摘要:
The present invention comprises pyridopyrimidinediamine compounds of the general formula I: The compounds of the present invention are potent inhibitors of PTP1B. Accordingly, the invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
摘要:
The present invention provides compounds having formula (II): wherein X, n, R1-R12 are defined herein, or a pharmaceutically acceptable salt thereof. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound represented by formula (II) and a pharmaceutically acceptable carrier or excipient. The invention further provides a method for treating cancer comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound represented by formula (II).
摘要:
The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds which are useful for inhibiting protein tyrosine phosphatases, particularly PTP1B, and are useful for lowering blood glucose concentrations in mammals.
摘要:
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of obesity, hyperphagia, anxiety, depression and related disorders and diseases.
摘要:
Disclosed are novel diaminothiazoles that are selective inhibitors of Cdk4. These compounds and their pharmaceutically acceptable salts and esters are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds as well as intermediates useful in the preparation of the compounds.
摘要:
The present invention is directed to novel diaminothiazoles of formula These compounds inhibit cyclin-dependent kinase 4 (Cdk4) and are selective against Cdk2 and Cdk1. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung and colon and prostate tumors.
摘要:
Data analysis of a food item based on one or more digital images of the food item is disclosed. In one embodiment, the method comprises displaying, on a display unit of the smart device, first and second digital images of a meal, where the first digital image is captured before the second digital image. The method also comprises determining a volume of each food item in the first digital image and a volume of each food item in the second digital image by analyzing the first digital image and the second digital image using a digital image processing technique. The method further comprises generating, on the display unit, an amount of intake for the meal based on a difference between the volume of each food item in the first digital image and the volume of each food item in the second digital image.
摘要:
This invention relates to novel 3-aminopyridines of the formula wherein B1, B2 and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.
摘要:
Data sharing between networked smart devices is disclosed. One embodiment of the present disclosure pertains to a method for data sharing with one or more associated smart devices via a network. The method comprises displaying, on a display unit of the smart device, an image for each one of the associated smart devices within coverage of the network and an image of shared data. The method also comprises effecting a change in a first image for a first smart device of the associated smart devices when the first smart device is targeted as a target device for the data sharing. The method further comprises communicating the shared data with the first smart device via the network when, on the display unit, the image of the shared data is moved to or from a domain of the first image of the first smart device.
摘要:
The present disclosure is directed to a display device and a method of controlling the display device. The display device includes a memory that stores at least one first gesture image corresponding to at least one function, a camera that obtains a basic image including user's second gesture image, and a controller that extracts the second gesture image from the basic image and displays at least one third gesture image similar to the extracted second gesture image, wherein the third gesture image is included in the first gesture image stored in the memory. The display device and method of controlling the display device may guide a user to make a correct gesture by displaying a gesture image similar to a gesture made by the user among gesture images stored in a memory.