公开(公告)号：US20120316558A1

公开(公告)日：2012-12-13

申请号：US13578883

申请日：2011-02-22

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Gerhrdus Wilhelmus Lucassen ,  Rami Nachabe ,  Waltherus Cornelis Jozef Bierhoff ,  Adrien Emmanuel Desjardins

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Gerhrdus Wilhelmus Lucassen ,  Rami Nachabe ,  Waltherus Cornelis Jozef Bierhoff ,  Adrien Emmanuel Desjardins

IPC分类号： A61B18/14

CPC分类号： A61B18/1477 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B8/0841 ,  A61B18/02 ,  A61B2017/00057 ,  A61B2017/00061 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2018/00577 ,  A61B2034/2063 ,  A61B2090/378

摘要： An interventional ablation device (1) is proposed to comprise an ablation needle (3) with an elongated body (5) and a handle (7). Adjacent to an ablation element (9) provided on the body (5), at least one or preferably two or more sensors (11-21) are provided, preferably at both of opposing sides of the ablation element (9). The ablation device (1) is adapted for detecting physiological information of tissue (27, 29, 31) surrounding an ablation site (33) based on measurement values provided by the sensors. E.g., optical sensors may be used to measure a reflectance spectrum indicating whether the adjacent tissue is healthy tissue (31), tumorous tissue (27) or ablated tissue (29). Using such information, an ablation process may be controlled.

摘要翻译： 提出介入消融装置（1）包括具有细长主体（5）和手柄（7）的消融针（3）。 设置在主体（5）上的消融元件（9）附近，优选地在消融元件（9）的相对两侧提供至少一个或优选两个或更多个传感器（11-21）。 消融装置（1）适于基于由传感器提供的测量值来检测围绕消融部位（33）的组织（27,29,31）的生理信息。 例如，光学传感器可用于测量反映光谱，其指示相邻组织是健康组织（31），肿瘤组织（27）还是消融组织（29）。 使用这种信息，可以控制消融过程。

公开(公告)号：US20100282954A1

公开(公告)日：2010-11-11

申请号：US12810523

申请日：2008-12-22

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Augustinus Laurentius Braun ,  Nenad Mihajlovic ,  Gert 'T Hooft

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Augustinus Laurentius Braun ,  Nenad Mihajlovic ,  Gert 'T Hooft

IPC分类号： G01J1/58 ,  G01J1/00 ,  G02B26/10

CPC分类号： A61B5/0062 ,  A61B1/00096 ,  A61B1/00165 ,  A61B1/00183 ,  A61B1/0019 ,  A61B5/0084

摘要： The present invention relates to an optical probe (1) with an optical guide (2), e.g. an optical fibre, and a lens system (6) rigidly coupled to an end portion (2a) of the optical guide. The probe has a housing (3) with a cavity for the optical guide, the housing having at its distal end a transparent window (4), the window having an insignificant optical power as compared to the optical power of the said lens system (6). Actuation means (8) displaces the 5 lens system so as to enable optical scanning of a region of interest (ROI). The invention is particularly suited for miniature applications e.g. for in-vivo medical application. By attaching the lens system (6) to the optical guide (2) via the mount (7), the field of view (FOV) of the optical probe (1) may be determined directly by the transverse stroke of the optical fibre (2). Hence only a relatively small stroke is required. The field of view is thus 10 effectively no longer limited by the transverse stroke. The optical probe is especially advantageous for non-linear optical imaging where the optical guide may be an optical fibre with a relatively low exit numerical aperture.

摘要翻译： 本发明涉及一种具有光导（2）的光学探针（1），例如， 光纤，以及刚性地耦合到光导的端部（2a）的透镜系统（6）。 该探针具有一个具有用于光导的空腔的壳体（3），该壳体在其远端处具有透明窗口（4），该窗口与所述透镜系统（6）的光焦度相比具有无效的光焦度 ）。 驱动装置（8）使5透镜系统移位，以便对感兴趣区域（ROI）进行光学扫描。 本发明特别适用于微型应用，例如 用于体内医疗应用。 通过经由安装件（7）将透镜系统（6）附接到光导（2），光学探头（1）的视场（FOV）可以直接由光纤（2）的横向行程确定 ）。 因此，只需要相对较小的行程。 因此，视场10不再受横向行程的限制。 光学探头对于非线性光学成像特别有利，其中光导可以是具有相对低的出射数值孔径的光纤。

