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11.发明授权Production of recombinant proteins by autoproteolytic cleavage of a fusion protein 有权通过自身蛋白水解切割融合蛋白来生产重组蛋白公开(公告)号：US08163890B2
公开(公告)日：2012-04-24
申请号：US11919257
申请日：2006-04-25
摘要： Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprising the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically inactive form by an affinity chromatography system, b) refolding of the fusion polypeptide, thereby activating the autoproteolytic function of the fusion polypeptide and causing cleavage of the heterologous polypeptide of interest, and c) subsequently eluting the heterologous polypeptide of interest, wherein said steps are conducted on one affinity chromatography system.
摘要翻译： 公开了使用包含感兴趣的多肽的融合多肽和N末端具有表达自身蛋白水解功能的多肽来产生具有均质N末端的异源多肽的方法，所述方法包括以下步骤：a） 通过亲和层析系统以可溶性，自动蛋白水解无活性形式的融合多肽，b）融合多肽的折叠，从而激活融合多肽的自体蛋白水解功能，并导致感兴趣的异源多肽切割，以及c）随后将异源 多肽，其中所述步骤在一个亲和层析系统上进行。
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公开(公告)号：US20050074610A1
公开(公告)日：2005-04-07
申请号：US10941650
申请日：2004-09-15
申请人： Michael Kroll , Gunther Michael , Rainer Hahn , Stipan Katusic , Stefan Heberer , Ralph Brandes
发明人： Michael Kroll , Gunther Michael , Rainer Hahn , Stipan Katusic , Stefan Heberer , Ralph Brandes
CPC分类号： C09K3/1463 , B82Y30/00 , C01F17/0043 , C01P2002/60 , C01P2004/52 , C01P2004/62 , C01P2004/64 , C01P2006/11 , C01P2006/12 , C01P2006/80 , C09G1/02 , C09K3/1409 , Y10T428/2982
摘要： A dispersion of pyrogenically produced cerium oxide, which does not contain any particles larger than 1 μm, is produced by dispersing a pyrogenically produced cerium oxide in water by means of a dissolver, centrifuging it, separating the supernatant from the bottom product, and again dispersing the supernatant by means of ultrasound. The dispersion can be used for chemical-mechanical polishing (CMP).
摘要翻译： 不含任何大于1um的颗粒的热解产生的氧化铈的分散体是通过将热解产生的氧化铈通过溶解器分散在水中而制备的，将其离心，将上清液与底部产物分离，并再次分散 上清液通过超声波。 该分散体可用于化学机械抛光（CMP）。
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公开(公告)号：US06394802B1
公开(公告)日：2002-05-28
申请号：US09142484
申请日：2000-02-23
申请人： Rainer Hahn
发明人： Rainer Hahn
IPC分类号： A61Z900
CPC分类号： A61C9/0006
摘要： A tray for producing impressions of dental arches includes a peripheral edge wall that forms a sealing point with soft tissue in the patient's mouth. The interior of the tray is connected via a plurality of vacuum connection pieces to a suction arrangement. Disposed in an impression space provided by the tray is an impression material distributor tube that conveys impression material, preferably to the rear impression space. The distributor tube is connected to an impression material source.
摘要翻译： 用于产生牙弓印模的托盘包括周边边缘壁，其与患者口腔中的软组织形成密封点。 托盘的内部经由多个真空连接件连接到抽吸装置。 设置在由托盘提供的印模空间中的是压印材料分配器管，其传送印模材料，优选地传送到后印模空间。 分配器管连接到印模材料源。
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14.发明授权Material and implement for cleaning the surfaces of teeth and denture materials 失效用于清洁牙齿和义齿材料表面的材料和器具
公开(公告)号：US5953783A
公开(公告)日：1999-09-21
申请号：US849028
申请日：1997-06-25
申请人： Rainer Hahn
发明人： Rainer Hahn
CPC分类号： A46D1/00 , A46B9/04 , A46B2200/1066
摘要： A tooth cleaning apparatus has a working surface formed by fibrous cleaning elements of different lengths and of very small diameters at their working ends. The cleaning elements are fixed on a base fabric, which is reinforced by a foam layer and thus forms a deformable hollow unit that is then attached to a handle. The pile-like cleaning elements facilitate very effective cleaning even of the fine surface contours of curved tooth surfaces.
