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11.发明公开公开(公告)号：US20230384205A1
公开(公告)日：2023-11-30
申请号：US18248566
申请日：2021-11-09
Applicant: SCOPIO LABS LTD.
Inventor： Shahar KARNY , Ben LESHEM , Erez NA'AMAN , Eran SMALL , Itai HAYUT
CPC classification number: G01N15/1434 , G06T7/0012 , G06T3/4053 , G06V20/698 , G06V20/693 , G02B21/008 , G01N2015/008
Abstract: A microscope system for full field morphology analysis may include an optical scanning apparatus to scan the sample with an effective numerical aperture of at least 0.8, and a processor coupled to the scanning apparatus. The processor may be configured to: scan the sample with the optical scanning apparatus to produce a plurality of images of the sample, the plurality of images comprising at least 500 blood cells, analyze the plurality of images to determine at least 10 morphology parameters for each of the at least 500 blood cells, and output the at least 10 morphology parameters. The microscope system may include a display for presenting data. Various other systems and methods are provided.
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公开(公告)号：US20210149169A1
公开(公告)日：2021-05-20
申请号：US17098058
申请日：2020-11-13
Applicant: SCOPIO LABS LTD.
Inventor： Ben LESHEM , Eran SMALL , Erez NA'AMAN , Ittai MADAR
Abstract: A microscope for computational microscopic layer separation may include an imaging device that includes a lens and an image sensor, an illumination system for illuminating a sample, and an actuator to adjust an axial position of a focal plane with respect to the sample. The microscope may also include a processor operatively coupled to the imaging device and the illumination system. The processor may be configured to measure, using the image sensor and the illumination system, optical aberrations of the imaging device at the axial position, and determine whether to adjust the focal plane with respect to the sample in response to the one or more optical aberrations. Various other systems and methods are also disclosed.
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公开(公告)号：US20200278362A1
公开(公告)日：2020-09-03
申请号：US16875665
申请日：2020-05-15
Applicant: SCOPIO LABS LTD.
Inventor： Itai HAYUT , Erez NA'AMAN , Eran SMALL
Abstract: A microscope system may comprise a plurality of microscope modules, a cassette for holding a plurality of slides, a slide loader configured to move the plurality of slides between the cassette and the plurality of microscope modules, and a processor coupled to the slide loader. The processor may be configured with instructions which, when executed, cause the slide loader to move a slide into or from a selected microscope module among the plurality of microscope modules. Various other methods, systems, and computer-readable media are also disclosed.
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公开(公告)号：US20180120553A1
公开(公告)日：2018-05-03
申请号：US15795150
申请日：2017-10-26
Applicant: Scopio Labs Ltd.
Inventor： Ben LESHEM , Itai HAYUT , Erez NA'AMAN , Eran SMALL
CPC classification number: G02B21/365 , G01N21/17 , G01N21/25 , G02B21/14 , G02B21/34 , G02B21/367 , G16H30/40
Abstract: Disclosed herein are systems and methods for constructing an image of a sample using a plurality of images acquired under multiple illumination conditions. In some cases, a microscope may include an image capture device, an illumination assembly, and a processor configured to acquire a plurality of images of a sample and a fiducial marker under a plurality of different illumination conditions and to reconstruct a high resolution image in response to the plurality of images. The disclosure also provides a method for generating a high resolution image of a sample comprising acquiring a plurality of images of a sample and a fiducial marker under a plurality of different illumination conditions and reconstructing the high resolution image in response to the plurality of images.
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公开(公告)号：US20240420828A1
公开(公告)日：2024-12-19
申请号：US18705277
申请日：2022-11-17
Applicant: SCOPIO LABS LTD.
Inventor： Ittai MADAR , Ben LESHEM , Erez NA'AMAN , Eran SMALL
Abstract: An apparatus configured to process a sample to detect a pathogen receives a slide with the sample on the slide, in which the sample has been stained with one or more of a Gram stain, an Acid-Fast stain, or a Giemsa stain. An area of at least 5 mm2 of the sample is imaged at a rate of at least 15 mm2 per minute and a resolution of 0.3 pm or better to generate one or more images. The one or more images of the sample are processed with a classifier configured to detect the pathogen in the sample. In some embodiments, a plurality of cultured and stained samples on a plurality of slides are imaged at the resolution and processed with the classifier, which can increase the area processed and analyzed in order to decrease the culture time and corresponding time to diagnose the patient.
