公开(公告)号：US4965266A

公开(公告)日：1990-10-23

申请号：US296083

申请日：1988-10-18

申请人： Hitoshi Uno ,  Tatsuya Kon ,  Yoshinori Nishikawa ,  Tokuhiko Shindo ,  Hideo Nakamura ,  Katsumi Ishii

发明人： Hitoshi Uno ,  Tatsuya Kon ,  Yoshinori Nishikawa ,  Tokuhiko Shindo ,  Hideo Nakamura ,  Katsumi Ishii

IPC分类号： C07D233/54 ,  A61K31/34 ,  A61K31/341 ,  A61K31/40 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/42 ,  A61K31/421 ,  A61K31/423 ,  A61K31/435 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/454 ,  A61K31/47 ,  A61K31/495 ,  A61K31/496 ,  A61P11/00 ,  A61P27/16 ,  A61P37/08 ,  A61P43/00 ,  C07D207/337 ,  C07D213/64 ,  C07D213/82 ,  C07D215/14 ,  C07D215/48 ,  C07D215/54 ,  C07D215/56 ,  C07D217/02 ,  C07D217/16 ,  C07D217/26 ,  C07D235/06 ,  C07D235/26 ,  C07D237/08 ,  C07D239/26 ,  C07D241/12 ,  C07D241/24 ,  C07D241/44 ,  C07D261/06 ,  C07D261/20 ,  C07D263/30 ,  C07D263/54 ,  C07D307/54 ,  C07D401/06 ,  C07D401/12 ,  C07D409/04 ,  C07D409/06 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  C07D471/04 ,  C07D495/04

CPC分类号： C07D213/82 ,  C07D215/54 ,  C07D471/04

摘要： Heteroarylcarboxamide derivatives of the formula I: ##STR1## wherein A means an alkylene group, X means

公开(公告)号：US4778796A

公开(公告)日：1988-10-18

申请号：US884717

申请日：1986-07-11

申请人： Hitoshi Uno ,  Yoshinori Nishikawa ,  Tokuhiko Shindo ,  Hideo Nakamura ,  Katsumi Ishii

发明人： Hitoshi Uno ,  Yoshinori Nishikawa ,  Tokuhiko Shindo ,  Hideo Nakamura ,  Katsumi Ishii

IPC分类号： A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/455 ,  A61K31/495 ,  A61P7/02 ,  A61P37/08 ,  A61P43/00 ,  C07D213/30 ,  C07D213/48 ,  C07D213/55 ,  C07D213/56 ,  C07D213/57 ,  C07D213/59 ,  C07D213/61 ,  C07D213/62 ,  C07D213/64 ,  C07D213/643 ,  C07D213/65 ,  C07D213/70 ,  C07D213/72 ,  C07D213/74 ,  C07D213/80 ,  C07D213/84 ,  C07D213/87 ,  C07D213/89 ,  C07D215/14 ,  C07D215/38 ,  C07D215/60 ,  C07D243/00 ,  C07D401/12 ,  C07D403/06 ,  C12N9/99 ,  C07D401/14

CPC分类号： C07D213/64 ,  C07D213/56 ,  C07D213/57 ,  C07D213/61 ,  C07D213/643 ,  C07D213/65 ,  C07D213/70 ,  C07D213/72 ,  C07D213/80 ,  C07D213/89 ,  C07D401/12

摘要： Compounds of the formula: ##STR1## wherein X is alkylene or --(CR.sub.6 .dbd.CR.sub.7).sub.r -- wherein R.sub.6 is H, alkyl or phenyl, R.sub.7 is H, alkyl, cyano or phenyl, and r is 1 or 2; A is alkylene or alkylene interrupted by at least one double bond; R.sub.1 is H, halogen, alkyl, alkoxy, alkylthio, cycloalkyloxy, cycloalkylthio, alkoxycarbonyl, carboxy, phenyl, phenoxy, phenylthio, 3-pyridyloxy or 3-pyridylthio; R.sub.2 is H, hydroxy, alkanoyloxy or alkoxycarbonyloxy, or adjacent R.sub.1 and R.sub.2 may combine to form tetramethylene or --CH.sub.2 OCR.sub.8 R.sub.9 O-- (R.sub.8 and R.sub.9 are alkyl); R.sub.3 is H, alkyl or hydroxyalkyl; R.sub.4 is H or alkyl; R.sub.5 is phenyl, heteroaryl or --(CH.sub.2).sub.m --CHR.sub.10 R.sub.11 (R.sub.10 is H or phenyl, R.sub.11 is phenyl or pyridyl and m is 0 to 2); p is 0 or 1; and q is 2 or 3; the phenyl group or moiety being optionally substituted, and a salt thereof, process for the preparation thereof, and pharmaceutical composition containing the same. Said compounds and salts thereof show excellent antiallergic activity mainly through 5-lipoxygenase inhibiting activity, antihistamine activity and/or inhibitory activity against chemical mediator release and useful for treatment of allergic diseases.

