公开(公告)号：US20060003323A1

公开(公告)日：2006-01-05

申请号：US10453372

申请日：2003-06-03

申请人： John Alsobrook ,  Enrique Alvarez ,  David Anderson ,  Ferenc Boldog ,  Stacie Casman ,  Elina Catterton ,  Andrei Chapoval ,  Julie Crabtree-Bokor ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  Erik Gunther ,  Xiaojia (Sasha) Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Li Li ,  Xiaohong Liu ,  John MacDougall ,  Timothy Machlachlan ,  Uriel Malyankar ,  Amanda Mezick ,  Isabelle Millet ,  Vishnu Mishra ,  Muralidhara Padigaru ,  Meera Patturajan ,  Carol Pena ,  John Peyman ,  Debasish Raha ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Paul Sciore ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Corine Vernet ,  Edward Voss ,  Mei Zhong ,  Hiahong Zhong

发明人： John Alsobrook ,  Enrique Alvarez ,  David Anderson ,  Ferenc Boldog ,  Stacie Casman ,  Elina Catterton ,  Andrei Chapoval ,  Julie Crabtree-Bokor ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  Erik Gunther ,  Xiaojia (Sasha) Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Li Li ,  Xiaohong Liu ,  John MacDougall ,  Timothy Machlachlan ,  Uriel Malyankar ,  Amanda Mezick ,  Isabelle Millet ,  Vishnu Mishra ,  Muralidhara Padigaru ,  Meera Patturajan ,  Carol Pena ,  John Peyman ,  Debasish Raha ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Paul Sciore ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Corine Vernet ,  Edward Voss ,  Mei Zhong ,  Hiahong Zhong

IPC分类号： C12Q1/68

CPC分类号： C07K14/47 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US20050053930A1

公开(公告)日：2005-03-10

申请号：US10454246

申请日：2003-06-03

申请人： David Anderson ,  Ferenc Boldog ,  Catherine Burgess ,  Stacie Casman ,  Shlomit Edinger ,  Andrew Eisen ,  Karen Ellerman ,  Valerie Gerlach ,  Linda Gorman ,  Xiaojia Guo ,  Vladimir Gusev ,  Weizhen Ji ,  Li Li ,  John MacDougall ,  Uriel Malyankar ,  Isabelle Millet ,  Tatiana Ort ,  Muralidhara Padigaru ,  Sudhirdas Prayaga ,  Meera Patturajan ,  Carol Pena ,  John Peyman ,  Daniel Rieger ,  Mark Rothenberg ,  Paul Sciore ,  Suresh Shenoy ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Raymond Taupier ,  Velizar Tchernev ,  Corine Vernet ,  Edward Voss ,  Bryan Zerhusen ,  Mei Zhong

发明人： David Anderson ,  Ferenc Boldog ,  Catherine Burgess ,  Stacie Casman ,  Shlomit Edinger ,  Andrew Eisen ,  Karen Ellerman ,  Valerie Gerlach ,  Linda Gorman ,  Xiaojia Guo ,  Vladimir Gusev ,  Weizhen Ji ,  Li Li ,  John MacDougall ,  Uriel Malyankar ,  Isabelle Millet ,  Tatiana Ort ,  Muralidhara Padigaru ,  Sudhirdas Prayaga ,  Meera Patturajan ,  Carol Pena ,  John Peyman ,  Daniel Rieger ,  Mark Rothenberg ,  Paul Sciore ,  Suresh Shenoy ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Raymond Taupier ,  Velizar Tchernev ,  Corine Vernet ,  Edward Voss ,  Bryan Zerhusen ,  Mei Zhong

IPC分类号： A61K38/17 ,  C07H21/04 ,  C07K14/47 ,  C12Q1/68

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及多肽特异性的新型多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US07253266B2

