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公开(公告)号：US4578245A
公开(公告)日：1986-03-25
申请号：US534085
申请日：1983-09-20
申请人： Fuminori Arai , Yoshio Inagaki , Masao Kitajima
发明人： Fuminori Arai , Yoshio Inagaki , Masao Kitajima
CPC分类号： C12Q1/28 , G01N31/22 , G01N33/525 , C12Q2326/00 , C12Q2326/96
摘要： A multilayer analytical element comprising a water-impermeable, light-transmissive support, a reagent layer containing a color forming reagent composition for detection of hydrogen peroxide including at least combination of a chromogen and a coupler (a color indicator composition), and peroxidase, which produces a detectable change in the presence of peroxidase and hydrogen peroxide, and a porous spreading layer, which are superposed in this order,in which said chromogen is a 1,2,3-tri-substituted compound of 4-amino-3-pyrazolin-5-one having solubility in water at 25.degree. C. of lower than that of 4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one.
摘要翻译： 一种多层分析元件，包括不透水的透光性载体，含有用于检测至少包括色原和成色剂的组合物的过氧化氢的成色剂组合物（颜色指示剂组合物）的试剂层和过氧化物酶， 在过氧化物酶和过氧化氢的存在下产生可检测的变化，以及以该顺序重叠的多孔扩散层，其中所述色原是4-氨基-3-吡唑啉的1,2,3-三取代化合物 -5-酮在25℃下在水中的溶解度低于4-氨基-2,3-二甲基-1-苯基-3-吡唑啉-5-酮的溶解度。
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公开(公告)号：US4356149A
公开(公告)日：1982-10-26
申请号：US165444
申请日：1980-07-02
申请人： Masao Kitajima , Fuminori Arai , Asaji Kondo
发明人： Masao Kitajima , Fuminori Arai , Asaji Kondo
CPC分类号： C12Q1/58 , G01N33/526 , Y10S435/805
摘要： A multi-layer chemical analytical material comprising a support, a reagent layer on the support and a spreading layer on the reagent layer wherein the reagent layer is composed of a hydrophilic binder and fine hydrophobic particles dispersed in the hydrophilic binder, said hydrophobic particles containing a reagent capable of directly or indirectly reacting with the component being analyzed to produce a color change.
摘要翻译： 一种多层化学分析材料，包括载体，载体上的试剂层和试剂层上的扩散层，其中试剂层由亲水性粘合剂和分散在亲水性粘合剂中的细疏水性颗粒构成，所述疏水性颗粒含有 能够直接或间接地与被分析的组分反应以产生颜色变化的试剂。
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公开(公告)号：US4337222A
公开(公告)日：1982-06-29
申请号：US223062
申请日：1981-01-07
申请人： Masao Kitajima , Fuminori Arai , Asaji Kondo
发明人： Masao Kitajima , Fuminori Arai , Asaji Kondo
CPC分类号： G01N33/525
摘要： A hemoglobin concentration-determining article comprising a water-impermeable support having integrally provided thereon, in sequence, a hydrophilic binder layer and a porous spreading layer which has a hydrophilic surface and in which the surface of the internal voids or the interior is hydrophilic and water-insoluble, said porous spreading layer being constituted so that an aqueous sample applied thereto can be spread and incorporated therein in a substantially definite volume per unit area.
摘要翻译： 一种血红蛋白浓度测定制品，其包含一体地设置在其上的不透水性支持体，依次是亲水性粘合剂层和具有亲水性表面的多孔扩散层，其中内部空隙或内部的表面是亲水性的和水 不溶性，所述多孔扩散层构成为使得施加到其上的水性样品能够以每单位面积的基本上确定的体积扩散并结合在其中。
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公开(公告)号：US5569287A
公开(公告)日：1996-10-29
申请号：US353108
申请日：1994-12-09
CPC分类号： A61B5/15194 , A61B5/150022 , A61B5/150099 , A61B5/150435 , A61B5/150664 , A61B5/15111 , A61B5/15117
摘要： A means for collecting and spotting a small amount of blood which comprises a cylinder, a piston, and a puncturing tip, wherein: the piston is inserted airtightly into one end of the cylinder; the puncturing tip is airtightly and exchangeably fitted onto another end of the cylinder; the puncturing tip comprises a blood conduit and a needle suspended by a spring within the blood conduit; the blood conduit has a volume which is equal to a volume of blood to be spotted to analytical means; and the needle is arranged to be pushed out from the puncturing tip by descent of the piston and then return back by ascent of the piston.
