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11.发明申请SULFAMOYL-ARYLAMIDES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B 审中-公开磺酰亚胺及其作为治疗乙型肝炎的药物的用途公开(公告)号：US20160002155A1
公开(公告)日：2016-01-07
申请号：US14771448
申请日：2014-02-27
IPC分类号： C07C311/37 , A61K31/277 , A61K31/18 , A61K31/27 , A61K45/06
CPC分类号： C07C311/37 , A61K31/18 , A61K31/27 , A61K31/277 , A61K45/06 , C07C311/16 , C07C311/17 , C07C311/18 , C07C311/19 , C07C317/28 , A61K2300/00
摘要： Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, salts, hydrates and solvates thereof, wherein R1, R2, R3 and R4 have the meaning as defined herein.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
摘要翻译： 式（I）的HBV复制抑制剂包括立体化学异构体形式，其盐，水合物和溶剂化物，其中R1，R2，R3和R4具有如本文所定义的含义。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在HBV治疗中单独或与其它HBV抑制剂组合的用途。
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公开(公告)号：US10780089B2
公开(公告)日：2020-09-22
申请号：US16530385
申请日：2019-08-02
发明人： David McGowan , Pierre Jean-Marie Bernard Raboisson , Werner Embrechts , Tim Hugo Maria Jonckers , Stefaan Julien Last , Serge Maria Aloysius Pieters , Jaromir Vlach
IPC分类号： A61K31/513 , A61K31/5377 , A61K31/506 , A61P31/12 , C07D487/04 , C07D413/12 , C07D401/10 , C07D403/12 , C07D405/12 , C07D471/04 , C07D495/04 , C07D239/48 , A61K31/505 , C07D401/12 , C07D403/10
摘要： This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
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13.发明授权公开(公告)号：US10398677B2
公开(公告)日：2019-09-03
申请号：US15886766
申请日：2018-02-01
发明人： Koen Vandyck , Geerwin Yvonne Paul Haché , Stefaan Julien Last , Pierre Jean-Marie Bernard Raboisson
IPC分类号： C07D207/16 , C07D207/48 , A61K31/40 , C07D405/12 , C07D409/12 , C07D487/08 , C07D209/42 , A61K31/4025 , A61K31/403 , A61K31/404 , A61K31/407 , A61K45/06 , C07D209/52 , C07D403/12 , C07D487/04 , C07D491/107
摘要： Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, R1, R2, R3 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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14.发明授权公开(公告)号：US10253003B2
公开(公告)日：2019-04-09
申请号：US15591473
申请日：2017-05-10
发明人： Stefaan Julien Last , David Craig McGowan , Werner Embrechts , Serge Maria Aloysius Pieters , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson
IPC分类号： C07D239/84 , C07D239/95 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： This invention relates to heterocyclic substituted 2-amino-quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
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公开(公告)号：US20180207155A1
公开(公告)日：2018-07-26
申请号：US15867041
申请日：2018-01-10
发明人： David McGOWAN , Pierre Jean-Marie Bernard Raboisson , Werner Embrechts , Tim Hugo Maria Jonckers , Stefaan Julien Last , Serge Maria Aloysius Pieters , Jaromir Vlach
IPC分类号： A61K31/505 , A61K31/5377 , A61K31/506
摘要： This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
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![Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases](/abs-image/US/2017/02/16/US20170044169A1/abs.jpg.150x150.jpg)
16.发明申请Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases 审中-公开吡咯并[3,2-d]嘧啶衍生物，用于治疗病毒感染等疾病公开(公告)号：US20170044169A1
公开(公告)日：2017-02-16
申请号：US15333947
申请日：2016-10-25
发明人： David Craig Mc Gowan , Stefaan Julien Last , Serge Maria Aloysius Pieters , Werner Embrechts , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , A61K31/407 , A61K31/519 , A61P31/12 , C07D519/00
摘要： This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.
摘要翻译： 本发明涉及吡咯并[3,2-d]嘧啶衍生物，其制备方法，药物组合物及其在治疗和/或治疗疾病中的用途。
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17.发明授权公开(公告)号：US10995064B2
公开(公告)日：2021-05-04
申请号：US15681309
申请日：2017-08-18
发明人： Koen Vandyck , Stefaan Julien Last , Geert Rombouts , Wim Gaston Verschueren , Pierre Jean-Marie Bernard Raboisson
IPC分类号： A61K31/4164 , A61K31/426 , C07D207/36 , C07D277/36 , C07C311/37 , C07C311/14 , A61K31/18 , A61K31/337 , A61K31/341 , A61K31/351 , A61K31/44 , A61K31/4453 , A61K31/4468 , C07C311/16 , C07C311/20 , C07C311/51 , C07D211/96 , C07D305/08 , C07D307/22 , C07D205/04 , C07D207/273 , C07D213/42 , C07D307/60 , C07D213/81 , C07D213/82 , C07D333/38 , C07D333/48 , C07D233/90 , C07D491/107 , C07D207/14 , C07D493/08 , C07D277/56 , C07D211/28 , C07D295/13 , C07D211/56 , C07D211/76 , C07D295/26 , C07D307/68 , A61K31/34 , A61K31/397 , A61K31/495 , A61K31/5375 , A61K31/55 , C07D223/06 , C07D233/84 , C07D309/14 , A61K31/401 , A61K45/06
摘要： Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R1, R2 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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18.发明授权公开(公告)号：US10941113B2
公开(公告)日：2021-03-09
申请号：US16188238
申请日：2018-11-12
IPC分类号： C07C311/37 , A61K31/18 , C07C311/16 , C07C311/17 , C07C311/18 , C07C311/19 , C07C317/28 , A61K45/06 , A61K31/27 , A61K31/277
摘要： Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, salts, hydrates and solvates thereof, wherein R1, R2, R3 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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19.发明授权公开(公告)号：US10676429B2
公开(公告)日：2020-06-09
申请号：US14423963
申请日：2013-08-28
发明人： Koen Vandyck , Stefaan Julien Last , Geert Rombouts , Wim Gaston Verschueren , Pierre Jean-Marie Bernard Raboisson
IPC分类号： C07D213/42 , C07D213/81 , C07D213/82 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , C07C311/37 , C07C311/14 , C07C311/16 , C07C311/20 , C07C311/51 , A61K31/18 , A61K31/337 , A61K31/341 , A61K31/351 , A61K31/4164 , A61K31/426 , A61K31/4453 , A61K31/4468 , C07D211/96 , C07D305/08 , C07D307/22 , C07D205/04 , C07D207/273 , C07D307/60 , C07D333/38 , C07D333/48 , C07D233/90 , C07D491/107 , C07D207/14 , C07D207/36 , C07D277/56 , C07D211/28 , C07D295/13 , C07D211/56 , C07D211/76 , C07D295/26 , C07D307/68 , C07D493/08 , A61K31/34 , A61K31/397 , A61K31/495 , A61K31/5375 , A61K31/55 , C07D223/06 , C07D233/84 , C07D309/14 , A61K31/401 , A61K45/06
摘要： Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R1, R2 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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20.发明授权公开(公告)号：US10125094B2
公开(公告)日：2018-11-13
申请号：US14771448
申请日：2014-02-27
IPC分类号： C07C311/37 , A61K31/18 , C07C311/16 , C07C311/17 , C07C311/18 , C07C311/19 , C07C317/28 , A61K45/06 , A61K31/27 , A61K31/277
摘要： Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, salts, hydrates and solvates thereof, wherein R1, R2, R3 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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