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公开(公告)号：US08043836B2
公开(公告)日：2011-10-25
申请号：US11576421
申请日：2005-09-29
IPC分类号： C12P1/00 , C12P13/04 , C12P13/22 , C12P17/10 , C07D209/18
CPC分类号： C12P13/227 , C12P13/04 , C12R1/01 , C12R1/185 , C12R1/19
摘要： The present invention is to provide an industrially advantageous method for producing an amino acid derivative. Provided is a method for producing an amino acid derivative including contacting a microorganism and/or an enzyme with a hydroxyimino acid represented by the following general formula (I): wherein R1 represents an optionally substituted predetermined hydrocarbon group; R2 represents a C1 to C3 alkyl group or a hydrogen atom; and n is 0 or 1, to produce an amino acid derivative represented by the following general formula (III): wherein R1 and n have the same meanings as those of R1 and n in the general formula (I), wherein the microorganism and/or the enzyme is capable of catalyzing the reaction.
摘要翻译： 本发明提供一种工业上有利的氨基酸衍生物的制备方法。 本发明提供一种生产氨基酸衍生物的方法，其包括使微生物和/或酶与由以下通式（I）表示的肟基酸接触：其中R1表示任选取代的预定烃基; R2表示C1〜C3烷基或氢原子; 和n为0或1，以产生由以下通式（III）表示的氨基酸衍生物：其中R 1和n与通式（I）中的R 1和n的含义相同，其中微生物和/ 或者酶能够催化反应。
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12.发明申请公开(公告)号：US20100317068A1
公开(公告)日：2010-12-16
申请号：US12836984
申请日：2010-07-15
申请人： Shinji Kuroda , Masakazu Sugiyama , Kunihiko Watanabe , Shunichi Suzuki , Kenzo Yokozeki , Tatsuki Kashiwagi
发明人： Shinji Kuroda , Masakazu Sugiyama , Kunihiko Watanabe , Shunichi Suzuki , Kenzo Yokozeki , Tatsuki Kashiwagi
CPC分类号： C12N9/1029 , C12P13/04
摘要： The present invention describes a method for generating a serine derivative and an optically active isomer thereof by a convenient technique, and an enzyme and the like useful in the method. In the presence of the following protein (A) and/or (B) having an enzymatic activity, an α-amino acid is reacted with an aldehyde to form a serine derivative: (A) a protein comprising the amino acid sequence of SEQ ID NO:5, and (B) a protein comprising an amino acid sequence of SEQ ID NO: 5, but which includes substitution, deletion, insertion and addition of one or more amino acids and is able to catalyze the reaction to form the serine derivative.
摘要翻译： 本发明描述了通过方便的技术产生丝氨酸衍生物和光学活性异构体的方法，以及在该方法中有用的酶等。 在具有酶活性的下列蛋白质（A）和/或（B）的存在下，α-氨基酸与醛反应形成丝氨酸衍生物：（A）包含SEQ ID NO：1的氨基酸序列的蛋白质 （B）包含SEQ ID NO：5的氨基酸序列但包括取代，缺失，插入和加入一个或多个氨基酸的蛋白质，并且能够催化该反应以形成丝氨酸衍生物 。
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13.发明申请公开(公告)号：US20100255548A1
公开(公告)日：2010-10-07
申请号：US12758433
申请日：2010-04-12
IPC分类号： C12P13/04
CPC分类号： C12N9/1096 , C12P17/10
摘要： A D-aminotransferase can be modified so as to efficiently produce (2R,4R)-monatin having high sweetness intensity from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid by substituting an amino acid at least at one of positions (positions 100, 180 to 183, 243 and 244) involved in efficiently producing the (2R,4R)-monatin in an amino acid sequence of a wild-type D-aminotransferase represented in SEQ ID NO:2.
摘要翻译： 可以修饰D-氨基转移酶，以便通过用氨基酸至少在4-（吲哚-3-基甲基）-4-羟基-2-氧代戊二酸代替氨基酸，有效地产生具有高甜度强度的（2R，4R） 在SEQ ID NO：2所示的野生型D-氨基转移酶的氨基酸序列中有效产生（2R，4R） - 单抗的位置（位置100,180〜183,243和244）之一。
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公开(公告)号：US07745182B2
公开(公告)日：2010-06-29
申请号：US12345922
申请日：2008-12-30
CPC分类号： C12P13/04 , C12N9/1014
摘要： A method for producing β-hydroxy amino acid and its optically-active isomer is provided. The β-hydroxy amino acid is produced by reacting a predetermined D-α-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to the genera Paracoccus, Aminobacter, or Ensifer.
