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1.发明授权Chemical compounds having antiviral activity against Dengue virus and other Flaviviruses 有权对登革热病毒和其他黄病毒具有抗病毒活性的化合物公开(公告)号：US08722742B2
公开(公告)日：2014-05-13
申请号：US12919416
申请日：2009-02-27
申请人： Yuliet Mazola Reyes , Glay Chinea Santiago , Osmany Guirola Cruz , Roberto Vera Alvarez , Vivian Huerta Galindo , Noralvis Fleitas Salazar , Alexis Musacchio Lasa
发明人： Yuliet Mazola Reyes , Glay Chinea Santiago , Osmany Guirola Cruz , Roberto Vera Alvarez , Vivian Huerta Galindo , Noralvis Fleitas Salazar , Alexis Musacchio Lasa
IPC分类号： A01N41/06 , A61K31/18 , A61K31/535 , A61K31/497 , A61K31/4965 , A01N43/40 , A61K31/445
CPC分类号： A61K31/16 , A61K31/18 , A61K31/381 , A61K31/41 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/495 , A61K31/4965 , A61K31/50 , A61K31/506 , A61K31/535 , A61K31/55 , A61K47/54 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Use of chemical compounds obtained in silico for the preparation of pharmaceutical compositions to attenuate or inhibit Dengue virus infection. Particularly, through the interference or the modulation of several stages of viral replication cycle related with the entry of virus into host cells and the assembly of mature progeny virions. The invention also comprises the use of such pharmaceutical compositions for prophylactic and/or therapeutic treatment of infection caused by all four serotypes of Dengue virus and other flaviviruses.
摘要翻译： 使用在硅胶中获得的化学化合物用于制备药物组合物以减轻或抑制登革热病毒感染。 特别是通过与病毒进入宿主细胞相关的几个阶段的病毒复制循环的干扰或调节以及成熟后代病毒粒子的组装。 本发明还包括使用这种药物组合物预防和/或治疗由登革热病毒和其他黄病毒的四种血清型引起的感染。
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2.发明申请CHEMICAL COMPOUNDS HAVING ANTIVIRAL ACTIVITY AGAINST DENGUE VIRUS AND OTHER FLAVIVIRUSES 有权具有针对登革病毒和其他感染病毒的抗病毒活性的化学化合物公开(公告)号：US20110065686A1
公开(公告)日：2011-03-17
申请号：US12919416
申请日：2009-02-27
申请人： Yuliet Mazola Reyes , Glay Chinea Santiago , Osmany Guirola Cruz , Roberto Vera Alvarez , Vivian Huerta Galindo , Noralvis Fleitas Salazar , Alexis Musacchio Lasa
发明人： Yuliet Mazola Reyes , Glay Chinea Santiago , Osmany Guirola Cruz , Roberto Vera Alvarez , Vivian Huerta Galindo , Noralvis Fleitas Salazar , Alexis Musacchio Lasa
IPC分类号： A61K31/55 , C12Q1/70 , A61K31/18 , A61K31/36 , A61K31/4965 , A61K31/34 , A61K31/38 , A61K31/445 , A61K31/5375 , A61K31/50 , A61K31/505 , A61K31/428 , A61K31/5377 , A61P31/12
CPC分类号： A61K31/16 , A61K31/18 , A61K31/381 , A61K31/41 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/495 , A61K31/4965 , A61K31/50 , A61K31/506 , A61K31/535 , A61K31/55 , A61K47/54 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Use of chemical compounds obtained in silico for the preparation of pharmaceutical compositions to attenuate or inhibit Dengue virus infection. Particularly, through the interference or the modulation of several stages of viral replication cycle related with the entry of virus into host cells and the assembly of mature progeny virions. The invention also comprises the use of such pharmaceutical compositions for prophylactic and/or therapeutic treatment of infection caused by all four serotypes of Dengue virus and other flaviviruses.
