公开(公告)号：US20120316558A1

公开(公告)日：2012-12-13

申请号：US13578883

申请日：2011-02-22

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Gerhrdus Wilhelmus Lucassen ,  Rami Nachabe ,  Waltherus Cornelis Jozef Bierhoff ,  Adrien Emmanuel Desjardins

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Gerhrdus Wilhelmus Lucassen ,  Rami Nachabe ,  Waltherus Cornelis Jozef Bierhoff ,  Adrien Emmanuel Desjardins

IPC分类号： A61B18/14

CPC分类号： A61B18/1477 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B8/0841 ,  A61B18/02 ,  A61B2017/00057 ,  A61B2017/00061 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2018/00577 ,  A61B2034/2063 ,  A61B2090/378

摘要： An interventional ablation device (1) is proposed to comprise an ablation needle (3) with an elongated body (5) and a handle (7). Adjacent to an ablation element (9) provided on the body (5), at least one or preferably two or more sensors (11-21) are provided, preferably at both of opposing sides of the ablation element (9). The ablation device (1) is adapted for detecting physiological information of tissue (27, 29, 31) surrounding an ablation site (33) based on measurement values provided by the sensors. E.g., optical sensors may be used to measure a reflectance spectrum indicating whether the adjacent tissue is healthy tissue (31), tumorous tissue (27) or ablated tissue (29). Using such information, an ablation process may be controlled.

摘要翻译： 提出介入消融装置（1）包括具有细长主体（5）和手柄（7）的消融针（3）。 设置在主体（5）上的消融元件（9）附近，优选地在消融元件（9）的相对两侧提供至少一个或优选两个或更多个传感器（11-21）。 消融装置（1）适于基于由传感器提供的测量值来检测围绕消融部位（33）的组织（27,29,31）的生理信息。 例如，光学传感器可用于测量反映光谱，其指示相邻组织是健康组织（31），肿瘤组织（27）还是消融组织（29）。 使用这种信息，可以控制消融过程。

公开(公告)号：US09072475B2

公开(公告)日：2015-07-07

申请号：US13881379

申请日：2011-10-17

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Theodoor Jacques Marie Ruers

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Theodoor Jacques Marie Ruers

IPC分类号： A61B5/1459 ,  A61B5/00 ,  A61M25/06

CPC分类号： A61B5/1459 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/6848 ,  A61B5/6882 ,  A61M25/065

摘要： A needle comprises an elongated first shaft element with a C-shaped cross section and an elongated second shaft element with a C-shaped cross section. The first shaft element and the second shaft element are adapted to be detachably connected to each other. This is achieved by an overlap of respective end sections of the first and second shaft elements. Within the channel formed by the shaft elements, an optical probe may be accommodated from which the shaft elements may be removed by separating the two shaft elements from each other.

摘要翻译： 针包括具有C形横截面的细长的第一轴元件和具有C形横截面的细长的第二轴元件。 第一轴元件和第二轴元件适于彼此可拆卸地连接。 这通过第一和第二轴元件的相应端部部分的重叠来实现。 在由轴元件形成的通道内，可以容纳光学探针，通过将两个轴元件彼此分离，可以从中移除轴元件。

公开(公告)号：US20140121538A1

公开(公告)日：2014-05-01

申请号：US14127692

申请日：2012-06-13

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horiks ,  Susanne Dorien Van Den Bergdams ,  Christian Reich ,  Stephan Voss ,  Axel Winkel ,  Rami Nachabe ,  Manfred Muller ,  Marjolein Van Der Voort

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horiks ,  Susanne Dorien Van Den Bergdams ,  Christian Reich ,  Stephan Voss ,  Axel Winkel ,  Rami Nachabe ,  Manfred Muller ,  Marjolein Van Der Voort

IPC分类号： A61B5/00 ,  A61B10/02 ,  A61B1/00 ,  A61B1/06 ,  A61B1/07

CPC分类号： A61B1/00009 ,  A61B1/0646 ,  A61B1/0684 ,  A61B1/07 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/6848 ,  A61B10/0233 ,  F04C2270/0421 ,  Y10T29/49826

摘要： A needle is proposed including a cannula or hollow shaft with a multilumen insert inside. The insert comprises at least two lumen. Both the insert as well as the cannula have bevelled ends. In the insert substantially straight cleaved fibers are present that may be connected at the proximal end to a console. At least one of the distal fiber ends in the insert may protrude more than half the fiber diameter out of the insert. Furthermore, the bevel angle of the insert is different from the bevel angle of the cannula such that combination cannula and insert is such that the fiber ends do not protrude the bevel surface of the cannula.