摘要翻译： 其中X为亚烷基或 - （CR 6 = CR 7）r - ，其中R 6为H，烷基或苯基，R 7为H，烷基，氰基或苯基，且r为1或2; A是被至少一个双键中断的亚烷基或亚烷基; R 1是H，卤素，烷基，烷氧基，烷硫基，环烷氧基，环烷硫基，烷氧基羰基，羧基，苯基，苯氧基，苯硫基，3-吡啶基氧基或3-吡啶硫基。 R2是H，羟基，烷酰氧基或烷氧基羰基氧基，或相邻的R1和R2可以结合形成四亚甲基或-CH 2 OCR 8 R 9 O-（R 8和R 9是烷基）; R3是H，烷基或羟烷基; R4是H或烷基; R5是苯基，杂芳基或 - （CH2）m-CHR10R11（R10是H或苯基，R11是苯基或吡啶基，m是0-2）; p为0或1; q为2或3; 任选取代的苯基或部分，及其盐，其制备方法和含有该方法的药物组合物。 所述化合物及其盐主要通过5-脂氧合酶抑制活性，抗组织胺活性和/或对化学介质释放的抑制活性显示出优异的抗过敏活性，并且可用于治疗过敏性疾病。

公开(公告)号：US4080453A

公开(公告)日：1978-03-21

申请号：US663158

申请日：1976-03-02

申请人： Haruki Nishimura ,  Hitoshi Uno ,  Kagayaki Natsuka ,  Noriaki Shimokawa ,  Masanao Shimizu ,  Hideo Nakamura

发明人： Haruki Nishimura ,  Hitoshi Uno ,  Kagayaki Natsuka ,  Noriaki Shimokawa ,  Masanao Shimizu ,  Hideo Nakamura

IPC分类号： C07D295/02 ,  C07D295/03 ,  C07D295/096 ,  C07D295/14 ,  A61K31/495

CPC分类号： C07D295/03 ,  C07D295/096

摘要： 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives of the formula: ##STR1## wherein X is 2- or 3-hydroxy, 2-methoxy, 3-methyl, 3-alkoxy having 1 to 4 carbon atoms, or 2- or 3-alkanoyloxy having 2 to 5 carbon atoms; R is allyl, 3-hydroxyisoamyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, propyl, an unsubstituted monocycloalkyl having 5 to 8 carbon atoms, 2-chlorophenyl, or a phenyl substituted by hydroxy or methoxy; with proviso that when X is a substituent at position 2, R is cyclohexyl and when X is 3-methyl, R is 2-methoxyphenyl or an unsubstituted monocycloalkyl having 6 to 8 carbon atoms, and their pharmaceutically acceptable salts, and the preparation thereof, and analgesic or antitussive compositions containing the same as the essentially active ingredient.

摘要翻译： 1-取代的4-（1,2-二苯基乙基）哌嗪衍生物，其结构式如下：其中X是2-或3-羟基，2-甲氧基，3-甲基，具有1至4个碳原子的3-烷氧基， 或具有2至5个碳原子的2-或3-烷酰氧基; R是烯丙基，3-羟基异戊基，3-甲基-2-丁烯基，3-甲基-3-丁烯基，丙基，未取代的具有5-8个碳原子的单环烷基，2-氯苯基或被羟基或甲氧基取代的苯基; 条件是当X是位置2的取代基时，R是环己基，当X是3-甲基时，R是2-甲氧基苯基或未取代的具有6-8个碳原子的单环烷基及其药学上可接受的盐及其制备方法， 以及含有与基本上活性成分相同的镇痛或镇咳药物。

公开(公告)号：US4528299A

公开(公告)日：1985-07-09

申请号：US530096

申请日：1983-09-07

申请人： Hitoshi Uno ,  Tadahiko Karasawa ,  Tatsuya Kon ,  Tsugutaka Ito

发明人： Hitoshi Uno ,  Tadahiko Karasawa ,  Tatsuya Kon ,  Tsugutaka Ito

IPC分类号： C07D295/10 ,  A61K31/40 ,  A61P25/00 ,  A61P25/08 ,  C07D295/108 ,  C07D207/04

CPC分类号： C07D295/108

摘要： 1-(2,3-Dimethyl-4-methoxyphenyl)-2-methyl-3-(1-pyrrolidinyl)-1-propanone and its pharmaceutically acceptable acid addition salts, which are useful as centrally acting muscle relaxants in the treatment of spasticity in mammals including humans, process for the preparation thereof, and pharmaceutical composition containing said compound as an active ingredient.

