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    Mif adsorbant
    11.
    发明申请
    Mif adsorbant 审中-公开
    Mif吸附剂

    公开(公告)号：US20090163599A1

    公开(公告)日：2009-06-25

    申请号：US11596534

    申请日：2005-06-03

    申请人： Markus Storr ,  Reinhold Deppisch ,  Werner Beck ,  Jürgen Bernhagen ,  Ina Merz ,  Georg Geiger

    发明人： Markus Storr ,  Reinhold Deppisch ,  Werner Beck ,  Jürgen Bernhagen ,  Ina Merz ,  Georg Geiger

    IPC分类号： A61K31/137 ,  A61P29/00

    CPC分类号： B01J20/328 ,  A61M1/3679 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3251 ,  B01J20/3255 ,  B01J20/3274 ,  B01J20/3278

    摘要： The present invention concerns an apheresis material or adsorbant and a method for removing, depleting or inactivating MIF (macrophage migration inhibitory factor) from blood, blood plasma, blood serum or other body fluids. The present invention is also concerned with the use of said apheresis material or adsorbant. In order to prepare a novel means and novel method, which can reduce the activity or amount of the mediator for sepsis and septic shock, MIF, in a patient's body fluid in a manner which is more pleasant and tolerable for the patient than prior art means and methods, the invention proposes that the apheresis material or adsorbant comprises a solid carrier material on the surface of which MIF-binding molecules or functional groups are immobilized. The method proposes that the apheresis material or adsorbant be brought into contact extracorporeally with the blood, blood plasma, blood serum or other body fluids.

    摘要翻译： 本发明涉及一种分离物质或吸附剂以及从血液，血浆，血清或其他体液中去除，消耗或失活MIF（巨噬细胞迁移抑制因子）的方法。 本发明还涉及使用所述单采血浆物质或吸附剂。 为了制备一种新颖的方法和新颖的方法，其可以以比现有技术手段更令人愉快和可耐受的方式，减少患者体液中败血症和败血症休克的介体的活性或量 和方法，本发明提出，单采血浆材料或吸附剂在其表面上包含固定有MIF结合分子或官能团的固体载体材料。 该方法提出将血浆，血浆，血清或其他体液与体外血浆物质或吸附剂接触体外。

    ENZYME-FUNCTIONALIZED SUPPORTS
    13.
    发明申请
    ENZYME-FUNCTIONALIZED SUPPORTS 审中-公开
    酶功能化支持

    公开(公告)号：US20120208256A1

    公开(公告)日：2012-08-16

    申请号：US13503204

    申请日：2010-10-20

    申请人： Ralf Flieg ,  Manuela Klotz ,  Markus Storr ,  Martin Rempfer ,  Wolfgang Freudemann ,  Cornelia Winz ,  Bernd Krause ,  Markus Hornung

    发明人： Ralf Flieg ,  Manuela Klotz ,  Markus Storr ,  Martin Rempfer ,  Wolfgang Freudemann ,  Cornelia Winz ,  Bernd Krause ,  Markus Hornung

    IPC分类号： C12N11/06 ,  C12N11/02

    CPC分类号： C12N9/18 ,  C09D133/14 ,  C12N9/80 ,  C12N11/06 ,  C12N11/08

    摘要： An immobilized enzyme comprises a solid support, an enzyme linked to the solid support and a spacer for coupling the enzyme to the solid support. A method for the production of immobilized enzymes comprises: providing a solid support having amino-functional groups coupled to the support surface; covalently coupling the amino-functional groups with a thermally labile radical initiator; and, contacting the support surface with a solution of polymerizable monomers. The polymerizable monomers comprise functional groups which do not take part in radical polymerization, under conditions where thermally initiated graft copolymerization of the monomers takes place, to form polymer chains on the surface of the support. If the polymer chains do not already comprise primary amino-functional groups, the method further comprises transforming the functional groups in the polymer chains into groups comprising primary amino-functional groups. The method further comprises coupling the enzyme to amino-functional groups of the polymer chains.

    摘要翻译： 固定化酶包括固体支持物，与固体支持物连接的酶和用于将酶偶联到固体支持物的间隔物。 制备固定化酶的方法包括：提供具有与支持表面偶联的氨基官能团的固体支持物; 将氨基官能团与热不稳定的自由基引发剂共价偶联; 并且使支撑体表面与可聚合单体的溶液接触。 可聚合单体包括在发生单体的热引发接枝共聚的条件下不参与自由基聚合的官能团，以在载体的表面上形成聚合物链。 如果聚合物链不包括伯氨基官能团，则该方法还包括将聚合物链中的官能团转化为包含伯氨基官能团的基团。 该方法还包括将酶偶联到聚合物链的氨基官能团。

