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93 条记录 (耗时 0.049 秒)

    Method of Proliferating Plasma Cells
    11.
    发明申请
    Method of Proliferating Plasma Cells 失效
    增殖血浆细胞的方法

    公开(公告)号：US20080187537A1

    公开(公告)日：2008-08-07

    申请号：US11587701

    申请日：2005-04-27

    申请人： Masayuki Tsuchiya ,  Masami Suzuki ,  Kenji Yoshida ,  Etsuko Fujii ,  Miho Watanabe ,  Koichi Matsubara ,  Yu Jau Chen ,  Juliana Sim

    发明人： Masayuki Tsuchiya ,  Masami Suzuki ,  Kenji Yoshida ,  Etsuko Fujii ,  Miho Watanabe ,  Koichi Matsubara ,  Yu Jau Chen ,  Juliana Sim

    IPC分类号： A61K39/395 ,  A61K35/12 ,  C12P21/04 ,  C07H21/00 ,  A61P43/00 ,  C07K16/18 ,  A61K31/70 ,  G01N33/574

    CPC分类号： A01K67/027 ,  A01K2267/01 ,  A61K35/16 ,  C07K16/00 ,  C07K16/30

    摘要： An objective of the present invention is to facilitate the acquisition of antibody-producing cells that are infiltrating virus-infected cells, cancer cells, abnormal cells forming a benign hyperplasia, and the like, and to improve the efficiency of the production of antibodies as well as nucleic acids encoding them from the antibody-producing cells.The present inventors discovered that, when cancer tissues comprising infiltrating lymphocytes are transplanted into highly immunodeficient animals that do not have T cells, B cells, and NK cells and further exhibit a low IFN production ability, the differentiation and proliferation of infiltrating lymphocytes are unexpectedly promoted, and the number of plasma cells that produce antibodies recognizing cancer tissues increases dramatically, plasma cells can be separated easily, and antibodies or nucleic acids encoding them can be easily prepared from the plasma cells.

    摘要翻译： 本发明的目的是便于获得渗透病毒感染细胞的抗体产生细胞，癌细胞，形成良性增生的异常细胞等，以及提高抗体生产的效率 作为从抗体产生细胞编码它们的核酸。 本发明人发现，当将包含浸润淋巴细胞的癌组织移植到不具有T细胞，B细胞和NK细胞的高度免疫缺陷的动物中并且进一步表现出低的IFN产生能力时，意外地促进了浸润性淋巴细胞的分化和增殖 并且产生识别癌组织的抗体的浆细胞的数量急剧增加，可以容易地分离浆细胞，并且可以容易地从浆细胞制备抗体或编码它们的核酸。

    Novel gene having reverse transcriptas motif
    13.
    发明申请
    Novel gene having reverse transcriptas motif 审中-公开
    具有逆转录本基序的新基因

    公开(公告)号：US20050272092A1

    公开(公告)日：2005-12-08

    申请号：US11199124

    申请日：2005-08-09

    申请人： Masayuki Tsuchiya ,  Kenji Yoshida

    发明人： Masayuki Tsuchiya ,  Kenji Yoshida

    IPC分类号： C07H21/04 ,  C12N9/12 ,  C12N9/22 ,  C12N15/12 ,  C12Q1/68

    CPC分类号： C12N9/1276 ,  C12Y207/07049

    摘要： The present invention aims to provide a novel gene having a reverse transcriptase motif. The invention isolates a novel gene having a reverse transcriptase motif, and gives its complete base sequence determined. The invention also provides a protein encoded by the gene, and an antibody against the protein. The use of them is useful in developing a method for detecting telomerase activity, a method for detecting a cancer cell, a telomerase activity inhibitor, and a method for screening a telomerase activity inhibitor.

