公开(公告)号：US09950068B2

公开(公告)日：2018-04-24

申请号：US15379284

申请日：2016-12-14

Applicant: ModernaTX, Inc.

Inventor： Antonin De Fougerolles ,  Sayda M. Elbashir

IPC: A61K31/7088 ,  A61K31/7115 ,  C07K14/535 ,  C12N15/87 ,  C12N9/64 ,  A61K47/18 ,  A61K38/48 ,  A61K47/22 ,  A61K47/28 ,  A61K38/19 ,  A61K48/00

CPC classification number: A61K47/18 ,  A61K31/7088 ,  A61K31/7115 ,  A61K38/193 ,  A61K38/4846 ,  A61K47/22 ,  A61K47/28 ,  A61K48/00 ,  C07K14/535 ,  C12N9/644 ,  C12N15/67 ,  C12N15/87 ,  C12N2310/335

Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.

公开(公告)号：US20180086816A1

公开(公告)日：2018-03-29

申请号：US15591820

申请日：2017-05-10

Applicant: ModernaTX, Inc.

Inventor： Stephen G. Hoge ,  Eric Yi-Chun Huang ,  Tirtha Chakraborty ,  Sayda M. Elbashir

IPC: C07K14/76 ,  C07K14/61 ,  C07K14/50 ,  C07K14/535 ,  C07K14/59 ,  C07K14/605 ,  C12N15/67 ,  C07K14/765 ,  C07K16/00

CPC classification number: C07K14/76 ,  A61K48/00 ,  C07K14/50 ,  C07K14/535 ,  C07K14/59 ,  C07K14/605 ,  C07K14/61 ,  C07K14/765 ,  C07K16/00 ,  C07K2319/00 ,  C12N15/67

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of long-lived polynucleotides, primary transcripts and mmRNA molecules.

公开(公告)号：US10772975B2

公开(公告)日：2020-09-15

申请号：US15790246

申请日：2017-10-23

Applicant: ModernaTX, Inc.

Inventor： Stephane Bancel ,  Tirtha Chakraborty ,  Antonin De Fougerolles ,  Sayda M. Elbashir ,  Matthias John ,  Atanu Roy ,  Susan Whoriskey ,  Kristy M. Wood ,  Paul Hatala ,  Jason P. Schrum ,  Kenechi Ejebe ,  Jeff Lynn Ellsworth ,  Justin Guild

IPC: C07K14/535 ,  A61K38/17 ,  A61K48/00 ,  C12N15/85 ,  C07K14/47 ,  C07K14/62 ,  A61K31/7115 ,  C12N9/88 ,  A61K9/127 ,  C12N15/11 ,  C07K14/705 ,  C07K14/505 ,  C12N9/64 ,  C12N9/10 ,  C12N9/00 ,  C12N9/42 ,  C12N15/87 ,  C12P13/04 ,  A61K38/45 ,  C07K14/005 ,  C12N9/16 ,  C12N9/24 ,  C12N15/52 ,  C07K14/435 ,  C12P21/00 ,  C07K14/485 ,  C07H21/02 ,  C07K14/475 ,  C07K14/495 ,  C07K14/525 ,  C07K14/54 ,  C07K14/56 ,  C07K14/61 ,  C07K14/745 ,  C07K16/28 ,  C07K16/40 ,  C12N9/02 ,  C12N9/12 ,  C12N9/68 ,  A61K47/54 ,  A61K9/14 ,  A61K9/51 ,  A61K38/18 ,  A61K38/19 ,  A61K38/21 ,  A61K38/48 ,  C07K14/515 ,  C07K16/00 ,  A61K31/7088 ,  A61K47/10 ,  A61K38/00

Abstract: The invention relates to a pharmaceutical composition including a plurality of lipid nanoparticles having a mean particle size of between 80 nm and 160 nm and containing an mRNA encoding a polypeptide. The lipid nanoparticles include a cationic lipid, a neutral lipid, a cholesterol, and a PEG lipid. The mRNA contains a 5′-cap, 5′-UTR, a 3′-UTR, and a poly-A region with at least 100 nucleotides.

公开(公告)号：US09828416B2

公开(公告)日：2017-11-28

申请号：US14750004

申请日：2015-06-25

Applicant: ModernaTX, Inc.

Inventor： Stephane Bancel ,  Tirtha Chakraborty ,  Antonin de Fougerolles ,  Sayda M. Elbashir ,  Matthias John ,  Atanu Roy ,  Susan Whoriskey ,  Kristy M. Wood ,  Paul Hatala ,  Jason P. Schrum ,  Kenechi Ejebe ,  Jeff Lynn Ellsworth ,  Justin Guild

IPC: C12N15/85 ,  A61K31/7088 ,  A61K47/48 ,  C07K14/535 ,  A61K48/00 ,  C12N15/88 ,  A61K9/127 ,  A61K9/50 ,  C07K19/00 ,  A61K38/18 ,  A61K38/19 ,  A61K38/48 ,  C07K14/47 ,  A61K9/14 ,  A61K38/17 ,  A61K47/10 ,  A61K38/21 ,  A61K38/36 ,  A61K38/44 ,  A61K39/395 ,  C07K14/475 ,  C07K14/505 ,  C07K14/525 ,  C07K14/56 ,  C07K14/565 ,  C07K14/745 ,  C07K14/75 ,  C07K16/28 ,  C07K16/32 ,  C12N9/02 ,  C12N9/64 ,  A61K9/00

CPC classification number: C07K14/535 ,  A61K9/0019 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/1277 ,  A61K9/14 ,  A61K9/5031 ,  A61K31/7088 ,  A61K38/1767 ,  A61K38/1816 ,  A61K38/1866 ,  A61K38/191 ,  A61K38/193 ,  A61K38/212 ,  A61K38/215 ,  A61K38/36 ,  A61K38/363 ,  A61K38/44 ,  A61K38/4833 ,  A61K38/4846 ,  A61K39/3955 ,  A61K47/10 ,  A61K47/54 ,  A61K47/542 ,  A61K48/00 ,  A61K48/0033 ,  A61K48/0066 ,  A61K48/0075 ,  C07K14/47 ,  C07K14/475 ,  C07K14/505 ,  C07K14/525 ,  C07K14/56 ,  C07K14/565 ,  C07K14/745 ,  C07K14/75 ,  C07K16/2887 ,  C07K16/32 ,  C07K19/00 ,  C12N9/0069 ,  C12N9/644 ,  C12N15/85 ,  C12N15/88 ,  C12N2840/00 ,  C12Y113/12007 ,  C12Y304/21005 ,  C12Y304/21022

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.

公开(公告)号：US20170258915A1

公开(公告)日：2017-09-14

申请号：US15379284

申请日：2016-12-14

Applicant: ModernaTX, Inc.

Inventor： Antonin de FOUGEROLLES ,  Sayda M. Elbashir

IPC: A61K47/18 ,  A61K31/7088 ,  A61K31/7115 ,  A61K38/19 ,  A61K38/48 ,  A61K47/22 ,  A61K47/28 ,  C07K14/535 ,  C12N15/87 ,  C12N9/64 ,  A61K48/00

CPC classification number: A61K47/18 ,  A61K31/7088 ,  A61K31/7115 ,  A61K38/193 ,  A61K38/4846 ,  A61K47/22 ,  A61K47/28 ,  A61K48/00 ,  C07K14/535 ,  C12N9/644 ,  C12N15/67 ,  C12N15/87 ,  C12N2310/335

Abstract: Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the delivery of biological moieties, and are useful for production of proteins.