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公开(公告)号：US08623397B2
公开(公告)日：2014-01-07
申请号：US12101993
申请日：2008-04-13
Applicant: Peter X. Ma , Xiaohua Liu , Laurie McCauley
Inventor： Peter X. Ma , Xiaohua Liu , Laurie McCauley
CPC classification number: A61K9/0024 , A61K9/0092 , A61K9/2072 , A61K9/209 , A61K9/2095 , A61K31/7052 , A61K38/29 , B33Y80/00
Abstract: A delivery device includes a hollow container, and a plurality of biodegradable and/or erodible polymeric layers established in the container. A layer including a predetermined substance is established between each of the plurality of polymeric layers, whereby degradation of the polymeric layer and release of the predetermined substance occur intermittently. Methods for forming the device are also disclosed herein.
Abstract translation: 输送装置包括中空容器和建立在容器中的多个可生物降解和/或可侵蚀的聚合物层。 在多个聚合物层之间建立包含预定物质的层，由此聚合物层的降解和预定物质的释放间歇地发生。 本文还公开了形成装置的方法。
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公开(公告)号：US08568769B2
公开(公告)日：2013-10-29
申请号：US13564874
申请日：2012-08-02
Applicant: Peter X. Ma , Guobao Wei
Inventor： Peter X. Ma , Guobao Wei
IPC: A61K9/70
CPC classification number: A61K9/0024 , A61K9/1647 , A61K9/1652 , A61K9/1658 , A61K9/1694 , A61K9/5153 , A61K9/5161 , A61K9/5169 , A61K9/70 , A61K48/0008 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/258 , A61L2300/43 , A61L2300/602 , A61L2300/622 , A61L2300/624
Abstract: Porous materials and methods for forming them are disclosed. One method for immobilizing micro-particles and/or nano-particles onto internal pore surfaces and/or external pore surfaces of porous materials includes suspending the micro-particles and/or nano-particles in a liquid adapted to swell, soften, and/or deform either the porous materials and/or the particles, thereby forming a liquid-particle suspension. The method further includes adding the suspension to the porous materials; and removing the liquid, thereby forming the porous materials having the micro-particles and/or nano-particles immobilized on the internal pore surfaces and/or the external pore surfaces.
Abstract translation: 公开了用于形成它们的多孔材料和方法。 将微粒和/或纳米颗粒固定在多孔材料的内孔表面和/或外孔表面上的一种方法包括将微粒和/或纳米颗粒悬浮在适于膨胀，软化和/或 使多孔材料和/或颗粒变形，从而形成液体 - 颗粒悬浮液。 该方法还包括将悬浮液加入到多孔材料中; 并除去液体，由此形成具有固定在内孔表面和/或外孔表面上的微粒和/或纳米颗粒的多孔材料。
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公开(公告)号：US07993738B2
公开(公告)日：2011-08-09
申请号：US12020488
申请日：2008-01-25
Applicant: Peter X. Ma , Xiaohua Liu
Inventor： Peter X. Ma , Xiaohua Liu
CPC classification number: C08J9/36 , Y10T428/249953 , Y10T428/249957 , Y10T428/249965 , Y10T428/249975 , Y10T428/249978 , Y10T428/249979 , Y10T428/249986 , Y10T428/24999
Abstract: Modified porous materials are disclosed having interconnected, complexly shaped three-dimensional surfaces. The modification is accomplished by crosslinking the three-dimensional surfaces or by incorporating, in situ, an inorganic material onto or into three-dimensional surfaces. The porous materials are macro structures including at least one of nano-features, micro-features, and combinations thereof. The modifying accomplishes changing surface properties of the porous materials, changing the three-dimensional surfaces, and/or rendering the porous materials substantially stable in a predetermined environment.
