公开(公告)号：US20150362714A1

公开(公告)日：2015-12-17

申请号：US14833252

申请日：2015-08-24

Applicant: OLYMPUS CORPORATION

Inventor： Yasunobu IGA ,  Shintaro TAKAHASHI

IPC: G02B21/00 ,  G02B27/28 ,  G02B23/24 ,  G02B21/06 ,  G01N21/64

CPC classification number: G02B21/0064 ,  A61B1/00172 ,  A61B1/063 ,  G01N21/6402 ,  G01N21/6458 ,  G01N2021/6478 ,  G02B21/002 ,  G02B21/0072 ,  G02B21/0076 ,  G02B21/0084 ,  G02B21/06 ,  G02B23/2453 ,  G02B23/2469 ,  G02B27/283

Abstract: A beam splitter apparatus including demultiplexing portions that split an input pulsed light beam into a plurality of optical paths; relay optical systems that individually relay the pulsed light beams in the plurality of optical paths; a multiplexing portion that multiplexes the plurality of pulsed light beams that have been relayed through the optical paths; and delaying portions and divergence-angle setting portions that respectively give the pulsed light beams, which are individually guided through the plurality of optical paths, relative time delays that are large enough to separate the signal lights and divergence angles that are different from each other.

Abstract translation: 一种分束器装置，包括将输入脉冲光束分成多个光路的解复用部分; 中继光学系统，其分别中继多个光路中的脉冲光束; 复用部分，其多路复用已经通过光路中继的多个脉冲光束; 以及分别给出通过多个光路分别引导的脉冲光束的延迟部分和发散角设定部分，其相对时间延迟足够大以分离彼此不同的信号光和发散角。

公开(公告)号：US20230371817A1

公开(公告)日：2023-11-23

申请号：US17971819

申请日：2022-10-24

Applicant: OLYMPUS CORPORATION

Inventor： Masaru MIZUNAKA ,  Yasunobu IGA ,  Takeshi SUGA ,  Chikashi OTA

IPC: A61B5/00 ,  A61B1/06 ,  A61N5/06 ,  A61B1/045 ,  A61B1/00

CPC classification number: A61B5/0071 ,  A61B1/0646 ,  A61B1/0655 ,  A61N5/0603 ,  A61N5/062 ,  A61B1/045 ,  A61B1/0005

Abstract: An endoscope system according to the present invention includes: an illumination light source that emits illumination light for illuminating an object; a therapeutic light source that emits therapeutic light for causing a photoreactive reagent accumulated in a treatment target site to react; a guide light source that emits guide light having a wavelength shorter than a wavelength band of the therapeutic light source; an imager that captures an optical image, the imager including an optical filter that cuts light in the wavelength band of the therapeutic light and transmits a part of white light, the guide light, and fluorescence emitted by the reagent; a controller that controls emission timings of the illumination light source, the therapeutic light source, and the guide light source; and an image processor that generates an image on the basis of an optical image obtained by light emitted from the illumination light source, the therapeutic light source, and the guide light source, in which the controller causes the image processor to generate an illumination light image based on an optical image acquired during a period in which the illumination light source and the guide light source are ON and to generate a fluorescence image based on a fluorescence image acquired during a period in which the therapeutic light source is ON and the illumination light source and the guide light source are OFF.

公开(公告)号：US20200339939A1

公开(公告)日：2020-10-29

申请号：US16929228

申请日：2020-07-15

Applicant: OLYMPUS CORPORATION

Inventor： Yasunobu IGA ,  Taiji MINE ,  Yoshinobu AKAHORI

IPC: C12M1/34 ,  G02B21/06 ,  G02B21/36 ,  G06T7/00

Abstract: A cell analyzing device includes a control circuit. The control circuit acquires data of an observation image. The control circuit specifies a colony of a cultured cell in the observation image. The control circuit calculates a ratio at which the cultured cell occupies a predetermined range included in the observation image as an occupancy rate. The control circuit calculates a size of the colony. The control circuit determines a state of the cultured cell based on the occupancy rate and the size of the colony.

