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97 条记录 (耗时 0.023 秒)

    Process for the production of pyrocatechol and hydroquinone
    12.
    发明授权
    Process for the production of pyrocatechol and hydroquinone 失效
    邻苯二酚和氢醌生产方法

    公开(公告)号：US4618730A

    公开(公告)日：1986-10-21

    申请号：US587652

    申请日：1984-03-08

    申请人： Karlheinz Drauz ,  Axel Kleemann

    发明人： Karlheinz Drauz ,  Axel Kleemann

    IPC分类号： C07C27/00 ,  C07C37/60 ,  C07C39/08 ,  C07C67/00 ,  C07C39/10

    CPC分类号： C07C37/60 ,  Y02P20/582

    摘要： The known nuclear hydroxylation of phenol with organic solutions of hydrogen peroxide in the presence of a catalyst is carried out in improved manner by employing both (1) a special, practically water free solution of hydrogen peroxide in an organic solvent which forms an azeotrope with water, which azeotrope boils below the boiling point of hydrogen peroxide, and (2) sulfur dioxide as a catalyst. Through this, the nuclear hydroxylation is substantially simpler than previously; difficult separations, e.g., from water-phenol, or the separation and recovery of the catalyst are eliminated. Besides, the yields are increased.

    摘要翻译： 在催化剂存在下，酚与有机过氧化物的已知核羟基化反应是通过使用（1）在与水形成共沸物的有机溶剂中的特殊的实际上无水的过氧化氢溶液来进行的 ，其共沸物沸点低于过氧化氢的沸点，和（2）二氧化硫作为催化剂。 通过这一点，核羟基化比以前简单得多; 难以分离，例如来自水 - 苯酚，或者分离和回收催化剂。 此外，收益率上升。

    Process for the production of dihydroxybenzenes
    13.
    发明授权
    Process for the production of dihydroxybenzenes 失效
    二羟基苯的制备方法

    公开(公告)号：US4533766A

    公开(公告)日：1985-08-06

    申请号：US587654

    申请日：1984-03-08

    申请人： Karlheinz Drauz ,  Axel Kleemann

    发明人： Karlheinz Drauz ,  Axel Kleemann

    IPC分类号： C07C43/23 ,  C07C27/00 ,  C07C37/60 ,  C07C39/08 ,  C07C41/00 ,  C07C41/26 ,  C07C67/00 ,  C07C37/00

    CPC分类号： C07C37/60 ,  C07C41/26 ,  Y02P20/582

    摘要： The known nuclear hydroxylation of substituted phenols or phenol ethers with organic solutions of hydrogen peroxide in the presence of a catalyst is carried out in improved manner by employing both (1) a special, practically water free solution of hydrogen peroxide in an organic solvent which forms an azeotrope with water, which azeotrope boils below the boiling point of hydrogen peroxide, and (2) sulfur dioxide as a catalyst. Through this, the nuclear hydroxylation is substantially simpler than previously; difficult separations, e.g., from water-phenol, or the separation and recovery of the catalyst are eliminated. Besides, the yields are increased.

    摘要翻译： 在催化剂存在下，用有机过氧化氢溶液对已取代的酚或苯酚醚进行已知的核羟基化反应是通过使用（1）特殊的实际上无水的过氧化氢溶液在有机溶剂中形成的 与水共沸，共沸物沸点低于过氧化氢的沸点，和（2）二氧化硫作为催化剂。 通过这一点，核羟基化比以前简单得多; 难以分离，例如来自水 - 苯酚，或者分离和回收催化剂。 此外，收益率上升。

    Process for the production of L-proline
    14.
    发明授权
    Process for the production of L-proline 失效
    生产L-脯氨酸的方法

    公开(公告)号：US4469876A

    公开(公告)日：1984-09-04

    申请号：US418841

    申请日：1982-09-16

    申请人： Karlheinz Drauz ,  Axel Kleemann ,  Jurgen Martens ,  Paul Scherberich ,  Franz Effenberger

    发明人： Karlheinz Drauz ,  Axel Kleemann ,  Jurgen Martens ,  Paul Scherberich ,  Franz Effenberger

    IPC分类号： C07D207/16 ,  C07D207/22 ,  C07D207/12

    CPC分类号： C07D207/16 ,  C07D207/22

    摘要： L-proline is produced from the methyl or ethyl ester of L-pyroglutamic acid by reacting this with at least twice the molar amount of phosgene to form the corresponding 1-chlorocarbonyl-5,5-dichloroproline ester, producing the corresponding 2-chloro-1-chlorocarbonyl-pyrrolin-(2)-carboxylic acid ester-(5) therefrom by splitting off hydrogen chloride, catalytically hydrogenating the pyrrolin-(2) compound to the corresponding N-chlorocarbonyl-proline ester and hydrolyzing the latter with acid to form L-proline.

