公开(公告)号：US20090022683A1

公开(公告)日：2009-01-22

申请号：US11568851

申请日：2006-11-03

Applicant: Soo-Chang Song ,  Sun-Mi Lee ,  Chang-Won Kim ,  Mi-Ran Park

Inventor： Soo-Chang Song ,  Sun-Mi Lee ,  Chang-Won Kim ,  Mi-Ran Park

IPC: A61K38/00 ,  C08G79/02 ,  A61K9/00 ,  A61K38/02 ,  A61K39/00 ,  A61K48/00 ,  A61K47/30 ,  A61K38/21 ,  A61K38/26 ,  A61K38/18 ,  A61K38/20 ,  A61K38/28 ,  A61K38/22 ,  A61K38/23 ,  A61K38/27 ,  A61K39/395 ,  A61K39/29 ,  A61K31/337 ,  A61K31/704

CPC classification number: A61K9/06 ,  A61K9/0024 ,  A61K9/08 ,  A61K47/34 ,  A61K47/6903 ,  C08G79/025

Abstract: The present invention relates to a biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances. According to the present invention, poly(organophosphazene) is a phosphagen-based polymer showing biodegradability, thermosensitivity, and sol-gel phase transition depending on temperature change, whereby when administered into a living body with bioactive substances such as drugs, the poly(organophosphazene) forms a gel-phase at body temperature to be capable of controlled release of the bioactive substances. Further, the poly(organophosphazene) has functional groups to chemically bind with bioactive substances through an ionic bond, covalent bond, or coordinate covalent bond to be capable of a sustained release of the bioactive substances due to its good binding property. Therefore, the poly(organophosphazene) is useful as a delivery material for bioactive substances.

Abstract translation: 本发明涉及具有官能团的生物可降解和热敏聚（有机膦腈），其制备方法及其用于递送生物活性物质的用途。 根据本发明，聚（有机膦腈）是基于温度变化显示生物降解性，热敏性和溶胶 - 凝胶相变的基于磷酸酯的聚合物，其中当用生物活性物质如药物施用于生物体时，聚（有机膦腈 ）在体温下形成凝胶相以能够控制释放生物活性物质。 此外，聚（有机膦腈）具有通过离子键，共价键或配位共价键与生物活性物质化学结合的官能团，由于其良好的结合性能，能够持续释放生物活性物质。 因此，聚（有机膦腈）可用作生物活性物质的递送材料。

公开(公告)号：US20130004455A1

公开(公告)日：2013-01-03

申请号：US13173783

申请日：2011-06-30

Applicant: Soo-Chang SONG ,  Thrimoorthy Potta ,  Mi-Ran Park

Inventor： Soo-Chang SONG ,  Thrimoorthy Potta ,  Mi-Ran Park

IPC: A61K31/80 ,  C12N9/96 ,  C08G69/48 ,  A61P19/04 ,  A61P9/00

CPC classification number: A61L27/18 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/80 ,  C08G79/02 ,  C08G79/025 ,  C08J3/075 ,  C08J2385/02 ,  C08L85/02

Abstract: Provided are a use of chemically-crosslinkable, poly(organophosphazene)s for biomaterials, chemically-crosslinkable poly(organophosphazene)s with a physiologically active substance covalently-bonded thereto, a use thereof for biomaterials, and a process for preparing the same. The chemical crosslinkings can be made by UV irradiation, and/or a crosslinker, and/or an additive, and/or an enzyme, and/or a mixing of at least one polymer.

Abstract translation: 提供了用于生物材料的化学交联的聚（有机膦腈），与共价键合的生理活性物质的化学交联的聚（有机膦腈），其生物材料的用途及其制备方法的用途。 化学交联可以通过UV照射和/或交联剂，/或添加剂和/或酶进行，和/或至少一种聚合物的混合。

公开(公告)号：US08030188B2

公开(公告)日：2011-10-04

申请号：US12508382

申请日：2009-07-23

Applicant: Mi-Ran Park ,  Jae-Sik Sim ,  Yong-Hwan Kwon ,  Bongki Mheen ,  Dae Kon Oh

Inventor： Mi-Ran Park ,  Jae-Sik Sim ,  Yong-Hwan Kwon ,  Bongki Mheen ,  Dae Kon Oh

IPC: H01L21/20 ,  H01L21/36

CPC classification number: H01L21/2258

Abstract: Provided is a method of forming a compound semiconductor device. In the method, a dopant element layer is formed on an undoped compound semiconductor layer. An annealing process is performed to diffuse dopants in the dopant element layer into the undoped compound semiconductor layer, thereby forming a dopant diffusion region. A rapid cooling process is performed using liquid nitrogen with respect to the substrate having the dopant diffusion region.

