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    Rationale, Methods, and Assays for Identifying Human and Non-Human Primate Taste Specific Genes and Use Thereof in Taste Modulator and Therapeutic Screening Assays
    14.
    发明申请
    Rationale, Methods, and Assays for Identifying Human and Non-Human Primate Taste Specific Genes and Use Thereof in Taste Modulator and Therapeutic Screening Assays 有权
    用于鉴别人和非人灵长类特异性基因的原理，方法和分析及其在口味调节剂和治疗筛选试验中的用途

    公开(公告)号：US20090208946A1

    公开(公告)日：2009-08-20

    申请号：US12134302

    申请日：2008-06-06

    申请人： Bryan Moyer ,  Albert Zlotnik ,  Peter Hevezi ,  Hortensia Soto ,  Dalia Kalabat ,  Min Lu ,  Na Gao ,  Evan Carl White

    发明人： Bryan Moyer ,  Albert Zlotnik ,  Peter Hevezi ,  Hortensia Soto ,  Dalia Kalabat ,  Min Lu ,  Na Gao ,  Evan Carl White

    IPC分类号： C12Q1/68 ,  C12Q1/02 ,  C12N5/08

    CPC分类号： G01N33/566 ,  C12Q1/6806 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  C40B30/04 ,  C40B40/10 ,  G01N33/5005 ,  G01N33/5044 ,  G01N33/6872 ,  G01N2333/726 ,  G01N2500/10

    摘要： This invention relates to novel rationale and methods for identifying human and primate taste-specific genes, including genes involved in salty taste perception, especially human salty taste perception, but also genes involved in sweet, bitter, umami, and sour taste perception, and genes involved in other taste cell or taste receptor related activities such as digestive function and digestive related diseases, taste cell turnover, immunoregulation of the oral and digestive tract, and metabolic regulation such as in diabetes and obesity, the genes identified using these methods, and assays for identifying taste modulators (enhancers or blockers) and potential therapeutics using these genes. These compounds have potential application in modulating (enhancing or blocking) taste perception, especially salty taste perception and as potential therapeutics. In addition, this invention relates to novel methods for identifying taste-specific genes that can be used as markers for different taste cell types, including sweet, bitter, umami, sour, salty, and other taste cells in mammals as well as assays that measure the activity of the sweet, bitter, umami, or sour receptor in the presence of these genes to identify modulators of sweet, bitter, umami, and sour taste and to identify therapeutics especially for treating digestive or metabolic disorders, taste loss, and oral infections. Particularly, the genes identified herein and antibodies or oligos thereto can be used as markers to identify and/or purify specific taste cells e.g., from taste cell suspensions by use of FACS or magnetic bead cell selection or other known cell purification and isolation procedures.

    摘要翻译： 本发明涉及用于鉴定人类和灵长类动物特异性基因的新的理论和方法，包括涉及咸味感知的基因，特别是人类咸味感知，以及参与甜味，苦味，鲜味和酸味感觉的基因以及基因 参与其他味觉细胞或味觉受体相关活性，如消化功能和消化相关疾病，味觉细胞周转，口服和消化道的免疫调节，以及代谢调节，如糖尿病和肥胖症，使用这些方法鉴定的基因和测定 用于鉴定使用这些基因的味觉调节剂（增强子或阻断剂）和潜在的治疗剂。 这些化合物具有潜在的应用于调节（增强或阻断）味觉，特别是咸味感和作为潜在的疗法。 此外，本发明涉及用于鉴定可用作哺乳动物中不同味道细胞类型（包括甜味，苦味，鲜味，酸味，咸味和其他味觉细胞）的标记的味道特异性基因的新方法，以及测量 在这些基因存在下甜味，苦味，鲜味或酸性受体的活性，以鉴定甜味，苦味，鲜味和酸味的调节剂，并鉴定治疗剂，特别是用于治疗消化或代谢紊乱，口味丧失和口腔感染 。 特别地，本文鉴定的基因和其抗体或寡核苷酸可以用作标识物，以通过使用FACS或磁珠细胞选择或其他已知的细胞纯化和分离程序来鉴定和/或纯化特定味细胞，例如来自味细胞悬浮液。