Abstract translation: 公开了具有互连的，复杂形状的三维表面的改性多孔材料。 该改性是通过将三维表面交联或通过将无机材料原位并入三维表面而实现的。 多孔材料是包括纳米特征，微特征及其组合中的至少一个的宏观结构。 修饰完成了改变多孔材料的表面性质，改变三维表面和/或使多孔材料在预定环境中基本稳定。
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公开(公告)号：US06867240B2
公开(公告)日：2005-03-15
申请号：US09939838
申请日：2001-08-27
Applicant: Peter X. Ma , Ruiyun Zhang
Inventor： Peter X. Ma , Ruiyun Zhang
CPC classification number: C08J9/28 , C08J2201/0482 , C08J2201/0484 , C08J2367/00 , C12N5/0068 , C12N2533/12 , C12N2533/18 , C12N2533/30 , C12N2533/40 , G01N15/14
Abstract: Methods and compositions are described that provide three dimensional porous matrices as structural templates for cells. The porous matrices of the present invention have desirable mechanical properties suitable to a variety of applications, including platforms for in vitro cell cultivation, implants for tissue and organ engineering, and materials suitable for chromatography and filtration.
Abstract translation: 描述了提供三维多孔基质作为细胞结构模板的方法和组合物。 本发明的多孔基质具有适合于各种应用的理想的机械性能，包括用于体外细胞培养的平台，用于组织和器官工程的植入物，以及适用于色谱和过滤的材料。
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公开(公告)号：US08445588B2
公开(公告)日：2013-05-21
申请号：US12543381
申请日：2009-08-18
Applicant: Peter X. Ma , Jianxiang Zhang
Inventor： Peter X. Ma , Jianxiang Zhang
IPC: C08B31/00
CPC classification number: C08B37/0012 , A61K47/60 , A61K47/6951 , B82Y5/00
Abstract: A water soluble copolymer includes first and second hydrophilic block segments or graft chains. The first hydrophilic block segment or graft chain contains cyclodextrin groups in at least a majority of its repeating units, and the second hydrophilic block segment or graft chain contains repeating units other than cyclodextrin groups. The first and second block segments or graft chains are covalently linked.
Abstract translation: 水溶性共聚物包括第一和第二亲水嵌段链段或接枝链。 第一亲水性嵌段段或接枝链在其至少大部分重复单元中含有环糊精基团，第二亲水嵌段段或接枝链含有除环糊精基团以外的重复单元。 第一和第二块段或接枝链共价连接。
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Patent Agency Ranking
公开(公告)号：US08268344B2
公开(公告)日：2012-09-18
申请号：US11410480
申请日：2006-04-25
Applicant: Peter X. Ma , Guobao Wei
Inventor： Peter X. Ma , Guobao Wei
IPC: A61K9/70
CPC classification number: A61K9/0024 , A61K9/1647 , A61K9/1652 , A61K9/1658 , A61K9/1694 , A61K9/5153 , A61K9/5161 , A61K9/5169 , A61K9/70 , A61K48/0008 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/258 , A61L2300/43 , A61L2300/602 , A61L2300/622 , A61L2300/624
Abstract: Porous materials and methods for forming them are disclosed. One method for immobilizing micro-particles and/or nano-particles onto internal pore surfaces and/or external pore surfaces of porous materials includes suspending the micro-particles and/or nano-particles in a liquid adapted to swell, soften, and/or deform either the porous materials and/or the particles, thereby forming a liquid-particle suspension. The method further includes adding the suspension to the porous materials; and removing the liquid, thereby forming the porous materials having the micro-particles and/or nano-particles immobilized on the internal pore surfaces and/or the external pore surfaces.
Abstract translation: 公开了用于形成它们的多孔材料和方法。 将微粒和/或纳米颗粒固定在多孔材料的内孔表面和/或外孔表面上的一种方法包括将微粒和/或纳米颗粒悬浮在适于膨胀，软化和/或 使多孔材料和/或颗粒变形，从而形成液体 - 颗粒悬浮液。 该方法还包括将悬浮液加入到多孔材料中; 并除去液体，从而形成具有固定在内孔表面和/或外孔表面上的微粒和/或纳米颗粒的多孔材料。
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公开(公告)号：US20080317816A1
公开(公告)日：2008-12-25
申请号：US11972531
申请日：2008-01-10
Applicant: Peter X. Ma , Guobao Wei , William V. Giannobile , Qiming Jin
Inventor： Peter X. Ma , Guobao Wei , William V. Giannobile , Qiming Jin
CPC classification number: A61L31/16 , A61K9/14 , A61K9/146 , A61K38/1816 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/1858 , A61K38/1875 , A61K38/1891 , A61K38/191 , A61K38/2053 , A61K38/206 , A61L27/18 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/426 , A61L2300/602 , A61L2300/622 , A61L2300/624 , A61L2400/12 , C08L67/04
Abstract: A porous object includes a porous material having internal pore surfaces and external pore surfaces. Releasing material encapsulated biomolecules are immobilized on at least one of the internal pore surfaces, at least one of the external pore surfaces, or combinations thereof.