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Patent Agency Ranking
公开(公告)号：US20220415480A1
公开(公告)日：2022-12-29
申请号：US17755356
申请日：2020-11-15
Applicant: SCOPIO LABS LTD.
Inventor： Ben LESHEM , Eran SMALL , Erez NA'AMAN , Itai HAYUT , Shahar KARNY , Ofek AIZENMAN
Abstract: A microscope system for scanning a bone marrow aspirate (BMA) sample may include a scanning apparatus for scanning the BMA sample and a processor coupled to the scanning apparatus and a memory. The microscope system may obtain, using the scanning apparatus, scan data of the BMA sample and detect cells in the BMA sample from the scan data. The microscope system may also classify the detected cells into a plurality of cell types, and store, in the memory, cell data of the classified cells. The microscope system may include a display for presenting the cell data. Various other systems and methods are provided.
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公开(公告)号：US20220350129A1
公开(公告)日：2022-11-03
申请号：US17812374
申请日：2022-07-13
Applicant: SCOPIO LABS LTD.
Inventor： Ittai MADAR , Eran SMALL , Itai HAYUT , Erez NA'AMAN
Abstract: A microscope comprising an illumination assembly, an image capture device and a processor can be configured to selectively identify regions of a sample comprising artifacts or empty space. By selectively identifying regions of the sample that have artifacts or empty space, the amount of time to generate an image of the sample and resources used to generate the image can be decreased substantially while providing high resolution for appropriate regions of the computational image. The processor can be configured to change the imaging process in response to regions of the sample that comprises artifacts or empty space. The imaging process may comprise a higher resolution process to output higher resolution portions of the computational image for sample regions comprising valid sample material, and a lower resolution process to output lower resolution portions of the computational image for sample regions comprising valid sample material.
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公开(公告)号：US20190384962A1
公开(公告)日：2019-12-19
申请号：US16338668
申请日：2017-10-26
Applicant: SCOPIO LABS LTD.
Inventor： Itai HAYUT , Erez NA'AMAN , Eran SMALL , Chen BRESTEL
Abstract: Methods and systems are provided for improved imaging and analyzing of a sample with a large field-of-view at a high image resolution. A diagnostic system may comprise: a microscope comprising a low collection numerical aperture (NA); an imaging device coupled to the microscope; and a processor coupled to the imaging device. The imaging device may be configured to capture a plurality of low-resolution images of a region of a sample viewed by the microscope. The region of the sample may comprise cells. The processor may comprise instructions configured to reconstruct a high-resolution image of the region of the sample using the plurality of low-resolution images. The processor may further comprise instructions configured to analyze a spatial field of the high-resolution image to identify at least one of a cell type or a cell structure of at least one of the cells of the region of the sample.
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公开(公告)号：US20180373016A1
公开(公告)日：2018-12-27
申请号：US15774855
申请日：2016-11-10
Applicant: SCOPIO LABS LTD.
Inventor： Ben LESHEM, III , Eran SMALL , Ittay MADAR , Erez NAAMAN , Itai HAYUT
Abstract: A microscope includes an illumination assembly configured to illuminate a sample under two or more different illumination conditions, at least one image capture device configured to capture image information associated with the sample at each of the two or more different illumination conditions, at least one processing device programmed to generate an image of the sample based on a combination of image information captured at each of the two or more different illumination conditions, and at least one refractive index matching material between the illumination assembly and the sample. The refractive index matching material is different from a medium between the at least one image capture device and the sample.
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公开(公告)号：US20180329194A1
公开(公告)日：2018-11-15
申请号：US15775370
申请日：2016-11-10
Applicant: Scopio Labs Ltd.
Inventor： Eran SMALL , Ittay MADAR , Chen BRESTEL , Erez NAAMAN
Abstract: Systems and methods are disclosed for focusing a microscope using images acquired under multiple illumination conditions. In one implementation, an autofocus microscope may include an image capture device, a focus actuator, an illumination assembly, and a controller. The controller may cause the illumination assembly to illuminate a sample at a first illumination condition and at a second illumination condition. The controller may acquire a first image of the sample illuminated from the first illumination angle and a second image of the sample illuminated from the second illumination angle. The controller may further determine an amount of shift between image features present in the first image of the sample and a corresponding image features present in the second image of the sample, If the amount of determined shift is non-zero, the focus actuator may change the distance between the sample and the focal plane.
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