摘要翻译： 1-（2,3-二甲基-4-甲氧基苯基）-2-甲基-3-（1-吡咯烷基）-1-丙酮及其药学上可接受的酸加成盐，其用作中枢作用的肌肉松弛剂用于治疗痉挛状态 在包括人的哺乳动物中，其制备方法和含有所述化合物作为活性成分的药物组合物。

公开(公告)号：US4649144A

公开(公告)日：1987-03-10

申请号：US632853

申请日：1984-07-20

申请人： Jun-ichi Matsumoto ,  Teruyuki Miyamoto ,  Hitoshi Uno ,  Shinichi Nakamura

发明人： Jun-ichi Matsumoto ,  Teruyuki Miyamoto ,  Hitoshi Uno ,  Shinichi Nakamura

IPC分类号： C07D487/04 ,  A61K31/435 ,  A61K31/4375 ,  A61P31/04 ,  C07D207/12 ,  C07D207/14 ,  C07D213/61 ,  C07D213/78 ,  C07D213/80 ,  C07D213/85 ,  C07D401/04 ,  C07D471/04

CPC分类号： C07D213/78 ,  C07D207/12 ,  C07D207/14 ,  C07D213/61 ,  C07D213/80 ,  C07D213/85 ,  C07D401/04 ,  C07D471/04

摘要： The present invention relates to a 1,8-naphthyridine derivative of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different and each hydrogen or lower alkyl having 1 to 5 carbon atoms; and esters thereof and salts thereof and processes for preparation thereof. These compounds show excellent antibacterial activity and are useful antibacterial agents.

摘要翻译： 本发明涉及下式的1,8-萘啶衍生物，其中R 1，R 2和R 3相同或不同，每个氢或具有1至5个碳原子的低级烷基; 及其酯及其盐及其制备方法。 这些化合物显示出优异的抗菌活性，并且是有用的抗菌剂。

公开(公告)号：US3948928A

公开(公告)日：1976-04-06

申请号：US340195

申请日：1973-03-12

申请人： Haruki Nishimura ,  Masanao Shimizu ,  Hitoshi Uno ,  Tetsuo Hirooka ,  Yoshinobu Masuda ,  Mikio Kurokawa

发明人： Haruki Nishimura ,  Masanao Shimizu ,  Hitoshi Uno ,  Tetsuo Hirooka ,  Yoshinobu Masuda ,  Mikio Kurokawa

IPC分类号： A61K31/42 ,  C07D261/20

CPC分类号： A61K31/42 ,  C07D261/20

摘要： 3-Substituted-1,2-benzisoxazole derivative of the following formula: ##SPC1##Wherein R.sub.1 is hydrogen, hydroxy, nitro, alkyl, alkoxy, halogen or amino; R.sub.2 is hydroxyamino, amino, hydrazino, mono- or di- alkyl substituted amino, aralkylamino, acyloxyamino, morpholino, piperazine which is unsubstituted or substituted with alkyl, aralkyl or aryl at 4 position, or pyrrolidino, or R.sub.2 may combine with imino group and form together with the adjacent carbon atom a heterocyclic ring such as imidazoline or tetrahydropyrimidine; and n is an integer of 0 to 3, and its pharmaceutically acceptable acid addition salt, and preparation thereof. The present compounds show valuable pharmacological properties, such as anti-reserpine activity, central nervous depressing activity, anti-hypertensive activity and l-dopa potentiating activity.

摘要翻译： 3-取代的1,2-苯并异恶唑衍生物：

公开(公告)号：US5955918A

公开(公告)日：1999-09-21

申请号：US997895

申请日：1997-12-24

申请人： Hitoshi Uno

发明人： Hitoshi Uno

IPC分类号： H03G11/00 ,  H03F3/08 ,  H03F3/45 ,  H03F1/02

CPC分类号： H03F3/087

摘要： An amplifier circuit unit is composed of an offset compensation circuit for equalizing and issuing a DC potential in data input period of one input signal of differential input signals, and a DC potential in data input period of other input signal, and an amplitude limiting amplifier circuit for receiving a differential output signal from this offset compensation circuit as an input signal, and issuing to a differential output terminal as a differential output signal kept in a constant output signal amplitude while amplifying in a linear region. This amplifier circuit unit is connected in cascade in plural stages as required, and is applied to an amplifier circuit of an optical receiving circuit and others.

