-
公开(公告)号：US08105606B2
公开(公告)日：2012-01-31
申请号：US13094287
申请日：2011-04-26
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质的嵌合链，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
-
公开(公告)号：US20110200628A1
公开(公告)日：2011-08-18
申请号：US13094287
申请日：2011-04-26
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质的嵌合链，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
-
公开(公告)号：US07947281B2
公开(公告)日：2011-05-24
申请号：US12483607
申请日：2009-06-12
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Richardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Richardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质的嵌合链，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
-
14.发明申请Methods and Proteins for the Prophylactic and/or Therapeutic Treatment of Four Serotypes of Dengue Virus and Other Flaviviruses 审中-公开用于预防和/或治疗四种登革热病毒和其他黄病毒血清型的方法和蛋白质公开(公告)号：US20090312190A1
公开(公告)日：2009-12-17
申请号：US12094503
申请日：2006-11-21
申请人： Glay Chinea Santiago , Vivian Huerta Galindo , Alejandro Miguel Martin Dunn , Jorge Victor Gavilondo Cowley , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Jeovanis Gil Valdés , Aída Zulueta Morales , Lisset Hermida Cruz , Marta Ayala Avila , Diamilé Gonzáles Roche , Rolando Paez Meireles , Patricia Gabriela Toledo Mayora , Mónica Sarria Núnez , Alexis Musacchio Lasa , Yuliet Mazola Reyes
发明人： Glay Chinea Santiago , Vivian Huerta Galindo , Alejandro Miguel Martin Dunn , Jorge Victor Gavilondo Cowley , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Jeovanis Gil Valdés , Aída Zulueta Morales , Lisset Hermida Cruz , Marta Ayala Avila , Diamilé Gonzáles Roche , Rolando Paez Meireles , Patricia Gabriela Toledo Mayora , Mónica Sarria Núnez , Alexis Musacchio Lasa , Yuliet Mazola Reyes
IPC分类号： C40B30/02 , A61K39/00 , A61K39/12 , C12N7/00 , C12N5/00 , C40B30/04 , C40B40/10 , C07K16/00 , C07H21/04 , A61K39/02
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/55566 , C07K2319/02 , C07K2319/21 , C12N2770/24022 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to the field of the pharmaceutical industry, and describes a conserved area on the surface of the E protein that can be used for the development of wide-spectrum antiviral molecules to be employed in the prophylaxis and/or treatment of infections due to Dengue Virus serotypes 1-4 and other flaviviruses. The invention also covers chimeric proteins to be used as vaccines or as a prophylactic or therapeutic treatment against the four serotypes of Dengue Virus and other flaviviruses.
摘要翻译： 本发明涉及制药工业的领域，并且描述了可用于开发用于预防和/或治疗感染的广谱抗病毒分子的E蛋白表面上的保守区域 由于登革热病毒血清型1-4和其他黄病毒。 本发明还涵盖用作疫苗的嵌合蛋白或针对登革热病毒和其他黄病毒的四种血清型的预防或治疗性治疗。
-
15.发明授权Chemical compounds having antiviral activity against Dengue virus and other Flaviviruses 有权对登革热病毒和其他黄病毒具有抗病毒活性的化合物公开(公告)号：US08722742B2
公开(公告)日：2014-05-13
申请号：US12919416
申请日：2009-02-27
申请人： Yuliet Mazola Reyes , Glay Chinea Santiago , Osmany Guirola Cruz , Roberto Vera Alvarez , Vivian Huerta Galindo , Noralvis Fleitas Salazar , Alexis Musacchio Lasa
发明人： Yuliet Mazola Reyes , Glay Chinea Santiago , Osmany Guirola Cruz , Roberto Vera Alvarez , Vivian Huerta Galindo , Noralvis Fleitas Salazar , Alexis Musacchio Lasa
IPC分类号： A01N41/06 , A61K31/18 , A61K31/535 , A61K31/497 , A61K31/4965 , A01N43/40 , A61K31/445
CPC分类号： A61K31/16 , A61K31/18 , A61K31/381 , A61K31/41 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/495 , A61K31/4965 , A61K31/50 , A61K31/506 , A61K31/535 , A61K31/55 , A61K47/54 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Use of chemical compounds obtained in silico for the preparation of pharmaceutical compositions to attenuate or inhibit Dengue virus infection. Particularly, through the interference or the modulation of several stages of viral replication cycle related with the entry of virus into host cells and the assembly of mature progeny virions. The invention also comprises the use of such pharmaceutical compositions for prophylactic and/or therapeutic treatment of infection caused by all four serotypes of Dengue virus and other flaviviruses.
