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81 条记录 (耗时 0.043 秒)

    REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES
    13.
    发明申请
    REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES 审中-公开
    用于提供表面涂层的试剂和方法

    公开(公告)号：US20120004339A1

    公开(公告)日：2012-01-05

    申请号：US13234270

    申请日：2011-09-16

    申请人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    发明人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    IPC分类号： C08F8/00

    CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

    摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

    摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

    Reagent and method for providing coatings on surfaces
    14.
    发明授权
    Reagent and method for providing coatings on surfaces 失效
    用于在表面上提供涂层的试剂和方法

    公开(公告)号：US07736689B2

    公开(公告)日：2010-06-15

    申请号：US11846955

    申请日：2007-08-29

    申请人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    发明人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    IPC分类号： A61L33/00

    CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

    摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

    摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

    Catheter assembly
    16.
    发明授权
    Catheter assembly 有权

    公开(公告)号：US10596355B2

    公开(公告)日：2020-03-24

    申请号：US13173164

    申请日：2011-06-30

    申请人： Ralph A. Chappa

    发明人： Ralph A. Chappa

    IPC分类号： A61M25/10

    摘要： A catheter assembly includes an expandable and collapsible structure having an outer surface. The expandable and collapsible structure is adapted to expand between a contracted state and a dilated state. A coating is disposed on the outer surface of the expandable and collapsible structure. The coating includes a bioactive agent. A sleeve is disposed over the coating. The sleeve is adapted to expand between a compressed state and an enlarged state and to return to the compressed state. The sleeve defines a plurality of openings in the compressed state. An outer diameter of the coating is less than an outer diameter of the sleeve when the expandable and collapsible structure is in the contracted state and greater than the outer diameter of the sleeve when the expandable and collapsible structure is in the dilated state.

    Method and apparatus for coating balloon catheters
    17.
    发明授权
    Method and apparatus for coating balloon catheters 有权
    球囊导管涂敷方法及装置

    公开(公告)号：US09295820B2

    公开(公告)日：2016-03-29

    申请号：US12583112

    申请日：2009-08-14

    申请人： Ralph A. Chappa ,  Mark F. Carlson

    发明人： Ralph A. Chappa ,  Mark F. Carlson

    IPC分类号： B05D7/00 ,  B05B1/00 ,  A61M25/10 ,  B05B13/02 ,  B05D1/00 ,  B05C13/00 ,  B05D1/02

    CPC分类号： A61M25/1029 ,  A61M25/1018 ,  A61M25/1027 ,  A61M2025/1031 ,  A61M2025/105 ,  B05B13/0214 ,  B05B13/0228 ,  B05C13/00 ,  B05D1/002 ,  B05D1/02 ,  B05D3/12

    摘要： A coating apparatus for coating the balloon portion of a balloon catheter is described. The coating apparatus includes a rotatable member in which the catheter portion of the balloon catheter is mounted and fixed, and which causes rotation of the balloon catheter. The apparatus also includes a support member in which the distal tip of the catheter is inserted and free to rotate; and a spray nozzle directing sprayed material on the balloon surface. The inventive configuration of the coating apparatus allows the balloon catheter to be rotated along its axis with insubstantial or no wobble, which significantly improves the quality of the coating applied to the surface of the balloon.

    摘要翻译： 描述了一种用于涂覆球囊导管的球囊部分的涂覆装置。 涂覆装置包括可旋转构件，其中气囊导管的导管部分被安装和固定，并且引起气囊导管的旋转。 该装置还包括支撑构件，其中导管的远侧末端插入并自由旋转; 以及将喷射材料引导到气球表面上的喷嘴。 涂覆装置的本发明构造允许球囊导管沿着其轴线旋转，具有非实质或无摆动，这显着地改善了施加到气球表面的涂层的质量。

    Catheter assembly with guard
    18.
    发明授权
    Catheter assembly with guard 有权
    导管总成与守卫

    公开(公告)号：US08961457B2

    公开(公告)日：2015-02-24

    申请号：US13248462

    申请日：2011-09-29

    申请人： Ralph A. Chappa

    发明人： Ralph A. Chappa

    IPC分类号： A61M37/00 ,  A61M25/10 ,  A61M25/00

    CPC分类号： A61M25/10 ,  A61M2025/0057 ,  A61M2025/105 ,  A61M2025/1081

    摘要： A catheter assembly includes an expandable and collapsible structure having an outer surface. The expandable and collapsible structure is adapted to expand between a contracted state and a dilated state. A guard is bonded to the outer surface of the expandable and collapsible structure. The guard and the expandable and collapsible structure cooperatively define a plurality of reservoirs. A coating disposed in the reservoirs. The coating includes a bioactive agent. The coating protrudes from the reservoirs when the expandable and collapsible structure is expanded to the dilated state.

    摘要翻译： 导管组件包括具有外表面的可膨胀和可折叠结构。 可膨胀和可折叠结构适于在收缩状态和膨胀状态之间膨胀。 防护件结合到可膨胀和可折叠结构的外表面。 护罩和可膨胀和可折叠结构协同地限定了多个储存器。 设置在储存器中的涂层。 涂层包括生物活性剂。 当可膨胀和可折叠结构膨胀到膨胀状态时，涂层从储存器突出。