosphoinositide (PI) 3-kinase activity. Such polypeptides are involved in pathways responsible for cellular growth and differentiation. An isolated polypeptide which possesses PI3-kinase activity when produced by recombinant production in insect cells is disclosed.
摘要翻译： PCT No.PCT / GB93 / 00761 Sec。 371日期1994年2月7日 102（e）1994年2月7日PCT 1993年4月13日PCT PCT。 公开号WO93 / 21328 PCT 日期1995年10月28日本发明涉及表现出激酶活性的新多肽，更具体地说，其表现出磷酸肌醇（PI）3-激酶活性。 这些多肽参与负责细胞生长和分化的途径。 公开了在昆虫细胞中通过重组生产产生时具有PI3-激酶活性的分离的多肽。
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16.发明授权公开(公告)号：US08669347B2
公开(公告)日：2014-03-11
申请号：US12598394
申请日：2008-05-01
IPC分类号： C07K14/00
CPC分类号： C12N9/12 , C07K14/4702 , C07K14/705 , C07K16/40 , C07K2317/24 , C07K2317/76 , C12P21/02 , C12Q1/485 , C12Q1/6876 , C12Q2600/156 , C12Q2600/158 , C12Y207/11001 , G01N33/5008 , G01N2440/14
摘要： The invention relates to mTORbeta, a splice form of mTOR, nucleic acids encoding mTOR beta, and antibodies against mTOR beta. The invention also relates to methods of producing mTOR beta and methods of screening for an agent that modulates mTOR beta expression and/or activity. The invention further relates to a method of treating a disease associated with aberrant expression of mTOR beta by administration of an agent that alters mTOR activity and/or expression.
摘要翻译： 本发明涉及mTORbeta，mTOR的剪接形式，编码mTORβ的核酸和针对mTORβ的抗体。 本发明还涉及产生mTORβ的方法和筛选调节mTORβ表达和/或活性的试剂的方法。 本发明还涉及通过施用改变mTOR活性和/或表达的试剂来治疗与mTORβ异常表达相关的疾病的方法。
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公开(公告)号：US06274327B1
公开(公告)日：2001-08-14
申请号：US09085957
申请日：1998-05-27
申请人： Ian D. Hiles , Michael J. Fry , Ritu Dhand , Michael D. Waterfield , Peter J. Parker , Masayuki Otsu , George Panayoutou , Stefano Volinia , Ivan Gout
发明人： Ian D. Hiles , Michael J. Fry , Ritu Dhand , Michael D. Waterfield , Peter J. Parker , Masayuki Otsu , George Panayoutou , Stefano Volinia , Ivan Gout
IPC分类号： G01N3353
CPC分类号： C12P9/00 , A61K38/00 , C07K16/40 , C12N9/12 , C12N2799/026
摘要： This invention relates to new polypeptides which exhibit kinase activity or, more specifically, which show phosphoinositide (PI) 3-kinase activity. Such polypeptides are involved in pathways responsible for cellular growth and differentiation. An isolated polypeptide which possesses PI3-kinase activity when produced by recombinant production in insect cells is disclosed.
摘要翻译： 本发明涉及表现出激酶活性的新多肽，更具体地说，其表现出磷酸肌醇（PI）3-激酶活性。 这些多肽参与负责细胞生长和分化的途径。 公开了在昆虫细胞中通过重组生产产生时具有PI3-激酶活性的分离的多肽。
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