摘要翻译： 使用在硅胶中获得的化学化合物用于制备药物组合物以减轻或抑制登革热病毒感染。 特别是通过与病毒进入宿主细胞相关的几个阶段的病毒复制循环的干扰或调节以及成熟后代病毒粒子的组装。 本发明还包括使用这种药物组合物预防和/或治疗由登革热病毒和其他黄病毒的四种血清型引起的感染。
-
16.发明申请CHEMICAL COMPOUNDS HAVING ANTIVIRAL ACTIVITY AGAINST DENGUE VIRUS AND OTHER FLAVIVIRUSES 有权具有针对登革病毒和其他感染病毒的抗病毒活性的化学化合物公开(公告)号：US20110065686A1
公开(公告)日：2011-03-17
申请号：US12919416
申请日：2009-02-27
申请人： Yuliet Mazola Reyes , Glay Chinea Santiago , Osmany Guirola Cruz , Roberto Vera Alvarez , Vivian Huerta Galindo , Noralvis Fleitas Salazar , Alexis Musacchio Lasa
发明人： Yuliet Mazola Reyes , Glay Chinea Santiago , Osmany Guirola Cruz , Roberto Vera Alvarez , Vivian Huerta Galindo , Noralvis Fleitas Salazar , Alexis Musacchio Lasa
IPC分类号： A61K31/55 , C12Q1/70 , A61K31/18 , A61K31/36 , A61K31/4965 , A61K31/34 , A61K31/38 , A61K31/445 , A61K31/5375 , A61K31/50 , A61K31/505 , A61K31/428 , A61K31/5377 , A61P31/12
CPC分类号： A61K31/16 , A61K31/18 , A61K31/381 , A61K31/41 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/495 , A61K31/4965 , A61K31/50 , A61K31/506 , A61K31/535 , A61K31/55 , A61K47/54 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Use of chemical compounds obtained in silico for the preparation of pharmaceutical compositions to attenuate or inhibit Dengue virus infection. Particularly, through the interference or the modulation of several stages of viral replication cycle related with the entry of virus into host cells and the assembly of mature progeny virions. The invention also comprises the use of such pharmaceutical compositions for prophylactic and/or therapeutic treatment of infection caused by all four serotypes of Dengue virus and other flaviviruses.
摘要翻译： 使用在硅胶中获得的化学化合物用于制备药物组合物以减轻或抑制登革热病毒感染。 特别是通过与病毒进入宿主细胞相关的几个阶段的病毒复制循环的干扰或调节以及成熟后代病毒粒子的组装。 本发明还包括使用这种药物组合物预防和/或治疗由登革热病毒和其他黄病毒的四种血清型引起的感染。
-
17.发明申请RECOMBINANT ANTIBODIES AGAINST THE VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) 审中-公开对血管内皮生长因子（VEGF）的重组抗体公开(公告)号：US20100151566A1
公开(公告)日：2010-06-17
申请号：US12447711
申请日：2007-10-30
申请人： Humberto Lamdan Ordás , Jorge Víctor Gavilondo Cowley , Marta Ayala Avila , Gertrudis Rojas Dorantes , Yanelys Morera Díaz , Osmany Guirola Cruz , Glay Chinea Santiago , Nelson Francisco Santiago Vispo
发明人： Humberto Lamdan Ordás , Jorge Víctor Gavilondo Cowley , Marta Ayala Avila , Gertrudis Rojas Dorantes , Yanelys Morera Díaz , Osmany Guirola Cruz , Glay Chinea Santiago , Nelson Francisco Santiago Vispo
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/52 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2319/00
摘要： The present invention deals with recombinant polypeptide molecules related to antibodies, that specifically recognize the human Vascular Endothelial Growth Factor A (VEGF-A), and interfere with its in vitro stimulatory effects and pro-angiogenic activity in vivo. These recombinant polypeptide molecules affect proliferation of human endothelial cells in vitro, subcutaneous angiogenesis in mice induced by Matrigel pellets that contain VEGF-A and the growth of human tumors transplanted in nude athymic mice. Several of these moleculas prevent choroideal neovascularization in a non human primate experimental model. These molecules can be employed for passive immunotherapy in pathological entities which have in its base an abnormal increase in blood vessels, as: age-related macular degeneration (wet variant), cancer and its metastases, neovascular glaucoma, diabetic and newborn retinopathies, acute and chronic inflammatory processes, infectious diseases, autoimmune diseases, organ transplant rejection, hemangioma, angiofibroma, and others.
摘要翻译： 本发明涉及与抗体相关的重组多肽分子，其特异性识别人血管内皮生长因子A（VEGF-A），并且干扰其在体内的体外刺激作用和促血管生成活性。 这些重组多肽分子影响体外人体内皮细胞的增殖，小鼠皮下血管生成，由含有VEGF-A的Matrigel颗粒诱导，并且移植在裸露无胸腺小鼠中的人类肿瘤的生长。 这些分子中的几个在非人灵长类动物实验模型中阻止氯化物新生血管形成。 这些分子可用于病理实体中的被动免疫治疗，其基础是血管异常增加，如：年龄相关性黄斑变性（湿性变体），癌症及其转移，新生血管性青光眼，糖尿病和新生儿视网膜病变，急性和 慢性炎症过程，传染病，自身免疫性疾病，器官移植排斥，血管瘤，血管纤维瘤等。
-
公开(公告)号：US20090274718A1
公开(公告)日：2009-11-05
申请号：US12483607
申请日：2009-06-12
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
IPC分类号： A61K39/07 , C07K14/245 , A61K38/16
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质的嵌合链，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
-
公开(公告)号：US07566457B2
公开(公告)日：2009-07-28
申请号：US11705696
申请日：2007-02-13
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonspecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
-
公开(公告)号：US07279164B2
公开(公告)日：2007-10-09
申请号：US10484114
申请日：2002-07-12
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
-
-
-
-
-
-
-
-
-
搜索结果
20 条记录 (耗时 0.066 秒)