公开(公告)号：US20080231987A1

公开(公告)日：2008-09-25

申请号：US10597176

申请日：2005-01-14

申请人： Waltherus Cornelis Jozef Bierhoff

发明人： Waltherus Cornelis Jozef Bierhoff

IPC分类号： G11B15/68

CPC分类号： G11B23/0307 ,  G11B23/0035 ,  G11B23/0312

摘要： A disk cartridge comprises a disk (1) having a central hub (4) for engagement with a disk drive. The disk is accommodated in a housing (2). The housing and disk are dimensioned such that there is limited clearance in a direction parallel to and perpendicular to the plane of the disk. The cartridge comprises a clamping member (11), such as a magnet, to clamp the disk to one side of the cartridge housing when the cartridge is free from the disk drive. The housing and the disk have co-operating centering members (13, 14), preferably near the center of the disk, so as to center the disk with respect to the cartridge housing when the disk is clamped to the housing by the clamping member. In this way, the disk is always in the correct position for a next engagement by the disk drive.

摘要翻译： 磁盘盒包括具有用于与磁盘驱动器接合的中心集线器（4）的磁盘（1）。 盘容纳在壳体（2）中。 壳体和盘的尺寸使得在平行于和垂直于盘的平面的方向上具有有限的间隙。 该盒包括诸如磁体的夹紧构件（11），以在盒从盘驱动器脱离时将盘夹紧到盒壳体的一侧。 壳体和盘具有合适的对中构件（13,14），优选地靠近盘的中心，以便当盘通过夹紧构件夹紧到壳体时使盘相对于盒壳体居中。 以这种方式，磁盘总是处于正确的位置，以供下一次由磁盘驱动器进行接合。

公开(公告)号：US09757201B2

公开(公告)日：2017-09-12

申请号：US14131518

申请日：2012-07-05

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Nicolaas Jan Noordhoek ,  Gerhardus Wilhelmus Lucassen ,  Pieter Maria Mielekamp ,  Rami Nachabė ,  Marjolein Van Der Voort ,  Waltherus Cornelis Jozef Bierhoff

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Nicolaas Jan Noordhoek ,  Gerhardus Wilhelmus Lucassen ,  Pieter Maria Mielekamp ,  Rami Nachabė ,  Marjolein Van Der Voort ,  Waltherus Cornelis Jozef Bierhoff

IPC分类号： A61B18/04 ,  A61B19/00 ,  A61B18/14 ,  A61B18/00 ,  A61B34/10

CPC分类号： A61B34/10 ,  A61B18/14 ,  A61B2018/00577 ,  A61B2034/101

摘要： The invention relates to an energy application planning apparatus for planning an application of energy to an object (3) like a tumor. An energy application element representation represents an energy application element (5) like an ablation needle including an energy application part for applying energy and a sensing part (7). An arrangement of the energy application element (5) with respect to the object (3) is determined depending on the positions of the energy application part and the sensing part (7) with respect to the energy application element (5) as defined by the energy application element representation and depending on the object representation. The application of energy can therefore not only be planned such that the application of energy is performed as desired, but also such that the object and/or a surrounding of the object are sensible as desired. In this way, the planning procedure can be improved.

公开(公告)号：US09036140B2

公开(公告)日：2015-05-19

申请号：US13496213

申请日：2010-09-10

申请人： Nenad Mihajlovic ,  Jeroen Jan Lambertus Horikx ,  Waltherus Cornelis Jozef Bierhoff ,  Cornelius Antonius Hezemans ,  Bernardus Hendrikus Wilhelmus Hendriks

发明人： Nenad Mihajlovic ,  Jeroen Jan Lambertus Horikx ,  Waltherus Cornelis Jozef Bierhoff ,  Cornelius Antonius Hezemans ,  Bernardus Hendrikus Wilhelmus Hendriks

IPC分类号： G01J1/00 ,  A61B5/00 ,  G02B26/10

CPC分类号： A61B5/0062 ,  A61B5/0068 ,  A61B5/0084 ,  G02B26/103

摘要： An optical probe system having a probe with an optical guide (G) having a distal end. The optical guide (G) is mounted inside a housing (H) so that the distal end is displaceable with respect to the housing (H). A set of actuators (A), e.g. electromagnetic drive coils, can displace the distal end by application of a drive signal (Vx, Vy). A control unit (CU) generates the drive signal (Vx, Vy) so as to provide a scanning frequency which varies according to an amplitude of the drive signal (Vx, Vy). With such probe system it is possible to scan a field of view with a scanning frequency that varies with the scanning radius. Taking into account the maximum allowable drive current, it is possible to increase scanning speed compared to scanning at the mechanical resonance frequency of the optical system, since small radii can be scanned at a high scanning frequency.