    摘要翻译： 通过将其与至少两倍摩尔量的光气反应形成相应的1-氯羰基-5,5-二氯脯氨酸酯，由L-焦谷氨酸的甲酯或乙酯制备L-脯氨酸，产生相应的2-氯 - 通过分离氯化氢，将吡咯啉 - （2）化合物催化氢化成相应的N-氯羰基 - 脯氨酸酯并用酸水解后者形成1-氯羰基 - 吡咯啉 - （2） - 羧酸酯 - （5） L-脯氨酸。

    Production of 1-(3-hydroxy-propyl)-1,4-diazepane and 1,4-bis(3,4,5-trimethoxy-benzoyloxy)-propyl-diazepane derivatives thereof
    18.
    发明授权
    Production of 1-(3-hydroxy-propyl)-1,4-diazepane and 1,4-bis(3,4,5-trimethoxy-benzoyloxy)-propyl-diazepane derivatives thereof 失效
    1-（3-羟基 - 丙基）-1,4-二氮杂环庚烷和1,4-双（3,4,5-三甲氧基 - 苯甲酰氧基） - 丙基 - 二氮杂环庚烷衍生物的制备

    公开(公告)号：US4751298A

    公开(公告)日：1988-06-14

    申请号：US693344

    申请日：1985-01-22

    申请人： Axel Kleemann ,  Bernd Lehmann ,  Klaus Deller

    发明人： Axel Kleemann ,  Bernd Lehmann ,  Klaus Deller

    IPC分类号： A61K31/55 ,  B01J27/00 ,  C07B61/00 ,  C07C67/00 ,  C07C253/00 ,  C07C255/24 ,  C07D243/08

    CPC分类号： C07C255/00 ,  C07D243/08

    摘要： There is disclosed a process for the production of 1,4-bis-[3-(3,4,5-trimethoxybenzyloxy)-propyl]-diazepane which consists of first reacting 3-aminopropanol with acrylonitrile and subsequently reacting in aqueous solution with formaldehyde and hydrocyanic acid or with formaldehyde and an alkali cyanide in the presence of alkali hydrogen sulfite to form cyanomethyl-(2-cyano-ethyl)-(3-hydroxy-propyl)-amine; hydrogenating the thus obtained reaction product in the presence of a hydrogenating catalyst and ammonia to 1 (3-hydroxy-propyl)-1,4-diazepane and reacting the latter compound for example with 3-halogen propanol or with allyl alcohol and introducing two 3,4,5-trimethoxy-benzoyl groups into the thus obtained reaction product by esterification.

    摘要翻译： 公开了一种生产1,4-双[3-（3,4,5-三甲氧基苄氧基） - 丙基] - 二氮杂环丁烷的方法，该方法由首先使3-氨基丙醇与丙烯腈反应，随后在水溶液中与甲醛反应 和氢氰酸，或在碱金属亚硫酸盐存在下与甲醛和碱金属氰化物反应，形成氰基甲基 - （2-氰基 - 乙基） - （3-羟基 - 丙基） - 胺; 将由此得到的反应产物在氢化催化剂和氨的存在下氢化成1（3-羟基 - 丙基）-1,4-二氮杂环丁烷，并使后者化合物例如与3-卤素丙醇或烯丙醇反应并引入两个3 ，4,5-三甲氧基苯甲酰基通过酯化转化成如此得到的反应产物。

    Process for the separation of L-leucine and L-isoleucine
    20.
    发明授权
    Process for the separation of L-leucine and L-isoleucine 失效
    分离L-亮氨酸和L-异亮氨酸的方法

    公开(公告)号：US4562153A

    公开(公告)日：1985-12-31

    申请号：US612803

    申请日：1984-05-22

    申请人： Axel Kleemann ,  Jurgen Martens ,  Horst Weigel

    发明人： Axel Kleemann ,  Jurgen Martens ,  Horst Weigel

    IPC分类号： C12P13/06 ,  C07C67/00 ,  C07C227/00 ,  C07C227/20 ,  C07C227/40 ,  C07C229/08

    CPC分类号： C07C227/40 ,  C07C231/02 ,  C12P13/06

    摘要： The separation of L-leucine and L-isoleucine in aminoacid mixtures containing at least 30 weight percent L-leucine, at most 70 weight percent L-isoleucine and at most 40 weight percent of other aminoacids is accomplished by acetylating the mixture, precipitating the acetylation product by acidification, subjecting the aqueous solution to a saponification by an L-aminoacid acylase until 25 to 95% of the N-acetyl-L-leucine is saponified, crystallizing pure L-leucine from the saponification mixture and separating it off, isolating N-acetyl-L-isoleucine from the mother liquor and saponifying it in known manner to the free aminoacid and isolating the free aminoacid.

    摘要翻译： L-亮氨酸和L-异亮氨酸在含有至少30重量％L-亮氨酸，至多70重量％L-异亮氨酸和至多40重量％其它氨基酸的氨基酸混合物中的分离通过乙酰化该混合物来实现，使乙酰化 通过酸化将水溶液进行L-氨基酸酰基转移酶皂化，直到25-95％的N-乙酰基-L-亮氨酸被皂化，从皂化混合物中结晶出纯的L-亮氨酸并将其分离出来，分离N 乙酰基-L-异亮氨酸，并以已知方式将其皂化成游离氨基酸并分离游离氨基酸。