公开(公告)号：US20060035894A1

公开(公告)日：2006-02-16

申请号：US10524650

申请日：2003-08-18

申请人： Magnus Walter ,  Barry Clark ,  Peter Gallagher ,  Helen Haughton ,  Helene Rudyk

发明人： Magnus Walter ,  Barry Clark ,  Peter Gallagher ,  Helen Haughton ,  Helene Rudyk

IPC分类号： A61K31/5377 ,  C07D413/02 ,  A61K31/535

CPC分类号： C07D265/30

摘要： Compounds of formula (I): wherein A is S or O; R is H; Ar is an optionally substituted phenyl group; X is an optionally substituted phenyl group, a C1-C4 alkyl, a C3-C6 cycloalkyl group or a CH2(C3-C6 cycloalkyl) group; R′ is H or C1-C4 alkyl; and each R1 is independently H or C1-C4 alkyl; and pharmaceutically acceptable salts thereof are selective inhibitors of norepinephrine reuptake.

摘要翻译： 式（I）的化合物：其中A是S或O; R为H; Ar是任选取代的苯基; X是任选取代的苯基，C 1 -C 4烷基，C 3 -C 6亚烷基， 环烷基或CH 2（C 3 -C 6环烷基）基团; R'是H或C 1 -C 4烷基; 且每个R 1独立地为H或C 1 -C 4烷基; 和其药学上可接受的盐是去甲肾上腺素再摄取的选择性抑制剂。

公开(公告)号：US20060014779A1

公开(公告)日：2006-01-19

申请号：US10532657

申请日：2003-10-24

申请人： Serge Boulet ,  Ann Filla ,  Peter Gallagher ,  Kevin Hudziak ,  Anette Johansson ,  Rushad Karanjawla ,  John Masters ,  Victor Matassa ,  Brian Mathes ,  Richard Rathmell ,  Maria Whatton ,  Chad Wolfe

发明人： Serge Boulet ,  Ann Filla ,  Peter Gallagher ,  Kevin Hudziak ,  Anette Johansson ,  Rushad Karanjawla ,  John Masters ,  Victor Matassa ,  Brian Mathes ,  Richard Rathmell ,  Maria Whatton ,  Chad Wolfe

IPC分类号： A61K31/4745 ,  A61K31/4743 ,  A61K31/4704 ,  A61K31/428 ,  A61K31/423

CPC分类号： C07C217/20 ,  C07C217/34 ,  C07D333/54

摘要： There is provided a compound of formula (I) wherein A is selected from —O— and —S—; X is selected from C2-C8 alkyl, C2-C8 alkenyl, C3-C8 cycloalkyl and C4-C8 cycloalkylalkyl, each of which may be optionally substituted with up to 3 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n— where n is 0, 1 or 2, —CF3, —CN and —CONH2; Y is selected from phenyl, naphthyl, dihydrobenzothienyl, benzothiazolyl, benzoisothiazolyl, quinolyl, isoquinolyl, naphthyridyl, thienopyridyl, indanyl, 1,3-benzodioxolyl, benzothienyl, indolyl and benzofuranyl, each of which may be optionally substituted with up to 4 or, where possible, 5 substituents each independently selected from halo, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkyl-S(O)n— where n is 0, 1 or 2, nitro, acetyl, —CF3, —SCF3 and cyano; and when Y is indolyl it may be substituted or further substituted by an N-substituent selected from C1-C4 alkyl; Z is selected from H, OR3 or F, wherein R3 is selected from H, C1-C6 alkyl and phenyl C1-C6 alkyl; R1 and R2 are each independently H or C1-C4 alkyl; with the proviso that, when Z is H, then Y may not be optionally substituted phenyl or optionally substituted naphthyl.