摘要翻译： 提出了一种针头，其中包括插入件或空心轴，其中具有多孔插入件。 插入件包括至少两个内腔。 插入件以及套管均具有倾斜端部。 在插入件中，存在基本上直的切割的纤维，其可以在近端连接到控制台。 插入件中的远端纤维端部中的至少一个可以突出超过插入件的纤维直径的一半以上。 此外，插入件的斜角与插管的斜角不同，使得组合插管和插入件使得纤维端部不突出套管的斜面。

公开(公告)号：US20140117256A1

公开(公告)日：2014-05-01

申请号：US14127719

申请日：2012-06-21

申请人： Manfred Mueller ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horikx ,  Rami Nachabe ,  Marjolein Van Der Voort

发明人： Manfred Mueller ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horikx ,  Rami Nachabe ,  Marjolein Van Der Voort

IPC分类号： A61B5/00

CPC分类号： A61B5/0071 ,  A61B5/0075 ,  A61B5/0084

摘要： In order to improve fluorescence measurements, there is provided an apparatus and, a method and a computer program for optical analysis of an associated tissue sample, the apparatus comprising a spectrometer comprising an optical detector, a light source, a first light emitter 219 arranged for emitting photons into the associated tissue sample, a first light collector 221 arranged for receiving photons from the associated tissue sample, a second light emitter 223, a second light collector 225, wherein a reflectance spectrum is obtained via the first light emitter 219 and collector 221 and a fluorescence spectrum is obtained via the second light emitter 223 and collector 225, and where a first distance d1 between the first light emitter and collector is larger than a second distance d2 between the second light emitter and collector. By combining the data thus obtained, an intrinsic fluorescence spectrum may be obtained.

摘要翻译： 为了改进荧光测量，提供了一种用于相关组织样本的光学分析的装置和方法以及计算机程序，该装置包括光谱仪，该光谱仪包括光学检测器，光源，第一光发射器219， 将光子发射到相关联的组织样本中，布置成从相关联的组织样本接收光子的第一光收集器221，第二光发射器223，第二光收集器225，其中通过第一光发射器219和集电极221获得反射光谱 并且通过第二光发射器223和集电极225获得荧光光谱，并且其中第一光发射器和集电极之间的第一距离d1大于第二发光体和集电极之间的第二距离d2。 通过组合由此获得的数据，可以获得固有的荧光光谱。

公开(公告)号：US20130217989A1

公开(公告)日：2013-08-22

申请号：US13881379

申请日：2011-10-17

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Theodoor Jacques Marie Ruers

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Rami Nachabe ,  Theodoor Jacques Marie Ruers

IPC分类号： A61B5/1459

CPC分类号： A61B5/1459 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/6848 ,  A61B5/6882 ,  A61M25/065

摘要： A needle comprises an elongated first shaft element with a C-shaped cross section and an elongated second shaft element with a C-shaped cross section. The first shaft element and the second shaft element are adapted to be detachably connected to each other. This is achieved by an overlap of respective end sections of the first and second shaft elements. Within the channel formed by the shaft elements, an optical probe may be accommodated from which the shaft elements may be removed by separating the two shaft elements from each other.

