公开(公告)号：US20220202721A1

公开(公告)日：2022-06-30

申请号：US17569881

申请日：2022-01-06

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

Inventor： Carlo Giovanni Traverso ,  Joshua Korzenik ,  Robert S. Langer ,  Christoph Winfried Johannes Steiger

IPC: A61K9/20 ,  A61K9/28 ,  A61K9/48

Abstract: Articles and methods for delivering a therapeutic agent to a subject are described. These articles and methods may be useful, in some cases, for the delivery of therapeutic agents to the colon of a subject. In some embodiments, an article is configured to release a secretion inducing agent e.g., to stimulate the release of intestinal fluids. The article, in some embodiments, comprises a therapeutic agent such that the stimulated release of intestinal fluid increases the amount of therapeutic agent available for absorption by the colon. For example, in some embodiments, the articles and methods described herein advantageously promote increased absorption of therapeutic agents in subjects as compared to traditionally administered therapeutic agents without additional components such as a secretion inducing agent. In some embodiments, articles and methods described herein may increase the motility of the colon of a subject. The increase in contractions and movement of fluidic in the colon caused by increase motility may advantageously facilitate the dissolution or absorption of the therapeutic agent.

公开(公告)号：US20220193399A1

公开(公告)日：2022-06-23

申请号：US17512156

申请日：2021-10-27

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

Inventor： Robert S. Langer ,  Carlo Giovanni Traverso ,  Alex G. Abramson ,  David Dellal

IPC: A61N1/05 ,  A61L31/02 ,  A61N1/36 ,  A61N1/372

Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one 5 or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In certain embodiments, the self-righting article a tissuel0 interfacing components. In some embodiments, each tissue-interfacing component may comprise an electrically-conductive portion configured for electrical communication with tissue and an insulative portion configured to not be in electrical communication with tissue.

公开(公告)号：US11357723B2

公开(公告)日：2022-06-14

申请号：US17174458

申请日：2021-02-12

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

Inventor： Andrew Bellinger ,  Shiyi Zhang ,  Carlo Giovanni Traverso ,  Robert S. Langer ,  Stacy Mo ,  Tyler Grant ,  Mousa Jafari ,  Dean Liang Glettig ,  Angela DiCiccio ,  Lowell L. Wood, Jr. ,  Philip A. Eckhoff

IPC: A61K9/00 ,  A61K9/48 ,  A61K31/357 ,  A61K31/65 ,  A61K31/7048 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/40 ,  A61K47/42 ,  A61K47/58 ,  A61K47/69 ,  C08G18/42 ,  C08G63/08 ,  C08G18/73 ,  C08G83/00 ,  C08L33/02 ,  C08L33/08 ,  C08L33/14 ,  A61M31/00

Abstract: Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

公开(公告)号：US11311489B2

公开(公告)日：2022-04-26

申请号：US16614172

申请日：2018-05-17

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

Inventor： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer

IPC: A61K9/48 ,  A61J3/07 ,  A61K9/00 ,  A61B5/145 ,  A61B10/02 ,  A61M5/142 ,  A61M37/00 ,  A61N1/32 ,  A61N1/36 ,  A61M5/20 ,  A61M5/32 ,  A61M31/00 ,  A61K38/28 ,  A61M5/158 ,  A61N1/05

Abstract: Components with relatively high loading of active pharmaceutical ingredients are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent and a supporting material such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt % versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, GI mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle. In some cases, a physiologically relevant dose may be present in a single tissue interfacing component.

公开(公告)号：US20220110410A1

公开(公告)日：2022-04-14

申请号：US17497380

申请日：2021-10-08

Applicant: President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

Inventor： Robert S. Langer ,  Katia Bertoldi ,  Carlo Giovanni Traverso ,  Sahab Babaee ,  Ahmad Rafsanjani Abbasi ,  Simo Pajovic

IPC: A43B13/22

Abstract: A shoe comprises an upper portion, a sole, and a sheet of material. The upper portion is configured to receive a foot of a user. The sole is attached to the upper portion. The sheet of material is coupled to the sole. The material includes a substrate and one or more movable projections. The one or more movable projections are configured to extend from the substrate. The one or more movable projections are configured to move between a first orientation and a second orientation relative to the substrate, in response to the sole of the shoe moving between a generally flat configuration and a generally flexed configuration. The movable projections can have a triangular shape, a concave shape, a convex shape, a rectangular shape, or a barbed shape; and can be arranged in a one-direction pattern, a three-column pattern, a half pattern, a 16x2 pattern, or a checkerboard pattern.