    Separating material
    14.
    发明授权
    Separating material 有权
    分离材料

    公开(公告)号：US08142844B2

    公开(公告)日：2012-03-27

    申请号：US10572703

    申请日：2004-08-30

    申请人： Markus Storr ,  Egbert Müller ,  Wolfgang Freudemann

    发明人： Markus Storr ,  Egbert Müller ,  Wolfgang Freudemann

    IPC分类号： B05D3/12 ,  B01D39/14

    CPC分类号： A61L2/0017 ,  B01D63/02 ,  B01D63/026 ,  B01D67/0006 ,  B01D67/0018 ,  B01D67/0093 ,  B01D69/08 ,  B01D69/125 ,  B01D71/40 ,  B01D71/78 ,  B01D2313/44 ,  B01D2323/38 ,  B01J20/26 ,  B01J20/28023 ,  B01J20/28033 ,  B01J20/3278 ,  B01J2220/62 ,  C08F257/02 ,  C08F265/04 ,  C08F265/10 ,  C08F267/10 ,  C08F271/00 ,  C08F271/02 ,  C08F285/00 ,  C08F289/00 ,  C08F291/00

    摘要： The present invention provides a separating material producable by a) providing a solid substrate, having amino-functional groups coupled to the substrate surface, b) covalently coupling of the amino-functional groups with a thermally labile radical initiator, c) contacting the substrate surface with a solution of polymerizable monomers under conditions, where thermally initiated graft copolymerization of the monomers takes place, to form a structure of adjacent functional polymer chains on the surface of the substrate. The present invention further provides a method for the production of a separating material by a) providing a solid substrate, having aminofunctional groups coupled to the substrate surface, b) covalently coupling of the aminofunctional groups with a thermally labile radical initiator, c) contacting the substrate surface with a solution of polymerizable monomers under conditions, where thermally initiated graft copolymerization of the monomers takes place, to form a structure of adjacent functional polymer chains on the surface of the substrate.

    摘要翻译： 本发明提供一种分离材料，其可通过以下步骤提供：a）提供具有与基底表面偶联的氨基官能团的固体基质，b）将氨基官能团与热不稳定的自由基引发剂共价偶联，c）使基材表面 在可发生单体的热引发的接枝共聚的条件下，使可聚合单体的溶液形成在基材表面上的相邻的官能聚合物链的结构。 本发明还提供了一种用于制备分离材料的方法，该方法是：a）提供具有偶联到基底表面的氨基官能团的固体基质，b）将氨基官能团与热不稳定的自由基引发剂共价偶联，c） 在单体发生热引发的接枝共聚的条件下，在基材表面上形成相邻的官能聚合物链的结构的条件下，可聚合单体的溶液的底物表面。

    Separating material
    15.
    发明申请
    Separating material 有权
    分离材料

    公开(公告)号：US20060264355A1

    公开(公告)日：2006-11-23

    申请号：US10572703

    申请日：2004-08-30

    申请人： Markus Storr ,  Egbert Muller ,  Wolfgang Freudemann

    发明人： Markus Storr ,  Egbert Muller ,  Wolfgang Freudemann

    IPC分类号： A61K38/00 ,  A61M37/00

    CPC分类号： A61L2/0017 ,  B01D63/02 ,  B01D63/026 ,  B01D67/0006 ,  B01D67/0018 ,  B01D67/0093 ,  B01D69/08 ,  B01D69/125 ,  B01D71/40 ,  B01D71/78 ,  B01D2313/44 ,  B01D2323/38 ,  B01J20/26 ,  B01J20/28023 ,  B01J20/28033 ,  B01J20/3278 ,  B01J2220/62 ,  C08F257/02 ,  C08F265/04 ,  C08F265/10 ,  C08F267/10 ,  C08F271/00 ,  C08F271/02 ,  C08F285/00 ,  C08F289/00 ,  C08F291/00

    摘要： The present invention provides a separating material producable by a) providing a solid substrate, having amino-functional groups coupled to the substrate surface, b) covalently coupling of the amino-functional groups with a thermally labile radical initiator, c) contacting the substrate surface with a solution of polymerizable monomers under conditions, where thermally initiated graft copolymerization of the monomers takes place, to form a structure of adjacent functional polymer chains on the surface of the substrate. The present invention further provides a method for the production of a separating material by a) providing a solid substrate, having aminofunctional groups coupled to the substrate surface, b) covalently coupling of the aminofunctional groups with a thermally labile radical initiator, c) contacting the substrate surface with a solution of polymerizable monomers under conditions, where thermally initiated graft copolymerization of the monomers takes place, to form a structure of adjacent functional polymer chains on the surface of the substrate.

    摘要翻译： 本发明提供一种分离材料，其可通过以下步骤提供：a）提供具有与基底表面偶联的氨基官能团的固体基质，b）将氨基官能团与热不稳定的自由基引发剂共价偶联，c）使基材表面 在可发生单体的热引发的接枝共聚的条件下，使可聚合单体的溶液形成在基材表面上的相邻的官能聚合物链的结构。 本发明还提供了一种用于制备分离材料的方法，该方法是：a）提供具有偶联到基底表面的氨基官能团的固体基质，b）将氨基官能团与热不稳定的自由基引发剂共价偶联，c） 在单体发生热引发的接枝共聚的条件下，在基材表面上形成相邻的官能聚合物链的结构的条件下，可聚合单体的溶液的底物表面。

