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公开(公告)号:US20090062633A1
公开(公告)日:2009-03-05
申请号:US12264835
申请日:2008-11-04
申请人: James H. Brauker , Mark A. Tapsak , Mark Shults , Victoria Carr-Brendel , Jack C. Fisher , William J. Seare, JR. , Paul V. Neale
发明人: James H. Brauker , Mark A. Tapsak , Mark Shults , Victoria Carr-Brendel , Jack C. Fisher , William J. Seare, JR. , Paul V. Neale
IPC分类号: A61B5/1473
CPC分类号: A61B5/14865 , A61B5/0031 , A61B5/14532 , A61B5/6882
摘要: An implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor. The sensor further provides a transmitter for RF transmission through the sensor body, electronic circuitry, and a power source optimized for long-term use in the miniaturized sensor body.
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公开(公告)号:US20060258761A1
公开(公告)日:2006-11-16
申请号:US11404418
申请日:2006-04-14
申请人: Robert Boock , Monica Rixman , Mark Tapsak , Mark Shults , Rathbun Rhodes
发明人: Robert Boock , Monica Rixman , Mark Tapsak , Mark Shults , Rathbun Rhodes
IPC分类号: C08J9/00
CPC分类号: C08L83/04 , A61B5/14532 , A61B5/14865 , A61B5/6848 , B01D69/141 , B01D71/54 , B01D71/80 , C08G77/12 , C08G77/20 , C08G77/46 , C12Q1/002 , C08L2666/14
摘要: Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.
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公开(公告)号:US20070032718A1
公开(公告)日:2007-02-08
申请号:US11546157
申请日:2006-10-10
申请人: Mark Shults , Stuart Updike , Rathbun Rhodes , Barbara Gilligan , Mark Tapsak
发明人: Mark Shults , Stuart Updike , Rathbun Rhodes , Barbara Gilligan , Mark Tapsak
IPC分类号: A61B5/05
CPC分类号: C12Q1/006 , A61B5/0031 , A61B5/14532 , A61B5/14558 , A61B5/14865
摘要: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
摘要翻译: 描述了用于确定分析物水平的装置和方法。 装置和方法允许植入分析物监测装置,例如葡萄糖监测装置,其导致输送可靠的血液流以将样品输送到植入装置。 这些设备在传感器区域中包括独特的架构布置,可以在长时间内获得准确的数据。
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公开(公告)号:US20060086624A1
公开(公告)日:2006-04-27
申请号:US11280672
申请日:2005-11-16
申请人: Mark Tapsak , Rathbun Rhodes , Mark Shults , Jason McClure
发明人: Mark Tapsak , Rathbun Rhodes , Mark Shults , Jason McClure
IPC分类号: G01N27/26
CPC分类号: A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/1486 , A61B2562/028 , A61B2562/125 , A61L31/12 , B01D69/141 , B01D71/54 , B01D71/80 , B05D3/007 , B05D5/00 , C12Q1/002 , C12Q1/006 , Y10T428/31551
摘要: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
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公开(公告)号:US20060068208A1
公开(公告)日:2006-03-30
申请号:US11280102
申请日:2005-11-16
申请人: Mark Tapsak , Rathbun Rhodes , Mark Shults , Jason McClure
发明人: Mark Tapsak , Rathbun Rhodes , Mark Shults , Jason McClure
IPC分类号: B32B27/40
CPC分类号: A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/1486 , A61B2562/028 , A61B2562/125 , A61L31/12 , B01D69/141 , B01D71/54 , B01D71/80 , B05D3/007 , B05D5/00 , C12Q1/002 , C12Q1/006 , Y10T428/31551
摘要: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
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公开(公告)号:US20050124873A1
公开(公告)日:2005-06-09
申请号:US11039269
申请日:2005-01-19
申请人: Mark Shults , Stuart Updike , Rathbun Rhodes , Barbara Gilligan , Mark Tapsak
发明人: Mark Shults , Stuart Updike , Rathbun Rhodes , Barbara Gilligan , Mark Tapsak
CPC分类号: C12Q1/006 , A61B5/0031 , A61B5/14532 , A61B5/14558 , A61B5/14865
摘要: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that slows accurate date to be obtained over long periods of time.