公开(公告)号：US20220091099A1

公开(公告)日：2022-03-24

申请号：US17404286

申请日：2021-08-17

Applicant: Massachusetts Institute of Technology ,  President and Fellows of Harvard College

Inventor： Armon R. Sharei ,  Marc Lajoie ,  Klavs F. Jensen ,  Robert S. Langer

IPC: G01N33/50 ,  G01N33/487 ,  C12N15/87

Abstract: Gene editing can be performed by introducing gene-editing components into a cell by mechanical cell disruption. Related apparatus, systems, techniques, and articles are also described.

公开(公告)号：US20220054642A1

公开(公告)日：2022-02-24

申请号：US17517111

申请日：2021-11-02

Applicant: Massachusetts Institute of Technology

Inventor： Matthew J. Webber ,  Eric Andrew Appel ,  Robert S. Langer ,  Daniel Griffith Anderson

IPC: A61K47/54 ,  A61K47/60 ,  A61K47/34 ,  C07K14/62 ,  C07D519/00 ,  C07K14/605 ,  A61K47/68 ,  A61K38/26 ,  A61K38/28 ,  C07K16/28

Abstract: The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.

公开(公告)号：US11191841B2

公开(公告)日：2021-12-07

申请号：US15765585

申请日：2016-10-06

Applicant: Massachusetts Institute of Technology

Inventor： Matthew J. Webber ,  Eric Andrew Appel ,  Robert S. Langer ,  Daniel Griffith Anderson

IPC: A61K47/60 ,  A61K47/34 ,  C07K14/62 ,  C07D519/00 ,  C07K14/605 ,  A61K47/54 ,  A61K47/68 ,  A61K38/26 ,  A61K38/28 ,  C07K16/28

Abstract: The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.

公开(公告)号：US11167066B2

公开(公告)日：2021-11-09

申请号：US15055012

申请日：2016-02-26

Applicant: Massachusetts Institute of Technology ,  The General Hospital Corporation

Inventor： Laura Indolfi ,  Elazer R. Edelman ,  Robert S. Langer ,  Jeffrey W. Clark ,  David T. Ting ,  Cristina Rosa Annamaria Ferrone ,  Matteo Ligorio

IPC: A61K9/70 ,  A61K31/337 ,  A61K47/34 ,  A61F2/04 ,  A61L31/10 ,  A61K9/00 ,  A61L31/16 ,  A61L31/14 ,  A61F2/915

Abstract: Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting device having a film which includes a mixture of a degradable polymer and a chemotherapeutic drug, wherein the film has a thickness from about 2 μm to about 1000 μm, into a tissue site and releasing a therapeutically effective amount of the chemotherapeutic drug from the film to treat the tumor, wherein the release of the therapeutically effective amount of the drug from the film is controlled by in vivo degradation of the polymer at the tissue site.

公开(公告)号：US20210290921A1

公开(公告)日：2021-09-23

申请号：US17342978

申请日：2021-06-09

Applicant: Massachusetts Institute of Technology

Inventor： Kevin McHugh ,  Ana Jaklenec ,  Robert S. Langer

IPC: A61M31/00 ,  A61K9/16 ,  A61B5/145 ,  A61K39/00 ,  A61K9/127 ,  A61M5/142 ,  A61K47/34 ,  A61K39/12 ,  A61K9/00

Abstract: Microdevices with complex three-dimensional (3D) internal and external structures are described. The microdevices are made by a method combining micromolding and soft lithography with an aligned sintering process. The microfabrication method, termed StampEd Assembly of polymer Layers (SEAL), generates microdevices with complex geometries and with fully-enclosed internal cavities containing a solid or liquid. The microdevices are useful for biomedical, electromechanical, energy and environmental applications.