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公开(公告)号：US08080399B2
公开(公告)日：2011-12-20
申请号：US11720488
申请日：2005-11-29
Applicant: Kishan Dholakia , Christian Thomas Alcuin Brown , Lynn Paterson
Inventor： Kishan Dholakia , Christian Thomas Alcuin Brown , Lynn Paterson
IPC: C12N13/00
Abstract: An opening is formed in a cell using laser radiation. A Bessel beam is formed using the laser radiation and the Bessel beam is directed onto the cell to form an opening. The guiding of material towards the opening may be involved using optical trapping/manipulation. The material may change cellular function or analyse cell behaviour. Both pulsed laser radiation and continuous wave radiation may be formed using the same laser.
Abstract translation: 在使用激光辐射的电池中形成开口。 使用激光辐射形成贝塞尔光束，并且贝塞尔光束被引导到细胞上以形成开口。 材料向开口的引导可能涉及使用光学捕获/操纵。 该物质可能改变细胞功能或分析细胞行为。 可以使用相同的激光器来形成脉冲激光辐射和连续波辐射。
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公开(公告)号：US09568741B2
公开(公告)日：2017-02-14
申请号：US13640453
申请日：2011-04-13
Applicant: Kishan Dholakia , Jorg Baumgartl , Michael Mazilu , Anna Chiara De Luca
Inventor： Kishan Dholakia , Jorg Baumgartl , Michael Mazilu , Anna Chiara De Luca
CPC classification number: G02B27/58 , G02B2207/125
Abstract: A method of optimising at least one measure that is a quadratic function of a wavefunction, such as the spot size of a laser, the method comprising: superimposing a plurality of wavefunctions; determining a relationship between the superimposed wavefunctions and the quadratic measure, and using the determined relationship to identify the superimposed wavefunctions that provide a desired or optimised quadratic measure.
Abstract translation: 一种优化作为波函数的二次函数的至少一个度量的方法，例如激光器的光斑尺寸，该方法包括：叠加多个波函数; 确定叠加的波函数和二次测量之间的关系，并且使用确定的关系来识别提供期望或优化的二次方法的叠加波函数。
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公开(公告)号：US08638431B2
公开(公告)日：2014-01-28
申请号：US12892640
申请日：2010-09-28
Applicant: Praveen Cheriyan Ashok , Gajendra Pratap Singh , Kishan Dholakia , Khay Tan
Inventor： Praveen Cheriyan Ashok , Gajendra Pratap Singh , Kishan Dholakia , Khay Tan
IPC: G01J3/44
CPC classification number: G01N21/65 , G01N21/05 , G01N2021/0346 , G01N2201/08
Abstract: A microfluidic device comprising at least one microfluidic channel with an input and an output for allowing fluid flow; and at least one Raman fiber based probe having an excitation fiber probe and/or a collection fiber probe positioned so that one end of the probe is in the microfluidic channel.
Abstract translation: 一种微流体装置，包括至少一个具有输入的微流体通道和用于允许流体流动的输出; 以及至少一个具有激发纤维探针和/或收集纤维探针的拉曼光纤探针，其定位使得探针的一端在微流体通道中。
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公开(公告)号：US20130164828A1
公开(公告)日：2013-06-27
申请号：US13643279
申请日：2011-06-10
Applicant: Kishan Dholakia , Na Ma , Praveen Cheriyan Ashok , David Stevenson , Francis James Gunn-Moore
Inventor： Kishan Dholakia , Na Ma , Praveen Cheriyan Ashok , David Stevenson , Francis James Gunn-Moore
IPC: C12N15/85
Abstract: An integrated fibre based device for transfecting material into a cell comprising an optical fiber that has a lens formed at its end for directing light to a surface of the cell, and a channel for delivery of the material for transfection into the cell.
Abstract translation: 一种用于将材料转染到细胞中的集成的基于纤维的装置，包括具有在其端部形成的用于将光引导到细胞表面的透镜的光纤，以及用于将所述材料输送到细胞中的通道。
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公开(公告)号：US08269962B2
公开(公告)日：2012-09-18
申请号：US12532723
申请日：2008-03-10
Applicant: Kishan Dholakia , Iain Cormack , Michael Mazilu
Inventor： Kishan Dholakia , Iain Cormack , Michael Mazilu
IPC: G01J3/44
CPC classification number: G01J3/44 , G01J3/10 , G01J2003/4424
Abstract: A Raman spectrometer comprising means for illuminating a sample with a shaped laser beam and a detector that is operable to detect light that is reflected from or transmitted through a sample. Preferably, the shaped laser beam has a dark spot at its center.