摘要翻译： 一种光探头系统，其具有具有远端的具有光导（G）的探针。 光导（G）安装在壳体（H）内，使得远端可相对于壳体（H）移动。 一组致动器（A），例如。 电磁驱动线圈可通过施加驱动信号（Vx，Vy）来移位远端。 控制单元（CU）产生驱动信号（Vx，Vy），以提供根据驱动信号（Vx，Vy）的振幅而变化的扫描频率。 利用这种探测系统，可以扫描具有随扫描半径变化的扫描频率的视场。 考虑到最大允许驱动电流，与在光学系统的机械共振频率下的扫描相比，可以增加扫描速度，因为可以以高扫描频率扫描小半径。

公开(公告)号：US20140117256A1

公开(公告)日：2014-05-01

申请号：US14127719

申请日：2012-06-21

申请人： Manfred Mueller ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horikx ,  Rami Nachabe ,  Marjolein Van Der Voort

发明人： Manfred Mueller ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horikx ,  Rami Nachabe ,  Marjolein Van Der Voort

IPC分类号： A61B5/00

CPC分类号： A61B5/0071 ,  A61B5/0075 ,  A61B5/0084

摘要： In order to improve fluorescence measurements, there is provided an apparatus and, a method and a computer program for optical analysis of an associated tissue sample, the apparatus comprising a spectrometer comprising an optical detector, a light source, a first light emitter 219 arranged for emitting photons into the associated tissue sample, a first light collector 221 arranged for receiving photons from the associated tissue sample, a second light emitter 223, a second light collector 225, wherein a reflectance spectrum is obtained via the first light emitter 219 and collector 221 and a fluorescence spectrum is obtained via the second light emitter 223 and collector 225, and where a first distance d1 between the first light emitter and collector is larger than a second distance d2 between the second light emitter and collector. By combining the data thus obtained, an intrinsic fluorescence spectrum may be obtained.

摘要翻译： 为了改进荧光测量，提供了一种用于相关组织样本的光学分析的装置和方法以及计算机程序，该装置包括光谱仪，该光谱仪包括光学检测器，光源，第一光发射器219， 将光子发射到相关联的组织样本中，布置成从相关联的组织样本接收光子的第一光收集器221，第二光发射器223，第二光收集器225，其中通过第一光发射器219和集电极221获得反射光谱 并且通过第二光发射器223和集电极225获得荧光光谱，并且其中第一光发射器和集电极之间的第一距离d1大于第二发光体和集电极之间的第二距离d2。 通过组合由此获得的数据，可以获得固有的荧光光谱。

公开(公告)号：US20130217989A1

公开(公告)日：2013-08-22

申请号：US13881379

申请日：2011-10-17

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Theodoor Jacques Marie Ruers

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Theodoor Jacques Marie Ruers

IPC分类号： A61B5/1459

CPC分类号： A61B5/1459 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/6848 ,  A61B5/6882 ,  A61M25/065

摘要： A needle comprises an elongated first shaft element with a C-shaped cross section and an elongated second shaft element with a C-shaped cross section. The first shaft element and the second shaft element are adapted to be detachably connected to each other. This is achieved by an overlap of respective end sections of the first and second shaft elements. Within the channel formed by the shaft elements, an optical probe may be accommodated from which the shaft elements may be removed by separating the two shaft elements from each other.

摘要翻译： 针包括具有C形横截面的细长的第一轴元件和具有C形横截面的细长的第二轴元件。 第一轴元件和第二轴元件适于彼此可拆卸地连接。 这通过第一和第二轴元件的相应端部部分的重叠来实现。 在由轴元件形成的通道内，可以容纳光学探针，通过将两个轴元件彼此分离，可以从中移除轴元件。

公开(公告)号：US08324562B2

公开(公告)日：2012-12-04

申请号：US12668905

申请日：2008-07-14

申请人： Waltherus Cornelis Jozef Bierhoff ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Nanad Mihajlovic

发明人： Waltherus Cornelis Jozef Bierhoff ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Nanad Mihajlovic

IPC分类号： H01J3/14

CPC分类号： G02B26/101 ,  A61B5/0062 ,  A61B5/0084

摘要： A fiber scanning system is provided comprising a housing (102) with a fiber (13), the fiber (13) comprising a fixed part and a free end, the fixed part being attached to a bottom of the housing (102) and the fiber (13) extending parallel to the wall of the housing (102). At least one electrical coil (12) is attached to the wall at a position in between the fixed part and the free end of the fiber (13), a winding of the electrical coil (12) being in a plane parallel to the fiber (13). A magnet (11) is attached to the fiber (13), such that the electrical coil (12) may induce a force on the magnet (11). The magnet (11) is attached to the fiber (13) at a position just before or after the electrical coil (12), a width of the magnet (11) being such that the magnet (11) extends over the electrical coil (12).