公开(公告)号：USD442069S1

公开(公告)日：2001-05-15

申请号：US29123658

申请日：2000-05-22

申请人： Peter Gallagher

设计人： Peter Gallagher

公开(公告)号：US20070093526A1

公开(公告)日：2007-04-26

申请号：US10597795

申请日：2005-02-11

申请人： Serge Boulet ,  Barry Clark ,  John Fairhurst ,  Peter Gallagher ,  Anette Johansson ,  Maria Whatton ,  Virginia Wood

发明人： Serge Boulet ,  Barry Clark ,  John Fairhurst ,  Peter Gallagher ,  Anette Johansson ,  Maria Whatton ,  Virginia Wood

IPC分类号： A61K31/4545 ,  A61K31/454 ,  C07D403/02 ,  C07D401/02

CPC分类号： C07D513/04 ,  A61K31/454 ,  A61K31/4545 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

摘要： The present invention provides compounds of formula (I) where n, R1, R2, R3, R4, R5 and Heteroaryl are defined herein. The compounds are inhibitors of the uptake of one or more monoamines selected from serotonin, norepinephrine and dopamine and, as such, may be useful in the treatment of disorders of the central and/or peripheral nervous system.

摘要翻译： 本发明提供式（I）化合物，其中n，R 1，R 2，R 3，R 4，R 5和杂芳基如本文所定义。 这些化合物是一种或多种选自5-羟色胺，去甲肾上腺素和多巴胺的单胺摄取的抑制剂，因此可用于治疗中枢和/或周围神经系统疾病。

公开(公告)号：US20060079554A1

公开(公告)日：2006-04-13

申请号：US10536295

申请日：2003-11-25

申请人： Peter Barry ,  Manuel Cases-Thomas ,  Peter Gallagher ,  Jeremy Gilmore ,  John Masters ,  Graham Timms ,  Maria Whatton ,  Virginia Wood

发明人： Peter Barry ,  Manuel Cases-Thomas ,  Peter Gallagher ,  Jeremy Gilmore ,  John Masters ,  Graham Timms ,  Maria Whatton ,  Virginia Wood

IPC分类号： A61K31/445 ,  C07D211/56

CPC分类号： C07D405/12 ,  C07D211/58

摘要： N,N-disubstituted 4-amino-piperidines of the general Formula (I) are inhibitors of the uptake of serotonin and/or norepinephrine and/or dopamine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.

摘要翻译： 通式（I）的N，N-二取代的4-氨基 - 哌啶是5-羟色胺和/或去甲肾上腺素和/或多巴胺摄取的抑制剂。 因此，它们可用于治疗中枢和/或周围神经系统的病症。

公开(公告)号：US06844338B2

公开(公告)日：2005-01-18

申请号：US10258356

申请日：2001-05-04

申请人： John Fairhurst ,  Peter Gallagher

发明人： John Fairhurst ,  Peter Gallagher

IPC分类号： A61P25/24 ,  C07D401/14 ,  C07D417/14 ,  A61K31/517 ,  A61K31/5415

CPC分类号： C07D401/14 ,  C07D417/14

摘要： A pharmaceutical compound of the formula (I) in which R1 and R2 are each hydrogen or C1-6 alkyl, R3 is —SR10, —SOR10, —SO2R10, —COR10, —CH2OH or —CONHR11, where R10 is C1-6 alkyl and R11 is hydrogen or C1-6 alkyl, R4, R5, R6 and R7 are each hydrogen or C1-6alkyl, provided that at least one of R4, R5, R6 and R7 is C1-6alkyl, R8 and R9 are each hydrogen, halo, C1-6 alkyl or cyano, n is 0 or 1 and m is 2 or 3, x is a (a) or (b), and y is (c) or (d), wherein R12 and R13 are each hydrogen, C1- alkyl, cyclopropyl or cyclopropyl-C1-6 alkyl; and salts thereof.