摘要翻译： 针包括具有C形横截面的细长的第一轴元件和具有C形横截面的细长的第二轴元件。 第一轴元件和第二轴元件适于彼此可拆卸地连接。 这通过第一和第二轴元件的相应端部部分的重叠来实现。 在由轴元件形成的通道内，可以容纳光学探针，通过将两个轴元件彼此分离，可以从中移除轴元件。

公开(公告)号：US10105057B2

公开(公告)日：2018-10-23

申请号：US13995967

申请日：2011-12-22

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe ,  Gerhardus Wilhelmus Lucassen ,  Adrien Emmanuel Desjardins ,  Theodoor Jacques Marie Ruers

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe ,  Gerhardus Wilhelmus Lucassen ,  Adrien Emmanuel Desjardins ,  Theodoor Jacques Marie Ruers

IPC分类号： A61B6/00 ,  A61B5/00 ,  A61B1/00 ,  G01N21/25 ,  A61B18/18

摘要： The present invention relates to an apparatus 100 and, a method and a computer program for determining a parameter indicative of a tissue type of an associated tissue 116. In particular, the invention relates to an apparatus 100 comprising a spectrometer 102, which spectrometer comprises a light source 104 and a detector 106, 108 arranged to measure an optical spectrum. This enables determination of a first parameter being indicative of a bile concentration. As the inventors of the present invention have made the insight that bile concentration may serve as a discriminative feature for different tissue types, the apparatus is arranged to determine a second parameter indicative of a tissue type based on a concentration of bile. According to a specific embodiment, the apparatus further comprises an interventional device 112.

公开(公告)号：US20140200459A1

公开(公告)日：2014-07-17

申请号：US13995967

申请日：2011-12-22

申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe ,  Gerhardus Wilhelmus Lucassen ,  Adrien Emmanuel Desjardins ,  Theodoor Jacques Marie Ruers

发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Rami Nachabe ,  Gerhardus Wilhelmus Lucassen ,  Adrien Emmanuel Desjardins ,  Theodoor Jacques Marie Ruers

IPC分类号： A61B5/00 ,  A61B18/18

CPC分类号： A61B5/0075 ,  A61B1/00 ,  A61B5/0084 ,  A61B5/4836 ,  A61B18/18 ,  G01N21/25

摘要： The present invention relates to an apparatus 100 and, a method and a computer program for determining a parameter indicative of a tissue type of an associated tissue 116. In particular, the invention relates to an apparatus 100 comprising a spectrometer 102, which spectrometer comprises a light source 104 and a detector 106, 108 arranged to measure an optical spectrum. This enables determination of a first parameter being indicative of a bile concentration. As the inventors of the present invention have made the insight that bile concentration may serve as a discriminative feature for different tissue types, the apparatus is arranged to determine a second parameter indicative of a tissue type based on a concentration of bile. According to a specific embodiment, the apparatus further comprises an interventional device 112.

摘要翻译： 本发明涉及一种用于确定指示相关组织116的组织类型的参数的装置100和方法和计算机程序。特别地，本发明涉及一种包括分光计102的装置100，该分光计包括： 光源104和被布置成测量光谱的检测器106,108。 这使得能够确定指示胆汁浓度的第一参数。 本发明的发明人已经认识到胆汁浓度可以用作不同组织类型的鉴别特征，该装置被设置为基于胆汁的浓度来确定指示组织类型的第二参数。 根据具体实施例，该装置还包括介入装置112。

公开(公告)号：US20110218445A1

公开(公告)日：2011-09-08

申请号：US13129206

申请日：2009-06-15

申请人： Augustinus Laurentius Braun ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rik Harbers ,  Marjolein Van Der Voort ,  Adrien Emmanuel Desjardins ,  Rami Nachabe ,  Bernardus Wilhelmus Johannes Wassink ,  Franciscus Marinus Antonius Maria Van Gaal ,  Nenad Mihajlovic ,  Drazenko Babic

发明人： Augustinus Laurentius Braun ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Rik Harbers ,  Marjolein Van Der Voort ,  Adrien Emmanuel Desjardins ,  Rami Nachabe ,  Bernardus Wilhelmus Johannes Wassink ,  Franciscus Marinus Antonius Maria Van Gaal ,  Nenad Mihajlovic ,  Drazenko Babic

IPC分类号： A61B6/00 ,  B21G3/18

CPC分类号： A61B5/6848 ,  A61B5/0075 ,  A61B5/0084

摘要： Needles equipped with fibres allow tissue inspection based on optical spectroscopy to diagnose whether tissue is cancerous or not. This requires integration of optical fibers into needles. The problem is how to manufacture the needle having at least one fiber exit at the distal end of the needle, where the fiber does not obstruct the hollow part of the needle if present as well as does not extend beyond the outer cylinder geometry. To solve this problem we propose to manufacture the needle consisting of four parts: an inner cylinder tube, an outer hollow cylinder tube, a needle tip part with integrated fiber exit and a holder part, wherein the hollow spacing between the inner and the outer cylinder is larger or equal to the outer diameter of the fibers, the inner and the outer cylinder are mounted in the holder part and where the tip part is mounted on the two cylinders.