摘要翻译： 提供一种纤维扫描系统，其包括具有纤维（13）的壳体（102），所述纤维（13）包括固定部分和自由端，所述固定部分附接到所述壳体（102）的底部，并且所述纤维 （13）平行于壳体（102）的壁延伸。 至少一个电线圈（12）在所述固定部分和所述光纤（13）的所述自由端之间的位置附接到所述壁，所述电线圈（12）的绕组处于与所述光纤平行的平面（ 13）。 磁体（11）附着在光纤（13）上，使得电线圈（12）可以在磁铁（11）上产生一个力。 磁体（11）在刚好在电线圈（12）之前或之后的位置处附接到光纤（13），磁体（11）的宽度使得磁体（11）在电线圈（12）上方延伸 ）。

公开(公告)号：US20120170030A1

公开(公告)日：2012-07-05

申请号：US13496213

申请日：2010-09-10

申请人： Nenad Mihajlovic ,  Jeroen Jan Lambertus Horikx ,  Waltherus Cornelis Jozef Bierhoff ,  Cornelius Antonius Hezemans ,  Bernardus Hendrikus Wilhelmus Hendriks

发明人： Nenad Mihajlovic ,  Jeroen Jan Lambertus Horikx ,  Waltherus Cornelis Jozef Bierhoff ,  Cornelius Antonius Hezemans ,  Bernardus Hendrikus Wilhelmus Hendriks

IPC分类号： G01J1/00

CPC分类号： A61B5/0062 ,  A61B5/0068 ,  A61B5/0084 ,  G02B26/103

摘要： An optical probe system having a probe with an optical guide (G) having a distal end. The optical guide (G) is mounted inside a housing (H) so that the distal end is displaceable with respect to the housing (H). A set of actuators (A), e.g. electromagnetic drive coils, can displace the distal end by application of a drive signal (Vx, Vy). A control unit (CU) generates the drive signal (Vx, Vy) so as to provide a scanning frequency which varies according to an amplitude of the drive signal (Vx, Vy). With such probe system it is possible to scan a field of view with a scanning frequency that varies with the scanning radius. Taking into account the maximum allowable drive current, it is possible to increase scanning speed compared to scanning at the mechanical resonance frequency of the optical system, since small radii can be scanned at a high scanning frequency.

摘要翻译： 一种光探头系统，其具有具有远端的具有光导（G）的探针。 光导（G）安装在壳体（H）内，使得远端可相对于壳体（H）移动。 一组致动器（A），例如。 电磁驱动线圈可通过施加驱动信号（Vx，Vy）来移位远端。 控制单元（CU）产生驱动信号（Vx，Vy），以提供根据驱动信号（Vx，Vy）的振幅而变化的扫描频率。 利用这种探测系统，可以扫描具有随扫描半径变化的扫描频率的视场。 考虑到最大允许驱动电流，与在光学系统的机械共振频率下的扫描相比，可以增加扫描速度，因为可以以高扫描频率扫描小半径。

公开(公告)号：US20100169903A1

公开(公告)日：2010-07-01

申请号：US12063238

申请日：2006-07-28

申请人： Waltherus Cornelis Jozef Bierhoff

发明人： Waltherus Cornelis Jozef Bierhoff

IPC分类号： G11B7/00

CPC分类号： G11B7/08511 ,  G11B7/1376 ,  G11B2007/0013

摘要： The invention provides a drive system for driving a lens holder (6) of the optical system in a disk drive unit. It comprises a movable part (8) connected to the lens holder, and a base (7) including a guide (9) for guiding the movable part. A drive motor comprises a stator (12) fixed with respect to the base and a translator (13) movable with respect to the stator upon actuation of the motor. A return mechanism (21) is connected between the translator and the movable part for bringing the rotor/translator in a starting position with respect to the movable part in a rest condition of the drive motor. A portion (18) of the movable part is in the path of movement of the translator, while there is a free stroke (20) between the portion of the movable part and the translator in the starting position of the translator. As a result, the translator will hit the movable part, thereby overcoming the static friction between the movable part and the base.

摘要翻译： 本发明提供一种驱动系统，用于驱动光盘驱动单元中的光学系统的透镜架（6）。 它包括连接到透镜保持器的可移动部分（8）和包括用于引导可移动部分的引导件（9）的基座（7）。 驱动电动机包括相对于基座固定的定子（12）和在电动机致动时相对于定子可移动的平移器（13）。 在平移器和可移动部件之间连接有一个返回机构（21），用于在驱动马达的静止状态下使转子/转子相对于可动部件处于起始位置。 可移动部分的一部分（18）处于平移机的移动路径中，而在可移动部分的部分与平移器的起始位置之间存在自由行程（20）。 结果，翻译器将撞击可移动部分，从而克服可移动部件和底座之间的静摩擦。