公开(公告)号：US20200049970A1

公开(公告)日：2020-02-13

申请号：US16657473

申请日：2019-10-18

Applicant: S.D. Sight Diagnostics Ltd.

Inventor： Yochay Shlomo ESHEL ,  Natalie LEZMY ,  Dan GLUCK ,  Arnon HOURI YAFIN ,  Joseph Joel POLLAK

IPC: G02B21/36 ,  G01N21/88 ,  G06K9/00 ,  G06T7/00

Abstract: Apparatus and methods for analyzing a bodily sample are described. A microscope system acquires one or more microscope images of the bodily sample. A computer processor identifies, in the one or more images, at least one element as being a candidate of a given entity. The computer processor extracts, from the one or more images, at least one candidate-informative feature associated with the candidate of the given entity, and at least one sample-informative feature that is indicative of a characteristic of the bodily sample as a whole. The computer processor processes the candidate-informative feature in combination with the sample-informative feature, and generates an output upon the output device, in response thereto. Other applications are also described.

公开(公告)号：US20230159982A1

公开(公告)日：2023-05-25

申请号：US18100181

申请日：2023-01-23

Applicant: S.D. Sight Diagnostics Ltd.

Inventor： JOSEPH JOEL POLLAK ,  Daniel LEVNER ,  Yonatan BILU ,  Arnon HOURI YAFIN ,  Noam YORAV-RAPHAEL ,  Yuval GREENFIELD

IPC: C12Q1/68 ,  G01N1/30

CPC classification number: C12Q1/68 ,  G01N1/30

Abstract: Apparatus and methods for use with a blood sample are described. The blood sample is stained with a first dye that predominantly stains DNA, and a second dye that stains at least one other cellular component being different from DNA. A plurality of images of the blood sample are acquired. A candidate object is identified as being a candidate of a given entity. A first stained area, which is stained by the first dye and which is disposed within the candidate object, is identified. A second stained area, which is stained by the second dye and which is disposed within the candidate object, is identified. The entity is detected by determining that features of the stained areas satisfy predetermined criteria associated with the entity. Other applications are also described.

公开(公告)号：US20220390734A1

公开(公告)日：2022-12-08

申请号：US17882702

申请日：2022-08-08

Applicant: S.D. Sight Diagnostics Ltd.

Inventor： Joseph Joel POLLAK ,  Arnon HOURI YAFIN ,  Seth J. SALPETER

IPC: G02B21/34 ,  G01N1/28 ,  G01N1/38 ,  G01N21/64 ,  G02B21/00 ,  G02B21/36 ,  G02B21/16

Abstract: Apparatus and methods are described including introducing a cell suspension comprising red blood cells into a carrier that is a closed cavity that includes a base surface and a closed top, via an inlet defined by the carrier. The cells in the cell suspension are allowed to settle on the base surface of the carrier to form a monolayer of cells on the base surface of the carrier. At least one microscope image of at least a portion of the monolayer of cells is acquired. Other applications are also described.

公开(公告)号：US20220381672A1

公开(公告)日：2022-12-01

申请号：US17770365

申请日：2020-10-22

Applicant: S.D. SIGHT DIAGNOSTICS LTD.

Inventor： Sharon PECKER ,  Yochay Shlomo ESHEL ,  Amir ZAIT ,  Dan GLUCK ,  Noam YORAV-RAPHAEL ,  Arnon HOURI YAFIN ,  Sarah LEVY SCHREIER ,  Joseph Joel POLLAK ,  Daniel LEVNER ,  Yonatan HALPERIN ,  Natalie LEZMY ,  Itamar WEISS

IPC: G01N15/14 ,  G01N33/49 ,  G06V20/69

Abstract: Apparatus and methods are described including placing at least a portion of a blood sample within a sample chamber (52), and acquiring microscopic images of the portion of the blood sample. Candidates of a given entity within the blood sample are identified, within the microscopic image. At least some of the candidates as being the given entity are validated, by performing further analysis of the candidates. A count of the candidates of the given entity is compared to a count of the validated candidates of the given entity, and at least the portion of the sample is invalidated from being used for performing at least some measurements upon the sample, at least partially based upon a relationship between the count of candidates and the count of validated candidates. Other applications are also described.

公开(公告)号：US20190145963A1

公开(公告)日：2019-05-16

申请号：US16099270

申请日：2017-05-11

Applicant: S.D. Sight Diagnostics Ltd.

Inventor： Amir ZAIT ,  Arnon HOURI YAFIN ,  Dan GLUCK ,  Sharon PECKER ,  Yochay Shlomo ESHEL ,  Sarah LEVY SCHREIER ,  Joseph Joel POLLAK

IPC: G01N33/50 ,  G01N33/49 ,  G01N33/569 ,  G01N15/06

Abstract: Apparatus and methods are described for use with a blood sample (48, 50), including measuring hemoglobin concentration within at least a portion (48) of the blood sample, by performing a first measurement on the blood sample. Mean corpuscular hemoglobin in the blood sample (48, 50) is measured, by performing a second measurement on the blood sample (48, 50). A parameter of the blood sample is determined, based on a relationship between the concentration of hemoglobin and the mean corpuscular hemoglobin. Other applications are also described.

公开(公告)号：US20190002950A1

公开(公告)日：2019-01-03

申请号：US16106085

申请日：2018-08-21

Applicant: S.D. SIGHT DIAGNOSTICS LTD.

Inventor： Joseph Joel POLLAK ,  Arnon HOURI YAFIN ,  Seth J. SALPETER

IPC: C12Q1/04 ,  G01N21/64 ,  G01N1/38 ,  G01N1/28 ,  G01N15/14

Abstract: Apparatus and methods are described including introducing a cell suspension comprising red blood cells into a carrier that is a closed cavity that includes a base surface, via an inlet defined by the carrier. The cells in the cell suspension are allowed to settle on the base surface of the carrier to form a monolayer of cells on the base surface of the carrier. At least one microscope image of at least a portion of the monolayer of cells is acquired. Other applications are also described.

公开(公告)号：US20180246313A1

公开(公告)日：2018-08-30

申请号：US15760782

申请日：2016-09-15

Applicant: S.D. SIGHT DIAGNOSTICS LTD

Inventor： Yochay Shlomo ESHEL ,  Natalie LEZMY ,  Dan GLUCK ,  Arnon HOURI YAFIN ,  Joseph Joel POLLAK

IPC: G02B21/36 ,  G01N21/88 ,  G06T7/00 ,  G06K9/00

CPC classification number: G02B21/367 ,  G01N21/8851 ,  G01N2021/8887 ,  G02B21/365 ,  G06K9/00134 ,  G06K9/00147 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/30024 ,  G06T2207/30101

Abstract: Apparatus and methods are described including a microscope system (11) configured to acquire one or more micro scope images of a bodily sample, an output device (34), and at least one computer processor (28). The computer processor identifies, in the one or more images, at least one element as being a pathogen candidate, and extracts, from the one or more images, at least one candidate-informative feature associated with the pathogen candidate. The compute processor extracts, from the one or more images, at least one sample-informative feature that is indicative of contextual information related to the bodily sample. The computer processor classifies a likelihood of the bodily sample being infected with a pathogenic infection, by processing the candidate-informative feature in combination with the sample-informative feature, and generates an output upon the output device, in response thereto. Other applications are also described.