摘要翻译： 一种用于收集和检测少量血液的装置，包括一个气缸，活塞和一个穿刺尖端，其中：活塞被气密地插入气缸的一端; 穿刺尖端气密地并且可交换地安装在气缸的另一端上; 穿刺尖端包括血液导管和由血液导管内的弹簧悬挂的针头; 血液导管的体积等于要分析的血液量; 并且针被布置成通过活塞下降从穿刺尖端推出，然后通过活塞的上升返回。
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15.发明授权
公开(公告)号：US5122969A
公开(公告)日：1992-06-16
申请号：US480466
申请日：1990-02-15
申请人： Osamu Seshimoto , Masao Kitajima
发明人： Osamu Seshimoto , Masao Kitajima
CPC分类号： G01N35/00029 , G01N35/00594 , G01N35/00693 , G01N35/00732 , G01N2035/00039 , G01N2035/00356 , G01N2035/00702 , G01N2035/00752
摘要： A biochemical analysis apparatus comprises a movement device which moves analysis media containing a reagent or an electrochemical sensor, which will interact with a specific biochemical substance contained in liquid samples and give rise to changes in the analysis media, along a movement path connecting an introducing section and an ejecting section. While the analysis media are present in the movement path, a measurement device measures changes which have occurred in analysis media. A reading device reads information about correction values, which are to be used in order to correct a calibration curve so that it becomes suitable for analysis media used in analyses, from a correction value recording medium. A correction device corrects the calibration curve on the basis of the correction values. An operation device uses the corrected calibration curve in order to determine the concentration or the activity of the specific biochemical substance in a liquid sample from the value measured by the measurement device.
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公开(公告)号：US4981805A
公开(公告)日：1991-01-01
申请号：US682478
申请日：1984-12-17
申请人： Kenichiro Yazawa , Masao Kitajima , Asaji Kondo
发明人： Kenichiro Yazawa , Masao Kitajima , Asaji Kondo
CPC分类号： B01L3/508 , G01N21/8483 , G01N33/525 , G02B21/34 , B01L2200/142 , B01L2300/041 , B01L2300/048 , B01L2300/069 , B01L2300/0822 , B01L2400/0406
摘要： A method of using a chemical analysis slide comprising a slide frame and a sheet-like or film-like chemical analysis element for colorimetric determination of a specific component in an aqueous liquid sample, which comprisesapplying an aqueous liquid sample to the chemical analysis element, andcovering the upper face of the side of the slide frame to which the sample is applied with a sheet-like, plate-like or block or brick-like cover to thereby ensure a space between the chemical analysis element and the cover and to prevent evaporation of water or to control evaporation rate of water.
摘要翻译： 一种使用包括滑动框架和片状或膜状化学分析元件的化学分析载玻片的方法，用于比色测定水性液体样品中的特定组分，其包括将水性液体样品施加到化学分析元件， 并且将覆盖样品的滑动框架的侧面的上表面覆盖有片状，板状或块状或砖状的盖，从而确保化学分析元件与盖之间的空间，并防止 蒸发水或控制水的蒸发速率。
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公开(公告)号：US4870005A
公开(公告)日：1989-09-26
申请号：US787713
申请日：1985-10-16
申请人： Yutaka Akiyoshi , Asaji Kondo , Masao Kitajima
发明人： Yutaka Akiyoshi , Asaji Kondo , Masao Kitajima
IPC分类号： G01N33/543
CPC分类号： G01N33/54386 , Y10S435/805 , Y10S435/97 , Y10S436/81
摘要： A dry type multilayer analysis element comprises at least one porous medium layer comprising a membrane filter, to which an antigen (or antibody) is immobilized, and at least one reagent layer through which a substance(s) which did not participate in an antigen-antibody reaction can permeate.The multilayer analysis element is effective for assaying components present in body fluids, blood, urine, etc., in a simple manner.
