公开(公告)号：US10577403B2

公开(公告)日：2020-03-03

申请号：US16438735

申请日：2019-06-12

Applicant: ModernaTX, Inc.

Inventor： Antonin De Fougerolles ,  Justin Guild

IPC: A61K48/00 ,  A61K38/17 ,  A61K47/54 ,  A61K9/127 ,  C07K14/535 ,  A61K31/7088 ,  A61K38/48 ,  C07K14/745 ,  C07K16/28 ,  C07K16/32 ,  C12N9/02 ,  C12N9/64 ,  A61K38/19 ,  A61K38/21 ,  A61K38/36 ,  A61K38/44 ,  A61K39/395 ,  C07K14/475 ,  C07K14/505 ,  C07K14/525 ,  C07K14/56 ,  C07K14/565 ,  C07K14/75 ,  A61K47/10 ,  A61K38/18 ,  A61K9/14 ,  C07K14/47 ,  C12N15/85 ,  A61K9/50 ,  C12N15/88 ,  C07K19/00 ,  A61K31/7115 ,  C07K14/005 ,  C12N15/11 ,  C12N9/00 ,  A61K9/00

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

公开(公告)号：US10155029B2

公开(公告)日：2018-12-18

申请号：US15429532

申请日：2017-02-10

Applicant: ModernaTX, Inc.

Inventor： Tirtha Chakraborty ,  Stephane Bancel ,  Stephen G. Hoge ,  Atanu Roy ,  Antonin De Fougerolles ,  Noubar B. Afeyan

IPC: A61K39/00 ,  C12N15/67

Abstract: The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.

公开(公告)号：US09790531B2

公开(公告)日：2017-10-17

申请号：US15356132

申请日：2016-11-18

Applicant: ModernaTX, Inc.

Inventor： Yuxun Wang ,  Divakar Ramakrishnan ,  Antonin De Fougerolles ,  Susan Whoriskey

IPC: C12P19/34 ,  C12N9/12 ,  C12N15/52 ,  C12N15/54 ,  C12N15/63 ,  C12N15/70

CPC classification number: C12P19/34 ,  C12N9/1241 ,  C12N9/1247 ,  C12N9/1252 ,  C12Y207/07006 ,  C12Y207/07007 ,  C12Y207/0705

Abstract: The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.

公开(公告)号：US11708396B2

公开(公告)日：2023-07-25

申请号：US17162061

申请日：2021-01-29

Applicant: ModernaTX, Inc.

Inventor： Stephen G. Hoge ,  Tirtha Chakraborty ,  Joshua P. Frederick ,  Matthias John ,  Antonin De Fougerolles

IPC: A61K48/00 ,  C07K14/47 ,  C12N15/85 ,  C12N15/113 ,  A61K31/7105 ,  A61K31/711 ,  A61K38/00

CPC classification number: C07K14/47 ,  A61K31/711 ,  A61K31/7105 ,  A61K48/0058 ,  C12N15/113 ,  C12N15/85 ,  A61K38/00 ,  C12N2310/141

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of signal-sensor polynucleotides, primary transcripts and mmRNA molecules.

公开(公告)号：US11564998B2

公开(公告)日：2023-01-31

申请号：US16577734

申请日：2019-09-20

Applicant: ModernaTX, Inc.

Inventor： Antonin De Fougerolles ,  Justin Guild

IPC: A61K48/00 ,  C12N15/85 ,  C07K14/47 ,  C12N9/64 ,  C07K14/62 ,  A61K31/7115 ,  C12N9/88 ,  A61K9/127 ,  C12N15/11 ,  C07K14/705 ,  C07K14/505 ,  C07K14/535 ,  C12N9/10 ,  C12N9/00 ,  C12N9/42 ,  C12N15/87 ,  C12P13/04 ,  A61K38/45 ,  C07K14/005 ,  C12N9/16 ,  C12N9/24 ,  C12N15/52 ,  A61K38/17 ,  C07K14/435 ,  C12P21/00 ,  C07K14/485 ,  C07H21/02 ,  C07K14/475 ,  C07K14/495 ,  C07K14/525 ,  C07K14/54 ,  C07K14/56 ,  C07K14/61 ,  C07K14/745 ,  C07K16/28 ,  C07K16/40 ,  C12N9/02 ,  C12N9/12 ,  C12N9/68 ,  A61K47/54 ,  A61K9/14 ,  A61K9/51 ,  A61K38/18 ,  A61K38/19 ,  A61K38/21 ,  A61K38/48 ,  C07K14/515 ,  C07K16/00 ,  A61K38/00

Abstract: The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.

公开(公告)号：US20190142971A1

公开(公告)日：2019-05-16

申请号：US16050845

申请日：2018-07-31

Applicant: ModernaTX, Inc.

Inventor： Stephen G. Hoge ,  Örn Almarsson ,  David D. Hile ,  Ciáran Lawlor ,  John Podobinski ,  Staci Sabnis ,  Antonin De Fougerolles ,  Divakar Ramakrishnan ,  Kristy M. Wood

IPC: A61K48/00 ,  A61K47/52 ,  C12N15/88 ,  C12N15/87

Abstract: The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.

公开(公告)号：US09950068B2

公开(公告)日：2018-04-24

申请号：US15379284

申请日：2016-12-14

Applicant: ModernaTX, Inc.

Inventor： Antonin De Fougerolles ,  Sayda M. Elbashir

IPC: A61K31/7088 ,  A61K31/7115 ,  C07K14/535 ,  C12N15/87 ,  C12N9/64 ,  A61K47/18 ,  A61K38/48 ,  A61K47/22 ,  A61K47/28 ,  A61K38/19 ,  A61K48/00

CPC classification number: A61K47/18 ,  A61K31/7088 ,  A61K31/7115 ,  A61K38/193 ,  A61K38/4846 ,  A61K47/22 ,  A61K47/28 ,  A61K48/00 ,  C07K14/535 ,  C12N9/644 ,  C12N15/67 ,  C12N15/87 ,  C12N2310/335

Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.