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    APPRATUS FOR OPTICAL ANALYSIS OF AN ASSOCIATED TISSUE SAMPLE
    4.
    发明申请
    APPRATUS FOR OPTICAL ANALYSIS OF AN ASSOCIATED TISSUE SAMPLE 审中-公开
    用于相关组织样品的光学分析的规定

    公开(公告)号：US20140117256A1

    公开(公告)日：2014-05-01

    申请号：US14127719

    申请日：2012-06-21

    申请人： Manfred Mueller ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horikx ,  Rami Nachabe ,  Marjolein Van Der Voort

    发明人： Manfred Mueller ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Gerhardus Wilhelmus Lucassen ,  Jeroen Jan Lambertus Horikx ,  Rami Nachabe ,  Marjolein Van Der Voort

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0071 ,  A61B5/0075 ,  A61B5/0084

    摘要： In order to improve fluorescence measurements, there is provided an apparatus and, a method and a computer program for optical analysis of an associated tissue sample, the apparatus comprising a spectrometer comprising an optical detector, a light source, a first light emitter 219 arranged for emitting photons into the associated tissue sample, a first light collector 221 arranged for receiving photons from the associated tissue sample, a second light emitter 223, a second light collector 225, wherein a reflectance spectrum is obtained via the first light emitter 219 and collector 221 and a fluorescence spectrum is obtained via the second light emitter 223 and collector 225, and where a first distance d1 between the first light emitter and collector is larger than a second distance d2 between the second light emitter and collector. By combining the data thus obtained, an intrinsic fluorescence spectrum may be obtained.

    摘要翻译： 为了改进荧光测量，提供了一种用于相关组织样本的光学分析的装置和方法以及计算机程序，该装置包括光谱仪，该光谱仪包括光学检测器，光源，第一光发射器219， 将光子发射到相关联的组织样本中，布置成从相关联的组织样本接收光子的第一光收集器221，第二光发射器223，第二光收集器225，其中通过第一光发射器219和集电极221获得反射光谱 并且通过第二光发射器223和集电极225获得荧光光谱，并且其中第一光发射器和集电极之间的第一距离d1大于第二发光体和集电极之间的第二距离d2。 通过组合由此获得的数据，可以获得固有的荧光光谱。

    OPTICAL PROBE WITH FEEDBACK CORRECTION
    7.
    发明申请
    OPTICAL PROBE WITH FEEDBACK CORRECTION 失效
    具有反馈校正的光学探头

    公开(公告)号：US20120113491A1

    公开(公告)日：2012-05-10

    申请号：US13320601

    申请日：2010-05-10

    申请人： Cornelius Antonius Hezemans ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Augustinus Laurentius Braun ,  Nenad Mihajlovic

    发明人： Cornelius Antonius Hezemans ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Waltherus Cornelis Jozef Bierhoff ,  Augustinus Laurentius Braun ,  Nenad Mihajlovic

    IPC分类号： G02B26/10

    CPC分类号： A61B5/6848 ,  A61B5/0068 ,  A61B5/0084 ,  G02B21/0012 ,  G02B21/0036 ,  G02B23/2423 ,  G02B23/26 ,  G02B26/103

    摘要： The present invention relates to an optical probe (1) suitable for miniature applications. An example application is a fibre-based confocal miniaturized microscope. The optical probe comprises a coil-based actuation system (9, 10) comprising drive coils (9) capable of displacing the distal end (3) of an optical guide (2) housed (4) by the optical probe. The probe makes use of a feedback loop which alternate between driving the displacement of the optical guide by driving a current through the drive coils and switching off the current through the drive coils, and while the drive current being switched off, measure the speed of the distal end of the optical guide. The measured speed is compared to the set-point speed, and if a difference is detected, the drive current is adjusted to eliminate, or at least bring down, this difference.

    摘要翻译： 本发明涉及适合于微型应用的光学探头（1）。 一个示例应用是基于光纤的共聚焦微型显微镜。 光探头包括基于线圈的致动系统（9,10），其包括驱动线圈（9），该驱动线圈能够移动由光学探头容纳（4）的光导（2）的远端（3）。 探头利用反馈回路，通过驱动通过驱动线圈的电流驱动光导的位移和切断通过驱动线圈的电流之间的交替，并且在驱动电流被切断时，测量速度 光导的远端。 将测量的速度与设定点速度进行比较，并且如果检测到差异，则调节驱动电流以消除或至少降低该差异。

    OPTICAL SCANNING PROBE ASSEMBLY
    8.
    发明申请
    OPTICAL SCANNING PROBE ASSEMBLY 有权
    光学扫描探头组件

    公开(公告)号：US20110201941A1

    公开(公告)日：2011-08-18

    申请号：US13125392

    申请日：2009-10-19

    申请人： Franciscus Martinus Antonius Maria Van Gaal ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Cornelius Antonius Hezemans ,  Waltherus Cornelis Jozef Bierhoff

    发明人： Franciscus Martinus Antonius Maria Van Gaal ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Augustinus Laurentius Braun ,  Cornelius Antonius Hezemans ,  Waltherus Cornelis Jozef Bierhoff

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0062 ,  A61B5/0084 ,  G02B23/2461 ,  G02B26/103

    摘要： The present invention relates to an optical scanning probe assembly for microscopic guide optic scanning and inspection of tissues suitable for application in, e.g. in vivo medical inspection and biopsy. The assembly comprises an outer housing (3) comprising: i) a spring element for a scanning motor, the spring element formed as a hollow tube (5) adapted to receive an optical guide, the hollow tube having mechanical stiffness larger than the optical guide to be received, ii) a lens system (7) and iii) N means for deflecting (6) the distal end of the hollow tube in directions transverse to the longitudinal extension of the hollow tube, so as to form an optical scan pattern. The optical assembly is particularly advantageous as it increases the freedom to optimize the optical and mechanical performance of the system which is defined respectively by the optical guide and by the hollow tube. The probe can be used in resonant and non-resonant scanning modes.

    摘要翻译： 本发明涉及一种光学扫描探针组件，用于微观引导光学扫描和检查适用于例如， 体内检查和活检。 该组件包括外壳（3），包括：i）用于扫描电机的弹簧元件，弹簧元件形成为适于容纳光导的中空管（5），所述中空管的机械刚度大于光导 ii）透镜系统（7），以及iii）用于使中空管的远端沿垂直于中空管的纵向延伸的方向偏转（6）的装置，以形成光学扫描图案。 光学组件是特别有利的，因为它增加了由光导和中空管分别限定的优化系统的光学和机械性能的自由度。 探头可用于谐振和非谐振扫描模式。