摘要翻译： 干式多层分析元件包括至少一个多孔介质层，该多孔介质层包括固定有抗原（或抗体）的膜过滤器，以及至少一个试剂层，通过该试剂层不参与抗原 - 抗体反应可以渗透。 该多层分析元件以简单的方式有效地测定体液，血液，尿液等中存在的成分。
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公开(公告)号：US4437970A
公开(公告)日：1984-03-20
申请号：US500600
申请日：1983-06-02
CPC分类号： G01N27/307 , G01N27/3335
摘要： A device for determining ionic activity composed of, as essential components, plural pairs of ion-selective solid electrodes each pair having two electrodes (one electrode on each of two sides) and each pair having a different ion-selective layer; two liquid distribution porous members, each member disposed over all the electrodes of each said side of the plural pairs; and a porous capillary bridge disposed on or between the liquid distribution porous members. The bridge can be in liquid contact with all the electrodes through the liquid distribution porous members and achieve electrical conduction between two electrodes in each pair after spotting a test solution and a reference solution. The device preferably further comprises a support frame and a cover having two apertures for liquid spotting. The device can simultaneously determine ionic activities of a plurality of different ions in a test solution, such as whole blood, plasma, serum, urine, etc., by spotting a test solution and a reference solution each in one operation and measuring an electrical potential difference of each pair.
摘要翻译： 用于确定离子活性的装置，作为必要组分，每对具有两对电极（两侧各一个电极）和每对具有不同离子选择层的多对离子选择性固体电极， 两个液体分配多孔构件，每个构件设置在多对的每个所述侧的所有电极上; 以及布置在液体分配多孔构件之间或之间的多孔毛细管桥。 桥接器可以通过液体分配多孔构件与所有电极液体接触，并且在点样测试溶液和参考溶液之后实现每对中两个电极之间的导电。 该装置优选地还包括支撑框架和具有用于液体点样的两个孔的盖。 该装置可以通过在一个操作中分别检测测试溶液和参考溶液来测量测试溶液中的多种不同离子的离子活性，例如全血，血浆，血清，尿等，并测量电位 每对差异。
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19.发明授权
公开(公告)号：US4135976A
公开(公告)日：1979-01-23
申请号：US776556
申请日：1977-03-10
申请人： Masao Kitajima
发明人： Masao Kitajima
IPC分类号： C02F1/32 , C02F3/28 , C02F3/34 , C12P3/00 , C22B3/18 , G03C5/31 , G03C5/395 , C02C5/10 , C22B11/00
CPC分类号： C12P3/00 , C02F1/32 , C02F3/28 , C02F3/345 , C22B3/18 , G03C5/31 , G03C5/3952 , Y02P10/234 , Y10S423/17
摘要： A process of treating a waste photographic processing solution containing reductive sulfur compounds, in particular, a waste fix solution for silver halide photographic materials, by applying thereto photosynthetic sulfur bacteria under anaerobic conditions with the irradiation of light. When the waste solution contains silver, the decontamination of the waste solution and the recovery of silver are performed simultaneously by the process.
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公开(公告)号：US06045699A
公开(公告)日：2000-04-04
申请号：US118633
申请日：1998-07-17
申请人： Kenichiro Yazawa , Fumio Sugaya , Masao Kitajima
发明人： Kenichiro Yazawa , Fumio Sugaya , Masao Kitajima
CPC分类号： G01N33/491 , B01D39/1692 , B01D39/2017 , Y10T436/255
摘要： This invention provides a method of filtering blood using a filtering material comprising glass fiber filter, capable of obtaining a desired amount of plasma or serum without hemolysis and leakage of blood cells easily which comprises keeping pressure difference between blood inlet side and filtrate outlet side 50 mmHg or less at least for 5 seconds from contacting the blood to be filtered, and keeping the pressure difference 200 mmHg or less throughout the filtering of the blood.
摘要翻译： 本发明提供一种使用包含玻璃纤维过滤器的过滤材料过滤血液的方法，其能够容易地获得所需量的血浆或血清而不溶血和泄漏血细胞，其包括保持血液入口侧和滤液出口侧之间的压力差为50mmHg 或更少至少5秒以内接触要过滤的血液，并且在整个血液过滤中保持压力差为200mmHg或更小。
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