摘要翻译： 使用在硅胶中获得的化学化合物用于制备药物组合物以减轻或抑制登革热病毒感染。 特别是通过与病毒进入宿主细胞相关的几个阶段的病毒复制循环的干扰或调节以及成熟后代病毒粒子的组装。 本发明还包括使用这种药物组合物预防和/或治疗由登革热病毒和其他黄病毒的四种血清型引起的感染。
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3.发明申请Methods and Proteins for the Prophylactic and/or Therapeutic Treatment of Four Serotypes of Dengue Virus and Other Flaviviruses 审中-公开用于预防和/或治疗四种登革热病毒和其他黄病毒血清型的方法和蛋白质公开(公告)号：US20090312190A1
公开(公告)日：2009-12-17
申请号：US12094503
申请日：2006-11-21
申请人： Glay Chinea Santiago , Vivian Huerta Galindo , Alejandro Miguel Martin Dunn , Jorge Victor Gavilondo Cowley , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Jeovanis Gil Valdés , Aída Zulueta Morales , Lisset Hermida Cruz , Marta Ayala Avila , Diamilé Gonzáles Roche , Rolando Paez Meireles , Patricia Gabriela Toledo Mayora , Mónica Sarria Núnez , Alexis Musacchio Lasa , Yuliet Mazola Reyes
发明人： Glay Chinea Santiago , Vivian Huerta Galindo , Alejandro Miguel Martin Dunn , Jorge Victor Gavilondo Cowley , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Jeovanis Gil Valdés , Aída Zulueta Morales , Lisset Hermida Cruz , Marta Ayala Avila , Diamilé Gonzáles Roche , Rolando Paez Meireles , Patricia Gabriela Toledo Mayora , Mónica Sarria Núnez , Alexis Musacchio Lasa , Yuliet Mazola Reyes
IPC分类号： C40B30/02 , A61K39/00 , A61K39/12 , C12N7/00 , C12N5/00 , C40B30/04 , C40B40/10 , C07K16/00 , C07H21/04 , A61K39/02
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/55566 , C07K2319/02 , C07K2319/21 , C12N2770/24022 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to the field of the pharmaceutical industry, and describes a conserved area on the surface of the E protein that can be used for the development of wide-spectrum antiviral molecules to be employed in the prophylaxis and/or treatment of infections due to Dengue Virus serotypes 1-4 and other flaviviruses. The invention also covers chimeric proteins to be used as vaccines or as a prophylactic or therapeutic treatment against the four serotypes of Dengue Virus and other flaviviruses.
摘要翻译： 本发明涉及制药工业的领域，并且描述了可用于开发用于预防和/或治疗感染的广谱抗病毒分子的E蛋白表面上的保守区域 由于登革热病毒血清型1-4和其他黄病毒。 本发明还涵盖用作疫苗的嵌合蛋白或针对登革热病毒和其他黄病毒的四种血清型的预防或治疗性治疗。
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4.发明授权Chimerical peptidic molecules with antiviral properties against the viruses of the Flaviviridae family 有权具有针对黄病毒科病毒的抗病毒特性的嵌合肽分子公开(公告)号：US08674063B2
公开(公告)日：2014-03-18
申请号：US12513085
申请日：2007-10-30
申请人： Glay Chinea Santiago , Vivian Huerta Galindo , Alejandro Miguel Martin Dunn , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Mónica Sarría Núñez , Alexis Musacchio Lasa , Olvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Anìa Cabrales Rico
发明人： Glay Chinea Santiago , Vivian Huerta Galindo , Alejandro Miguel Martin Dunn , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Mónica Sarría Núñez , Alexis Musacchio Lasa , Olvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Anìa Cabrales Rico
IPC分类号： C07K14/00
CPC分类号： A61K47/48315 , A61K38/00 , A61K47/645 , C07K14/005 , C07K2319/04 , C07K2319/10 , C12N2770/24022 , C12N2770/24122 , C12N2770/24222 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： The present invention is relative to chimerical peptides, whose primary structure holds at least one segment which inhibits the activation of the NS3 protease of a virus from the Flaviviridae family, they also contain a cell penetrating segment and they are capable of inhibiting or attenuate the viral infection. This invention is also relative to pharmaceutical compounds which contain these chimerical peptides for the prevention and/or treatment of the infection caused by a virus of the Flaviviridae family.
摘要翻译： 本发明是相对于嵌合肽，其主要结构保持至少一个片段，其抑制来自黄病毒科的病毒的NS3蛋白酶的活化，它们还含有细胞穿透片段，并且它们能够抑制或减弱病毒 感染。 本发明还涉及含有这些嵌合肽用于预防和/或治疗由黄病毒科病毒引起的感染的药物化合物。
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5.发明申请公开(公告)号：US20110212105A1
公开(公告)日：2011-09-01
申请号：US12298808
申请日：2007-04-26
申请人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martín Dunn , Mónica Sarría Núñez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sánchez Puente , Vladimir Armando Besada Pérez , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramón Padrón Palomares , Luis Javier González López
发明人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martín Dunn , Mónica Sarría Núñez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sánchez Puente , Vladimir Armando Besada Pérez , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramón Padrón Palomares , Luis Javier González López
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/70596 , C07K14/8107 , C12N2770/24122 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
摘要翻译： 本发明涉及一种基于干扰病毒包膜蛋白与细胞受体的直接相互作用或其通过载体蛋白与所述细胞受体的间接相互作用而阻断登革热病毒感染细胞的方法，以及相关的 用途; 其中所述细胞受体是α-2巨球蛋白受体，也称为低密度受体相关蛋白或CD91，所述载体蛋白是人α-2巨球蛋白。
