摘要:
A bone-related carboxypeptidase-like protein named OSF-5 which is obtained from bone tissue of a mammal including mouse or human, and a process for its production. This protein is a novel naturally occurring mammal protein which belongs to a group of carboxypeptidase molecules.OSF-5 acts as an adhesion molecule or a growth factor which takes part in the process of osteogenesis at the site of bone induction. OSF-5 can be used as an agent for treating bone metabolic diseases, and its high organ specificity for bones enables its use as a diagnostic reagent for bone metabolic diseases.
摘要:
Disclosed are two PTH analog ligands, SP-PTH-AAK and Aib-SP-PTH-AAK, that have long-acting activity at the PTH receptor, as demonstrated both in vitro and in vivo. These polypeptides are thus particularly useful in the treatment of diseases, such as hypoparathyroidism, in which long-acting activity is desired. The method of making the analog polypeptides is also disclosed.
摘要:
The present invention provides screening methods for GPCRs based on the discovery that the affinity of a receptor agonist for a GPCR (such as the parathyroid hormone receptor) when not bound to a G-protein is correlated with the length of time over which the agonist is effective, independently of its pharmacokinetic properties. The invention also provides PTH- and PTHrP-derived polypeptides.
摘要:
An optical disc recording and reproducing apparatus for recording and reproducing data in and from an optical disc by the use of the optical disc as a recording medium, comprises analog processing means including a binarization unit for subjecting a signal read from the optical disc to binarization and a servo unit for controlling recording and reproducing a signal in and from the optical disc; synchronous clock generating means for generating a synchronous clock signal which is synchronized with the signal read from the optical disc; address detecting means for detecting address information indicating a physical position on the optical disc based on the signal read from the optical disc, and outputting a signal indicating the address information and a signal indicating that the address has been detected when the address information has been detected; a sector counter for holding a sector count value of a sector as a recording unit on the optical disc, and updating the sector count value according to the synchronous clock signal and the signal output from the address detecting means; and gate signal generation switching means for generating gate a signal which controls the analog processing means, based on one of the sector count value held in the sector counter and information obtained from the analog processing means, according to the signal indicating that the address has been detected, which is output from the address detecting means.
摘要:
A digital data demodulator which can reduce a loss of decodable digital data, and increase capability of reproducing digital data inputted through a transmission line even when an error occurs in the transmission line. In the digital data demodulator, a specific pattern detector (113) detects a specific pattern to be included in a modulation code, from a bit string inputted through a transmission line (104). A modulation code identifying unit (117) generates a demodulation data strobe signal (119) according to a phase of the modulation code including the specific pattern. An error corrector (121) samples demodulation data (109) in response to the demodulation data strobe signal (119) and reproduces the data to the original digital data.
摘要:
To provide an optical disk drive having an enhanced replaying capability in case of an abnormality occurring in various kinds of synchronization of the optical disk drive or in replay of a defective sector.A frame synchronization counter value address translation decoder 202, low order ID address translation decoder 203, adder/subtracter 204, high order ID address translation decoder 205, and adder 206 are used to translate information read from an optical disk medium into an absolute storage address in a storage medium, and thus data that is highly replayed can be stored in the storage medium.
摘要:
A fast synchronization pull-in and an optimum error correction are achieved in a reproduction apparatus for reproducing data recorded on a recording medium even in the case where the quality of input data involving a seek or defect is low. A seek amount detection block 190 is provided, a seek change signal 201 is generated, and the width of a synchronization detection window pulse 161 and a correction algorithm in a correction block 230 are modified.
摘要:
A voice recording/reproducing apparatus in accordance with the present invention includes a recording medium, a recording unit, a playback unit, and a reproduction manipulating unit. The recording unit records by voice the items of a schedule for each day on the recording medium. The playback unit reproduces by voice the items of a schedule for each day which are recorded on the recording medium. The playback manipulating unit is used to designate a day of a year for which a schedule must be played back, and to instruct the playback unit to play back the items of the schedule for the designated day. The recording unit can record a plurality of schedule items as the items of a schedule for each day. All the schedule items for the designated day are played back responsive to one manipulation performed on the playback manipulating unit.
摘要:
An optical disc recording and reproducing apparatus for recording and reproducing data in and from an optical disc by the use of the optical disc as a recording medium, comprises analog processing means including a binarization unit for subjecting a signal read from the optical disc to binarization and a servo unit for controlling recording and reproducing a signal in and from the optical disc; synchronous clock generating means for generating a synchronous clock signal which is synchronized with the signal read from the optical disc; address detecting means for detecting address information indicating a physical position on the optical disc based on the signal read from the optical disc, and outputting a signal indicating the address information and a signal indicating that the address has been detected when the address information has been detected; a sector counter for holding a sector count value of a sector as a recording unit on the optical disc, and updating the sector count value according to the synchronous clock signal and the signal output from the address detecting means; and gate signal generation switching means for generating gate a signal which controls the analog processing means, based on one of the sector count value held in the sector counter and information obtained from the analog processing means, according to the signal indicating that the address has been detected, which is output from the address detecting means.
摘要:
A digital data demodulator which can reduce a loss of decodable digital data, and increase capability of reproducing digital data inputted through a transmission line even when an error occurs in the transmission line. In the digital data demodulator, a specific pattern detector (113) detects a specific pattern to be included in a modulation code, from a bit string inputted through a transmission line (104). A modulation code identifying unit (117) generates a demodulation data strobe signal (119) according to a phase of the modulation code including the specific pattern. An error corrector (121) samples demodulation data (109) in response to the demodulation data strobe signal (119) and reproduces the data to the original digital data.