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    Apparatus for Performing Nucleic Acid Analysis
    11.
    发明申请
    Apparatus for Performing Nucleic Acid Analysis 审中-公开
    用于进行核酸分析的装置

    公开(公告)号：US20090227006A1

    公开(公告)日：2009-09-10

    申请号：US12373276

    申请日：2007-07-05

    申请人： Martin Kopp ,  Hans-Peter Wahl ,  Emad Sarofim ,  Oliver Elsenhans ,  Goran Savatic ,  Roland Christof Hutter

    发明人： Martin Kopp ,  Hans-Peter Wahl ,  Emad Sarofim ,  Oliver Elsenhans ,  Goran Savatic ,  Roland Christof Hutter

    IPC分类号： C12M1/00

    CPC分类号： B01L3/502715 ,  G01N35/0099 ,  G01N2035/00346

    摘要： The embodiments of the present invention are directed to an automatic apparatus (55), which is designed for performing nucleic acid analysis, optionally including sample preparation, with integrated disposable sample holding and processing devices (1), which devices (1) comprise a sample to be analyzed with the apparatus (55). The apparatus (55) comprises workstations (17, 40) for receiving, holding and processing such integrated disposable devices (1), a reagents station (56) for reagents (25), transfer means (36) for performing movements of an actuator, fluid actuation means for processing the sample (32) and reagents in said disposable devices (1), temperature control means (37) for heating or cooling, detection means for measuring a property of the processed samples (32), and control means for controlling the sample (32) preparation, the handling of the disposable devices (1) and the sample analysis performed by the apparatus (55).

    摘要翻译： 本发明的实施例涉及一种自动装置（55），其被设计用于执行核酸分析，任选地包括样品制备，具有集成的一次性样品保持和处理装置（1），所述装置（1）包括样品 用装置（55）进行分析。 装置（55）包括用于接收，保持和处理这种集成的一次性装置（1），用于试剂（25）的试剂台（56），用于执行致动器的运动的传送装置（36） 用于处理所述一次性装置（1）中的样品（32）和试剂的流体致动装置，用于加热或冷却的温度控制装置（37），用于测量经处理样品（32）的性质的检测装置，以及用于控制 样品（32）制备，一次性装置（1）的处理和由装置（55）进行的样品分析。

    PLASMA SEPARATION DEVICE AND METHOD THEREOF
    12.
    发明申请
    PLASMA SEPARATION DEVICE AND METHOD THEREOF 审中-公开
    等离子体分离装置及其方法

    公开(公告)号：US20080290048A1

    公开(公告)日：2008-11-27

    申请号：US12131512

    申请日：2008-06-02

    申请人： Rainer Jaeggi ,  Patrick Griss ,  Hans-Peter Wahl

    发明人： Rainer Jaeggi ,  Patrick Griss ,  Hans-Peter Wahl

    IPC分类号： B04B3/00 ,  B01D33/15 ,  G01N21/07 ,  G01N33/48

    CPC分类号： G01N21/07 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2300/0806 ,  B01L2300/0816 ,  B01L2300/0858 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/086 ,  G01N33/491

    摘要： A device and method thereof for at least partially fractioning or separating fluid from higher density and/or solid particles contained in liquid samples are disclosed. The present invention provides a movable or drivable device having a flow path defined by inner and outer wall surfaces and arranged such that the flow velocity of the liquid sample along the outer wall surface is higher than the flow velocity along the opposite inner wall surface. The flow path provides elements to at least delay the flow of the liquid sample along the outer wall surface. The device is, e.g., suitable for the separation of blood, e.g., of plasma from at least red blood cells, and from red and white blood cells to achieve blood plasma with high purity for analytical reasons.

    摘要翻译： 公开了一种用于至少部分地分馏或分离液体样品中包含的较高密度和/或固体颗粒的流体的装置及其方法。 本发明提供了一种可移动或可驱动的装置，其具有由内壁和外壁表面限定的流动路径，并且布置成使得液体样品沿着外壁表面的流速高于沿着相对的内壁表面的流速。 流动路径提供元件以至少延迟液体样品沿着外壁表面的流动。 例如，该装置适于从至少红细胞和红细胞和白细胞分离血液，例如血浆，以实现高纯度的血浆，用于分析的原因。

    DEVICE WITH INSERT FOR ANALYTICAL SYSTEMS
    13.
    发明申请
    DEVICE WITH INSERT FOR ANALYTICAL SYSTEMS 审中-公开
    具有分析系统插入的设备

    公开(公告)号：US20080011062A1

    公开(公告)日：2008-01-17

    申请号：US11776367

    申请日：2007-07-11

    申请人： Emad Sarofim ,  Hans-Peter Wahl

    发明人： Emad Sarofim ,  Hans-Peter Wahl

    IPC分类号： G01N1/28

    CPC分类号： B01L3/502715 ,  B01L3/5025 ,  B01L2400/0622 ,  B01L2400/0633

    摘要： A analytical device comprising a body comprising a fluidic unit comprising a first chamber having an outlet opening and a first channel exiting said outlet opening, wherein said first chamber further contains an insert comprising recesses between ribs touching the walls of said first chamber and a second channel, said insert being located in a first position wherein said insert is not engaged with said outlet opening, said insert being moveable from said first position to a second position within said first chamber, wherein said insert is engaged with said outlet opening such that said second channel extends said first channel into said first chamber and in the part pointing towards said outlet opening resembles the shape of said first chamber.

