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37 条记录 (耗时 0.019 秒)

    Process for producing trans-L-hydroxyproline
    11.
    发明授权
    Process for producing trans-L-hydroxyproline 失效
    生产反式-L-羟脯氨酸的方法

    公开(公告)号：US5364775A

    公开(公告)日：1994-11-15

    申请号：US972824

    申请日：1992-11-06

    申请人： Ryoichi Katsumata ,  Takashi Ohshiro ,  Haruhiko Yokoi ,  Michio Shiomi

    发明人： Ryoichi Katsumata ,  Takashi Ohshiro ,  Haruhiko Yokoi ,  Michio Shiomi

    IPC分类号： C12P13/04 ,  C12P13/24 ,  C12R1/01 ,  C12R1/37

    CPC分类号： C12P13/24 ,  C12P13/04 ,  Y10S435/822 ,  Y10S435/873

    摘要： The present invention provides a process for producing trans-L-hydroxyproline, which comprises culturing a microorganism which is capable of decomposing amino acids other than trans-L-hydroxyproline but which is substantially incapable of decomposing trans-L-hydroxyproline in a culture medium containing collagen hydrolyzate, and recovering trans-L-hydroxyproline from the resulting culture.The process enhances the content of trans-L-hydroxyproline based on the total weight of amino acids contained in collagen hydrolyzate, and enables efficient production of trans-L-hydroxyproline which is useful as a starting material for the synthesis of medicines.

    摘要翻译： 本发明提供了生产反式-L-羟基脯氨酸的方法，该方法包括培养能够分解反式-L-羟基脯氨酸以外的氨基酸但基本上不能分解反式-L-羟脯氨酸的微生物，该培养基含有 胶原水解产物，并从所得培养物中回收反式-L-羟脯氨酸。 该方法基于胶原蛋白水解产物中所含的氨基酸的总重量，提高了反式-L-羟脯氨酸的含量，能有效地制备可用作药物合成起始原料的反式-L-羟脯氨酸。

    Process for producing L-tryptophan by a Corynebacterium strain having decreased phosphoenolpyruvate carboxylase activity
    14.
    发明授权
    Process for producing L-tryptophan by a Corynebacterium strain having decreased phosphoenolpyruvate carboxylase activity 失效
    通过具有降低的磷酸烯醇丙酮酸羧化酶活性的棒状杆菌菌株产生L-色氨酸的方法

    公开(公告)号：US5484716A

    公开(公告)日：1996-01-16

    申请号：US130995

    申请日：1993-10-04

    申请人： Ryoichi Katsumata ,  Kuniki Kino

    发明人： Ryoichi Katsumata ,  Kuniki Kino

    IPC分类号： C12P13/22 ,  C12R1/13 ,  C12R1/15

    CPC分类号： C12P13/22 ,  Y10S435/84 ,  Y10S435/843

    摘要： The invention relates to a bacterial process for producing L-tryptophan, L-tyrosine or L-phenylalanine. The process utilizes a coryneform glutamic acid-producing bacterium being capable of producing L-tryptophan, L-tyrosine or L-phenylalanine and also decreased or lacked in phosphoenolpyruvate carboxylase activity. The mutant strain is then cultured in order to accumulate the amino acid in a medium and the amino acid is recovered therefrom.

    摘要翻译： 本发明涉及生产L-色氨酸，L-酪氨酸或L-苯丙氨酸的细菌方法。 该方法利用产生L-色氨酸，L-酪氨酸或L-苯丙氨酸的棒状谷氨酸生产细菌，并且还降低或缺乏磷酸烯醇丙酮酸羧化酶活性。 然后培养突变菌株以将氨基酸在培养基中积累，并从中回收氨基酸。

    Process for producing 4-hydroxy-L-proline
    15.
    发明授权
    Process for producing 4-hydroxy-L-proline 失效
    生产4-羟基-L-脯氨酸的方法

    公开(公告)号：US5374542A

    公开(公告)日：1994-12-20

    申请号：US39482

    申请日：1993-04-26

    申请人： Ryoichi Katsumata ,  Haruhiko Yokoi

    发明人： Ryoichi Katsumata ,  Haruhiko Yokoi

    IPC分类号： C12N1/21 ,  C12N9/12 ,  C12P13/24 ,  C12N15/09 ,  C12N15/70

    CPC分类号： C12P13/24 ,  C12N9/12

    摘要： Disclosed are a process for producing 4-hydroxy-L-proline by the conversion of 4-hydroxy-2-oxoglutaric acid in an aqueous medium in the presence of an amino group donor and an enzyme source belonging to the genus Escherichia and capable of converting 4-hydroxy-2-oxoglutaric acid into 4-hydroxy-L-proline; and a microorganism which belongs to the genus Escherichia, holds a recombinant DNA incorporating a gene coding for .gamma.-glutamylkinase released from the feedback inhibition caused by L-proline, and contains the above enzyme source.

