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96 条记录 (耗时 0.055 秒)

    Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom
    11.
    发明授权
    Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom 失效
    被含有一个氮原子的五，六或七元杂环取代的咪唑烷基

    公开(公告)号：US6100279A

    公开(公告)日：2000-08-08

    申请号：US185973

    申请日：1998-11-05

    申请人： Wayne D. Vaccaro ,  Ronald L. Wolin ,  Daniel M. Solomon ,  Robert G. Aslanian ,  John J. Piwinski ,  Stuart B. Rosenblum

    发明人： Wayne D. Vaccaro ,  Ronald L. Wolin ,  Daniel M. Solomon ,  Robert G. Aslanian ,  John J. Piwinski ,  Stuart B. Rosenblum

    IPC分类号： A61K31/415 ,  A61K31/445 ,  A61K31/495 ,  A61K45/06 ,  C07D401/06 ,  C07D403/06

    CPC分类号： C07D401/06 ,  A61K31/415 ,  A61K31/445 ,  A61K31/495 ,  A61K45/06 ,  C07D403/06

    摘要： Disclosed are compounds of Formula I ##STR1## or pharmaceutically acceptable salts or solvates thereof. Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier and an effective amount of a Compound of Formula I. Further disclosed is a method of treating allergy (for example asthma), inflammation, hypotension, raised intraocular pressure (such as glaucoma)--i.e., a method of lowering intraocular pressure, sleeping disorders, states of hyper and hypo motility and acidic secretion of the gastrointestinal tract, hypo and hyperactivity of the central nervous system (for example, agitation and depression) and other CNS disorders (such as Alzheimer's, schizophrenia, obesity and migraine) comprising administering an effective amount of a compound of Formula I to a patient in need of such treatment. Also disclosed are methods for treatment of upper airway allergic responses comprising administering a compound, or salt or solvate thereof, of formula I in combination or admixture with a histamine H, receptor antagonist.

    摘要翻译： 公开了式I的化合物或其药学上可接受的盐或溶剂化物。 还公开了包含药学上可接受的载体和有效量的式I化合物的药物组合物。还公开了治疗过敏（例如哮喘），炎症，低血压，升高的眼内压（如青光眼）的方法， 降低眼内压，睡眠障碍，超低运动状态和胃肠道酸性分泌的方法，中枢神经系统的低血压和多动症（例如，激动和抑郁）和其他CNS疾病（例如阿兹海默氏症，精神分裂症 ，肥胖症和偏头痛）包括向需要这种治疗的患者施用有效量的式I化合物。 还公开了治疗上呼吸道过敏反应的方法，包括与组胺H受体拮抗剂组合或混合施用式I化合物或其盐或溶剂合物。

    Gamma secretase modulators
    15.
    发明授权
    Gamma secretase modulators 有权
    伽玛分泌酶调节剂

    公开(公告)号：US08426595B2

    公开(公告)日：2013-04-23

    申请号：US12747011

    申请日：2008-12-09

    申请人： Xianhai Huang ,  Anandan Palani ,  Robert G. Aslanian

    发明人： Xianhai Huang ,  Anandan Palani ,  Robert G. Aslanian

    IPC分类号： C07D498/02 ,  A61K31/44

    CPC分类号： C07D487/04 ,  C07D471/04

    摘要： This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula [Chemical formula should be inserted here as it appears on abstract in electronic form.] Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).

    摘要翻译： 本发明提供了作为γ分泌酶调节剂的新型化合物。 化合物具有式[化学式应该插入在此，其以电子形式的摘要出现。]还公开了使用式（I）化合物调节γ-分泌酶活性的方法和治疗阿尔茨海默氏病的方法。