摘要翻译： R 1和R 2各自为氢或C 1-6烷基的式（I）的药物化合物，R 3为-SR 10，-SOR 10，-SO 2 R 10 ，-COR 10，-CH 2 OH或-CONHR 11，其中R 10是C 1-6烷基，R 11是氢或C 1-6烷基，R 4，R 5， R 6和R 7各自为氢或C 1-6烷基，条件是R 4，R 5，R 6和R 7中的至少一个为C 1-6烷基，R 8为 和R 9各自为氢，卤素，C 1-6烷基或氰基，n为0或1，m为2或3，x为a（a）或（b），y为（c）或（ d），其中R 12和R 13各自为氢，C 1烷基，环丙基或环丙基-C 1-6烷基; 及其盐。

公开(公告)号：US06706258B1

公开(公告)日：2004-03-16

申请号：US09294173

申请日：1999-04-19

申请人： Peter Gallagher ,  Tipawan Kreu-Nopakun ,  Andrew Malcolm Murray

发明人： Peter Gallagher ,  Tipawan Kreu-Nopakun ,  Andrew Malcolm Murray

IPC分类号： A61K706

CPC分类号： A61K8/737 ,  A61K8/068 ,  A61K8/442 ,  A61K8/463 ,  A61K8/891 ,  A61K8/892 ,  A61K2800/5426 ,  A61Q5/02 ,  Y10S514/852 ,  Y10S514/88 ,  Y10S514/881

摘要： An aqueous shampoo composition comprising, in addition to water: i) at least one cleansing surfactant; ii) a cationic deposition polymer, and iii) a silicone component consisting of a blend of: (a) emulsified particles of an insoluble silicone, in which the emulsified particles of insoluble silicone are incorporated into the shampoo composition as a preformed aqueous emulsion having an average silicone particle size in the emulsion and in the shampoo composition of from 0.15 to 30 microns, and (b) microemulsified particles of an insoluble silicone, in which the microemulsified particles of insoluble silicone are incorporated into the shampoo composition as a preformed aqueous microemulsion having an average-silicone particle size in the microemulsion and in the shampoo composition of less than 0.10 microns.

摘要翻译： 一种水性洗发剂组合物，除了水以外还包含：i）至少一种清洁表面活性剂; ii）阳离子淀积聚合物，和ii）由以下共混物组成的硅氧烷组分：（a）不溶性硅氧烷的乳化颗粒，其中 将不溶性硅氧烷的乳化颗粒作为预乳液组合物掺入到预乳液中，乳液中的平均硅氧烷颗粒尺寸和洗发组合物中的0.15至30微米，和（b）不溶性硅氧烷的微乳化颗粒，其中 将不溶性硅氧烷的微乳化颗粒作为在微乳液和洗发剂组合物中的平均硅氧烷颗粒尺寸小于0.10微米的预成型水性微乳液掺入洗发剂组合物中。

公开(公告)号：US06277360B1

公开(公告)日：2001-08-21

申请号：US09196816

申请日：1998-11-20

申请人： Peter Simon Carew ,  Peter Gallagher ,  Peter Christopher Konidaris ,  Stanley Lam ,  Euan Stuart Reid ,  Ian Berkeley Walton

发明人： Peter Simon Carew ,  Peter Gallagher ,  Peter Christopher Konidaris ,  Stanley Lam ,  Euan Stuart Reid ,  Ian Berkeley Walton

IPC分类号： A61K706

CPC分类号： C11D17/0013 ,  A61K8/463 ,  A61K8/4933 ,  A61K8/737 ,  A61K8/891 ,  A61K2800/5426 ,  A61Q5/02 ,  A61Q17/005 ,  C11D3/373 ,  C11D3/48 ,  Y10S514/938

摘要： The invention provides a washing composition for washing a surface to deposit thereon a solid active agent, the washing composition comprising an emulsion of silicone droplets, the silicone droplets comprising: (a) a continuous silicone phase, and; (b) a dispersed phase of solid particulate active agent. Preferably the solid active agent is a solid antimicrobial such as zinc pyridinethione.