公开(公告)号：US20200234032A1

公开(公告)日：2020-07-23

申请号：US16835704

申请日：2020-03-31

Applicant: OLYMPUS CORPORATION

Inventor： Taiji MINE ,  Yasunobu IGA ,  Yoshinobu AKAHORI ,  Koji SAKAI ,  Kazunari TOKUDA

IPC: G06K9/00 ,  C12M1/34 ,  G06T7/00

Abstract: A culture information processing device includes: a feature value computing unit that computes growth feature values indicating features of growth characteristics of cells from data acquired in a particular first subculturing process selected from among a plurality of subculturing processes included in a culture period of the cells; a condition setting unit that sets culturing conditions of a second subculturing process one process after the first subculturing process; and an information computing unit that computes, on the basis of the growth feature values computed by the feature value computing unit and the culturing conditions set by the condition setting unit, characteristics-related information related to growth characteristics in the second subculturing process.

公开(公告)号：US20190180080A1

公开(公告)日：2019-06-13

申请号：US16275504

申请日：2019-02-14

Applicant: Olympus Corporation

Inventor： Yasunobu IGA ,  Hitoshi Echigo ,  Akira Matsushita

IPC: G06K9/00 ,  H04N5/225 ,  G01N15/14

Abstract: A cell-state measurement device acquires an image of a culture surface in a vessel formed of an optically transparent material, measures a state of cells being cultured on the culture surface, and includes: a housing including a stage on which the vessel is placed; and an image acquisition unit accommodated in the housing and configured to acquire an image of the cells in the vessel, wherein the image acquisition unit includes: a line sensor including a plurality of light receiving elements linearly arranged; an objective lens disposed between the sensor and the stage; an illuminator illuminating a field of view of the objective lens; and a scanner moving the sensor, wherein the illuminator emits illumination light upward, and wherein the illumination light emitted by the illuminator is reflected downward by the vessel, is transmitted through the culture surface and is incident on the objective lens.

公开(公告)号：US20170313965A1

公开(公告)日：2017-11-02

申请号：US15653967

申请日：2017-07-19

Applicant: OLYMPUS CORPORATION

Inventor： Yasunobu IGA ,  Yohei TANIKAWA ,  Shinichi TAKIMOTO ,  Yoshinobu AKAHORI

IPC: C12M1/34 ,  G01N21/88 ,  G01N21/01

CPC classification number: C12M1/3446 ,  C12M41/46 ,  C12M41/48 ,  G01N21/8851 ,  G01N2021/0143

Abstract: A cell analysis apparatus including: a cell image acquisition unit that acquires an image of cells in a culture vessel in which cells are cultured; a smoothing processing unit that smooths luminance values in the image acquired by the cell image acquisition unit; a minimum-value detecting unit that detects minimum values of the luminance values smoothed by the smoothing processing unit; a smallest-minimum-value extracting unit that extracts smallest minimum values which are the smallest in regions according to the sizes of the cells, from the minimum values detected by the minimum-value detecting unit; a counting unit that counts the number of smallest minimum values extracted by the smallest-minimum-value extracting unit; and a cell-count calculating unit that calculates the number of cells in the culture vessel on the basis of the number of smallest minimum values counted by the counting unit.

公开(公告)号：US20170261732A1

公开(公告)日：2017-09-14

申请号：US15607666

申请日：2017-05-29

Applicant: OLYMPUS CORPORATION

Inventor： Shintaro TAKAHASHI ,  Tadashi HIRATA ,  Yasunobu IGA ,  Shinichi TAKIMOTO ,  Takashi MIYOSHI

IPC: G02B21/06 ,  G02B21/24 ,  C12M1/34 ,  G02B21/36

CPC classification number: G02B21/06 ,  C12M1/34 ,  G02B21/084 ,  G02B21/14 ,  G02B21/24 ,  G02B21/361

Abstract: Provided is an observation apparatus and an observation method with which it is possible to observe imaging subjects, such as cells or the like, without labeling the imaging subjects and without causing an increase in the apparatus size. Provided is an observation apparatus including: a light-source unit that emits illumination light upward from below a sample; and an image-capturing optical system that has an objective lens that collects transmitted light, which is the illumination light emitted from the light-source unit that has passed through the sample by being reflected above the sample and that captures, below the sample, the transmitted light collected by the objective lens.