公开(公告)日：2007-08-07

申请号：US10174394

申请日：2002-06-17

申请人： Richard A. Shimkets ,  Michael Jeffers ,  Sudhirdas K. Prayaga ,  Ferenc L. Boldog ,  Meijia Yang ,  Catherine Burgess ,  Elma Fernandes ,  John L. Herrmann ,  William J. LaRochelle ,  Henri Lichenstein ,  Linda Gorman ,  Mei Zhong ,  Muralidhara Padigaru ,  Carol E. A. Pena ,  John P. Alsobrook, II ,  Denise M. Lepley ,  Daniel K. Rieger ,  William Grosse

发明人： Richard A. Shimkets ,  Michael Jeffers ,  Sudhirdas K. Prayaga ,  Ferenc L. Boldog ,  Meijia Yang ,  Catherine Burgess ,  Elma Fernandes ,  John L. Herrmann ,  William J. LaRochelle ,  Henri Lichenstein ,  Linda Gorman ,  Mei Zhong ,  Muralidhara Padigaru ,  Carol E. A. Pena ,  John P. Alsobrook, II ,  Denise M. Lepley ,  Daniel K. Rieger ,  William Grosse

IPC分类号： C07K14/50 ,  A61K38/18 ,  A61K38/00 ,  G01N33/53

CPC分类号： C07K14/50 ,  A61K38/1825 ,  A61K48/00 ,  A61K2039/505 ,  Y10S435/975

摘要： The present invention provides FGF-CX, a novel isolated polypeptide, as well as a polynucleotide encoding FGF-CX and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FGF-CX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as other uses.

摘要翻译： 本发明提供了FGF-CX，一种新的分离的多肽，以及编码FGF-CX的多核苷酸和免疫特异性结合FGF-CX或FGF-CX多肽的任何衍生物，变体，突变体或片段的多核苷酸或 抗体。 本发明另外提供了FGF-CX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

公开(公告)号：US07108972B2

公开(公告)日：2006-09-19

申请号：US10080334

申请日：2002-02-21

申请人： Carol E. A. Pena ,  Richard A. Shimkets ,  Li Li ,  Suresh G. Shenoy ,  Ramesh Kekuda ,  Kimberly A. Spytek ,  Corine A. M. Vernet ,  Uriel M. Malyankar ,  Xiaojia (Sasha) Guo ,  Vladimir Y. Gusev ,  Stacie J. Casman ,  Ferenc L. Boldog ,  Katarzyna Furtak ,  Velizar T. Tchernev ,  Meera Patturajan ,  Esha A. Gangolli ,  Muralidhara Padigaru ,  Xiaohong Liu ,  Jason C. Baumgartner ,  Valerie Gerlach ,  Steven K. Spaderna ,  Bryan D. Zerhusen

发明人： Carol E. A. Pena ,  Richard A. Shimkets ,  Li Li ,  Suresh G. Shenoy ,  Ramesh Kekuda ,  Kimberly A. Spytek ,  Corine A. M. Vernet ,  Uriel M. Malyankar ,  Xiaojia (Sasha) Guo ,  Vladimir Y. Gusev ,  Stacie J. Casman ,  Ferenc L. Boldog ,  Katarzyna Furtak ,  Velizar T. Tchernev ,  Meera Patturajan ,  Esha A. Gangolli ,  Muralidhara Padigaru ,  Xiaohong Liu ,  Jason C. Baumgartner ,  Valerie Gerlach ,  Steven K. Spaderna ,  Bryan D. Zerhusen

IPC分类号： C12Q1/68

CPC分类号： G05B19/408 ,  A61K31/713 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US07034132B2

公开(公告)日：2006-04-25

申请号：US10162335

申请日：2002-06-03

申请人： David W. Anderson ,  Jason C. Baumgartner ,  Ferenc L. Boldog ,  Stacie J. Casman ,  Shlomit R. Edinger ,  Esha A. Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  Xiaojia Guo ,  Tord Hjalt ,  Ramesh Kekuda ,  Li Li ,  John R. MacDougall ,  Uriel M. Malyankar ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  Carol E. A. Pena ,  Luca Rastelli ,  Richard A. Shimkets ,  David J. Stone ,  Kimberly A. Spytek ,  Corine A. M. Vernet ,  Edward Z. Voss ,  Bryan D. Zerhusen