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公开(公告)号：US08420311B2
公开(公告)日：2013-04-16
申请号：US12298808
申请日：2007-04-26
申请人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martin Dunn , Monica Sarria Nunez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sanchez Puente , Vladimir Armando Besada Perez , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramon Padron Palomares , Luis Javier Gonzalez Lopez
发明人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martin Dunn , Monica Sarria Nunez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sanchez Puente , Vladimir Armando Besada Perez , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramon Padron Palomares , Luis Javier Gonzalez Lopez
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/70596 , C07K14/8107 , C12N2770/24122 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
摘要翻译： 本发明涉及一种基于干扰病毒包膜蛋白与细胞受体的直接相互作用或其通过载体蛋白与所述细胞受体的间接相互作用而阻断登革热病毒感染细胞的方法，以及相关的 用途; 其中所述细胞受体是α-2巨球蛋白受体，也称为低密度受体相关蛋白或CD91，所述载体蛋白是人α-2巨球蛋白。
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7.发明申请CHIMERICAL PEPTIDIC MOLECULES WITH ANTIVIRAL PROPERTIES AGAINST THE VIRUSES OF THE FLAVIVIRIDAE FAMILY 有权具有抗FLAVIVIRIDIDE家族病毒抗性特性的二肽分子公开(公告)号：US20100273702A1
公开(公告)日：2010-10-28
申请号：US12513085
申请日：2007-10-30
申请人： Glay Chinea Santiago , Vivian Juerta Galindo , Alejandro Miguel Martin Dunn , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Mónica Srria Nüñez , Alexis Musacchio Lasa , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico
发明人： Glay Chinea Santiago , Vivian Juerta Galindo , Alejandro Miguel Martin Dunn , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Mónica Srria Nüñez , Alexis Musacchio Lasa , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico
CPC分类号： A61K47/48315 , A61K38/00 , A61K47/645 , C07K14/005 , C07K2319/04 , C07K2319/10 , C12N2770/24022 , C12N2770/24122 , C12N2770/24222 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： The present invention is relative to chimerical peptides, whose primary structure holds at least one segment which inhibits the activation of the NS3 protease of a virus from the Flaviviridae family, they also contain a cell penetrating segment and they are capable of inhibiting or attenuate the viral infection. This invention is also relative to pharmaceutical compounds which contain these chimerical peptides for the prevention and/or treatment of the infection caused by a virus of the Flaviviridae family.
摘要翻译： 本发明是相对于嵌合肽，其主要结构保持至少一个片段，其抑制来自黄病毒科的病毒的NS3蛋白酶的活化，它们还含有细胞穿透片段，并且它们能够抑制或减弱病毒 感染。 本发明还涉及含有这些嵌合肽用于预防和/或治疗由黄病毒科病毒引起的感染的药物化合物。
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8.发明申请RECOMBINANT ANTIBODIES AGAINST THE VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) 审中-公开对血管内皮生长因子（VEGF）的重组抗体公开(公告)号：US20100151566A1
公开(公告)日：2010-06-17
申请号：US12447711
申请日：2007-10-30
申请人： Humberto Lamdan Ordás , Jorge Víctor Gavilondo Cowley , Marta Ayala Avila , Gertrudis Rojas Dorantes , Yanelys Morera Díaz , Osmany Guirola Cruz , Glay Chinea Santiago , Nelson Francisco Santiago Vispo
发明人： Humberto Lamdan Ordás , Jorge Víctor Gavilondo Cowley , Marta Ayala Avila , Gertrudis Rojas Dorantes , Yanelys Morera Díaz , Osmany Guirola Cruz , Glay Chinea Santiago , Nelson Francisco Santiago Vispo
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/52 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2319/00
摘要： The present invention deals with recombinant polypeptide molecules related to antibodies, that specifically recognize the human Vascular Endothelial Growth Factor A (VEGF-A), and interfere with its in vitro stimulatory effects and pro-angiogenic activity in vivo. These recombinant polypeptide molecules affect proliferation of human endothelial cells in vitro, subcutaneous angiogenesis in mice induced by Matrigel pellets that contain VEGF-A and the growth of human tumors transplanted in nude athymic mice. Several of these moleculas prevent choroideal neovascularization in a non human primate experimental model. These molecules can be employed for passive immunotherapy in pathological entities which have in its base an abnormal increase in blood vessels, as: age-related macular degeneration (wet variant), cancer and its metastases, neovascular glaucoma, diabetic and newborn retinopathies, acute and chronic inflammatory processes, infectious diseases, autoimmune diseases, organ transplant rejection, hemangioma, angiofibroma, and others.
摘要翻译： 本发明涉及与抗体相关的重组多肽分子，其特异性识别人血管内皮生长因子A（VEGF-A），并且干扰其在体内的体外刺激作用和促血管生成活性。 这些重组多肽分子影响体外人体内皮细胞的增殖，小鼠皮下血管生成，由含有VEGF-A的Matrigel颗粒诱导，并且移植在裸露无胸腺小鼠中的人类肿瘤的生长。 这些分子中的几个在非人灵长类动物实验模型中阻止氯化物新生血管形成。 这些分子可用于病理实体中的被动免疫治疗，其基础是血管异常增加，如：年龄相关性黄斑变性（湿性变体），癌症及其转移，新生血管性青光眼，糖尿病和新生儿视网膜病变，急性和 慢性炎症过程，传染病，自身免疫性疾病，器官移植排斥，血管瘤，血管纤维瘤等。
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