    摘要翻译： 本发明旨在提供具有逆转录酶基序的新基因。 本发明分离具有逆转录酶基序的新基因，并确定其完整的碱基序列。 本发明还提供了由该基因编码的蛋白质和针对该蛋白质的抗体。 其使用可用于开发端粒酶活性检测方法，癌细胞检测方法，端粒酶活性抑制剂及筛选端粒酶活性抑制剂的方法。

    Polynucleotides which encode reshaped IL-8-specific antibodies and methods to produce the same
    15.
    发明授权
    Polynucleotides which encode reshaped IL-8-specific antibodies and methods to produce the same 失效
    编码重组的IL-8特异性抗体的多核苷酸及其制备方法

    公开(公告)号：US5994524A

    公开(公告)日：1999-11-30

    申请号：US765783

    申请日：1997-03-07

    申请人： Kouji Matsushima ,  Yoshihiro Matsumoto ,  Yoshiki Yamada ,  Koh Sato ,  Masayuki Tsuchiya ,  Tatsumi Yamazaki

    发明人： Kouji Matsushima ,  Yoshihiro Matsumoto ,  Yoshiki Yamada ,  Koh Sato ,  Masayuki Tsuchiya ,  Tatsumi Yamazaki

    IPC分类号： C07K16/24 ,  C12N15/13 ,  C12P21/08 ,  C07H21/04 ,  C12N5/10

    CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00

    摘要： The present invention discloses a reshaped human antibody against human IL-8 comprising:(A) L chains each comprising:(1) a human L chain C region; and,(2) an L chain V region comprising a human Lchain FR, and an L chain CDR of mouse monoclonal antibody against human IL-8; and,(B) H chains each comprising:(1) a human H chain C region; and,(2) an H chain V region comprising a human Hchain FR, and an H chain CDR of mouse monoclonal antibody against human IL-8. Since the majority of this reshaped human antibody originates in human antibody and the CDR has low antigenicity, the reshaped human antibody of the present invention has low antigenicity to humans, and can therefore be expected to be useful in medical treatment. The present invention further discloses polynucleotides which encode reshaped antibodies against IL-8, as well as host cells and methods to produce these antibodies.

    摘要翻译： PCT No.PCT / JP95 / 01396 Sec。 371日期1997年3月7日 102（e）1997年3月7日PCT PCT 1995年7月12日PCT公布。 出版物WO97 / 02576 日本1996年2月1日本发明公开了针对人IL-8的重构人抗体，其包含：（A）L链，各自包含：（1）人L链C区; 和（2）包含人L链FR的L链V区和针对人IL-8的小鼠单克隆抗体的L链CDR; 和（B）H链，其各自包含：（1）人H链C区; 和（2）包含人H链FR的H链V区和针对人IL-8的小鼠单克隆抗体的H链CDR。 由于这种重整人抗体的大部分源于人抗体，CDR具有低抗原性，所以本发明的重构人抗体对人的抗原性低，因此可以预期可用于治疗。 本发明进一步公开了编码针对IL-8的重整抗体以及宿主细胞的多核苷酸以及产生这些抗体的方法。

    Method and system for processing a document transmitted via facsimile in an initially input form stored in a knowledge base
    18.
    发明授权
    Method and system for processing a document transmitted via facsimile in an initially input form stored in a knowledge base 失效
    用于处理以存储在知识库中的初始输入形式通过传真发送的文档的方法和系统

    公开(公告)号：US5666549A

    公开(公告)日：1997-09-09

    申请号：US386182

    申请日：1995-02-09

    申请人： Masayuki Tsuchiya ,  Hiroshi Fujise ,  Masato Teramoto

    发明人： Masayuki Tsuchiya ,  Hiroshi Fujise ,  Masato Teramoto

    IPC分类号： G06F3/00 ,  G06K9/20 ,  H04N1/00 ,  G06F13/00

    CPC分类号： G06K9/00449 ,  G06F3/002 ,  G06K9/2054 ,  H04N1/00204 ,  H04N1/0036 ,  H04N1/00968 ,  G06K2209/01 ,  H04N2201/0015 ,  H04N2201/3205 ,  H04N2201/3219 ,  H04N2201/3278