摘要翻译： 本发明提供了一种洗涤组合物，用于洗涤其上沉积有固体活性剂的表面，洗涤组合物包含硅氧烷液滴的乳液，该硅氧烷液滴包含：（a）连续的硅氧烷相，和（b）分散相 固体颗粒活性剂。优选固体活性剂是固体抗微生物剂如吡啶硫酮锌。

公开(公告)号：US5570505A

公开(公告)日：1996-11-05

申请号：US455775

申请日：1995-05-31

申请人： Alan P. Downie ,  Peter Gallagher ,  John J. Garrity ,  Brian L. Robertson

发明人： Alan P. Downie ,  Peter Gallagher ,  John J. Garrity ,  Brian L. Robertson

IPC分类号： H05K1/11 ,  H01L25/04 ,  H01L25/18 ,  H05K1/14 ,  H05K3/00 ,  H05K3/34 ,  H05K3/36 ,  H05K3/40 ,  H05K3/42

CPC分类号： H05K1/141 ,  H05K3/403 ,  H05K2201/09181 ,  H05K3/0052 ,  H05K3/3442 ,  H05K3/368 ,  H05K3/42 ,  Y10T29/49144 ,  Y10T29/49165 ,  Y10T29/49789

摘要： A direct chip attach module (DCAM) 10, comprises of one or more electronic components 30, electrically bonded to a printed circuit 40, on a substrate 20. The DCAM 10, is bonded to an electronic circuit assembly by connection pads 50, formed on the edge of the DCAM substrate 10. This enables easy visual inspection of solder joints between the DCAM and the assembly.DCAM substrates 10, are initially formed in a panel form 70, and vias 50, are drilled and filled with electrically conductive media 55, at predetermined connection points. The DCAM 10, is then excised from the parent panel 70, and the cut vias provide connection pads 55, along the edge of the substrate 10.

摘要翻译： 直接芯片连接模块（DCAM）10由在基板20上电连接到印刷电路40的一个或多个电子部件30组成.DCAM 10通过连接焊盘50结合到电子电路组件上， DCAM基板10的边缘。这使得能够容易地目视检查DCAM和组件之间的焊点。 DCAM基板10最初以面板形式70形成，并且在预定的连接点处钻出并填充有导电介质55的通孔50。 然后将DCAM 10从母板70切除，并且切割通孔沿着基板10的边缘提供连接焊盘55。

公开(公告)号：US5471368A

公开(公告)日：1995-11-28

申请号：US254342

申请日：1994-06-03

申请人： Alan P. Downie ,  Peter Gallagher ,  John J. Garrity ,  Brian L. Robertson

发明人： Alan P. Downie ,  Peter Gallagher ,  John J. Garrity ,  Brian L. Robertson

IPC分类号： H05K1/11 ,  H01L25/04 ,  H01L25/18 ,  H05K1/14 ,  H05K3/00 ,  H05K3/34 ,  H05K3/36 ,  H05K3/40 ,  H05K3/42 ,  H05K7/02

CPC分类号： H05K1/141 ,  H05K3/403 ,  H05K2201/09181 ,  H05K3/0052 ,  H05K3/3442 ,  H05K3/368 ,  H05K3/42 ,  Y10T29/49144 ,  Y10T29/49165 ,  Y10T29/49789

摘要： A direct chip attach module (DCAM) 10, comprises of one or more electronic components 30, electrically bonded to a printed circuit 40, on a substrate 20. The DCAM 10, is bonded to an electronic circuit assembly by connection pads 50, formed on the edge of the DCAM substrate 10. This enables easy visual inspection of solder joints between the DCAM and the assembly. DCAM substrates 10, are initially formed in a panel form 70, and vias 50, are drilled and filled with electrically conductive media 55, at predetermined connection points. The DCAM 10, is then excised from the parent panel 70, and the cut vias provide connection pads 55, along the edge of the substrate 10.

摘要翻译： 直接芯片连接模块（DCAM）10由在基板20上电连接到印刷电路40的一个或多个电子部件30组成.DCAM 10通过连接焊盘50结合到电子电路组件上， DCAM基板10的边缘。这使得能够容易地目视检查DCAM和组件之间的焊点。 DCAM基板10最初以面板形式70形成，并且在预定的连接点处钻出并填充有导电介质55的通孔50。 然后将DCAM 10从母板70切除，并且切割通孔沿着基板10的边缘提供连接焊盘55。