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75 条记录 (耗时 0.022 秒)

    Process for producing methyl methacrylate
    13.
    发明授权
    Process for producing methyl methacrylate 失效
    生产甲基丙烯酸甲酯的方法

    公开(公告)号：US5087736A

    公开(公告)日：1992-02-11

    申请号：US530089

    申请日：1990-05-29

    申请人： Hirofumi Higuchi ,  Koichi Kida

    发明人： Hirofumi Higuchi ,  Koichi Kida

    IPC分类号： C07C67/317 ,  C07C67/20 ,  C07C67/327 ,  C07C69/54

    CPC分类号： C07C67/20 ,  C07C67/327

    摘要： Disclosed is a process for producing methyl methacrylate which comprises:(I) a step of reacting acetone and prussic acid to form acetonecyanhydrin;(II) a step of hydrating the acetonecyanhydrin obtained in the step (I) to form .alpha.-hydroxyisobutyric acid amide;(III) a step of reacting the .alpha.-hydroxyisobutyric acid amide obtained in the step (II) which methyl formate to form methyl .alpha.-hydroxyisobutyrate and formamide;(IV) a step of dehydrating the methyl .alpha.-hydroxyisobutyrate obtained in the step (III) to form methyl methancrylate; and(V) a step of decomposing the formamide obtained in the step (IV) into ammonia and carbon monoxide.The process can produce methyl methacrylate at high yields without by-production of acidic ammonium sulfate.

    ULTRASONIC SENSOR DEVICE
    14.
    发明申请
    ULTRASONIC SENSOR DEVICE 有权
    超声波传感器装置

    公开(公告)号：US20140157902A1

    公开(公告)日：2014-06-12

    申请号：US14117050

    申请日：2012-06-12

    申请人： Makiko Sugiura ,  Hirofumi Higuchi

    发明人： Makiko Sugiura ,  Hirofumi Higuchi

    IPC分类号： G01S15/50

    CPC分类号： G01S15/50 ,  B06B1/0666 ,  G01S7/521

    摘要： An ultrasonic sensor device includes a substrate, a piezoelectric vibrator, and a Q-factor adjuster. The piezoelectric vibrator includes a pair of detection electrodes that face each other in a thickness direction of the substrate and a piezoelectric body interposed between the electrodes. The piezoelectric vibrator provides a membrane structure which is formed on a surface of the substrate and has rigidity lower than that of a remaining portion of the substrate. An ultrasonic wave is transmitted by the piezoelectric vibrator, and its reflected wave is received by the same piezoelectric vibrator. The Q-factor adjuster adjusts a Q-factor of the piezoelectric vibrator so that the Q-factor can be larger during a transmission period where the piezoelectric vibrator transmits the ultrasonic wave than during a reception period where the piezoelectric vibrator receives the ultrasonic wave.

    摘要翻译： 超声波传感器装置包括基板，压电振动器和Q因子调节器。 压电振子包括在基板的厚度方向上彼此相对的一对检测电极和插在电极之间的压电体。 压电振动器提供形成在基板的表面上的膜结构，其刚性低于基板的剩余部分的刚度。 超声波由压电振子传递，其反射波被同一压电振子接收。 Q因子调节器调节压电振动器的Q因子，使得压电振动器发送超声波的传播期间的Q因子可以比在压电振动器接收超声波的接收时段期间更大。

    Humanized anti-human α9-integrin antibody
    15.
    发明授权
    Humanized anti-human α9-integrin antibody 有权
    人源化抗人α9整联蛋白抗体

    公开(公告)号：US08603476B2

    公开(公告)日：2013-12-10

    申请号：US12812341

    申请日：2009-01-09

    申请人： Kenji Uehara ,  Hirofumi Higuchi ,  Toshihiro Nakashima ,  Daisuke Ishikawa ,  Nobuchika Yamamoto ,  Hirotada Fujita ,  Fumihiko Sakai

    发明人： Kenji Uehara ,  Hirofumi Higuchi ,  Toshihiro Nakashima ,  Daisuke Ishikawa ,  Nobuchika Yamamoto ,  Hirotada Fujita ,  Fumihiko Sakai

    IPC分类号： A61K39/395

    CPC分类号： C07K16/2839 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

    摘要： The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.