摘要翻译： PCT No.PCT / EP95 / 04676 Sec。 371日期：1997年6月25日 102（e）日期1997年6月25日PCT提交1995年11月28日PCT公布。 公开号WO96 / 16573 日期1996年6月6日牙齿清洁装置具有由工作端不同长度和非常小直径的纤维清洁元件形成的工作表面。 清洁元件固定在基底织物上，基底织物被泡沫层增强，从而形成可变形的中空单元，然后将其附接到手柄上。 桩状清洁元件有助于非常有效地清洁即使曲面齿表面的精细表面轮廓。
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公开(公告)号：US5775911A
公开(公告)日：1998-07-07
申请号：US589126
申请日：1996-01-22
申请人： Rainer Hahn
发明人： Rainer Hahn
CPC分类号： A61C13/0016 , A61C13/0003 , A61C13/0022
摘要： A shaped article, specifically an artificial tooth, is made of two parts. individually shaped first part 18, specifically the head part or superstructure of the artificial tooth, has a standardized locking portion 26 for engagement with a standardized counter-locking portion 24 provided on a pre-fabricated second part 16, specifically the shaft part of the tooth to be implanted in a patient's jaw. The individually shaped part 18 is manufactured by using a pre-fabricated sonotrode 38 for producing the configuration of the locking portion 26 and one or more individually produced shaping sonotrodes 44 are used for generating the parts of the surface other than the locking portion 26. This permits the individually shaped part to be produced in an economic way yet with high precision of the locking portion.
摘要翻译： 成形制品，特别是人造牙齿由两部分组成。 独立成形的第一部分18，特别是人造牙齿的头部或上部结构具有标准化的锁定部分26，用于与设置在预制的第二部分16上的标准化的反向锁定部分24接合，具体地说， 将牙齿植入患者的下巴。 通过使用用于产生锁定部分26的构造的预制超声波发生器38来制造单独成形部件18，并且使用一个或多个单独制造的成型超声焊丝44来产生除了锁定部分26之外的表面的部分。 允许单独成形的部件以经济的方式生产，同时具有高锁定部分的精度。
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公开(公告)号：US5709823A
公开(公告)日：1998-01-20
申请号：US714365
申请日：1996-09-16
申请人： Rainer Hahn
发明人： Rainer Hahn
CPC分类号： A61C13/0016 , A61C13/0003 , B28D1/30 , B28D5/047
摘要： A dental restoration part is produced from a ceramic material by a method ultrasonic working. The method includes forming a negative mold from a master sonotrode, forming a pre-working sonotrode from the negative mold, and ultrasonically working a workpiece using the pre-working sonotrode. The master sonotrode is then used to ultrasonically work the workpiece to form the dental restoration part.
摘要翻译： 通过超声波加工的方法由陶瓷材料制成牙齿修复部。 该方法包括从主超声波发生器形成负模具，从负模具形成预加工超声波发生器，并使用预加工超声波超声波加工工件。 然后使用主超声波发生器超声波加工工件以形成牙齿修复部分。
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17.发明授权Process and device for manufacturing a structural part, especially of a ceramic tooth restoration, and a process of making sonotrode crowns 失效用于制造结构部件的方法和装置，特别是陶瓷牙齿修复体的制造和制造方法以及制造超声波冠的方法
公开(公告)号：US5490810A
公开(公告)日：1996-02-13
申请号：US126208
申请日：1993-09-24
申请人： Rainer Hahn , Bernd Burger
发明人： Rainer Hahn , Bernd Burger
CPC分类号： A61C13/0016 , A61C5/10 , B24B1/04 , B28D1/30 , B28D5/047
摘要： In a process and apparatus for the overall machining of a ceramic tooth restoration and producing of appropriate sonotrode crowns, these sonotrode crowns act on a workpiece one after the other, however from the same direction in space and are activated by the same ultrasonic transmitter. For the production of said sonotrode crowns, a geometrical model corresponding to the ultrasonic machining apparatus is used.