摘要翻译： 放大器电路单元由偏移补偿电路构成，用于在差分输入信号的一个输入信号的数据输入周期中平衡并发出DC电位，并且在其他输入信号的数据输入周期中的DC电位和限幅放大器电路 用于接收来自该偏移补偿电路的差分输出信号作为输入信号，并且在线性区域放大的同时，向差分输出端子发出作为保持在恒定输出信号幅度的差分输出信号。 该放大器电路单元根据需要以多级级联连接，并被应用于光接收电路等的放大电路。

公开(公告)号：US4889858A

公开(公告)日：1989-12-26

申请号：US180104

申请日：1988-02-17

申请人： Hitoshi Uno ,  Mikio Kurokawa ,  Fuminori Sato ,  Shunsuke Naruto ,  Yoshinobu Masuda

发明人： Hitoshi Uno ,  Mikio Kurokawa ,  Fuminori Sato ,  Shunsuke Naruto ,  Yoshinobu Masuda

IPC分类号： C07D313/12 ,  C07D401/12 ,  C07D409/12

CPC分类号： C07D401/12 ,  C07D313/12 ,  C07D409/12

摘要： The present invention relates to compounds represented by the general formula (I): ##STR1## wherein R.sub.1 is H or methoxy, R.sub.2 is H, methoxy, OH or F, R.sub.3 is H or F, R.sub.4 is H or F at 7-, 8- or 9-position, and .circle.Ar is a benzene, thiophene or pyridine ring, provided that (i) at least two of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are H, (ii) R.sub.2 or R.sub.3 is F when R.sub.4 is F, (iii) R.sub.1, R.sub.3 and R.sub.4 are H when R.sub.2 is methoxy or OH, (iv) R.sub.2 and R.sub.3 are not simultaneously F, and (v) R.sub.2 and R.sub.3 are H or F, and both R.sub.1 and R.sub.4 are H when .circle.Ar is a thiophene or pyridine ring, or a physiologically acceptable acid addition salt thereof. The compounds of the present invention have an excellent protective effect against cerebral anoxia and some of them have also an inhibitory effect on lipid peroxidation of mitochondrial membrane of brain and an anti-convulsant activity and are useful as an agent for prevention or treatment of cerebral diseases caused by hypoxia in mammals including human.

公开(公告)号：US3992391A

公开(公告)日：1976-11-16

申请号：US280953

申请日：1972-08-16

申请人： Hitoshi Uno ,  Junji Nakano ,  Toshiaki Kadokawa

发明人： Hitoshi Uno ,  Junji Nakano ,  Toshiaki Kadokawa

IPC分类号： C07D213/75 ,  C07D213/74

CPC分类号： C07D213/75

摘要： 1,3-Disubstituted thiourea compounds represented by the following formula: ##EQU1## and their pharmaceutically acceptable acid addition salts which are useful especially for prevention and treatment of hypoxemia and further various diseases caused by hypoxia in local tissues, and process for the preparation of the present compounds set forth above and pharmaceutical composition containing the present compounds as an essential active ingredient.

摘要翻译： 由下式表示的1,3-二取代硫脲化合物：R-HNCNH-R'PARALLEL S及其药学上可接受的酸加成盐，其特别用于预防和治疗低氧血症以及局部组织中由缺氧引起的各种疾病，以及 制备本发明化合物的方法和含有本发明化合物作为必需活性成分的药物组合物。

公开(公告)号：US06633224B1

公开(公告)日：2003-10-14

申请号：US09125402

申请日：1999-06-28

申请人： Toshihiro Hishida ,  Hidetaka Ohto ,  Hitoshi Uno ,  Kazunori Watanabe ,  Masakazu Kawano ,  Hiromi Wada ,  Yasunori Tanaka ,  Yoshifumi Yonemoto

发明人： Toshihiro Hishida ,  Hidetaka Ohto ,  Hitoshi Uno ,  Kazunori Watanabe ,  Masakazu Kawano ,  Hiromi Wada ,  Yasunori Tanaka ,  Yoshifumi Yonemoto

IPC分类号： G08B522

CPC分类号： G08B5/229

摘要： A radio pager system includes a radio pager that can receive messages and can specify a specific output mode, including a display, a sound output, a vibration, and a light emission appropriate to a particular type of message. The radio pager can further reduce difficulties in retransmitting and/or replying to messages and save time in the transmission period. The radio pager can receive and implement a radio message that includes control information which can be utilized for generating the specific output mode of the display.

摘要翻译： 无线寻呼机系统包括可以接收消息并且可以指定特定输出模式的无线寻呼机，包括显示器，声音输出，振动和适合于特定类型的消息的发光。 无线寻呼机可以进一步减少在重发和/或回复消息方面的困难，并节省传输时间。 无线寻呼机可以接收和实现包括可用于生成显示器的特定输出模式的控制信息的无线电消息。