    摘要翻译： 本发明提供与供体小鼠抗人α9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人α9整联蛋白抗体，即包含重链可变区的人源化抗人α9整联蛋白抗体，其包含 的SEQ ID NO：11所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，含有重链可变区的人源化抗人α9整联蛋白抗体包含由 由SEQ ID NO：13所示的氨基酸序列和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，含有重链可变区的人源化抗人α9整联蛋白抗体 由SEQ ID NO：15所示的氨基酸序列和由SEQ ID NO：9所示的氨基酸序列组成的轻链可变区，以及预防或治疗涉及 人类α9整联蛋白在发病机制中使用抗体。

    Physical quantity sensor
    16.
    发明申请
    Physical quantity sensor 审中-公开
    物理量传感器

    公开(公告)号：US20090100931A1

    公开(公告)日：2009-04-23

    申请号：US12232120

    申请日：2008-09-11

    申请人： Hirofumi Higuchi

    发明人： Hirofumi Higuchi

    IPC分类号： G01P15/125

    CPC分类号： G01P15/125 ,  G01P15/131

    摘要： A physical quantity sensor has a weight mass movable in a detection direction. Auxiliary capacitors are formed at both side ends of the weight mass in a non-detection direction by auxiliary movable electrodes and auxiliary fixed electrodes, respectively. When capacitances of the auxiliary capacitors change due to movement of the weight mass in the non-detection direction, a limiter circuit feedback-controls voltages applied to the auxiliary fixed electrodes to maintain the position of the weight mass unchanged. Thus, the weight mass is limited from moving in the non-detection direction thereby to improve accuracy in detection of the movement in the detection direction.

    摘要翻译： 物理量传感器具有在检测方向上可移动的重量。 辅助电容器分别通过辅助可动电极和辅助固定电极在非检测方向上形成在重量块的两侧。 当辅助电容器的电容由于重量质量在非检测方向的移动而变化时，限制器电路对施加到辅助固定电极的电压进行反馈控制，以保持重量质量的位置不变。 因此，重量质量被限制为在非检测方向上移动，从而提高检测方向上的运动的检测精度。

    Electrostatically oscillated device
    18.
    发明申请
    Electrostatically oscillated device 有权
    静电摆动装置

    公开(公告)号：US20050199063A1

    公开(公告)日：2005-09-15

    申请号：US11075708

    申请日：2005-03-10

    申请人： Hirofumi Higuchi

    发明人： Hirofumi Higuchi

    IPC分类号： B81B5/00 ,  G01C19/5762 ,  G01P15/08

    CPC分类号： G01C19/5762

    摘要： An oscillator is oscillatable in a predetermined direction. First and second driving electrodes are secured to the base and apply an electrostatic force to the oscillator to make drive oscillation of the oscillator in the predetermined direction. At the time of the drive oscillation of the oscillator, a predetermined electric charge is accumulated in the oscillator, and electric charges of opposite polarities are alternately and periodically accumulated in the first and second driving electrodes, respectively, to exert an attractive force between the oscillator and a corresponding one of the first and second driving electrodes and also to exert a repulsive force between the oscillator and the other one of the first and second driving electrodes, and vice versa.

    摘要翻译： 振荡器可在预定方向上振荡。 第一驱动电极和第二驱动电极固定到基座并向振荡器施加静电力，以使振荡器在预定方向上的驱动振荡。 在振荡器的驱动振荡时，在振荡器中累积预定的电荷，相反极性的电荷分别交替地周期地累积在第一和第二驱动电极中，以在振荡器之间施加吸引力 以及第一和第二驱动电极中的相应一个，并且还在振荡器和第一和第二驱动电极中的另一个之间施加排斥力，反之亦然。

    COMPLEX DEVICE AND ROBOT HAND DRIVE CONTROL APPARATUS
    19.
    发明申请
    COMPLEX DEVICE AND ROBOT HAND DRIVE CONTROL APPARATUS 有权
    复杂装置和机器人手动控制装置

    公开(公告)号：US20140214209A1

    公开(公告)日：2014-07-31

    申请号：US14343526

    申请日：2012-08-28

    申请人： Makiko Sugiura ,  Hirofumi Higuchi

    发明人： Makiko Sugiura ,  Hirofumi Higuchi

    IPC分类号： B25J9/16 ,  G01L1/16 ,  B06B1/06

    CPC分类号： B25J9/1612 ,  B06B1/0674 ,  B25J13/082 ,  G01B17/00 ,  G01L1/16 ,  G01L1/162 ,  G01L1/255 ,  G01L5/226

    摘要： A complex device includes: a substrate having a thick portion, a cavity and a membrane for bridging the cavity; and multiple piezoelectric elements having a lower electrode, a piezoelectric film and an upper electrode. A part of the piezoelectric elements has a projecting portion arranged on the upper electrode. The part of piezoelectric elements (30) provides a vertical pressure detection element. The piezoelectric elements further have an ultrasonic element other than the vertical pressure detection element. The ultrasonic element is arranged over at least the cavity of the substrate in a horizontal direction.

    摘要翻译： 复杂装置包括：具有厚部分的基底，用于桥接空腔的空腔和膜; 以及具有下电极，压电膜和上电极的多个压电元件。 压电元件的一部分具有布置在上电极上的突出部分。 压电元件（30）的一部分提供垂直压力检测元件。 压电元件还具有除垂直压力检测元件之外的超声波元件。 超声波元件在水平方向上至少布置在基板的空腔上。