公开(公告)号：US20180361345A1

公开(公告)日：2018-12-20

申请号：US15978523

申请日：2018-05-14

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Robert Hess ,  John Linton ,  Tanya S. Kanigan ,  Colin Brenan ,  Can Ozbal

IPC: B01J19/00 ,  G01N30/60 ,  C12M1/32 ,  B01L3/00

Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.

公开(公告)号：US10065189B2

公开(公告)日：2018-09-04

申请号：US15049710

申请日：2016-02-22

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Tanya S. Kanigan ,  Steve Smith ,  John Linton ,  Robert Hess ,  Karl Yoder ,  Colin John Herbert Brenan

IPC: B01L3/00 ,  B01L3/02 ,  B33Y70/00 ,  B33Y80/00

Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.

公开(公告)号：US09968903B2

公开(公告)日：2018-05-15

申请号：US15131101

申请日：2016-04-18

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Robert Hess ,  John Linton ,  Tanya S. Kanigan ,  Colin Brenan ,  Can Ozbal

IPC: B01J19/00 ,  B01L3/02 ,  B01L3/00 ,  C40B60/14 ,  G01N30/46 ,  G01N30/60 ,  B01L99/00 ,  C12M1/32 ,  G01N30/82 ,  G01N30/84

CPC classification number: B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/0036 ,  B01J2219/00369 ,  B01J2219/00387 ,  B01J2219/00389 ,  B01J2219/00423 ,  B01J2219/0043 ,  B01J2219/00479 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00673 ,  B01L3/0244 ,  B01L3/0262 ,  B01L3/0268 ,  B01L3/5025 ,  B01L3/50255 ,  B01L3/5085 ,  B01L3/50857 ,  B01L99/00 ,  B01L2200/0657 ,  B01L2300/0845 ,  C12M23/12 ,  C40B60/14 ,  G01N30/466 ,  G01N30/6091 ,  G01N30/6095 ,  G01N30/82 ,  G01N2030/8417

Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.

公开(公告)号：US20140031262A1

公开(公告)日：2014-01-30

申请号：US14042458

申请日：2013-09-30

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Tanya S. Kanigan ,  Steve Smith ,  John Linton ,  Robert Hess ,  Karl Yoder ,  Colin Brennan

IPC: B01L3/00

CPC classification number: B01L3/5085 ,  B01L3/0241 ,  B01L3/0244 ,  B01L3/5025 ,  B01L3/50857 ,  B01L3/563 ,  B01L2200/021 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0636 ,  B01L2200/0642 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2300/12 ,  B01L2300/161 ,  B33Y70/00 ,  B33Y80/00 ,  Y10T137/0318 ,  Y10T137/1624 ,  Y10T137/206 ,  Y10T436/2525

Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.

Abstract translation: 提供了用于将微流体样品存储在纳升级样品芯片中的界面。 流体通道结构从样品阱阵列向选定的样品阱子集提供流体通路区域。 流体引入机构将样品流体引入流体存取区域，使得所选择的子集中的样品孔填充有样品流体，而未选择的样品池填充有样品流体。