Abstract translation: 多孔物体包括具有内孔表面和外孔表面的多孔材料。 释放材料包封的生物分子被固定在至少一个内孔表面，至少一个外孔表面或其组合上。
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公开(公告)号：US20080254095A1
公开(公告)日：2008-10-16
申请号：US12101993
申请日：2008-04-13
Applicant: Peter X. Ma , Xiaohua Liu , Laurie McCauley
Inventor： Peter X. Ma , Xiaohua Liu , Laurie McCauley
IPC: A61F2/02 , A61K39/00 , A61K38/02 , A61K31/7052 , B29C33/40
CPC classification number: A61K9/0024 , A61K9/0092 , A61K9/2072 , A61K9/209 , A61K9/2095 , A61K31/7052 , A61K38/29 , B33Y80/00
Abstract: A delivery device includes a hollow container, and a plurality of biodegradable and/or erodible polymeric layers established in the container. A layer including a predetermined substance is established between each of the plurality of polymeric layers, whereby degradation of the polymeric layer and release of the predetermined substance occur intermittently. Methods for forming the device are also disclosed herein.
Abstract translation: 输送装置包括中空容器和建立在容器中的多个可生物降解和/或可侵蚀的聚合物层。 在多个聚合物层中的每一个之间建立包含预定物质的层，由此聚合物层的降解和预定物质的释放间歇地发生。 本文还公开了形成装置的方法。
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公开(公告)号：US07323208B2
公开(公告)日：2008-01-29
申请号：US10999459
申请日：2004-11-30
Applicant: Peter X. Ma , Xiaohua Liu
Inventor： Peter X. Ma , Xiaohua Liu
IPC: B05D5/00
CPC classification number: C08J9/36 , Y10T428/249967 , Y10T428/249991 , Y10T428/249992 , Y10T428/249993
Abstract: Modified porous materials are disclosed having interconnected, complexly shaped three-dimensional surfaces. The modification is accomplished by crosslinking the three-dimensional surfaces and/or by coating the three-dimensional surfaces with a layer of a predetermined material. The porous materials are macro structures including at least one of nano-features, micro-features, and combinations thereof. The modifying accomplishes changing surface properties of the porous materials, changing the three-dimensional surfaces, and/or rendering the porous materials substantially stable in a predetermined environment.
Abstract translation: 公开了具有互连的，复杂形状的三维表面的改性多孔材料。 通过使三维表面交联和/或通过用预定材料层涂覆三维表面来实现改性。 多孔材料是包括纳米特征，微特征及其组合中的至少一个的宏观结构。 修饰完成了改变多孔材料的表面性质，改变三维表面和/或使多孔材料在预定环境中基本稳定。
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公开(公告)号：US09187594B2
公开(公告)日：2015-11-17
申请号：US13576731
申请日：2011-02-09
Applicant: Peter X. Ma , Xiaohua Liu
Inventor： Peter X. Ma , Xiaohua Liu
IPC: C08G69/48 , B32B5/16 , A61K9/127 , B82Y40/00 , C08G63/08 , C08G73/02 , C08J3/12 , C08J9/00 , C08J9/28
CPC classification number: C08G63/08 , C08G73/028 , C08J3/12 , C08J9/0071 , C08J9/283 , C08J2377/00 , Y10T428/2982
Abstract: Nano-fibrous microspheres and methods for forming them are disclosed herein. In one embodiment the microsphere includes a plurality of nano-fibers aggregated together in a spherical shape; and a plurality of pores formed between at least some of the plurality of nano-fibers. The nano-fibers are formed of star-shaped polymers.
Abstract translation: 本文公开纳米纤维微球及其形成方法。 在一个实施方案中，微球包括以球形聚集在一起的多个纳米纤维; 以及在所述多个纳米纤维中的至少一些之间形成的多个孔。 纳米纤维由星形聚合物形成。
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