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公开(公告)号：US20080219988A1
公开(公告)日：2008-09-11
申请号：US11928383
申请日：2007-10-30
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Robert A. Henderson , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Robert A. Henderson , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick
IPC分类号： A61K39/395 , C07K7/06 , C07H21/00 , C12N15/63 , C12N1/00 , C07K16/00 , A61K35/12 , A61P35/00 , A61K38/16 , G01N33/574 , C07K14/00 , C12N5/00 , A61K38/08 , A61K31/7052
CPC分类号： C07K14/005 , A01K2227/105 , A01K2267/0331 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2035/124 , A61K2039/505 , A61K2039/5156 , A61K2039/53 , A61K2039/55566 , C07K14/47 , C07K14/4748 , C07K14/705 , C07K16/3069 , C07K2317/565 , C07K2317/73 , C07K2319/00 , C12N9/6424 , C12N2760/16222 , G01N33/57434
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
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12.发明授权公开(公告)号：US06680197B2
公开(公告)日：2004-01-20
申请号：US09834759
申请日：2001-04-13
申请人： Yuqiu Jiang , Davin C. Dillon , Jennifer L. Mitcham , Jiangchun Xu , Susan L. Harlocker , William T. Hepler , Robert A. Henderson
发明人： Yuqiu Jiang , Davin C. Dillon , Jennifer L. Mitcham , Jiangchun Xu , Susan L. Harlocker , William T. Hepler , Robert A. Henderson
IPC分类号： C12N508
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , A61K2039/5154 , A61K2039/57 , C07K14/4748 , C07K2319/00 , C12N9/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是乳腺癌的组合物和方法。 示例性组合物包含一种或多种乳腺肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是乳腺癌的诊断，预防和/或治疗。
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公开(公告)号：US06426072B1
公开(公告)日：2002-07-30
申请号：US09643597
申请日：2000-08-21
申请人： Tongtong Wang , Liqun Fan , Michael D. Kalos , Chaitanya S. Bangur , Nancy A. Hosken , Gary R. Fanger , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , Robert A. Henderson , Patricia D. McNeill
发明人： Tongtong Wang , Liqun Fan , Michael D. Kalos , Chaitanya S. Bangur , Nancy A. Hosken , Gary R. Fanger , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , Robert A. Henderson , Patricia D. McNeill
IPC分类号： A61K3900
CPC分类号： C07K16/3023
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.
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公开(公告)号：US07049063B2
公开(公告)日：2006-05-23
申请号：US09735705
申请日：2000-12-12
申请人： Tongtong Wang , Liqun Fan , Michael D. Kalos , Chaitanya S. Bangur , Nancy A. Hosken , Gary R. Fanger , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , Robert A. Henderson , Patricia D. McNeill , Neil Fanger
发明人： Tongtong Wang , Liqun Fan , Michael D. Kalos , Chaitanya S. Bangur , Nancy A. Hosken , Gary R. Fanger , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , Robert A. Henderson , Patricia D. McNeill , Neil Fanger
CPC分类号： C07K16/3023 , A61K38/00 , A61K39/00 , A61K2039/5154 , A61K2039/53 , A61K2039/6068 , C07K14/47 , C07K2317/21 , C07K2319/00 , C12Q1/6809 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是肺癌的组合物和方法。 说明性组合物包含一种或多种肺肿瘤多肽，其免疫原性部分，编码这种多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是肺癌的诊断，预防和/或治疗。
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公开(公告)号：US06737514B1
公开(公告)日：2004-05-18
申请号：US09630940
申请日：2000-08-02
申请人： Tongtong Wang , Liqun Fan , Michael D. Kalos , Chaitanya S. Bangur , Nancy A. Hosken , Gary R. Fanger , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , Robert A. Henderson , Patricia D. McNeill
发明人： Tongtong Wang , Liqun Fan , Michael D. Kalos , Chaitanya S. Bangur , Nancy A. Hosken , Gary R. Fanger , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , Robert A. Henderson , Patricia D. McNeill
IPC分类号： C07K1600
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , A61K2039/5154 , C07K16/3023 , C07K2319/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如肺癌。 组合物可以包含一种或多种肺肿瘤蛋白，其免疫原性部分，或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达肺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如肺癌的疾病。 还提供了基于检测样品中的肺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。
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公开(公告)号：US20080171690A1
公开(公告)日：2008-07-17
申请号：US11929579
申请日：2007-10-30
申请人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D. Kalos , Paul R. Sleath , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
发明人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D. Kalos , Paul R. Sleath , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K14/47 , C07K16/3023 , C07K2317/34 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12Q1/6886 , C12Q2600/158 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是肺癌的组合物和方法。 说明性组合物包含一种或多种肺肿瘤多肽，其免疫原性部分，编码这种多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是肺癌的诊断，预防和/或治疗。
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公开(公告)号：US20080292633A1
公开(公告)日：2008-11-27
申请号：US11929565
申请日：2007-10-30
申请人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D. Kalos , Paul R. Sleath , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
发明人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D. Kalos , Paul R. Sleath , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
IPC分类号： A61K39/395 , C07H21/00 , C07K14/00 , C12N15/00 , C12N5/00 , A61K35/12 , C07K16/00 , G01N33/574 , C12N5/02
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K14/47 , C07K16/3023 , C07K2317/34 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12Q1/6886 , C12Q2600/158 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
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公开(公告)号：US20080171048A1
公开(公告)日：2008-07-17
申请号：US11929572
申请日：2007-10-30
申请人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D. Kalos , Paul R. Sleath , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
发明人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Michael D. Kalos , Paul R. Sleath , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K14/4748 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K14/47 , C07K16/3023 , C07K2317/34 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12Q1/6886 , C12Q2600/158 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
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公开(公告)号：US20090062194A1
公开(公告)日：2009-03-05
申请号：US11929772
申请日：2007-10-30
申请人： Tongtong Wang , Robert A. Henderson , Teresa M. Foy , Patricia D. McNeill , Yoshihiro Watanabe , Michael D. Kalos , Gary R. Fanger , Chaitanya S. Bangur
发明人： Tongtong Wang , Robert A. Henderson , Teresa M. Foy , Patricia D. McNeill , Yoshihiro Watanabe , Michael D. Kalos , Gary R. Fanger , Chaitanya S. Bangur
CPC分类号： G01N33/57411 , A61K39/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/545 , C07K14/47 , C07K14/4748 , C07K16/3023 , C07K2317/21 , C07K2317/34 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/40 , C12N15/86 , C12N2710/10343 , C12N2710/10371 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/5088 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是肺癌的组合物和方法。 说明性组合物包含一种或多种肺肿瘤多肽，其免疫原性部分，编码这种多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是肺癌的诊断，预防和/或治疗。
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公开(公告)号：US06858204B2
公开(公告)日：2005-02-22
申请号：US10017754
申请日：2001-10-29
申请人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
发明人： Robert A. Henderson , Tongtong Wang , Yoshihiro Watanabe , Jeffrey C. Johnson , Marc W. Retter , Margarita Durham , Darrick Carter , Gary R. Fanger , Thomas S. Vedvick , Chaitanya S. Bangur , Andria McNabb
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C07K2319/00 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
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