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26 条记录 (耗时 0.029 秒)

    Multiple laminar flow-based particle and cellular separation with laser steering
    13.
    发明授权
    Multiple laminar flow-based particle and cellular separation with laser steering 有权
    多层次流动粒子与细胞分离与激光转向

    公开(公告)号：US07402131B2

    公开(公告)日：2008-07-22

    申请号：US11543773

    申请日：2006-10-06

    申请人： Daniel Mueth ,  Joseph Plewa ,  Jessica Shireman ,  Amy Anderson ,  Lewis Gruber ,  Neil Harris Rosenbaum

    发明人： Daniel Mueth ,  Joseph Plewa ,  Jessica Shireman ,  Amy Anderson ,  Lewis Gruber ,  Neil Harris Rosenbaum

    IPC分类号： B04B7/08

    CPC分类号： A61M1/3681 ,  A61M1/36 ,  A61M1/3693 ,  A61M1/38 ,  A61M2206/11 ,  B01L3/502761 ,  B03C1/28 ,  B03C5/005 ,  B03C2201/02 ,  B03C2201/18 ,  G01N30/0005 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2001/085 ,  Y10T436/25375

    摘要： The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

    摘要翻译： 本发明提供了一种用于分离血液和其他类型的细胞组分的方法，装置和系统，并且可以与全息光学捕获操作或其他形式的光学镊子组合。 示例性方法之一包括提供具有多个血液成分的第一流; 提供第二流; 使第一流与第二流接触以提供第一分离区; 以及将所述多个血液成分的第一血细胞成分差异沉积到所述第二流中，同时在所述第一流中同时维持所述多个血液成分的第二血细胞成分。 然后，具有第一血细胞成分的第二流与具有第二血细胞成分的第一流有差别地移除。 全息光学捕集器也可以与各种流动结合使用，以将选定的组分从一个流移动到另一个流，作为分离阶段的一部分或除了分离阶段之外。

    Method and apparatus for detecting targets
    18.
    发明申请
    Method and apparatus for detecting targets 审中-公开
    检测目标的方法和装置

    公开(公告)号：US20060174385A1

    公开(公告)日：2006-08-03

    申请号：US11048059

    申请日：2005-02-02

    申请人： Lewis Gruber ,  Joseph Plewa ,  Misty Gruber

    发明人： Lewis Gruber ,  Joseph Plewa ,  Misty Gruber

    IPC分类号： G01N23/00

    CPC分类号： G01N21/41 ,  B82Y15/00

    摘要： A nano-sensor for sensing one or more targets has a plurality of sensor units, each including a nano-structure and an encapsulating sensible medium surrounding the nano-structure. Each nano-sensor unit being positioned by holographic optical trapping and operative to produce a signal output indicative of the presence of a particular target. A substrate has a sensor location for each sensor unit, each operative to produce an output in response to the signal from the corresponding sensor unit indicative of the presence of a particular target. The sensor may employ a disposable support for the sensor units adapted to be positioned in registration with the sensor locations and disposed of after use.

    摘要翻译： 用于感测一个或多个靶的纳米传感器具有多个传感器单元，每个传感器单元包括纳米结构和围绕纳米结构的封装敏感介质。 每个纳米传感器单元通过全息光学捕获定位并且可操作以产生指示特定目标的存在的信号输出。 衬底具有用于每个传感器单元的传感器位置，每个传感器单元响应于来自相应传感器单元的指示存在特定目标的信号而产生输出。 传感器可以采用一次性支撑件，用于适于定位成与传感器位置对准的传感器单元并在使用后进行处理。