摘要翻译： 提供了一种生产β-羟基氨基酸及其光学活性异构体的方法。 β-羟基氨基酸通过使预定的D-α-氨基酸和5,10-亚甲基四氢叶酸在衍生自属于副球菌属，氨基杆菌属或Ensifer属的微生物的酶存在下反应来制备。
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公开(公告)号：US20090229880A1
公开(公告)日：2009-09-17
申请号：US11885152
申请日：2006-03-31
申请人： Kunihiko Watanabe
发明人： Kunihiko Watanabe
摘要： One aspect of the present invention can include a conductor to be installed on a vehicle for high current use including a stranded copper wire connected to an end portion of a single-core aluminum cable, an intermediary conductor made of copper is connected to the stranded copper wire and an end face of a core of the single-core aluminum cable is cold welded connected to an end face of a welding shaft formed on the intermediary conductor having approximately a same diameter as the core of the single-core aluminum cable.
摘要翻译： 本发明的一个方面可以包括安装在用于大电流的车辆上的导体，包括连接到单芯铝电缆的端部的绞合铜线，由铜制成的中间导体连接到绞合的铜 电线和单芯铝电缆的芯的端面被冷焊接连接到形成在中间导体上的焊接轴的端面，其具有与单芯铝电缆的芯大致相同的直径。
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公开(公告)号：US07556947B2
公开(公告)日：2009-07-07
申请号：US12345887
申请日：2008-12-30
CPC分类号： C12P13/04 , C12N9/1014
摘要： A method for producing β-hydroxy amino acid and its optically-active isomer is provided. The β-hydroxy amino acid is produced by reacting a predetermined D-α-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to the genera Paracoccus, Aminobacter, or Ensifer.
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公开(公告)号：US07351569B2
公开(公告)日：2008-04-01
申请号：US11066542
申请日：2005-02-28
摘要： 4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erwinia, Flavobacterium, or Xanthomonas.
摘要翻译： 可用作合成莫纳甜的中间体的4-（吲哚-3-基甲基）-4-羟基-2-氧戊二酸，可以由吲哚丙酮酸和丙酮酸（和/或草酰乙酸）通过使用 衍生自假单胞菌属，欧文氏菌属，黄杆菌属或黄单胞菌属的新型醛缩酶。
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公开(公告)号：US07297800B2
公开(公告)日：2007-11-20
申请号：US10876468
申请日：2004-06-28
申请人： Masakazu Sugiyama , Kunihiko Watanabe , Nao Funakoshi , Yusuke Amino , Shigeru Kawahara , Tadashi Takemoto
发明人： Masakazu Sugiyama , Kunihiko Watanabe , Nao Funakoshi , Yusuke Amino , Shigeru Kawahara , Tadashi Takemoto
IPC分类号： C07D209/00 , C12P17/00
摘要： The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same
摘要翻译： 本发明涉及通过在式（2）的存在下将式（1）的取代的α-酮酸转化为式（2）的谷氨酸衍生物而有效地生产谷氨酸衍生物（包括其盐）的莫纳甜的方法 催化其转化
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公开(公告)号：US20060016859A1
公开(公告)日：2006-01-26
申请号：US11185696
申请日：2005-07-21
申请人： Kunihiko Watanabe , Toshiaki Suzuki , Shiko Kodama
发明人： Kunihiko Watanabe , Toshiaki Suzuki , Shiko Kodama
CPC分类号： B23K20/02 , B21K25/00 , B23K2101/16 , Y10T29/49474 , Y10T29/516
摘要： A welded metal product includes a first metal plate having a first surface and a second surface opposed to the first surface; and a second metal plate being cold-pressure welded with the second surface of the first metal plate by directly pressing the first metal plate with the die. The first surface has a recess portion which is deformed by directly pressing with a die. A hardness of the first metal plate is greater than a hardness of the second metal plate.
摘要翻译： 焊接金属制品包括具有第一表面和与第一表面相对的第二表面的第一金属板; 并且通过用所述模具直接按压所述第一金属板，将第二金属板与所述第一金属板的所述第二表面进行冷压焊。 第一表面具有通过与模具直接挤压而变形的凹部。 第一金属板的硬度大于第二金属板的硬度。
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公开(公告)号：US20060003610A1
公开(公告)日：2006-01-05
申请号：US11168850
申请日：2005-06-29
IPC分类号： H01R12/00
CPC分类号： H01R43/02 , H01R4/10 , H01R13/113 , H01R31/00 , H01R2101/00
摘要： A conductive path includes a terminal metal piece; and a bus bar overlapped with the terminal metal piece. The terminal piece and the bus bar are bonded while the terminal piece and the bus bar are deformed to form a recess portion on a surface where the terminal metal piece is overlapped with the bus bar by pressing the terminal metal piece and the bus bar with a die in a direction of intersecting with an overlapped face between the terminal metal piece and the bus bar.
摘要翻译： 导电路径包括端子金属片; 以及与端子金属片重叠的母线。 端子片和汇流条在端子件和汇流条变形的同时被接合，以在端子金属片与母线重叠的表面上形成凹部，通过用端子金属片和汇流条 在与端子金属片和母线之间的重叠面相交的方向上死亡。
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