    摘要翻译： 一种包括主体的分析装置，包括流体单元，所述流体单元包括具有出口开口的第一室和离开所述出口开口的第一通道，其中所述第一室还包含插入件，所述插入件包括接触所述第一室的壁的肋之间的凹部， 所述插入件位于第一位置，其中所述插入件不与所述出口开口接合，所述插入件可从所述第一位置移动到所述第一室内的第二位置，其中所述插入件与所述出口开口接合，使得所述第二 通道将所述第一通道延伸到所述第一室中，并且指向所述出口的部分类似于所述第一室的形状。

    Disposable device for analyzing a liquid sample containing a nucleic acid with a nucleic acid amplification apparatus
    15.
    发明授权
    Disposable device for analyzing a liquid sample containing a nucleic acid with a nucleic acid amplification apparatus 有权
    用于使用核酸扩增装置分析含有核酸的液体样品的一次性装置

    公开(公告)号：US08642293B2

    公开(公告)日：2014-02-04

    申请号：US12373517

    申请日：2007-07-05

    申请人： Emad Sarofim ,  Olivier Elsenhans ,  Martin Kopp ,  Hans-Peter Wahl

    发明人： Emad Sarofim ,  Olivier Elsenhans ,  Martin Kopp ,  Hans-Peter Wahl

    IPC分类号： C12P19/34 ,  C12M1/00 ,  C12Q1/68

    CPC分类号： B01L3/502715 ,  B01L3/502707 ,  B01L2200/10 ,  B01L2300/0809

    摘要： The invention is directed to a disposable sample holding and processing device (1) dimensioned for being operated in a nucleic acid amplification apparatus for analyzing a liquid sample containing a nucleic acid by a nucleic acid amplification technique. The device (1) comprises chambers (15, 16) and channels (44) designed to perform the steps of capturing, amplification and detection of the nucleic acid within the device (1), and optionally also a lysis chamber (3). The binding chamber (15) contains a solid phase (14) for immobilization of a component of the sample to be analyzed, and the amplification chamber (16) is connected to the binding chamber (15) by a fluid channel (44). The device (1) comprises a rigid body (42) and at least one channel (44), the binding chamber (15) and the amplification chamber (16) are situated on side-surfaces (50) of the body (42), each of those side-surfaces (50), on which a channel (44), the binding chamber (15) or the amplification chamber (16) is situated, is covered by at least one wall (41) and these side-surfaces (50) are substantially vertical planes when the device (1) is operated in the nucleic acid amplification apparatus.

    摘要翻译： 本发明涉及一种一次性样品保持和处理装置（1），其尺寸适于在用于通过核酸扩增技术分析含有核酸的液体样品的核酸扩增装置中操作。 设备（1）包括设计成执行在装置（1）内捕获，扩增和检测核酸以及任选还有裂解室（3）的步骤的室（15,16）和通道（44）。 装订室（15）包含用于固定待分析样品的组分的固相（14），并且扩散室（16）通过流体通道（44）连接到装订室（15）。 装置（1）包括刚体（42）和至少一个通道（44），装订室（15）和放大室（16）位于主体（42）的侧表面（50）上， 其中通道（44），装订室（15）或放大室（16）所在的那些侧表面（50）中的每一个被至少一个壁（41）和这些侧表面 50）在装置（1）在核酸扩增装置中操作时是基本垂直的平面。

    Methods and devices for determining analytes in liquids of small volumes
    16.
    发明授权
    Methods and devices for determining analytes in liquids of small volumes 有权
    用于确定小体积液体中分析物的方法和装置

    公开(公告)号：US08268245B2

    公开(公告)日：2012-09-18

    申请号：US10926926

    申请日：2004-08-26

    申请人： Hans-Peter Wahl

    发明人： Hans-Peter Wahl

    IPC分类号： G01N21/00

    CPC分类号： B01L3/502792 ,  B01L7/52 ,  B01L7/525 ,  B01L2200/10 ,  B01L2300/089 ,  B01L2400/0415 ,  B01L2400/0436

    摘要： A method for determining analytes in a liquid is provided comprising applying a liquid volume to be examined to a substrate of a transport plane; moving the liquid volume to be examined on the substrate of the transport plane to a site of examination; contacting the liquid volume to be examined with at least one sensory element, wherein the sensory element is located in a detection plane opposite to the substrate of the transport plane; and determining an analyte in the liquid volume to be examined by the sensory element, wherein the liquid volume is only in contact with the substrate of the transport plane during the step of moving the liquid volume to be examined on the substrate of the transport plane to a site of examination. The application also concerns a device for determining analytes in a liquid corresponding to the method according to the invention.