发明人： David W. Anderson ,  Jason C. Baumgartner ,  Ferenc L. Boldog ,  Stacie J. Casman ,  Shlomit R. Edinger ,  Esha A. Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  Xiaojia Guo ,  Tord Hjalt ,  Ramesh Kekuda ,  Li Li ,  John R. MacDougall ,  Uriel M. Malyankar ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  Carol E. A. Pena ,  Luca Rastelli ,  Richard A. Shimkets ,  David J. Stone ,  Kimberly A. Spytek ,  Corine A. M. Vernet ,  Edward Z. Voss ,  Bryan D. Zerhusen

IPC分类号： C07H21/02 ,  C07H21/04

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00

摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US20060084054A1

公开(公告)日：2006-04-20

申请号：US10455772

申请日：2003-06-04

申请人： John Alsobrook ,  David Anderson ,  Jason Baumgartner ,  Constance Berghs ,  Ferenc Boldog ,  Catherine Burgess ,  Stacie Casman ,  Elina Catterton ,  Mohanraj Dhanabal ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  William Grosse ,  Erik Gunther ,  Xiaojia Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Nikolai Khramtsov ,  William LaRochelle ,  Li Li ,  Hongping Liang ,  Kenneth Low ,  John MacDougall ,  Timothy Maclachlan ,  Uriel Malyankar ,  Kelly McQueeney ,  Amanda Mezick ,  Charles Miller ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  John Peyman ,  Xiaozhong Qian ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Sujatha Sukumaran ,  Edward Szekeres ,  Corine Vernet ,  Edward Voss ,  Adam Wolenc ,  Mei Zhong ,  Haihong Zhong

发明人： John Alsobrook ,  David Anderson ,  Jason Baumgartner ,  Constance Berghs ,  Ferenc Boldog ,  Catherine Burgess ,  Stacie Casman ,  Elina Catterton ,  Mohanraj Dhanabal ,  Shlomit Edinger ,  Karen Ellerman ,  Seth Ettenberg ,  Esha Gangolli ,  Valerie Gerlach ,  Linda Gorman ,  William Grosse ,  Erik Gunther ,  Xiaojia Guo ,  Vladimir Gusev ,  John Herrmann ,  Weizhen Ji ,  Ramesh Kekuda ,  Nikolai Khramtsov ,  William LaRochelle ,  Li Li ,  Hongping Liang ,  Kenneth Low ,  John MacDougall ,  Timothy Maclachlan ,  Uriel Malyankar ,  Kelly McQueeney ,  Amanda Mezick ,  Charles Miller ,  Isabelle Millet ,  Muralidhara Padigaru ,  Meera Patturajan ,  John Peyman ,  Xiaozhong Qian ,  Luca Rastelli ,  Daniel Rieger ,  Mark Rothenberg ,  Suresh Shenoy ,  Richard Shimkets ,  Glennda Smithson ,  Kimberly Spytek ,  David Stone ,  Sujatha Sukumaran ,  Edward Szekeres ,  Corine Vernet ,  Edward Voss ,  Adam Wolenc ,  Mei Zhong ,  Haihong Zhong

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N9/00

CPC分类号： C07K16/40 ,  C07K14/47

摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

摘要翻译： 本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。 公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US06903201B2

公开(公告)日：2005-06-07

申请号：US10037417

申请日：2002-01-04

申请人： Muralidhara Padigaru

发明人： Muralidhara Padigaru

IPC分类号： C07K14/47 ,  C12N15/12

CPC分类号： C07K14/47

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US20140142159A1

公开(公告)日：2014-05-22

申请号：US14127675

申请日：2012-06-22

申请人： Swati Ajay Piramal ,  Muralidhara Padigaru ,  Veena R Agarwal ,  Gandhali Ashwin Deshpande

