公开(公告)号：US20070010799A1

公开(公告)日：2007-01-11

申请号：US11518312

申请日：2006-09-11

Applicant: Michael Helmus

Inventor： Michael Helmus

IPC: A61K9/22 ,  A61F2/06

CPC classification number: A61K9/0024 ,  A61B17/064 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/0647 ,  A61B2017/1205 ,  A61B2018/00392 ,  A61M37/0069 ,  A61M2210/125

Abstract: The present invention relates to a system and method for the delivery of therapeutic agents, such as therapeutic drugs or genetic material, into the muscle or tissue that minimizes the loss of therapeutic agents due to contraction of the muscle. In one embodiment, an implant for delivering therapeutic agents into a muscle is provided, wherein the implant has at least one rod for insertion and delivery of therapeutic agents into the muscle and a patch that can be attached to the exterior surface of the muscle for preventing or minimizing therapeutic agent being expelled due to the contraction of the muscle, such as the beating of a heart muscle.

Abstract translation: 本发明涉及一种用于将诸如治疗药物或遗传物质的治疗剂递送到肌肉或组织中的系统和方法，其最小化由于肌肉收缩引起的治疗剂的损失。 在一个实施例中，提供了用于将治疗剂递送到肌肉中的植入物，其中所述植入物具有至少一个用于将治疗剂插入和递送到肌肉中的杆和可以附着到肌肉的外表面的贴片，用于防止 或最小化由于肌肉的收缩而被排出的治疗剂，例如心脏肌肉的跳动。

公开(公告)号：US20060088654A1

公开(公告)日：2006-04-27

申请号：US11296765

申请日：2005-12-06

Applicant: Ni Ding ,  Michael Helmus

Inventor： Ni Ding ,  Michael Helmus

IPC: A61L33/00

CPC classification number: A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61F2210/0014 ,  A61F2250/0067 ,  A61L27/227 ,  A61L31/10 ,  A61L31/141 ,  A61L31/16 ,  A61L33/0011 ,  A61L2300/236 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/606 ,  C08L83/04

Abstract: The present invention is directed to an expandable stent for implantation in a patient comprising a tubular metal body having open ends and a sidewall structure having openings therein and a coating disposed on a surface of said sidewall structure, said coating comprising a hydrophobic biostable elastomeric material and a biologically active material, wherein said coating continuously conforms to said structure in a manner that preserves said openings.

公开(公告)号：US20050187146A1

公开(公告)日：2005-08-25

申请号：US10781932

申请日：2004-02-20

Applicant: Michael Helmus ,  Robert Richard ,  Melissa Dixon

Inventor： Michael Helmus ,  Robert Richard ,  Melissa Dixon

IPC: A61L27/20 ,  A61L27/22 ,  A61K38/16 ,  A61K31/785

CPC classification number: A61L27/22 ,  A61L27/20

Abstract: The present invention relates to novel biomaterials and methods of using these new biomaterials to facilitate wound healing. The novel biomaterial may be a biocompatible polymer to which at least one bioactive polymer is covalently bonded by graft polymerization, copolymerization or cross-linking. Alternatively, the novel biomaterial may be a polymer blend comprising at least one biocompatible polymer and at least one bioactive polymer.

Abstract translation: 本发明涉及使用这些新生物材料以促进伤口愈合的新型生物材料和方法。 新型生物材料可以是生物相容性聚合物，至少一种生物活性聚合物通过接枝聚合，共聚或交联共价键合到该聚合物上。 或者，新型生物材料可以是包含至少一种生物相容性聚合物和至少一种生物活性聚合物的聚合物共混物。

公开(公告)号：US20050106210A1

公开(公告)日：2005-05-19

申请号：US10989946

申请日：2004-11-16

Applicant: Ni Ding ,  Michael Helmus

Inventor： Ni Ding ,  Michael Helmus

IPC: A61F20060101 ,  A61F2/00 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61K9/00 ,  A61L20060101 ,  A61L27/22 ,  A61L31/00 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L33/00 ,  A61F2/02 ,  A61F2/06 ,  B05D3/00

CPC classification number: A61L31/16 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61F2210/0014 ,  A61F2250/0067 ,  A61L27/227 ,  A61L31/10 ,  A61L31/141 ,  A61L33/0011 ,  A61L2300/222 ,  A61L2300/236 ,  A61L2300/406 ,  A61L2300/42 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2300/622 ,  A61L2420/02 ,  C08L71/02 ,  C08L83/04 ,  C08L83/00 ,  C08L83/08 ,  C08L5/00 ,  C08L75/04

Abstract: A method of coating implantable open lattice metallic stent prosthesis is disclosed which includes sequentially applying a plurality of relatively thin outer layers of a coating composition comprising a solvent mixture of uncured polymeric silicone material and crosslinker and finely divided biologically active species, possibly of controlled average particle size, to form a coating on each stent surface. The coatings are cured in situ and the coated, cured prosthesis are sterilized in a step that includes preferred pretreatment with argon gas plasma and exposure to gamma radiation electron beam, ethylene oxide, steam.