Abstract translation: 拉曼光谱仪，其包括用成形激光束照射样品的装置和可操作以检测从样品反射或透过样品的光的检测器。 优选地，成形激光束在其中心处具有黑点。
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Patent Agency Ranking
公开(公告)号：US20110133104A1
公开(公告)日：2011-06-09
申请号：US13057706
申请日：2009-08-28
Applicant: Kishan Dholakia , Michael Mazilu , Jorg Baumgartl
Inventor： Kishan Dholakia , Michael Mazilu , Jorg Baumgartl
IPC: G21K1/00
CPC classification number: G02B21/32
Abstract: A method for manipulating one or more particles comprising exposing the particle(s) to a beam of radiation that is able to lift and or impart an acceleration to the particle(s) to cause it to move in a curved trajectory.
Abstract translation: 一种用于操纵一种或多种颗粒的方法，包括将颗粒暴露于辐射束，所述辐射束能够提升和/或赋予颗粒加速度以使其在弯曲的轨迹中移动。
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公开(公告)号：US20100047761A1
公开(公告)日：2010-02-25
申请号：US12442327
申请日：2007-09-20
Applicant: Michael MacDonald , Kishan Dholakia , Igor Andreev
Inventor： Michael MacDonald , Kishan Dholakia , Igor Andreev
CPC classification number: C12M47/04 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0647 , B01L2400/0454 , G01N15/1484 , G01N2015/149
Abstract: A method for sorting particles, in particular cells A and B. The method uses a single channel with only one input and only one output. A particle mix A and B in a fluid is introduced into the channel and particles within the channel are sorted.
Abstract translation: 一种用于排序粒子的方法，特别是单元A和B.该方法使用单个通道，只有一个输入，只有一个输出。 将流体中的颗粒混合物A和B引入通道中，并且分配通道内的颗粒。
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公开(公告)号：US20100014078A1
公开(公告)日：2010-01-21
申请号：US12303526
申请日：2007-06-08
Applicant: Kishan Dholakia , Phillip Ronald Thomas Jess , Michael Mazilu
Inventor： Kishan Dholakia , Phillip Ronald Thomas Jess , Michael Mazilu
CPC classification number: G01J3/0297 , B01L3/5027 , G01J3/28 , G01J3/433 , G01J3/44 , G01J3/4412 , G01N21/65 , G01N2021/651 , G01N2021/656
Abstract: A micro-fluidic system comprising means for optically trapping a particle and a Raman excitation source for causing Raman scatter from the particle whilst it is in the optical trap.
Abstract translation: 微流体系统包括用于光学捕获颗粒和拉曼激发源的装置，用于在颗粒处于光阱中时引起来自颗粒的拉曼散射。
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公开(公告)号：US20080274529A1
公开(公告)日：2008-11-06
申请号：US11720488
申请日：2005-11-29
Applicant: Kishan Dholakia , Christian Thomas Alcuin Brown , Lynn Paterson
Inventor： Kishan Dholakia , Christian Thomas Alcuin Brown , Lynn Paterson
IPC: C12N13/00
Abstract: An opening is formed in a cell using laser radiation. A Bessel beam is formed using the laser radiation and the Bessel beam is directed onto the cell to form an opening. The guiding of material towards the opening may be involved using optical trapping/manipulation. The material may change cellular function or analyse cell behaviour. Both pulsed laser radiation and continuous wave radiation may be formed using the same laser.
Abstract translation: 在使用激光辐射的电池中形成开口。 使用激光辐射形成贝塞尔光束，并且贝塞尔光束被引导到细胞上以形成开口。 材料向开口的引导可能涉及使用光学捕获/操纵。 该物质可能改变细胞功能或分析细胞行为。 可以使用相同的激光器来形成脉冲激光辐射和连续波辐射。
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公开(公告)号：US20080017808A1
公开(公告)日：2008-01-24
申请号：US11596490
申请日：2005-05-10
Applicant: Kishan Dholakia , Thomas Krauss , Simon Cran-McGreehin
Inventor： Kishan Dholakia , Thomas Krauss , Simon Cran-McGreehin
IPC: G01N21/01
CPC classification number: G21K1/006 , B01L3/5027
Abstract: An on-chip micro-fluidic device (10) fabricated using a semiconductor material. The device has a micro-fluidic channel or chamber (14) defined within the material and one or more monolithically integrated semiconductor lasers (12) operate to form an optical trap in the channel or chamber (14).
Abstract translation: 使用半导体材料制造的片上微流体装置（10）。 所述装置具有限定在所述材料内的微流体通道或室（14），并且一个或多个单片集成半导体激光器（12）操作以在所述通道或室（14）中形成光阱。
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