摘要翻译： 配备纤维的针头允许基于光谱的组织检查来诊断组织是否是癌变的。 这需要将光纤集成到针中。 问题是如何制造在针的远端具有至少一个纤维出口的针，其中纤维不会阻塞针的中空部分，如果存在，并且不延伸超出外筒几何形状。 为了解决这个问题，我们建议制造由四部分组成的针：内筒管，外空心筒管，具有集成纤维出口的针尖部分和保持器部分，其中内筒和外筒之间的中空间隔 大于或等于纤维的外径，内筒和外筒安装在保持器部分中，并且尖端部分安装在两个气缸上。

公开(公告)号：US09687156B2

公开(公告)日：2017-06-27

申请号：US14342442

申请日：2012-09-07

申请人： Waltherus Cornelis Jozef Bierhoff ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Franciscus Marinus Antonius Maria Van Gaal

发明人： Waltherus Cornelis Jozef Bierhoff ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Franciscus Marinus Antonius Maria Van Gaal

IPC分类号： A61B6/00 ,  A61B5/00

CPC分类号： A61B5/0084 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/6844 ,  A61B5/6848

摘要： A needle device includes a hollow shaft, an elongated insert and an operating lever. The hollow shaft has a first distal end portion with a bevel, the elongated insert has a second distal end portion and is movably arranged within the hollow shaft, and the operating lever is shiftable between a first condition and a second condition. Furthermore, the operating lever is interconnected with the elongated insert such that the second distal end portion is located within the hollow shaft and proximally to the bevel when the operating lever is in the first condition, and that the second distal end portion is located outside the hollow shaft and distally to the bevel when the operating lever is in the second condition.

公开(公告)号：US20120113491A1

公开(公告)日：2012-05-10

申请号：US13320601

申请日：2010-05-10

申请人： Cornelius Antonius Hezemans ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Augustinus Laurentius Braun ,  Nenad Mihajlovic

发明人： Cornelius Antonius Hezemans ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Augustinus Laurentius Braun ,  Nenad Mihajlovic

IPC分类号： G02B26/10

CPC分类号： A61B5/6848 ,  A61B5/0068 ,  A61B5/0084 ,  G02B21/0012 ,  G02B21/0036 ,  G02B23/2423 ,  G02B23/26 ,  G02B26/103

摘要： The present invention relates to an optical probe (1) suitable for miniature applications. An example application is a fibre-based confocal miniaturized microscope. The optical probe comprises a coil-based actuation system (9, 10) comprising drive coils (9) capable of displacing the distal end (3) of an optical guide (2) housed (4) by the optical probe. The probe makes use of a feedback loop which alternate between driving the displacement of the optical guide by driving a current through the drive coils and switching off the current through the drive coils, and while the drive current being switched off, measure the speed of the distal end of the optical guide. The measured speed is compared to the set-point speed, and if a difference is detected, the drive current is adjusted to eliminate, or at least bring down, this difference.

摘要翻译： 本发明涉及适合于微型应用的光学探头（1）。 一个示例应用是基于光纤的共聚焦微型显微镜。 光探头包括基于线圈的致动系统（9,10），其包括驱动线圈（9），该驱动线圈能够移动由光学探头容纳（4）的光导（2）的远端（3）。 探头利用反馈回路，通过驱动通过驱动线圈的电流驱动光导的位移和切断通过驱动线圈的电流之间的交替，并且在驱动电流被切断时，测量速度 光导的远端。 将测量的速度与设定点速度进行比较，并且如果检测到差异，则调节驱动电流以消除或至少降低该差异。