    Rationale, methods, and assays for identifying human and non-human primate taste specific genes and use thereof in taste modulator and therapeutic screening assays
    19.
    发明授权
    Rationale, methods, and assays for identifying human and non-human primate taste specific genes and use thereof in taste modulator and therapeutic screening assays 有权
    用于鉴定人和非人灵长类动物味道特异性基因的理由，方法和测定及其在味觉调节剂和治疗性筛选测定中的用途

    公开(公告)号：US07932058B2

    公开(公告)日：2011-04-26

    申请号：US12134302

    申请日：2008-06-06

    申请人： Bryan Moyer ,  Albert Zlotnik ,  Peter Hevezi ,  Hortensia Soto ,  Dalia Kalabat ,  Min Lu ,  Na Gao ,  Evan Carl White

    发明人： Bryan Moyer ,  Albert Zlotnik ,  Peter Hevezi ,  Hortensia Soto ,  Dalia Kalabat ,  Min Lu ,  Na Gao ,  Evan Carl White

    IPC分类号： C12N15/10 ,  C07K14/705

    CPC分类号： G01N33/566 ,  C12Q1/6806 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  C40B30/04 ,  C40B40/10 ,  G01N33/5005 ,  G01N33/5044 ,  G01N33/6872 ,  G01N2333/726 ,  G01N2500/10

    摘要： This invention relates to novel rationale and methods for identifying human and primate taste-specific genes, including genes involved in salty taste perception, especially human salty taste perception, but also genes involved in sweet, bitter, umami, and sour taste perception, and genes involved in other taste cell or taste receptor related activities such as digestive function and digestive related diseases, taste cell turnover, immunoregulation of the oral and digestive tract, and metabolic regulation such as in diabetes and obesity, the genes identified using these methods, and assays for identifying taste modulators (enhancers or blockers) and potential therapeutics using these genes. These compounds have potential application in modulating (enhancing or blocking) taste perception, especially salty taste perception and as potential therapeutics. In addition, this invention relates to novel methods for identifying taste-specific genes that can be used as markers for different taste cell types, including sweet, bitter, umami, sour, salty, and other taste cells in mammals as well as assays that measure the activity of the sweet, bitter, umami, or sour receptor in the presence of these genes to identify modulators of sweet, bitter, umami, and sour taste and to identify therapeutics especially for treating digestive or metabolic disorders, taste loss, and oral infections. Particularly, the genes identified herein and antibodies or oligos thereto can be used as markers to identify and/or purify specific taste cells e.g., from taste cell suspensions by use of FACS or magnetic bead cell selection or other known cell purification and isolation procedures.

    摘要翻译： 本发明涉及用于鉴定人类和灵长类动物特异性基因的新的理论和方法，包括涉及咸味感知的基因，特别是人类咸味感知，以及参与甜味，苦味，鲜味和酸味感觉的基因以及基因 参与其他味觉细胞或味觉受体相关活性，如消化功能和消化相关疾病，味觉细胞周转，口服和消化道的免疫调节，以及代谢调节，如糖尿病和肥胖症，使用这些方法鉴定的基因和测定 用于鉴定使用这些基因的味觉调节剂（增强子或阻断剂）和潜在的治疗剂。 这些化合物具有潜在的应用于调节（增强或阻断）味觉，特别是咸味感和作为潜在的疗法。 此外，本发明涉及用于鉴定可用作哺乳动物中不同味道细胞类型（包括甜味，苦味，鲜味，酸味，咸味和其他味觉细胞）的标记的味道特异性基因的新方法，以及测量 在这些基因存在下甜味，苦味，鲜味或酸性受体的活性，以鉴定甜味，苦味，鲜味和酸味的调节剂，并鉴定治疗剂，特别是用于治疗消化或代谢紊乱，口味丧失和口腔感染 。 特别地，本文鉴定的基因和其抗体或寡核苷酸可以用作标识物，以通过使用FACS或磁珠细胞选择或其他已知的细胞纯化和分离程序来鉴定和/或纯化特定味细胞，例如来自味细胞悬浮液。