Abstract translation: 公开了一种涂覆可植入的开放格子金属支架假体的方法，其包括依次施加多个相对较薄的涂层组合物的外层，所述涂层组合物包含未固化的聚合物硅氧烷材料和交联剂的溶剂混合物以及细分的生物活性物质，可能是受控的平均颗粒 尺寸，以在每个支架表面上形成涂层。 涂层在原位固化，并且涂覆的固化假体在包括优选的氩气等离子体预处理和暴露于γ射线电子束，环氧乙烷，蒸汽的步骤中被灭菌。

公开(公告)号：US20070255423A1

公开(公告)日：2007-11-01

申请号：US11744614

申请日：2007-05-04

Applicant: Alain Carpentier ,  Sophie Carpentier ,  Crystal Cunanan ,  Lillian Quintero ,  Michael Helmus ,  Christine Loshbaugh ,  H. Chris Sarner

Inventor： Alain Carpentier ,  Sophie Carpentier ,  Crystal Cunanan ,  Lillian Quintero ,  Michael Helmus ,  Christine Loshbaugh ,  H. Chris Sarner

IPC: A61F2/02

CPC classification number: A61L27/3691 ,  A61L2/0088 ,  A61L27/3604 ,  A61L27/3641 ,  A61L27/3645 ,  A61L27/3683 ,  A61L27/3687 ,  A61L33/12 ,  A61L2400/02 ,  A61L2430/40 ,  Y10S623/901 ,  Y10S623/915 ,  Y10S623/917 ,  Y10S623/92

Abstract: A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto) and D) subjecting the bioprosthesis to terminal sterilization.

Abstract translation: 一种用于固定生物组织的方法，以及通过这种方法制备的生物假体装置。 该方法通常包括以下步骤：A）固定组织，B）用i）变性剂，ii）表面活性剂和iii）交联剂的混合物处理组织，C）制备或形成生物假体（例如，形成 组织并附着任何非生物成分）和D）使生物假体进行终末灭菌。

公开(公告)号：US20070048383A1

公开(公告)日：2007-03-01

申请号：US11211809

申请日：2005-08-25

Applicant: Michael Helmus

Inventor： Michael Helmus

IPC: A61K9/14

CPC classification number: A61K9/0019 ,  A61K9/5115 ,  A61K9/5169 ,  A61K47/6929 ,  A61K47/6941 ,  A61L31/16 ,  A61L2300/60 ,  A61L2300/624 ,  A61L2400/06 ,  A61L2400/12 ,  B82Y5/00 ,  C08L2201/12

Abstract: The present invention is directed to the formation of structures in situ through the principles of ligand binding. These structures are efficacious, for example, for tissue repair as well as for short- and long-term disease and condition management. According to one aspect of the invention, an injectable composition comprising self-assembling nanoparticles is provided. The self-assembling nanoparticles include: (a) a nanoparticle portion, (b) tissue binding ligands attached to the nanoparticle portion, which cause preferential binding and accumulation of the nanoparticles at one or more targeted tissue locations upon injection of the composition into the body, and (c) first and second interparticle binding ligands attached to the nanoparticle portion, which cause interparticle binding upon injection of the composition into the body.

Abstract translation: 本发明涉及通过配体结合原理原位形成结构。 这些结构是有效的，例如用于组织修复以及用于短期和长期疾病和病症管理。 根据本发明的一个方面，提供了包含自组装纳米颗粒的可注射组合物。 自组装纳米颗粒包括：（a）纳米颗粒部分，（b）附着于纳米颗粒部分的组织结合配体，其在将组合物注射入体内时在一个或多个目标组织位置引起纳米颗粒的优先结合和积聚 ，和（c）连接到纳米颗粒部分的第一和第二颗粒间结合配体，其在将组合物注射入体内时引起颗粒间结合。

公开(公告)号：US20060171985A1

公开(公告)日：2006-08-03

申请号：US11048616

申请日：2005-02-01

Applicant: Robert Richard ,  Frederick Strickler ,  Marlene Schwarz ,  Rudolf Faust ,  Shrirang Ranade ,  Michael Helmus

Inventor： Robert Richard ,  Frederick Strickler ,  Marlene Schwarz ,  Rudolf Faust ,  Shrirang Ranade ,  Michael Helmus

IPC: A61F2/00

CPC classification number: A61L31/129 ,  A61L27/48 ,  A61N1/05

Abstract: The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrable polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block and (b) at least one therapeutic agent which is released in vivo upon implantation or insertion of the medical device.