Abstract translation: 提供一种形成化合物半导体器件的方法。 在该方法中，在未掺杂的化合物半导体层上形成掺杂剂元素层。 执行退火处理以将掺杂剂元素层中的掺杂剂扩散到未掺杂的化合物半导体层中，从而形成掺杂剂扩散区域。 相对于具有掺杂剂扩散区域的基板，使用液氮进行快速冷却处理。

公开(公告)号：US08586020B2

公开(公告)日：2013-11-19

申请号：US13173783

申请日：2011-06-30

Applicant: Soo-Chang Song ,  Thrimoorthy Potta ,  Mi-Ran Park

Inventor： Soo-Chang Song ,  Thrimoorthy Potta ,  Mi-Ran Park

IPC: A61K31/74 ,  C12N9/96 ,  C08G69/48 ,  C08G63/91 ,  A61K47/48

CPC classification number: A61L27/18 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/80 ,  C08G79/02 ,  C08G79/025 ,  C08J3/075 ,  C08J2385/02 ,  C08L85/02

Abstract: Provided are a use of chemically-crosslinkable, poly(organophosphazene)s for biomaterials, chemically-crosslinkable poly(organophosphazene)s with a physiologically active substance covalently-bonded thereto, a use thereof for biomaterials, and a process for preparing the same. The chemical crosslinkings can be made by UV irradiation, and/or a crosslinker, and/or an additive, and/or an enzyme, and/or a mixing of at least one polymer.

Abstract translation: 提供了用于生物材料的化学交联的聚（有机膦腈），与共价键合的生理活性物质的化学交联的聚（有机膦腈），其生物材料的用途及其制备方法的用途。 化学交联可以通过UV照射和/或交联剂，/或添加剂和/或酶进行，和/或至少一种聚合物的混合。

公开(公告)号：US08422834B2

公开(公告)日：2013-04-16

申请号：US12746167

申请日：2008-06-03

Applicant: Jeong-Woo Park ,  Gyung-Ock Kim ,  Mi-Ran Park ,  Jong-Bum You

Inventor： Jeong-Woo Park ,  Gyung-Ock Kim ,  Mi-Ran Park ,  Jong-Bum You

IPC: G02F1/035 ,  G02F1/295 ,  G02B6/10 ,  G02B6/12

CPC classification number: G02F1/218 ,  G02F2001/212 ,  G02F2201/302

Abstract: Provided is a semiconductor integrated circuit. The semiconductor integrated circuit includes a semiconductor pattern disposed on a substrate and including an optical waveguide part and a pair of recessed portions. The optical waveguide part has a thickness ranging from about 0.05 μm to about 0.5 μm. The recessed portions are disposed on both sides of the optical waveguide part and have a thinner thickness than the optical waveguide part. A first doped region and a second doped region are disposed in the recessed portions, respectively. The first and second doped regions are doped with a first conductive type dopant and a second conductive type dopant, respectively. An intrinsic region is formed in at least the optical waveguide part to contact the first and second doped regions.

Abstract translation: 提供了一种半导体集成电路。 半导体集成电路包括设置在基板上并且包括光波导部分和一对凹部的半导体图案。 光波导部分的厚度范围为约0.05μm至约0.5μm。 凹部设置在光波导部分的两侧，并且具有比光波导部分更薄的厚度。 第一掺杂区域和第二掺杂区域分别设置在凹部中。 第一和第二掺杂区域分别掺杂有第一导电型掺杂剂和第二导电型掺杂剂。 在至少光波导部分中形成本征区域以接触第一和第二掺杂区域。