摘要翻译: 描述了用于确定分析物水平的装置和方法。 装置和方法允许植入分析物监测装置,例如葡萄糖监测装置,其导致输送可靠的血液流以将样品输送到植入装置。 这些设备在传感器区域中包括独特的架构布置,可以减慢长时间获得的准确日期。
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公开(公告)号:US20060195029A1
公开(公告)日:2006-08-31
申请号:US11333837
申请日:2006-01-17
申请人: Mark Shults , Rathburn Rhodes , Stuart Updike , James Brauker
发明人: Mark Shults , Rathburn Rhodes , Stuart Updike , James Brauker
IPC分类号: A61B5/05
CPC分类号: A61B5/14532 , A61B5/0002 , A61B5/14 , A61B5/1411 , A61B5/14514 , A61B5/14546 , A61B5/14865 , A61B5/1495 , A61B5/150022 , A61B5/6833 , A61B5/6848 , A61B5/6849 , A61B2560/0223
摘要: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.
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公开(公告)号:US09986942B2
公开(公告)日:2018-06-05
申请号:US11503367
申请日:2006-08-10
申请人: James H. Brauker , Robert Boock , Monica Rixman , Peter C. Simpson , Mark Brister , Mark Shults
发明人: James H. Brauker , Robert Boock , Monica Rixman , Peter C. Simpson , Mark Brister , Mark Shults
IPC分类号: A61B5/1486 , A61B5/1473 , G01N33/66 , A61B5/145 , A61B5/00 , C12Q1/00 , G01N33/543
CPC分类号: A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/411 , A61B5/418 , A61B5/6848 , A61B2562/08 , C12Q1/006 , G01N33/54366 , G01N33/66 , Y02A50/55 , Y02A50/58
摘要: Biointerface membranes are provided which can be utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device incorporating such membranes are provided.
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公开(公告)号:US20100087724A1
公开(公告)日:2010-04-08
申请号:US12633578
申请日:2009-12-08
申请人: James H. Brauker , Mark Shults , Mark A. Tapsak
发明人: James H. Brauker , Mark Shults , Mark A. Tapsak
IPC分类号: A61B5/1486 , A61B5/145
CPC分类号: A61B5/14735 , A61B5/076 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2562/02 , A61L31/10 , A61L31/14 , Y10T428/249921
摘要: The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.
摘要翻译: 本发明提供了一种用于与可植入装置一起使用的生物界面膜,其干扰屏障细胞层的形成,包括: 远离植入装置的第一区域,其中第一结构域支持组织附着并干扰阻挡细胞层形成,以及邻近可植入装置的第二结构域,其中第二结构域对细胞附着有抗性并且对细胞是不可渗透的。 此外,本发明提供了包括生物界面膜,包括这些传感器或生物界面膜的可植入装置的传感器,以及利用本发明的分析物检测可植入装置监测宿主中的葡萄糖水平的方法。 还提供了包括本发明的生物界面膜的其它可植入装置,例如用于细胞移植的装置,药物递送装置和电信号传送或测量装置。
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公开(公告)号:US20080086273A1
公开(公告)日:2008-04-10
申请号:US11691466
申请日:2007-03-26
申请人: Mark Shults , Apurv U. Kamath , Mark Brister , David K. Wong
发明人: Mark Shults , Apurv U. Kamath , Mark Brister , David K. Wong
IPC分类号: G06F19/00
CPC分类号: A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61B5/1495 , A61B5/412 , A61B5/6848 , A61B5/6849 , A61B2560/0223 , A61M5/14 , A61M5/16804 , A61M5/1723 , A61M2230/201
摘要: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.
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