公开(公告)号：US20060127442A1

公开(公告)日：2006-06-15

申请号：US11007866

申请日：2004-12-09

Applicant: Michael Helmus

Inventor： Michael Helmus

IPC: A61K6/083 ,  A61F2/06 ,  B05D3/02

CPC classification number: A61L31/14 ,  A61L27/50 ,  A61L29/146 ,  A61L31/146

Abstract: The present invention is directed to a method in which a supercritical fluid that comprises a carrier fluid and a biologically active agent is brought into contact with medical article that comprises a nanoporous surface region. A variety of medical articles may be used in the practice of the present invention, including implantable or insertable medical devices such as bone plates, joint prostheses, vascular grafts, stent grafts, stents, catheters, guide wires, balloons, filters, vascular patches, shunts, and coils, among others. The nanoporous surface region may be, for example, metallic, ceramic, or polymeric in nature. Examples of biologically active agents include antirestenotic agents and agents that promote tissue adhesion, among others. Carbon dioxide is one of many carrier fluids that may be employed.

Abstract translation: 本发明涉及包含载体流体和生物活性剂的超临界流体与包括纳米多孔表面区域的医疗制品接触的方法。 可以在本发明的实践中使用各种医疗制品，包括可植入或可插入的医疗装置，例如骨板，关节假体，血管移植物，支架移植物，支架，导管，导丝，球囊，过滤器，血管斑块， 分流器和线圈等。 纳米多孔表面区域可以是例如金属，陶瓷或聚合物。 生物活性剂的实例包括抗再狭窄剂和促进组织粘附等的试剂。 二氧化碳是可以使用的许多载体流体之一。

公开(公告)号：US20050208200A1

公开(公告)日：2005-09-22

申请号：US11116052

申请日：2005-04-27

Applicant: Ni Ding ,  Michael Helmus

Inventor： Ni Ding ,  Michael Helmus

IPC: A61F2/00 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61K9/00 ,  A61K47/32 ,  A61K47/34 ,  A61L27/00 ,  A61L27/22 ,  A61L31/08 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L33/00 ,  A61L33/10 ,  A61M37/00 ,  A61F2/06

CPC classification number: A61L33/0011 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61F2210/0014 ,  A61F2250/0067 ,  A61L27/227 ,  A61L31/08 ,  A61L31/10 ,  A61L31/141 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  C08L83/08 ,  C08L71/02 ,  C08L5/00 ,  C08L83/00 ,  C08L83/04

Abstract: A coating and method for a coating an implantable device or prostheses are disclosed. The coating includes an undercoat of polymeric material containing an amount of biologically active material, particularly heparin, dispersed therein. The coating further includes a topcoat which covers less than the entire surface of the undercoat and wherein the topcoat comprises a polymeric material substantially free of pores and porosigens. The polymeric material of the topcoat can be a biostable, biocompatible material which provides long term non-thrombogenicity to the device portion during and after release of the biologically active material.

Abstract translation: 公开了用于涂覆可植入装置或假体的涂层和方法。 该涂层包括聚合材料的底涂层，其中含有一定量的分散在其中的生物活性材料，特别是肝素。 涂层还包括覆盖低于底涂层整个表面的面漆，并且其中面漆包含基本上不含孔隙和孔隙体的聚合材料。 面漆的聚合材料可以是生物稳定的生物相容性材料，其在生物活性材料释放过程中和之后提供了对器件部分的长期非血栓形成。

公开(公告)号：US07601382B2

公开(公告)日：2009-10-13

申请号：US10914012

申请日：2004-08-05

Applicant: Jan Weber ,  Gordon Kocur ,  Michael Helmus ,  Maria Palasis

Inventor： Jan Weber ,  Gordon Kocur ,  Michael Helmus ,  Maria Palasis

IPC: A61L33/00 ,  B05D7/00 ,  B05D3/10 ,  A61F2/01

CPC classification number: A61L31/16 ,  A61F2250/0068 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/606

Abstract: Medical devices, such as stents, having a surface, a coating layer comprising a polymer disposed on at least a portion of the surface, and a composition comprising a biologically active material injected into or under the coating layer at one or more locations in the coating layer to form at least one pocket containing a biologically active material are disclosed. The composition may be injected using a nanometer- or micrometer-sized needle. Methods for making such medical devices are also disclosed. Using this method, a precise amount of the biologically active material may be disposed accurately and efficiently on the medical device at predefined locations.

Abstract translation: 医疗装置，例如具有表面的支架，包括设置在表面的至少一部分上的聚合物的涂层，以及包含在涂层中的一个或多个位置处注入到涂层内或下的生物活性物质的组合物 层以形成至少一个包含生物活性材料的口袋。 可以使用纳米或微米尺寸的针注射组合物。 还公开了制造这种医疗装置的方法。 使用该方法，精确量的生物活性材料可以在预定义的位置处精确而有效地设置在医疗装置上。