    摘要翻译： PCT No.PCT / JP91 / 01127 Sec。 371日期：1993年4月26日 102（e）日期1993年4月26日PCT 1991年8月26日PCT公布。 公开号WO93 / 04181 日期：1993年3月4日。未公开的是通过在氨基供体和属于下列物质的酶源的情况下在水性介质中转化4-羟基-2-氧代戊二酸来生产4-羟基-L-脯氨酸的方法 能够将4-羟基-2-氧代戊二酸转化为4-羟基-L-脯氨酸; 属于埃希氏杆菌属的微生物，含有由L-脯氨酸引起的反馈抑制释放的编码γ-谷氨酰基激酶的基因的重组DNA，并含有上述酶源。

    Process for producing L-arginine
    17.
    发明授权
    Process for producing L-arginine 失效
    L-精氨酸生产方法

    公开(公告)号：US5017482A

    公开(公告)日：1991-05-21

    申请号：US99798

    申请日：1987-09-22

    申请人： Ryoichi Katsumata ,  Haruhiko Yokoi

    发明人： Ryoichi Katsumata ,  Haruhiko Yokoi

    IPC分类号： C12N15/09 ,  C12N1/20 ,  C12N1/21 ,  C12N15/00 ,  C12N15/52 ,  C12N15/67 ,  C12N15/77 ,  C12P13/10 ,  C12R1/13 ,  C12R1/15

    CPC分类号： C12P13/10 ,  C12N15/52 ,  C12N15/67 ,  C12N15/77 ,  Y10S435/84 ,  Y10S435/843

    摘要： L-arginine is produced by constructing a recombinant DNA composed of a vector DNA and a DNA fragment derived from chromosomal DNA of a microorganism belonging to the genus Corynebacterium or Brevibacterium and bearing genetic information relating to the synthesis of L-arginine-biosynthetic enzyme, introducing the recombinant DNA in a microorganism belonging to the genus Corynebacterium or Brevibacterium, culturing the microorganism in a medium, and recovering L-arginine accumulated in the culture broth.

    摘要翻译： 通过构建由载体DNA构成的重组DNA和衍生自属于棒状杆菌属或短杆菌属的微生物的染色体DNA的DNA片段，并具有与L-精氨酸 - 生物合成酶的合成有关的遗传信息，引入L-精氨酸，引入L-精氨酸 属于棒杆菌属或短杆菌属的微生物的重组DNA，在培养基中培养微生物，并回收在培养液中积累的L-精氨酸。

    Process for producing an optically active .gamma.-hydroxy-L-glutamic acid
    20.
    发明授权
    Process for producing an optically active .gamma.-hydroxy-L-glutamic acid 失效
    用于制备光学活性的γ-羟基-L-谷氨酸的方法

    公开(公告)号：US5643769A

    公开(公告)日：1997-07-01

    申请号：US501177

    申请日：1995-07-11

    申请人： Ryoichi Katsumata ,  Shinichi Hashimoto

    发明人： Ryoichi Katsumata ,  Shinichi Hashimoto

    IPC分类号： C12P13/04 ,  C12P13/14 ,  C12P41/00

    CPC分类号： C12P13/04

    摘要： An object of the present invention is to provide a process for producing an optically active .gamma.-hydroxy-L-glutamic acid advantageously on an industrial scale. The present invention provides a process for producing an optically active .gamma.-hydroxy-L-glutamic acid, which comprises allowing biocatalyst I, an amino group donor, pyruvic acid and glyoxylic acid to coexist in an aqueous medium to form the optically active .gamma.-hydroxy-L-glutamic acid in the aqueous medium, and collecting the formed optically active .gamma.-hydroxy-L-glutamic acid therefrom, said biocatalyst I having activity of forming the optically active .gamma.-hydroxy-L-glutamic acid from pyruvic acid and glyoxylic acid in the presence of an amino group donor. The present invention also provides a process for producing an optically active .gamma.-hydroxy-L-glutamic acid, which comprises allowing biocatalyst II, an amino group donor and optically active 4-hydroxy-2-ketoglutaric acid to coexist in an aqueous medium to form the optically active .gamma.-hydroxy-L-glutamic acid in the aqueous medium, and collecting the formed optically active 4-hydroxy-2-ketoglutaric acid therefrom, said biocatalyst II having activity of converting an optically active 4-hydroxy-2-ketoglutaric acid into the optically active .gamma.-hydroxy-L-glutamic acid in the presence of an amino group donor.

    摘要翻译： 本发明的目的是提供一种有利于工业规模生产光学活性的γ-羟基-L-谷氨酸的方法。 本发明提供了一种光学活性γ-羟基-L-谷氨酸的制备方法，其包括使生物催化剂I，氨基供体，丙酮酸和乙醛酸在水性介质中共存，形成光学活性的γ-羟基 -L-谷氨酸，并从其中收集形成的光学活性的γ-羟基-L-谷氨酸，所述生物催化剂I具有从丙酮酸和乙醛酸形成光学活性的γ-羟基-L-谷氨酸的活性 在氨基供体的存在下。 本发明还提供了一种制备光学活性的γ-羟基-L-谷氨酸的方法，其包括允许生物催化剂II，氨基供体和光学活性的4-羟基-2-酮戊二酸共存于水性介质中以形成 在水性介质中的光学活性的γ-羟基-L-谷氨酸，并从其中收集形成的光学活性的4-羟基-2-酮戊二酸，所述生物催化剂II具有将光学活性的4-羟基-2-酮戊二酸 在氨基供体存在下转化为光学活性的γ-羟基-L-谷氨酸。