发明人： Swati Ajay Piramal ,  Muralidhara Padigaru ,  Veena R Agarwal ,  Gandhali Ashwin Deshpande

IPC分类号： C07D405/04

CPC分类号： A61K31/4025 ,  A61K45/06 ,  C07D405/04

摘要： The present invention relates to the pyrrolidine substituted with flavone derivatives, represented by the compounds of Formula (I) or a pharmaceutically acceptable salt, a solvate, a stereoisomer or a diastereoisomer thereof for use in the treatment of cancers associated with human papillomavirus. The present invention also relates to the pharmaceutical compositions containing the compounds of Formula (I) for the treatment of cancers associated with human papillomavirus.

摘要翻译： 本发明涉及用由治疗与人乳头状瘤病毒相关的癌症的式（I）化合物或其药学上可接受的盐，溶剂合物，立体异构体或非对映异构体代表的黄酮衍生物取代的吡咯烷。 本发明还涉及含有用于治疗与人乳头状瘤病毒相关的癌症的式（I）化合物的药物组合物。

公开(公告)号：US20060014153A1

公开(公告)日：2006-01-19

申请号：US10877346

申请日：2004-06-25

申请人： Valerie Gerlach ,  John MacDougall ,  Glennda Smithson ,  Isabelle Millet ,  David Stone ,  Erik Gunther ,  Karen Ellerman ,  William Grosse ,  John Alsobrook ,  Denise Lepley ,  Catherine Burgess ,  Muralidhara Padigaru ,  Ramesha Kekuda ,  Kimberly Spytek ,  Martin Leach ,  Richard Shimkets

发明人： Valerie Gerlach ,  John MacDougall ,  Glennda Smithson ,  Isabelle Millet ,  David Stone ,  Erik Gunther ,  Karen Ellerman ,  William Grosse ,  John Alsobrook ,  Denise Lepley ,  Catherine Burgess ,  Muralidhara Padigaru ,  Ramesha Kekuda ,  Kimberly Spytek ,  Martin Leach ,  Richard Shimkets

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/00

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US20050208514A1

公开(公告)日：2005-09-22

申请号：US10980659

申请日：2004-11-03

申请人： John Alsobrook ,  Ferenc Boldog ,  Michael Jeffers ,  William LaRochelle ,  Denise Lepley ,  Henri Lichenstein ,  Richard Shimkets ,  Meijia Yang ,  Marie Ruiz-Martinez ,  Galina Chernaya ,  Muralidhara Padigaru ,  Sudhirdas Prayaga ,  Mei Zhong

发明人： John Alsobrook ,  Ferenc Boldog ,  Michael Jeffers ,  William LaRochelle ,  Denise Lepley ,  Henri Lichenstein ,  Richard Shimkets ,  Meijia Yang ,  Marie Ruiz-Martinez ,  Galina Chernaya ,  Muralidhara Padigaru ,  Sudhirdas Prayaga ,  Mei Zhong

IPC分类号： A61K38/00 ,  A61K38/18 ,  C07K14/50 ,  C12Q1/68

CPC分类号： C07K14/50 ,  A61K38/00

摘要： The present invention generally relates to nucleic acids, proteins, and antibodies. The invention relates more particularly to nucleic acid molecules, proteins, and antibodies of Fibroblast Growth Factor-20 (FGF-20), or its fragments, derivatives, variants, homologs, analogs, or a combination thereof.

摘要翻译： 本发明一般涉及核酸，蛋白质和抗体。 本发明更具体涉及成纤维细胞生长因子-20（FGF-20）或其片段，衍生物，变体，同系物，类似物或其组合的核酸分子，蛋白质和抗体。