    摘要： A document processing method and system are provided in which data is inscribed as handwritten information on a blank form in a document form hitherto used or a blank form for a document produced by a word processor or the like. The blank form with the handwritten information data is facsimile-input and is transmitted to a computer which in turn receives the data directly and recognizes the received data to process the document. Initially, the contents or format of a blank form are read to obtain and store information regarding ruled lines and handwritten character input areas. Upon execution of document processing, an input document image received via facsimile is searched for reference ruled lines on the basis of the ruled line information initially stored to positionally adjust the document image and ruled line images in handwritten character input areas are erased from the adjusted document image on the basis of the handwritten character input area information initially stored to recognized handwritten characters. A function of returning the result of recognition or the result of processing by the computer to a sender facsimile or a function of eliminating improper facsimile transmission may be provided by receiving a sender facsimile number as data upon reception of the facsimile document image and storing it or comparing the received number with transmission-allowed facsimile numbers previously registered.

    摘要翻译： 提供了一种文件处理方法和系统，其中数据以迄今所使用的文档形式的空白形式被刻写为手写信息，或由文字处理器等产生的文档的空白形式。 具有手写信息数据的空白形式是传真输入的，并且被传送到计算机，计算机又直接接收数据并识别所接收的数据以处理该文档。 首先，读取空白形式的内容或格式，以获取和存储有关划线和手写字符输入区域的信息。 在执行文件处理时，基于最初存储的格线信息，基于经由传真接收的输入文档图像被搜索以对文档图像进行位置调整，并且手写字符输入区域中的划线图像被从调整文档中删除 基于最初存储到识别的手写字符的手写字符输入区域信息的图像。 可以通过在接收到传真文档图像时接收发送者传真号码作为数据并存储传真文件图像并将其存储或提供给传真机传真机或者消除不正确的传真传输功能的功能，将计算机的识别结果或处理结果返回给发送者传真或功能， 将接收的号码与先前注册的传输允许的传真号码进行比较。

    Method and system for displaying and processing image of form document
    19.
    发明授权
    Method and system for displaying and processing image of form document 失效
    用于显示和处理形式文件图像的方法和系统

    公开(公告)号：US5231579A

    公开(公告)日：1993-07-27

    申请号：US689071

    申请日：1991-06-20

    申请人： Masayuki Tsuchiya ,  Hiroshi Fujise ,  Hitoshi Suzuki

    发明人： Masayuki Tsuchiya ,  Hiroshi Fujise ,  Hitoshi Suzuki

    IPC分类号： G06F17/24

    CPC分类号： G06F17/243

    摘要： Method and system for dispensing a document form including input/output fields into which a character train or a numerical value data train is written on a screen such that the operator can easily correct it on the screen or by a format such that data can be easily input/output into/from the input/output fields thereof for processing. describing a format of the document is read out of a recording medium in which the document format has been written, the read data is displayed on the screen with a format which is the same as or similar to the format written on the recording medium. When the document form is displayed on the screen a character size per character displayed is decided from the read data, the cell is arranged on the basis of the decided character size, extra-cell data such as character or numerical value data or the like is arranged on the basis of the arranged cell, the cell and the extra-cell data are compressed so as not to overflow the display screen, and a processing procedure of items of the format displayed in the display screen is determined.

    摘要翻译： PCT No.PCT / JP90 / 01354 Sec。 371日期1991年6月20日 102（e）1991年6月20日PCT PCT 1990年10月19日PCT公布。 第WO91 / 06057号公报 日期：1991年5月2日。用于分发包括输入/​​输出字段的文档形式的方法和系统，字符列或数值数据列被写入屏幕上，使得操作者可以容易地在屏幕上或通过格式 使得数据可以容易地从其输入/输出字段输入/输出以进行处理。 从其中写入了文档格式的记录介质读出文档的格式，将读取的数据以与写在记录介质上的格式相同或类似的格式显示在屏幕上。 当在屏幕上显示文档形式时，从读取的数据确定显示的每个字符的字符大小，基于所确定的字符大小来排列单元格，诸如字符或数值数据等的超单元数据是 基于排列的单元布置，单元和超单元数据被压缩以便不会溢出显示屏幕，并且确定显示在显示屏幕中的格式的项目的处理过程。