    摘要翻译： 提供了一种用于确定液体中的分析物的方法，包括将待检查的液体体积施加到运输平面的基底; 将要检查的液体体积移动到运输平面的基板上，进行检查; 使待检查的液体体积与至少一个感觉元件接触，其中感觉元件位于与输送平面的基底相对的检测平面中; 以及通过所述感觉元件确定要检测的液体体积中的分析物，其中在将待检查的液体体积移动到所述运输平面的基底上的步骤期间，所述液体体积仅与所述输送平面的基底接触， 一个考场。 该应用还涉及用于确定与根据本发明的方法相对应的液体中的分析物的装置。

    SEALING CAP FOR A BODY FLUID CONTAINER AND A BLOOD COLLECTION DEVICE
    18.
    发明申请
    SEALING CAP FOR A BODY FLUID CONTAINER AND A BLOOD COLLECTION DEVICE 有权
    身体液体容器和血液收集装置的密封盖

    公开(公告)号：US20100113976A1

    公开(公告)日：2010-05-06

    申请号：US12617070

    申请日：2009-11-12

    申请人： Hans-Peter Wahl ,  Rolf Schneebeli ,  Renato Belz

    发明人： Hans-Peter Wahl ,  Rolf Schneebeli ,  Renato Belz

    IPC分类号： A61J1/14 ,  B65D51/22

    CPC分类号： B01L3/50825 ,  B01L2300/044 ,  B01L2300/0672

    摘要： A sealing cap for a body fluid container, and a body fluid collection device and system are disclosed. The sealing cap includes an inner cap placeable on an opening in the body fluid container forming a mouth, the inner cap has a shielding member which seals the mouth of the body fluid container, an outer cap resting on the inner cap, the outer cap being movable relative to the inner cap, and a channel member, wherein by a rotational movement the outer cap is movable between an first position in which the channel member is located separated from the shielding member and a second position in which the channel member extends through the shielding member, thereby establishing an open state of the shielding member, and wherein the shielding member returns to a closed state when the outer cap is moved back from the second position to the first position.

    摘要翻译： 公开了一种用于体液容器的密封帽和体液收集装置和系统。 所述密封盖包括可容纳在所述体液容器中的开口上形成口部的内盖，所述内盖具有密封所述体液容器的口部的遮蔽构件，位于所述内盖上的外盖，所述外盖为 可移动相对于内盖，以及通道构件，其中通过旋转运动，外盖可在第一位置和第二位置之间移动，在第一位置，通道构件与屏蔽构件分离，第二位置中通道构件延伸穿过 从而建立所述屏蔽构件的打开状态，并且其中当所述外盖从所述第二位置向后移动到所述第一位置时，所述屏蔽构件返回到关闭状态。

    PIPETTE TIP AND A METHOD FOR PIPETTING A CONGEALED BLOOD SAMPLE UTILIZING THE PIPETTE TIP
    19.
    发明申请
    PIPETTE TIP AND A METHOD FOR PIPETTING A CONGEALED BLOOD SAMPLE UTILIZING THE PIPETTE TIP 有权
    PIPETTE提示和一种使用管道提示来管理血液样本的方法

    公开(公告)号：US20100028934A1

    公开(公告)日：2010-02-04

    申请号：US12512171

    申请日：2009-07-30

    申请人： Gottlieb Schacher ,  Rolf Schneebeli ,  Hans-Peter Wahl

    发明人： Gottlieb Schacher ,  Rolf Schneebeli ,  Hans-Peter Wahl

    IPC分类号： C12Q1/02 ,  C12M1/26

    CPC分类号： B01L3/0275 ,  B01L2200/026 ,  Y10T436/2575

    摘要： A pipette tip and a method for pipetting a congealed blood sample utilizing the pipette tip are disclosed. The pipette tip includes an attachment section configured to be attached to a dispensing device, a liquid containing section configured to receive at least part of an aspired liquid sample, and a liquid aspiration section that is connected to the liquid containing section. The liquid aspiration section has a distal end aspiration opening and at least one further aspiration opening in a side wall.

    摘要翻译： 公开了移液管尖端和利用移液管尖端移液凝血血样的方法。 移液管末端包括被配置为附接到分配装置的附接部分，构造成容纳至少一部分吸取的液体样品的液体容纳部分和连接到液体容纳部分的液体抽吸部分。 液体抽吸部分具有远端抽吸开口和在侧壁中的至少一个另外的抽吸开口。