    High cut-off hemodialysis membranes for the treatment of chronic hemodialysis patients
    18.
    发明申请
    High cut-off hemodialysis membranes for the treatment of chronic hemodialysis patients 有权
    高截止血液透析膜用于治疗慢性血液透析患者

    公开(公告)号：US20100084339A1

    公开(公告)日：2010-04-08

    申请号：US12585054

    申请日：2009-09-01

    申请人： Colin Hutchison ,  Paul Cockwell ,  Hermann Göhl ,  Bernd Krause ,  Markus Storr

    发明人： Colin Hutchison ,  Paul Cockwell ,  Hermann Göhl ,  Bernd Krause ,  Markus Storr

    IPC分类号： B01D61/32

    CPC分类号： B01D61/243 ,  A61M1/16 ,  B01D67/0013 ,  B01D69/08 ,  B01D69/12 ,  B01D2325/022 ,  B01D2325/20

    摘要： The present invention relates to high cut-off hemodialysis membranes for the treatment of chronic hemodialysis (CHD) patients, with the potential to improve long-term survival of these patients by reducing the risk of cardiovascular disease, through down-regulation of monocyte activation in the blood. Monocytes are the major circulating blood cells involved in the progression of cardiovascular disease. High cut-off hemodialysis in chronic dialysis patients results in a sustained decrease in expression of monocyte cell-surface proteins that direct the movement of these cells from the blood to the walls of blood vessels, where they promote the progression of arterial disease (atherosclerosis) that leads to cardiovascular disease (CVD); heart disease, strokes and peripheral vascular disease.

    摘要翻译： 本发明涉及用于治疗慢性血液透析（CHD）患者的高截止血液透析膜，可通过降低心血管疾病的风险来改善这些患者的长期存活，通过下调单核细胞活化 血液。 单核细胞是涉及心血管疾病进展的主要循环血细胞。 慢性透析患者的高截止血液透析导致单核细胞表面蛋白质的表达持续下降，从而将这些细胞从血液移动到血管壁，在那里它们促进动脉疾病（动脉粥样硬化）的进展， 导致心血管疾病（CVD）; 心脏病，中风和外周血管疾病。

    Filtration Membrane
    19.
    发明申请
    Filtration Membrane 审中-公开
    过滤膜

    公开(公告)号：US20090057225A1

    公开(公告)日：2009-03-05

    申请号：US11887957

    申请日：2006-04-06

    申请人： Bernd Krause ,  Markus Hornung ,  Thomas Ertl ,  Markus Storr

    发明人： Bernd Krause ,  Markus Hornung ,  Thomas Ertl ,  Markus Storr

    IPC分类号： B01D71/68 ,  B01D67/00 ,  C08G75/00

    CPC分类号： B01D71/44 ,  B01D67/0011 ,  B01D69/02 ,  B01D69/08 ,  B01D69/087 ,  B01D69/12 ,  B01D71/52 ,  B01D71/60 ,  B01D71/68 ,  B01D71/82 ,  B01D2325/02 ,  B01D2325/026 ,  B01D2325/12 ,  B01D2325/16 ,  B01D2325/42

    摘要： The invention is directed to a ultrafiltration membrane that is capable for the retention of endotoxines and cytokine inducing substances (CIS) including bacterial DNA and/or DNA fragments from fluid and/or liquid media. The invention is further directed to a method of manufacturing such ultrafiltration membranes in a high quality and in an effective and time saving procedure, and to the use of such membranes for the retention of substances from fluids or liquids. The ultrafiltration membrane of the invention consists of a polymer blend comprising at least one hydrophobic polymer containing sulfur in its back bone, at least one hydrophilic, uncharged homo-polymer of polyvinylpyrrolidone and at least one polymer containing cationic charges. The method of manufacturing such a ultrafiltration membrane comprises dissolving at least one hydrophobic polymer containing sulfur in its back bone and at least one hydrophilic, uncharged polyvinylpyrrolidone and at least one polymer containing cationic charges in at least one solvent to form a polymer solution, subjecting the formed polymer solution to a diffusion-induced phase separation to prepare a ultrafiltration membrane, washing and subsequently drying of the ultrafiltration membrane.

    摘要翻译： 本发明涉及能够从流体和/或液体介质中保留包含细菌DNA和/或DNA片段的内毒素和细胞因子诱导物质（CIS）的超滤膜。 本发明进一步涉及以高质量和有效且节省时间的方法制造这种超滤膜的方法，以及使用这种膜来保持来自流体或液体的物质。 本发明的超滤膜由包含至少一种在其背骨中含有硫的疏水性聚合物，至少一种亲水的，不带电的聚乙烯吡咯烷酮的聚合物和至少一种含有阳离子电荷的聚合物组成的聚合物共混物构成。 制造这种超滤膜的方法包括将至少一种含有硫的疏水性聚合物溶解在其背骨中，并且至少一种亲水的，不带电的聚乙烯吡咯烷酮和至少一种含至少一种溶剂中的阳离子电荷的聚合物形成聚合物溶液， 形成的聚合物溶液进行扩散诱导的相分离以制备超滤膜，洗涤并随后干燥超滤膜。