公开(公告)号：US20170046362A1

公开(公告)日：2017-02-16

申请号：US15246411

申请日：2016-08-24

Applicant: OLYMPUS CORPORATION

Inventor： Yasunobu IGA ,  Yohei TANIKAWA ,  Shinichi TAKIMOTO

IPC: G06F17/30

CPC classification number: G06F16/5866 ,  G06F16/20 ,  G06F16/51 ,  G16B99/00

Abstract: A cell observation information processing system includes: a tag acquiring section that acquires tags, as search tags for searching for observation information acquired in response to an acquisition order at one time point; a storing section that stores into an archive respective sets of the observation information acquired at respective time points upon assigning to them the search tags; a retrieving section that retrieves a list of tags as possible search tags from the archive; and an output section that outputs the list of tags to a display. For retrieving the list of tags, the retrieving section designates a narrowing-down criterion and narrows down tags to the possible search tags using the narrowing-down criterion. The tag acquiring section acquires a tag selected by the user from the list of tags as displayed. This configuration can save operation effort and time of the user taken to acquire tags.

Abstract translation: 小区观测信息处理系统包括：标签获取部，其获取标签，作为用于搜索在一个时间点响应于获取次序获取的观察信息的搜索标签; 存储部，其在向其分配了所述搜索标签的同时，将在各个时间点获取的观察信息的各组中存储; 检索部分，其从归档中检索可能的搜索标签的标签列表; 以及将标签列表输出到显示器的输出部。 为了检索标签列表，检索部分指定缩小标准，并使用缩小标准将标签缩小到可能的搜索标签。 标签获取部分从显示的标签列表中获取用户选择的标签。 该配置可以节省用户获取标签的操作时间和时间。

公开(公告)号：US20160203165A1

公开(公告)日：2016-07-14

申请号：US15079237

申请日：2016-03-24

Applicant: OLYMPUS CORPORATION

Inventor： Yohei TANIKAWA ,  Yasunobu IGA ,  Shinichi TAKIMOTO

IPC: G06F17/30 ,  G06T7/00

CPC classification number: G06F16/5866 ,  G06F16/51 ,  G06F16/9535 ,  G06T7/0012 ,  G06T2207/30024 ,  G16B50/00

Abstract: A cell observation information processing system includes: a storing section that assigns, to each of observation information sets acquired in response to an acquisition order at each time point to carry an observation result containing a cell image and activity data, search tags including an image tag as a main tag and subordinate tags subordinately associated with the image tag, and stores the search-tagged observation information set into an archive; an image selector; a search criterion generator that searches through the archive using the selected image tag, retrieves a matched search-tagged observation information set, and automatically generates a search criterion based on subordinate tags assigned to the search-tagged observation information set having been retrieved; and a retrieving section that searches through the archive using the search criterion and retrieves data containing activity data in observation information sets to which search tags matched with the search criterion have been assigned.

Abstract translation: 小区观测信息处理系统包括：存储部分，其针对每个时间点响应于获取顺序而获取的每个观察信息集，分配包含小区图像和活动数据的观察结果，包括图像标签的搜索标签 作为与图像标签下属关联的主标签和下级标签，并将搜索标记的观察信息集合存储到档案中; 图像选择器 搜索标准生成器，使用所选择的图像标签搜索归档，检索匹配的搜索标记的观察信息集，并且基于分配给已经检索到的检索标签的观察信息集的下级标签自动生成搜索标准; 以及检索部分，其使用搜索标准搜索归档，并且检索包含与分配了搜索标准匹配的搜索标签的观察信息集中的活动数据的数据。