摘要翻译： 在用于整体加工陶瓷牙齿修复体并生产适当的超声波冠的方法和装置中，这些超声波冠冠随机地沿着相同的方向作用在工件上并由相同的超声波发射器激活。 为了生产所述超声波冠，使用对应于超声波加工装置的几何模型。
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公开(公告)号：US4427635A
公开(公告)日：1984-01-24
申请号：US318912
申请日：1981-11-06
申请人： Rainer Hahn
发明人： Rainer Hahn
CPC分类号： A62B21/00
摘要： A chemical oxygen generator is disclosed which includes a pressure vessel surrounding the container containing the chemical. In a space between the tank containing the chemical and the wall of the pressure vessel, a supply of pressurized oxygen is provided. A manually triggerable valve stem is operable to simultaneously open a passage from the pressurized supply and to initiate ignition of the chemical in the tank to generate a further supply of oxygen.
摘要翻译： 公开了一种化学氧气发生器，其包括围绕容纳化学品的容器的压力容器。 在包含化学品的罐和压力容器的壁之间的空间中，提供加压氧气供应。 可手动触发的阀杆可操作以同时打开来自加压供应的通道并且引发化学品在罐中的点燃以产生进一步的氧气供应。
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19.发明授权Production of recombinant proteins by autoproteolytic cleavage of a fusion protein 有权通过自身蛋白水解切割融合蛋白来生产重组蛋白公开(公告)号：US08372959B2
公开(公告)日：2013-02-12
申请号：US13348607
申请日：2012-01-11
摘要： Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprises the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically inactive form by an affinity chromatography system, b) refolding of the fusion polypeptide, thereby activating the autoproteolytic function of the fusion polypeptide and causing cleavage of the heterologous polypeptide of interest, and c) subsequently eluting the heterologous polypeptide of interest, wherein the steps are conducted on one affinity chromatography system.
摘要翻译： 公开了使用包含感兴趣的多肽的融合多肽和N末端具有表达自身蛋白水解功能的多肽来产生具有均质N末端的异源多肽的方法，所述方法包括以下步骤：a） 通过亲和层析系统以可溶性，自动蛋白水解无活性形式的融合多肽，b）融合多肽的折叠，从而激活融合多肽的自体蛋白水解功能，并导致感兴趣的异源多肽切割，以及c）随后将异源 多肽，其中所述步骤在一个亲和层析系统上进行。
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公开(公告)号：US20120107869A1
公开(公告)日：2012-05-03
申请号：US13348607
申请日：2012-01-11
摘要： Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprising the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically inactive form by an affinity chromatography system, b) refolding of the fusion polypeptide, thereby activating the autoproteolytic function of the fusion polypeptide and causing cleavage of the heterologous polypeptide of interest, and c) subsequently eluting the heterologous polypeptide of interest, wherein said steps are conducted on one affinity chromatography system.
摘要翻译： 公开了使用包含感兴趣的多肽的融合多肽和N末端具有表达自身蛋白水解功能的多肽来产生具有均质N末端的异源多肽的方法，所述方法包括以下步骤：a） 通过亲和层析系统以可溶性，自动蛋白水解无活性形式的融合多肽，b）融合多肽的折叠，从而激活融合多肽的自体蛋白水解功能，并导致感兴趣的异源多肽切割，以及c）随后将异源 多肽，其中所述步骤在一个亲和层析系统上进行。
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